人物簡介
高會樂：男，四川大學華西藥學院教授、博導。
教育經歷
2004.09-2008.07復旦大學藥學院，獲理學學士學位
2008.09-2013.06 復旦大學藥學院，獲藥劑學博士學位
2013.07-2014.06四川大學華西藥學院藥劑系講師
2014.07至今 四川大學華西藥學院藥劑系副教授、碩導
2015.10-2016.10 史丹福大學醫學院訪問學者
研究方向
1、新型腦靶向遞藥系統的構建和評價；
2、基於螢光碳量子點的納米遞藥系統的設計、表征及套用；
3、具有環境敏感性的納米遞藥系統及其材料的設計、合成和評價
主要課題
1、國家自然科學基金面上項目，“基於生物點擊化學的腫瘤微環境回響性納米載體的腫瘤靶向遞藥研究”，31571016，實施年限：2016.01.01-2019.12.31，主持。
2、國家自然科學基金青年項目，“基於粒徑智慧型調節、具有腫瘤微環境回響的腦轉移瘤靶向遞藥系統研究”，81402866，實施年限：2015.01.01-2017.12.31，主持。
3、四川大學優秀青年基金項目，“基於生物點擊化學的腫瘤微環境回響性納米載體的腫瘤靶向遞藥研究”，2015SCU04A14，實施年限：2015.1-2017.12，主持。
4、四川大學-瀘州市人民政府戰略合作科技項目，“（川大-瀘州）替莫唑胺膠囊的研製與研發”，2013CDLZ-S14，實施年限2014.01.01-2015.12.31，主持。
5、四川大學青年教師科研啟動基金，“靶向分子對納米系統與血漿蛋白相互作用及靶向性的影響”，2014SCU11044，實施年限：2014.01.01-2015.12.31，主持。
獲得榮譽
1、2015年10月獲中國藥學會中恆青年藥劑學獎
2、2015年04月博士論文獲上海市優秀博士論文
3、2014年12月獲四川大學青年骨幹教師稱號
研究論文
1、Zheng M, Ruan S, Liu S, Sun T, Qu D, Zhao H, Xie Z*, Gao H*, Jing X, Sun Z*. Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells. ACS Nano. 2015. (IF=12.881)
2、Ruan S, Cao X, Cun X, Hu G, Zhou Y, Zhang Y, Lu L, He Q, Gao H*. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. Biomaterials. 2015, 60: 100-110.(IF=8.557)
3、Ruan S, Yuan M, Zhang L, Hu G, Chen J, Cun X, Zhang Q, Yang Y, He Q*, Gao H*. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials. 2015, 37:425-435.(IF=8.557)
4、Ruan S, He Q, Gao H*. Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma. Nanoscale. 2015, 7(21): 9487-9496.(IF=7.394)
5、Hu G, Cun X, Wang Y, He Q, Gao H*. Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment. Oncotarget, 2015. (IF=6.359)
6、Ruan S, Chen J, Cun X, Long Y, Tang J, Qian J, Shen S, Jiang X, Zhu J, He Q*, Gao H*. Noninvasive in vivo diagnosis of brain gliomas using RGD-decorated fluorescent carbonaceous nanospheres. J Biomed Nanotech, 2015, 11(12): 2148-2157. (IF=5.338)
7、Gao H, Cao S, Yang Z, Zhang S, Pang Z, Jiang X. Preparation, characterization and anti-glioma effects of docetaxel-loaded, lipoprotein-like nanoparticles. J Biomed Nanotech. 2015.11(12):2137-2147. (IF=5.338)
8、Hu G, Wang Y, He Q*, Gao H*.Multistage drug delivery system based on microenvironment-responsive dendrimer-gelatin nanoparticles for deep tumor penetration.RSC Adv.2015, 5: 85933-85937. (IF=3.84)
9、Ruan S, Zhang L, Chen J, Cao T, Yang Y, Liu Y, He Q, Gao F*, Gao H*. Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer. RSC Adv.2015, 5:64303 - 64317. (IF=3.84)
10、Chen J, Cun X, Ruan S, Wang Y, Zhang Y, He Q*, Gao H*. Glioma cell targeting doxorubicin delivery and redox-responsive release using angiopep-2 decorated carbonaceous nanodots.RSC Adv.2015, 5: 57045 - 57049. (IF=3.84)
11、Chen J, Sun H, Ruan S, Wang Y, Shen S, Xu W, He Q, Gao H*. In vitro and in vivo toxicology of bare and PEGylated fluorescent carbonaceous nanodots in mice and zebrafish: the potential relation with autophagy.RSC Adv.2015, 5: 38547-38557. (IF=3.84)
12、Ruan S, Qian J, Shen S, Chen J, Cun X, Zhu J, Jiang X, He Q*, Gao H*. Non-invasive imaging of breast cancer using RGDyK functionalized fluorescent carbonaceous nanospheres. RSC Adv.2015, 5: 25428-25436. (IF=3.84)
