個人經歷
2003年在山東師範大學化學化工與材料科學學院取得學士學位,2009年初從中國科學院長春套用化學研究所、電分析化學國家重點實驗室獲得博士學位,獲中科院劉永齡獎學金特別獎。2009至2015年先後在丹麥奧胡斯大學化學系、交叉學科納米中心以及以色列耶路撒冷希伯來大學化學研究所、納米科學與技術中心做博士後研究工作。2015年加入武漢大學化學與分子科學學院,任教授、博導,入選國家青年千人計畫(2015)。
研究領域
感測界面、生物分析、功能化納米/生物材料、納米生物技術與納米藥物。包括核酸結構的組裝、調控及套用;納米感測體系的構築與性能研究;功能化生物材料的構建及套用等。相關成果發表在J.Am.Chem.Soc.,Angew.Chem.Int.Ed.(VIP論文),ACSNano,NanoLett.,Adv.Mater.,Anal.Chem.,Acc.Chem.Res.等國際知名期刊,其中有8篇入選ESI高引用文章,授權專利5項。
歡迎具有化學、生物或材料背景的本科生、研究生和博士後加入我們研究小組。
論文與專利
部分論文
1.FuanWang†,XiaoqingLiu†,ItamarWillner*,DNASwitches:FromPrinciplestoApplications.Angew.Chem.Int.Ed.2015,54,1098-1129.(†EqualContribution)
2.XiaoqingLiu,Chun-HuaLu,ItamarWillner*,SwitchableReconfigurationofNucleicAcidNanostructuresbyStimuli-ResponsiveDNAMachines.Acc.Chem.Res.2014,47,1673–1680.
3.LianzheHu†,XiaoqingLiu†,AlessandroCecconello,ItamarWillner*,DualSwitchableCRET-InducedLuminescenceofCdSe/ZnSQuantumDots(QDs)bytheHemin/G-Quadruplex-BridgedAggregationandDeaggregationofTwo-SizedQDs.NanoLett.2014,14,6030-6035.(†EqualContribution)
4.FuanWang,Chun-HuaLu,XiaoqingLiu,LinaFreage,ItamarWillner*,AmplifiedandMultiplexedDetectionofDNAUsingtheDendriticRollingCircleAmplifiedSynthesisofDNAzymeReporterUnits.Anal.Chem.2014,86,1614–1621.
5.Chun-HuaLu,Xiu-JuanQi,XiaoqingLiu,SimchaShimron,Huang-HaoYang,ItamarWillner*,AutonomousControlofInterfacialElectronTransferandtheActivationofDNAMachinesbyanOscillatorypHSystem.NanoLett.2013,13,4920–4924.
6.XiaoqingLiu,FuanWang,RuthAizen,OmerYehezkeli,ItamarWillner*,GrapheneOxide/NucleicAcid-StabilizedSilverNanoclusters:FunctionalHybridMaterialsforOpticalAptamerSensingandMultiplexedAnalysisofPathogenicDNAs.J.Am.Chem.Soc.2013,135,11832–11839.
7.FuanWang,XiaoqingLiu,Chun-HuaLu,ItamarWillner*,Cysteine-MediatedAggregationofAuNanoparticles:TheDevelopmentofaH2O2SensorandOxidase-BasedBiosensors.ACSNano,2013,7,7278–7286.
8.GiladPelossof,RanTel-Vered,XiaoqingLiu,ItamarWillner*,SwitchableMechanicalDNA“Arms”OperatingonNucleicAcidScaffoldsAssociatedwithElectrodesorSemiconductorQuantumDots.Nanoscale,2013,5,8977–8981.
9.XiaoqingLiu,FuanWang,AngelicaNiazov-Elkan,WeiweiGuo,ItamarWillner*,ProbingBiocatalyticTransformationswithLuminescentDNA/AgNanoclusters.NanoLett.2013,13,309–314.
