人員介紹
劉峰，博士，研究員，博士生導師，研究方向：定量系統生物學, 生物光學成像, 納米尺度輸運，輻射系統生物學。
教育簡歷
•1994年，山東大學物理學學士
•1998年，北京大學核技術及套用碩士
•2009年, 伊利諾伊大學生物物理及計算生物學博士
科研與學術工作經歷
•2009-2013年， 普林斯頓大學物理系博士後
•2013-2014年， 杜克大學物理系博士後
•2014年－， 北京大學物理學院重離子物理研究所特聘研究員，北京大學定量生物學中心研究員
研究領域
本課題組主要開展定量系統生物學的研究。在研究體系上以多細胞生物體系的生物網路為主，一是果蠅胚胎早期發育的調控細胞命運和遷移的基因網路，其核心問題是多細胞體系如何克服單細胞水平上的基因表達噪聲而產生具有高度可重複性的準確發育斑圖。二是調控癌細胞細胞極性和轉移的基因網路，這是理解癌症致死的主因——腫瘤轉移的關鍵之一。 在研究方法上我們側重於開發套用以快速三維生物光學定量成像為主要技術手段的生物定量測量，比如雙光子顯微鏡和光面顯微鏡等。 我們希望通過緊密結合定量實驗與理論模型，精確地測量生物分子網路的動態，從整體角度來探索生物分子網路的原理和機制，並在此基礎上來調控生物分子網路，為組織工程以及抑制和治療癌症開發新方法。除此以外，納米尺度的高分子膜核徑跡孔是模擬生物膜離子通道的理想實驗體系，我們針對核孔膜的製備，表征及其特異選擇性的離子輸運開展了一系列實驗和建模工作。輻射系統生物學方面的工作目前主要集中在開發測量方法來利用輻射導致DNA損傷的片段分布來解析細胞的30納米染色質結構。
主持或參加科研項目
•國家自然科學基金面上項目，31670852，果蠅胚胎早期發育轉錄調控網路魯棒性的分子機制研究，68萬，2016-2020，在研，主持
•國家自然科學基金重點項目，11434001，細胞遷移動力學的實驗和理論研究，360萬，2015-2020， 在研，參與
•國家自然科學基金重點項目，離子徑跡法製備納米孔及其能量轉化與物質輸運研究，11225003，360萬，2014-2019，在研，參與
代表性論文
Wen, Q.; D.X Yan,Liu.*; et al., Y.G. Wang*（2016），Highly selective ionic transport through subnanometer pores in polymer films,Advanced Functional Material, 26(32),5796.
Liang,Y., G. Yang,Liu.*; Y.G. Wang（2016）, Monte Carlo simulation of ionizing radiation induced DNA strand breaks utilizing coarse grained high-order chromatin structures,Phys Med Biol., 61(1), 445-60.
Wang, J., G.Yang, F. Liu*(2015), The application of physics in the study of cell polarity during tumor cell migration,Acta Phys. Sin.64(5): 058707, Invited Review
Petkova, MD, Little, SC,Liu, and T. Gregor (2014). “Maternal origins of developmental reproducibility”,Current Biology, 24(11), 1283-1288
Liu, F., A.H. Morrison, and T. Gregor (2013). ”Dynamic interpretation of transcription factor concentration in the Drosophila segmentation gene network”, PNAS, 110 (17), 6724- Research highlight inNature Reviews Genetics.
Liu, F., Y.G. Gao, and M. Gruebele (2010). “A survey of lambda repressor fragments from two-state to downhill folding”.Journal Molecular Biology, 397(3), 789-9.
Liu, F., Y.G. Gao, and M. Gruebele (2010). “A survey of lambda repressor fragments from two-state to downhill folding”.Journal Molecular Biology, 397(3), 789-9
Liu, F., C. Maynard, G. Scott, A. Melnykov, K.B. Hall, and M. Gruebele (2010). “A natural missing link between activated and downhill protein folding scenarios”.Physical Chemistry Chemical Physics,12, 3542 – 3549.
