簡歷
同年進入上海有機化學研究所攻讀博士學位，並於2003年獲得結構生物學專業博士學位。在2004年5月加入了明尼蘇達大學Kylie Walters博士的研究小組，開始博士後研究工作，並於2008年升職為助理研究員。2010 年作為中國科學院“百人計畫”入選者加入上海藥物研究所分析化學研究室。主要研究方向為運用NMR技術和計算機分子模擬技術研究蛋白質與蛋白質分子之間以及蛋白質與有機小分子之間的相互作用。
研究方向
運用NMR技術和計算機分子模擬技術研究蛋白質與蛋白質分子之間以及蛋白質與有機小分子之間的相互作用。
專家類別
研究員；百人計畫
職務
研究員
代表論著
Zhang, N.X., Walters, K.J.: “Insights into how protein dynamics affects arylamine N-acetyltransferase catalysis,” Biochemical and Biophysical Research Communications
Zhang N.X., Wang Q., Ehlinger A., Randles L., Lary J.W., Kang Y., Haririnia A., Storaska A.J., Cole J.L., Fushman D., Walters K.J.: “Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13,” Molecular Cell
Husnjak, K.*, Elsasser, S.*, Zhang, N.X.*, Chen, X., Randles, L., Shi, Y., Hofmann, K., Walters, K.J., Finley, D., Dikic, I.: “Proteasome subunit Rpn13 is a novel ubiquitin receptor,” Nature *Co-first authors
Zhang, N.X., Liu, L., Liu, F., Wagner, C.R., Hanna, P.E., Walters, K.J.: “NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity,“ Journal of Molecular Biology
Li, M.H.*, Zhang, N.X.*, Chen, X.Q., Wu, G., Wu, H.M., Hu, G.Y.: “Purification and pharmacological characterization of BmKK2 (alpha-KTx 14.2), a novel potassium channel-blocking peptide, from the venom of Asian scorpion Buthus martensi Karsch,” Toxicon*Co-first authors
Zhang, N.X., Wu, G., Wu, H.M., Chalmers, M.J., Gaskell, S.J.: “Purification, characterization and sequence determination of BmKK4, a novel potassium channel blocker from Chinese scorpion Buthus martensi Karsch,” Peptides
Zhang, N.X., Chen, X., Li, M.H., Cao, C.Y., Wang, Y.F., Wu, G., Hu, G.Y., Wu, H.M.: “Solution structure of BmKK4, the first member of subfamily α-KTx 17 of scorpion toxins,” Biochemistry
Zhang, N.X., Li, M.H., Chen, X., Wang, Y.F., Wu, G., Hu, G.Y., Wu, H.M.: “Solution structure of BmKK2, a new potassium channel blocker from the venom of Chinese scorpion Buthus martensi Karsch,” Proteins: Structure, Function, and Bioinformatics
