人物經歷
安徽農業大學理學院副教授2003年9月至2006年7月在華中科技大學物理學院生物物理學專業攻讀碩士學位，主要從事非編碼DNA序列的算法設計和數學建模；2007年8月至2010年7月在哈爾濱醫科大學生物信息科學與技術學院生物信息學專業攻讀博士學位，
主講課程
為本科生、研究生系統講授《生物信息學》、《生物統計學》、《食品實驗設計與數據分析》等課程。
研究方向
植物（茶樹）逆境和品質成分相關的計算系統生物學、功能基因組學以及化學信息學等方向，近階段尤其關注二代測序（新一代測序）多層面組學數據的整合分析
主要貢獻
作為主要參與人，參加全國農林院校“十二五”規劃教材《生物信息學》的編寫，農業出版社。
科研項目
1）基於網路建模解析水稻在不同非生物逆境下miRNA的串擾調控關係(國家自然科學青年基金，31301248)
2）植物非生物逆境下microRNA網路調控機制分析平台的構建(中國博士後科學基金面上項目，2013M531498）
3）2014年安徽農業大學生物統計學學科點學科骨幹培育項目（2014XKPY-37)
4）基於文本挖掘的人類遺傳疾病的相關性研究（11541298，黑龍江省教育廳科學技術研究項目）
論文論著
First-author and corresponding papers:
1）Shihua Zhang*, Hongdong Xuan*, Liang Zhang, Sicong Fu, Yijun Wang, Hua Yang, Yuling Tai, Youhong Song, Jinsong Zhang, Chi-Tang Ho, Shaowen Li andXiaochun Wan, TBC2health: a database of experimentally validated health-beneficial effects of tea bioactive compounds,Briefings in Bioinformatics 2016, doi: 10.1093/bib/bbw055
2) Linzhong Zhang, Hongdong Xuan, Yongchun Zuo, Gaojian XuPing Wang, Youhong Song,Shihua Zhang*,Topologicalcharacteristicsoftargetgenesregulatedbyabiotic-stress-responsiblemiRNAsinariceinteractomenetwork,Functional& Integrative Genomics 2016 DOI: 10.1007/S10142-016-0481-4 (通訊)
3) Hongdong Xuan, Linzhong Zhang, Xueshi Liu, Guomin Han, Juan Li, Xin Li, Aiguo Liu, Mingzhi Liao,Shihua Zhang*, PLNlncRbase: a resource for experimentally identified lncRNAs in plants,Gene2015, 573, 328-332 (通訊)
4) Leijie Li, Liangcai Zhang, Guiyou Liu, Rennan Feng, Lei Yang,Shihua Zhang*, Mingzhi Liao*, and Jinlian Hua*, Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks,PLoS ONE2014 9(8): e105180. doi:10.1371/journal.pone.0105180 (通訊)
5) Hongdong Xuan, Xin Li, Shenrong Ren,Shihua Zhang*, Modular organization of the human disease genes:a text-based network inference,Bioinformation2015,11(9): 432-436 (通訊)
6)Shihua Zhang, Yi Yue, Liang Sheng, Yunzhi Wu, Guohua Fan, Ao Li, Xiaoyi Hu, Mingzhu ShangGuan and Chaoling Wei*, PASmiR: a literature-curated database for miRNA molecular regulation in plant response to abiotic stress,BMC plant biology2013, 13 (33), 1-8
7)Shihua Zhang, Jing Xu, Chaoling Wei*, Sequence periodic pattern of HERV LTRs: A matrix simulation algorithm,Journal of biosciences2012, 37(1), 1-6
8)Shihua Zhang, Chunyu Wang, Bo Xi, Xia Li*, Association between tumor necrosis factor-α-308G/A polymorphism and chronic obstructive pulmonary disease: An update, Respirology2011, 16, 107-115
9)Shihua Zhang, Chao Wu, Xia Li*, Xi Chen, Wei Jiang, Binsheng Gong, Jiang Li , Yuqing Yan, From phenotype to gene: detecting disease-specific gene functional modules via a text-based disease phenotype network construction, FEBS letters2010, 584, 3635-3643
10)Shihua Zhangand Yi Xiao*, Quasiperiodic property in Alu repeats,Physical Review E2006, 74, 022901-4
Co-authorpapers:
11）Yuan Yang, Wenjing Wang, Liangcai Zhang,Shihua Zhang, Guiyou Liu, Yingcui Yu, Mingzhi Liao, Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer, Oncotarget. 2016 Mar 18. doi: 10.18632/oncotarget.8186.
12) Yongchun Zuo, Wenxia Su,Shihua Zhang, Shanshan Wang, Chengyan Wu, Lei Yang, Guangpeng Li, Discrimination of membrane transporter protein types using K-nearest neighbor method derived from similarity distance of total diversity measure,Molecular BioSystems2015 11(3):950-7.
13）Wei Liu, Xuefeng Bai, Yuejuan Liu, Wei Wang, Junwei Han, Qiuyu Wang, Yanjun Xu, Chunlong Zhang,Shihua Zhang, Xuecang Li, Zhonggui Ren, Jian Zhang, Chunquan Li, Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case,Scientific Reports, 2015, 5:1-15
14）Liang Zhang, Yuhui Han, Jinjun Shan, Yuhong Liang, Liwei Xu,Shihua Zhang, JunSong Li, Xiaochun Wan, Simultaneous determination of seven catechins in rat plasma by ultra-high performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetics study,Analytical Methods2015, 7(22), 9415-9420
15）Chao Wu, Fan Zhang, Xia Li,Shihua Zhang, Jiang Li, Fei Su, Kongning Li, Yuqing Yan, Composite functional module inference: detecting cooperation between transcriptional regulation and protein interaction by mantel test,BMC Systems Biology2010, 4:82
Conference papers:
16)Shihua Zhang, Mingzhi Liao, Xia Li*, The modular property implied in the human disease gene network,The 5th International Conference on Frontier of Computer Science and Technology - Workshop on Bioinformatics and System Biology, Start Page 58, Wuhan, June 4-6, 2010
17)Shihua Zhang, Chao Wu, Xia Li*, Mingzhi Liao, Yuqing Yan, Sequence periodicity of human endogenous retroviruses,The 5th International Conference on Frontier of Computer Science and Technology - Workshop on Bioinformatics and System Biology, Start Page 47, Wuhan, June 4-6, 2010
