司大勇

司大勇，男，1978年出生，現為林大學生命科學學院講師。

司大勇博士，1978年出生,
吉林大學生命科學學院講師。
主要研究領域為藥物代謝酶，在周慧教授的領導下，與鍾大方教授課題組合作，在國際上首先發現了CYP2C9*13的存在，此突變型之後在日韓也被發現；發現格列奇特由cyp2c19代謝，糾正了文獻報導的錯誤。
還發現了黃酮類化合物對CYP2C9的廣泛抑制作用
在國際著名刊物發表多篇學術論文，有一定影響：
Si Dayong, Guo Yingjie, Zhang Yifan, Yang Lei, Zhou Hui*, zhong Dafang. Identification of a novel variant CYP2C9 allele in Chinese.Pharmacogenetics (Pharmacogenetics and Genomics). 2004 Jul;14(7):465-9.
Zhang Yifan, Zhong Dafang*, Si Dayong, Guo Yingjie, Chen Xiaoyan, Zhou Hui. Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. Br J Clin Pharmacol. 2005 Jan;59(1):14-7.
Guo Yingjie, Zhang Yifan, Wang Ying, Chen Xiaoyan, Si Dayong, Zhong Dafang, Fawcett JP, Zhou Hui*. Role of CYP2C9 and its variants (CYP2C9*3 and CYP2C9*13) in the metabolism of lornoxicam in human. Drug Metab Dispos. 2005 Jun;33(6):749-53.
Guo Yingjie, Wang Ying, Si Dayong, Fawcett PJ, Zhong Dafang, Zhou Hui*. Catalytic activities of human cytochrome P450 2C9*1, 2C9*3 and 2C9*13. Xenobiotica 2005 Sep 1;35(9):853-861.
Zhang Yifan, Chen Xiaoyan, Guo Yingjie, Si Dayong, Zhong Dafang*, Zhou Hui. Impact of cytochrome P450 CYP2C9 variant allele CYP2C9*3 on the Pharmacokinetics of glibenclamide and Lornoxicam in Chinese subjects, 藥學學報 2005, 40(9):796-799
Zhou Yihan; Zheng Qingchuan; Li Zesheng*; Zhang Yuan; Sun Miao; Sun Chia-Chung; Si Dayong; Cai Lei; Guo Yingjie; Zhou Hui*,
On the human CYP2C9 variant *13 activity reduction: a molecular, dynamics simulation and docking study, Biochimie, 2006 Volume 88, Issue 10, :1457-1465　
Yifan Zhang, Dayong Si, Xiaoyan Chen, Nan Lin, Yingjie Guo, Hui Zhou, Dafang Zhong* Impacts of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects, The British Journal of Clinical Pharmacology,2007 Jul;64(1):67-74.
Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou*, Ze-Sheng Li, and J. Paul Fawcett，Mechanism of CYP2C9 Inhibition by Flavones and Flavonols ，Drug Metabolism and Disposition 2009 37: 629-634.
Ruimei Yuan , Xianwei Zhang , Qian Deng , Dayong Si, Yuan Wu , Feng Gao&
Biyun Zhou，Two novel SCN9A gene heterozygous mutations may cause partial deletion of pain perception，Pain Medicine, In Press
主持國家自然科學基金 ：81102508 和 兩項教育部自然科學基本科研業務費