Liu, F., M. Nakaema, and M. Gruebele (2009). “The transition state transit time of WW domain folding is controlled by energy landscape roughness”.Journal of Chemical Physics, 131, 19,195101-195110. JCP Editor’s Choice – 2009
Liu, F., C. Dumont, Y.J. Zhu, F. Gai and M. Gruebele (2009). “A one-dimensional free energy surface does not account for two-probe folding kinetics of protein 3D”.Journal of Chemical Physics, 130,6-11
Fuller, A.A., D.G. Du,Liu, J.E. Davoren, G. Kroon, H. J. Dyson, E.T. Powers, P. Wip, M. Gruebele, and J.W. Kelly (2009). “Evaluating β-Turn mimics as β-Sheet folding nucleators”.PNAS,106,11067-11072
Liu, F., D.G. Du, A.A. Fuller, J.E. Davoren, P. Wipf, J.W. Kelly, and M. Gruebele (2008).“An experimental survey of the transition between two-state and downhill protein folding scenarios”,PNAS,105, 2369-2374
Liu, F.and M. Gruebele (2008). “Downhill dynamics and the molecular phase in protein folding”.Chemical Physics Letters, Frontiers Article, 461,1-8. Invited review, cover highlight
Freddolino, P.L.,Liu, M. Gruebele, and K. Schulten (2008). “Ten-microsecond MD simulation of a fast-folding WW domain”.Biophysical Journal, 94, L75-L77.
Liu, F. and M. Gruebele (2007). “Tuning λ6-85towards downhill folding near the unfolding transition midpoint”,Journal Molecular Biology, 370 (3), 574-584.
1.Wen, Q.; D.X Yan,Liu.*; et al., Y.G. Wang*（2016），Highly selective ionic transport through subnanometer pores in polymer films,Advanced Functional Material, 26(32),5796.
2.Liang,Y., G. Yang,Liu.*; Y.G. Wang（2016）, Monte Carlo simulation of ionizing radiation induced DNA strand breaks utilizing coarse grained high-order chromatin structures,Phys Med Biol., 61(1), 445-60.
3.Wang, J., G.Yang, F. Liu*(2015), The application of physics in the study of cell polarity during tumor cell migration,Acta Phys. Sin.64(5): 058707, Invited Review
4.Petkova, MD, Little, SC,Liu, and T. Gregor (2014). “Maternal origins of developmental reproducibility”,Current Biology, 24(11), 1283-1288
5.Liu, F., A.H. Morrison, and T. Gregor (2013). ”Dynamic interpretation of transcription factor concentration in the Drosophila segmentation gene network”, PNAS, 110 (17), 6724- Research highlight inNature Reviews Genetics.
6.Liu, F., Y.G. Gao, and M. Gruebele (2010). “A survey of lambda repressor fragments from two-state to downhill folding”.Journal Molecular Biology, 397(3), 789-9.
7.Liu, F., Y.G. Gao, and M. Gruebele (2010). “A survey of lambda repressor fragments from two-state to downhill folding”.Journal Molecular Biology, 397(3), 789-9
8.Liu, F., C. Maynard, G. Scott, A. Melnykov, K.B. Hall, and M. Gruebele (2010). “A natural missing link between activated and downhill protein folding scenarios”.Physical Chemistry Chemical Physics,12, 3542 – 3549.
9.Liu, F., M. Nakaema, and M. Gruebele (2009). “The transition state transit time of WW domain folding is controlled by energy landscape roughness”.Journal of Chemical Physics, 131, 19,195101-195110. JCP Editor’s Choice – 2009
10.Liu, F., C. Dumont, Y.J. Zhu, F. Gai and M. Gruebele (2009). “A one-dimensional free energy surface does not account for two-probe folding kinetics of protein 3D”.Journal of Chemical Physics, 130,6-11
11.Fuller, A.A., D.G. Du,Liu, J.E. Davoren, G. Kroon, H. J. Dyson, E.T. Powers, P. Wip, M. Gruebele, and J.W. Kelly (2009). “Evaluating β-Turn mimics as β-Sheet folding nucleators”.PNAS,106,11067-11072
12.Liu, F., D.G. Du, A.A. Fuller, J.E. Davoren, P. Wipf, J.W. Kelly, and M. Gruebele (2008).“An experimental survey of the transition between two-state and downhill protein folding scenarios”,PNAS,105, 2369-2374
13.Liu, F.and M. Gruebele (2008). “Downhill dynamics and the molecular phase in protein folding”.Chemical Physics Letters, Frontiers Article, 461,1-8. Invited review, cover highlight
14.Freddolino, P.L.,Liu, M. Gruebele, and K. Schulten (2008). “Ten-microsecond MD simulation of a fast-folding WW domain”.Biophysical Journal, 94, L75-L77.
15.Liu, F. and M. Gruebele (2007). “Tuning λ6-85towards downhill folding near the unfolding transition midpoint”,Journal Molecular Biology, 370 (3), 574-584.
