研究方向
主要研究方向： 生物有機化學, 藥物化學, 有機化學
主要承擔在研項目：
黃志紓吡啶酮類化合物對高表達COX-2癌細胞抑制作用研究，負責，省基金
新靶點抗癌藥物－端粒/端粒酶抑制劑取代吲哚並喹啉類衍生物，國家自然科學基金，負責
具有抗流感病毒活性的黃酮類化合物的研究，留學回國人員科研啟動基金，負責
紫草萘醌類衍生物的抗瘤作用與機理研究, 國家自然科學基金, 第一參加人
近期發表論文
1.Hai-Qiang Wu, Zhi-Shu Huang*, Xian-Zhang Bu, Yu-Dong Shen, Zhu-Lin Zhang, Bing-Fen Xie, Zong-Chao Liu, Lian-Quan Gu, Albert S. C. Chan,, The Molecular Mechanisms Involved in the Cytotoxicity of Alkannin Derivatives, Eur. J. Med. Chem. 2005 (in press)
2.Sheng-Ling Zhang,, Lin-Kun An, Zhi-Shu Huang*, Lin Ma, Yue-Ming Li, Albert S. C. Chan and Lian-Quan Gu*, An intriguing reaction of 4-hydroxycoumarins with 2,3-dichloro-5,6-dicyanobenzoquinone Tetrahedron, 2005, 61(2), 3087-3090.)
3.Xindong Guo, Zhishu Huang*, Yadan Bao, Linkun An, Lin Ma, Lianquan Gu, Two New Sequiterpenoids from Helicteres Angustifolia, Chin. Chem. Lett., 2005, 16(1), 49-52.
4.Sheng-Ling Zhang, Zhi-Shu Huang*, Lin-Kun An, Xian-Zhang Bu, Lin Ma, Yue-Ming Li, Albert S. C. Chan, Lian-Quan Gu*, Synthesis of Zwitterionic 4-Hydroxycoumarin Derivatives through a Unique Reaction of 4-Hydroxycoumarins with p- Benzoquinone and Pyridine, Org. lett. 2004, 6(26), 4853-4855.
5.Zhi-Shu Huang*, Hai-Qiang Wu, Zhi-Fang Duan, Bing-Fen Xie, Zong-Chao Liu, Gong-Kan Feng, Lian-Quan Gu, Albert S. C. Chan, Yue-Ming Li, Synthesis and Cytotoxicity Study of Alkannin Derivatives， Eur. of J. Med. Chem. 2004, 39, 755-764.
6.Zhishu Huang, Qibo Zhang, and Hung-wen Liu*, Reconstitution of UDP-galactopyranose mutase with 1-deaza-FAD an 5-deaza-FAD: analysis and mechanistic implications, Bioorganic Chemistry 2003, 31, 494-502.