10.XiaoqingLiu,AngelicaNiazov-Elkan,FuanWang,ItamarWillner*,SwitchingPhotonicandElectrochemicalFunctionsofaDNAzymebyDNAMachines.NanoLett.2013,13,219–225.
11.FuanWang,XiaoqingLiu,ItamarWillner*,IntegrationofPhotoswitchableProteins,PhotosyntheticReactionCentersandSemiconductor/BiomoleculeHybridswithElectrodeSupportsforOptobioelectronicApplications.Adv.Mater.2013,25,349–377.
12.XiaoqingLiu,RuthAizen,RonitFreeman,OmerYehezkeli,ItamarWillner*,MultiplexedAptasensorsandAmplifiedDNASensorsUsingFunctionalizedGrapheneOxide:ApplicationforLogicGateOperations.ACSNano2012,6,3553–3563.
13.XiaoqingLiu,FreemanRonit,ItamarWillner*,AmplifiedFluorescenceAptamer-BasedSensorsUsingExonucleaseIIIfortheRegenerationoftheAnalyte.Chem.Eur.J.2012,18,2207–2211.
14.ZhanxiaZhang,EterySharon,RonitFreeman,XiaoqingLiu,ItamarWillner*,FluorescenceDetectionofDNA,Adenosine-5''''''''''''''''''''''''''''''''-TriphosphateandTelomeraseActivitybyZn(II)-ProtoporphyrinIX/G-QuadruplexasLabel.Anal.Chem.2012,84,4789–4797.
15.RonitFreeman†,XiaoqingLiu†,ItamarWillner*,ChemiluminescentandChemiluminescenceResonanceEnergyTransfer(CRET)DetectionofDNA,MetalIons,andAptamer-SubstrateComplexesUsingHemin/G-QuadruplexesandCdSe/ZnSQuantumDots.J.Am.Chem.Soc.2011,133,11597–11604.(†EqualContribution)
16.XiaoqingLiu,RonitFreeman,EyalGolub,ItamarWillner*,ChemiluminescenceandChemiluminescenceResonanceEnergyTransfer(CRET)AptamerSensorsUsingCatalyticHemin/G-Quadruplexes.ACSNano2011,5,7648–7655.DOI:
17.RonitFreeman,XiaoqingLiu,ItamarWillner*,AmplifiedMultiplexedAnalysisofDNAbytheExonucleaseIII-CatalyzedRegenerationoftheTargetDNAinthePresenceofFunctionalizedSemiconductorQuantumDots.NanoLett.2011,11,4456–4461.
18.GiladPelossof,RanTel-Vered,XiaoqingLiu,ItamarWillner*,AmplifiedSurfacePlasmonResonance-BasedDNABiosensors,Aptasensors,andHg2+SensorsUsingHemin/G-QuadruplexesandAuNanoparticles.Chem.Eur.J.2011,17,8904–8912.
19.XiaoqingLiu,FuanWang,YulingWang,ShuyunZhu,GuobaoXu*,FunctionalizedSingle-WalledCarbonNanohornsforElectrochemicalBiosensing.Biosens.Bioelectron.2010,25,2194-2199.
20.XiaoqingLiu,FuanWang,ShuangHan,LihongShi,GuobaoXu*,Self-AssemblyofgoldNanoparticles/ElectroactivePolyelectrolyteMultilayerFilmsforTunableElectrocatalysis.Electroanalysis2010,22,963-969.
21.FuanWang,XiaoqingLiu,GaipingLi,DanLi,ShaojunDong*,SelectiveElectrodissolutionofInorganicIons/DNAMultilayerFilmforTunableDNARelease.J.Mater.Chem.2009,19,286–291.
22.WenxinNiu,ShanliangZheng,DaweiWang,XiaoqingLiu,HaijuanLi,ShuangHan,JiuanChen,ZhiyongTang*,GuobaoXu*,SelectiveSynthesisofSingle-CrystallineRhombicDodecahedral,Octahedral,andCubicGoldNanocrystals.J.Am.Chem.Soc.2009,131,697–703.
