劉志傑[上海科技大學教授]

劉志傑，男，1984年獲天津師範大學學士學位，1994年獲中國科學院生物物理研究所博士學位。

人物經歷

1995-1995年在美國匹茲堡大學做博士後。

1995-1997年在美國喬治亞大學做博士後。

1997-2002年任美國喬治亞大學助理研究員。

2002-2006年任美國喬治亞大學副研究員。

2006-2013年任中國科學院生物物理研究所 “百人計畫”研究員。

2013年5月加入上海科技大學iHuman研究所。

研究方向

主要從事與人源細胞信號傳導相關蛋白，如G蛋白偶聯受體（GPCR）的結構生物學和基於結構的藥物設計研究。

主要集中在以下兩方面： 1. 人源細胞信號傳導相關蛋白的結構生物學研究； 2. 基於GPCR三維結構的藥物篩選與最佳化。

主要貢獻

近五年代表性論文：

Batyuk, L Galli, A Ishchenko, G W Han, C Gati, P Popov, M Lee, T. White, A Barty, A Aquila, M Hunter, M Liang, S Boutet, M Pu, Z-J Liu, G Nelson, D James, C Li, Y Zhao, J Spence, W Liu, P Fromme, V Katritch, U Weierstall, R Stevens, V Cherezov (2016) Native Phasing of X-ray Free Electron Laser data for a G protein-coupled receptor. Science Advances, accepted。

Liu B, Ouyang S, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. (2015) A primase subunit essential for efficient primer synthesis by an archaeal eukaryal-type primase. Nat Commun. DOI: 10.1038/ncomms8300。

Gu, Y. Feng, X. Feng, C. Sun, L. Lei, W. Ding, F. Niu, L. Jiao, M. Yang, Y. Li, X. Liu, J. Song, Z. Cui, D. Han, C. Du, Y. Yang, S. Ouyang, Z. J. Liu, W. Han, (2014) Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin, PLOS Pathogens, 10(5) e1004109。

Ntashin PV, Ding W, Eremeeva EV, Markova SV, Lee J, Vysotski ES, Liu ZJ., (2014) Structures of the Ca(2+)-regulated photoprotein obelin Y138F mutant before and after bioluminescence support the catalytic function of a water molecule in the reaction. Acta Cryst. D, 70(Pt3):720-32。

Zang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting J (2014) NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING , Immunity, 40(3): 329-341。

Zhao, L., Hua, t., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L., Ye, K., OuYang, S*, Cheng, G*, and Liu, Z. J*, (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage, Cell Res, 24(3):344-58。

Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., OuYang, S*, Cheng, G*, and Liu, J*, (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation, PNAS, 110(22):9054-9。

Ru, H., Ni, X., Zhao, L., Crowley, C., Ding, W., Hung, L., Shaw, N., Cheng, G*. and Liu, Z. J*, (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Research, 23(6):855-8。

Jiao, L., OuYang, S., N., Liang, M., Niu, F., Shaw, N., Wu, W., Ding, W., Jin, C., Peng, Y., Zhu, Y., Zhang, F., Wang, T., Li, C., Zuo, X., Luan, C.*, Li., D.*, and Liu, Z. J*, (2013) Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid protein in Complex with Suramin Reveals Therapeutic Potentials. J. VI, 87(12):6829-39。

Won, E, Xie, Y, Takemoto, C, Chen, L, Liu, J, Wang, B. C, Lee, D, Woo, E, Park, S, Shirouzu, M, Yokoyama, S, Kim, S and Chi, S, (2013) High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26, Acta Cryst D, 69(6):1160-70。

OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., Li, Y., Zhang, R., Cheng, G*., and Liu, J*, (2012) Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding, Immunity, 36(6): 1073-1086。

Parvatiyar, K., Zhang, Z., Teles, R. M., Ouyang, S., Jiang, Y., Iyer, S. S., Zaver, S. A., Schenk, M., Zeng, S., Zhong, W., Liu, Z. J., Modlin, R. L., Liu, Y. J*., and Cheng, G*. (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response, Nat Immunol 13, 1155-1161。

Ru, H., Zhao, L., Ding, W., Jiao, L., Shaw, N., Liang, W., Zhang, L., Hung, L., Matsugaki, N., Wakatsuki, S. and Liu, J*, (2012) The S-SAD phasing study of DR6 and its solution conformation revealed by SAXS. Acta Cryst, D68, 521–530。

Zhan, Z., OuYang, S., Liang, W., Zhang, Z., Liu, J* and Huang, L.*, (2012) Structural and functional characterization of the C-terminal catalytic domain of the SSV1 integrase. Acta Cryst D68, 659–670。

Liu, Z. J*, Chen, L., Wu, D., Ding, W., Zhang H., Zhou, W., Fu, Z. & Wang, BC*, (2011) A multi-dataset data-collection strategy produces better diffraction data. Acta Cryst A67, 544-549。