13、Gao H*, Zhang Q, Yang Y, Jiang X, He Q*. Tumor homing cell penetrating peptide decorated nanoparticles used for enhanced tumor targeting delivery and therapy. Int J Pharm. 2015, 478: 240-250.(IF=3.65)
14、Chen J, Sun H, Wang W, Xu W, He Q, Shen S, Qian J*, Gao H*.Polyethylene glycol modification reduces the cardiac toxicity of carbonaceous dots in mice and zebrafish model.Acta Pharmacol Sin. 2015.(IF=2.912)
15、Gao H, Yang Z, Cao S, Xiong Y, Zhang S, Pang Z, Jiang X. Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment. Biomaterials. 2014, 35(7): 2374-2382.(IF=8.557)(C級)
16、Ruan S, Qian J, Shen S, Zhu J, Jiang X, He Q, Gao H*. A simple one-step method to prepare fluorescent carbon dots and their potential application in non-invasive glioma imaging.Nanoscale. 2014, 6(17): 10040-10047.(IF=7.394)
17、Gao H, Yang Z, Zhang S, Pang Z, Liu Q, Jiang X. Study of the pharmacology mechanisms of dual targeting drug delivery system with tumor microenvironment assays. Acta Biomateria. 2014, 10(2): 858-867.(IF=6.025)高被引論文
18、Gao H, Hu G, Zhang Q, Zhang S, Jiang X, He Q. Pretreatment with chemotherapeutics for enhanced nanoparticles accumulation in tumor: the potential role of G2 cycle retention effect.Sci Rep. 2014,4: 4492.(IF=5.578)
19、Ruan S, Qian J, Shen S, Chen J, Zhu J, Jiang X, He Q*, Yang W*, Gao H*. Near-infrared fluorescent carbonaceous nanodots for glioma imaging after angiopep-2 decoration. Bioconjug Chem. 2014, 25: 2252-2259.(IF=4.513)
20、Ruan S, Wan J, Fu Y, Han K, Li X, Chen J, Zhang Q, Shen S, He Q, Gao H*.PEGylated fluorescent carbon nanoparticles for noninvasive heart imaging. Bioconjug Chem. 2014,25(6): 1061-1068.(IF=4.513)
21、Gao H, Zhang S, Cao S, Yang Z,Pang Z, Jiang X. Angiopep-2 and activatable cell penetrating peptide dual-functionalized nanoparticles for systemic glioma targeted delivery.Mol Pharm. 2014, 11(8): 2755-2763. (IF=4.384)
22、Gao H, Xiong Y, Zhang S, Yang Z, Cao S, Jiang X. RGD and interleukin-13 peptide functionalized nanoparticles for enhanced glioblastoma cells and neovasculature dual targeting delivery and elevated tumor penetration. Mol Pharm. 2014,11(3): 1042-1052. (IF=4.384)(D級)
23、Mei L, Zhang Q, Yang Y, He Q, Gao H*. Angiopep-2 and activatable cell penetrating peptide dual modified nanoparticles for enhanced tumor targeting and penetrating. Int J Pharm. 2014, 474: 95-102.(IF=3.65)
24、Gao H, Zhang S, Yang Z, Cao S, Jiang X, Pang Z. In vitro and in vivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide.Int J Pharm. 2014, 466(1-2): 8-17.(IF=3.65)(D級)
25、Gao H, Wang Y, Chen C, Chen J, Wei Y, Cao S, Jiang X. Incorporation of lapatinib into core-shell nanoparticles improves both the solubility and anti-glioma effects of the drug. Int J Pharm. 2014; 461(1-2): 478– 488.(IF=3.65)(D級)
26、Qian J, Ruan S, Cao X, Cun X, Chen J, Shen S, Jiang X, He Q, Zhu J*, Gao H*. Fluorescent carbonaceous nanospheres as biological probe for noninvasive brain imaging. JColloid Interf Sci. 2014, 436: 227-233.(IF=3.368)
27、Qian J, Chen J, Ruan S, Shen S, He Q, Jiang X, Zhu J*, Gao H*. Preparation and biological evaluation of photoluminescent carbonaceous nanospheres.JColloid Interf Sci. 2014, 429: 77-82.(IF=3.368)(D級)