23.XiaoqingLiu,LihongShi,WenxinNiu,HaijuanLi,GuobaoXu*,AmperometricGlucoseBiosensorBasedonSingle-WalledCarbonNanohorns.Biosens.Bioelectron.2008,23,1887–1890.
24.XiaoqingLiu,WenxinNiu,HaijuanLi,ShuangHan,LihongShi,GuobaoXu*,GlucoseBiosensorBasedonGoldNanoparticle-CatalyzedLuminolElectrochemiluminescenceonaThree-DimensionalSol-GelNetwork.Electrochem.Commun.2008,10,1250–1253.
25.FuanWang,JianlongWang,XiaoqingLiu,ShaojunDong*,Nanoparticle-amplifiedSurfacePlasmonResonanceStudyofProteinConformationalChangeatInterface.Talanta2008,77,628–634.
26.XiaoqingLiu,LihongShi,WenxinNiu,HaijuanLi,GuobaoXu*,EnvironmentallyFriendlyandHighlySensitiveRuthenium(II)Tris(2,2''''''''''''''''''''''''''''''''-bipyridyl)ElectrochemiluminescentSystemUsing2-(dibutylamino)ethanolasCo-Reactant.Angew.Chem.Int.Ed.2007,46,421–424.
27.XiaoqingLiu,LihongShi,HaijuanLi,WenxinNiu,GuobaoXu*,Tris(2,2''''''''''''''''''''''''''''''''-bipyridyl)ruthenium(II)ElectrochemiluminescentDetectionofCoreactantsContainingAromaticDiolGroupbytheInteractionBetweenDiolandBorateAnion.Electrochem.Commun.2007,9,2666–2670.
28.JingLi,MinghuaHuang,XiaoqingLiu,HuiWei,YuanhongXu,GuobaoXu,ErkangWang*,EnhancedElectrochemiluminescenceSensorfromTris(2,2''''''''''''''''''''''''''''''''-Bipyridyl)Ruthenium(II)IncorporatedintoMCM-41andanIonicLiquid-BasedCarbonPasteElectrode.Analyst2007,132,687–691.DOI:10.1039/B701842H
29.LihongShi,XiaoqingLiu,HaijuanLi,WenxinNiu,GuobaoXu*,ApplicationofCeramicCarbonMaterialsforSolid-PhaseExtractionofOrganicCompounds.Anal.Chem.2006,78,1345–1348.
30.LihongShi,XiaoqingLiu,HaijuanLi,GuobaoXu*,ElectrochemiluminescentDetectionBasedonSolid-PhaseExtractionatTris(2,2''''''''''''''''''''''''''''''''-Bipyridyl)Ruthenium(II)-ModifiedCeramicCarbonElectrode.Anal.Chem.2006,78,7330–7334.
專利
1.發明人:徐國寶,劉曉慶,史立紅,專利名稱:環境友好的高靈敏電化學發光檢測方法,專利號:200510016848.4,公開號:CN1696666,授權公告日:2010.01.27
2.發明人:徐國寶,史立紅,劉曉慶,牛文新,專利名稱:三聯吡啶釕電化學發光測定血漿鈣的方法,專利號:200510017231.4,公開號:CN1773259,授權公告日:2009.05.20
3.發明人:徐國寶,史立紅,劉曉慶,李海娟,專利名稱:溶膠-凝膠法製備的碳陶瓷材料的套用,專利號:200510017012.6,公開號:CN1736581,授權公告日:2007.10.10
4.發明人:徐國寶,史立紅,劉曉慶,專利名稱:Nafion-碳陶瓷複合材料電化學發光感測器的製備方法,專利號:CN200510016770.6,公開號:CN1693285,授權公告日:2007.05.09
5.發明人:李景虹,王美佳,劉曉慶,專利名稱:脫氧核糖核酸電化學納米感測器的製備方法,專利號:03127158.8,公開號:CN1525163,授權公告日:2005.08.17