28、Ruan S, Zhu B, Zhang H, Chen J, Shen S, Qian J, He Q, Gao H*. A simple one-step method for preparation of fluorescent carbon nanospheres and the potential application in cell organelles imaging. JColloid Interf Sci. 2014,422: 25-29.(IF=3.368)(D級)
29、Gao H, Yang Z, Zhang S, Pang Z, Jiang X. Internalization and subcellular fate of aptamer and peptide dual-functioned nanoparticles. J Drug Target.2014, 22(5): 450-459.(IF=2.741)(D級)
30、Zhang L, Zhang S, Ruan S, Zhang Q, He Q, Gao H*. Lapatinib incorporated lipoprotein-like nanoparticles: preparation and breast cancer targeting mechanism. Acta Pharmacol Sin. 2014,35(6): 846-852.(IF=2.912)(E級)
31、Gao H, Yang Z, Zhang S, Cao S, Pang Z, Yang X, Jiang X.Glioma-homing peptide with a cell-penetrating effect for targeting delivery with enhanced glioma localization, penetration and suppression of glioma growth. J Control Release.2013, 172(3):921-928. (IF=7.261)(C級)
32、Gao H, Cao S, Chen C,Cao S, Yang Z, Xi Z, Pan S, Zhang Q, Jiang X. Incorporation of lapatinib into lipoprotein-like nanoparticles with enhanced water solubility and anti-breast cancer effect. Nanomedicine (Lond).2013, 8(9): 1429-1442. (IF=5.824)(D級)
33、Gao H, Yang Z, Zhang S, Cao S, Pang Z, Jiang X. Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization. Sci Rep. 2013, 3: 2534.(IF=5.078)
34、Gao H, Hu Y, Xiong Y, Zhang S, Yang J, Yu L, Jiang X. Glioma targeting and anti-glioma effect of interleukin 13 peptide and RGD peptide dual functionalized nanoparticles.Curr Pharm Biotechnol. 2013, 14: 1118-1126.(IF=2.511)
35、Gao H, Chen C, Xi Z, Chen J, Zhang Q, Cao S, Jiang X. In Vivo Behavior and Safety of Lapatinib-Incorporated Lipid Nanoparticles. Curr Pharm Biotechnol. 2013, 14: 1062-1071.(IF=2.511)
36、Gao H, Qian J, Cao S, Yang Z, Pang Z, Pan S, Fan L, Xi Z, Jiang X, Zhang Q. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials. 2012, 33(20):5115-5123.(IF=7.604)高被引論文
37、Gao H, Qian J, Yang Z, Pang Z, Xi Z, Cao S, Wang Y, Pan S, Zhang S, Wang W, Jiang X, Zhang Q. Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(epsilon-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy. Biomaterials. 2012, 33(26): 6264-6272. (IF=7.604)
38、Gao H, Yang Z, Cao S, Xi Z, Zhang S, Pang Z, Jiang X. Behavior and anti-glioma effect of lapatinib-incorporated lipoprotein-like nanoparticles. Nanotechnology.2012,23(43):435101. (IF=3.842)
39、Gao H, Pang Z, Pan S, Cao S, Yang Z, Chen C, Jiang X. Anti glioma effect and safety of docetaxel-loaded nanoemulsion. Arch Pharm Res. 2012,35(2):333-341. (IF=1.538)
40、Gao H, Pan S, Yang Z, Cao S, Chen C, Jiang X, Pang Z, Hu Y. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein. Biomaterials. 2011, 32(33): 8669-8675. (IF=7.404)
41、Gao H, Pang Z, Lu W, Pan S, Jiang X. Encapsulation of cationic peptides into polymersomes through in situ gelatinization. J Microencapsul. 2011, 28(6): 465-471. (IF=1.553)
42、Gao H, Pang Z, Fan L, Hu K, Wu B, Jiang X. Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations. Acta Pharmacol Sin. 2010,31(2): 237-243. (IF=1.953)
