研究方向:
•多功能螢光分子探針設計合成及細胞內套用
•有機分子藥物傳遞及活體示蹤
•癌細胞螢光檢測及藥物篩選
•基於螢光分子探針的生物標誌物活體檢測
歡迎在螢光感測生命有機分析、高效液相色譜及質譜、有機發光分子合成研究方面有理想、有追求的有志青年報考!
教學:
主講課程:無機化學、無機化學實驗、高等無機化學(本)、專業英語、文獻檢索、高等無機化學(研)、配位化學。
獲獎:曾獲曲師大化學院青年教師教學比賽中獲得第二名,曲阜師範大學第四屆青年教師授課大賽優秀獎;指導本科生畢業設計獲校級優秀學士論文2篇(2007年、2013年),獲省級優秀學士論文1篇;曲阜師範大學2016年度教學獎。
教學項目:
•2007年:山東省基礎學科專項資金建設項目-無機化學
•2005年:曲阜師範大學《金屬有機化學》雙語教學研究
•2009年:曲阜師範大學《化學學科雙語教學研究》教學改革項目
•2017年:曲阜師範大學《無機化學》雙語教學項目
科研項目:
•主持:國家自然基金面上項目1項、山東省自然基金青年項目1項、山東省腫瘤標誌物檢測技術重點實驗室項目1項、完成曲師大校級科研項目2項;
•參與:國家自然基金面上項目3項、國家自然基金青年項目4項、省自然基金青年項目3項。
代表性論文:
Kun Dou, Guang Chen*, Fabiao Yub, Yuxia Liua, Lingxin Chenb, Ziping Caoa, Tao Chenc, Yulin Lic and Jinmao You* Bright sensitive ratiometric fluorescent probe enabling endogenous FA imaging and mechanistic exploration of indirect oxidative damage of FA in various living systems. Chemical Science (IF=9.12, JCR一區) 2017 , 2017, 8, 7851-7861.
G. Chen, Q. Fu, F. Yu, R. Ren, Y. Liu, Z. Cao, G. Li, X.-E. Zhao, L. Chen, H. Wang, Jinmao You. Wide-acidity-range pH fluorescence probes for evaluation of acidification in mitochondria and digestive tract mucosa. Anal. Chem . (IF=6.32, JCR 一區 )2017.
K. Dou, Q. Fu, G. Chen*, F. Yu, Y. Liu, Z. Cao, G. Li, X. Zhao, L. Xia, L. Chen, H. Wang, J. You, A novel dual-ratiometric-response fluorescent probe for SO2/ClO− detection in cells and in vivo and its application in exploring the dichotomous role of SO2 under the ClO− induced oxidative stress. Biomaterials . (IF=8.40, JCR 一區 )2017, 133, 82-93.
Q. Fu, Z. Chen, X. Ma, G. Chen*, Y. Liu, Z. Cao, F. Qu, D. Yang, X. Zhao, Z. Sun, G. Li, S. Zhang, F. Qu, R. Kong, H. Wang, J. You, Simultaneous absorbance-ratiometric, fluorimetric, and colorimetric analysis and biological imaging of α-ketoglutaric acid based on a special sensing mechanism. Sensor Actuat B-chem (IF=5.40, JCR 一區 )2017, 241, 1035-1042.
Q. Fu, G. Chen*, Y. Liu, Z. Cao, X. Zhao, G. Li, F. Yu, L. Chen, H. Wang, J. You, In situ quantification and evaluation of ClO−/H2S homeostasis in inflammatory gastric tissue by applying a rationally designed dual-response fluorescence probe featuring a novel H+-activated mechanism. Analyst (IF=3.89, JCR 二區 )2017, 142, 1619-1627.
X. Li, G. Chen*, J. Liu, Y. Liu, X. Zhao, Z. Cao, L. Xia, G. Li, Z. Sun, S. Zhang, H. Wang, J. You, A rapid, accurate and sensitive method with the new stable isotopic tags based on microwave-assisted dispersive liquid-liquid microextraction and its application to the determination of hydroxyl UV filters in environmental water samples. Talanta (IF=4.16, JCR 二區 ).2017, 167, 242-252.
M Liu, G Chen*, H Guo, B Fan, J Liu, Jinmao You. "Accurate Analysis and Evaluation of Acidic Plant Growth Regulators in Transgenic and Nontransgenic Edible Oils with Facile Microwave-Assisted Extraction." J. Agric. Food Chem ., (IF=3.15, JCR 一區 )2015, 63 (36), pp 8058–8067.
J. Liu, M. Liu, X. Li, X. Lu, G. Chen*, Z. Sun, G. Li, X. Zhao, S. Zhang, C. Song, Jinmao You. Development of ultrasonic-assisted closed in-syringe extraction and derivatization for the determination of labile abietic acid and dehydroabietic acid in cosmetics. J Chromatogr A (IF=4.02, JCR 二區 )2014, 1371, 20-29.
G. Chen,J. Liu, M. Liu, G. Li, Z. Sun, S. Zhang, C. Song, H. Wang, Y. Suo, J. You, Sensitive, accurate and rapid detection of trace aliphatic amines in environmental samples with ultrasonic-assisted derivatization microextraction using a new fluorescent reagent for high performance liquid chromatography J Chromatogr A (IF=4.02, JCR 二區 )2014, 1352, 8-19.
Chen, G ., J. Li, Jinmao You et al. (2013). "Rapid and sensitive ultrasonic-assisted derivatization microextraction (UDME) technique for Bitter taste-Free amino acids (FAA) study by HPLC-FLD." Food Chemistry. (IF=4.53, JCR 二區 )2014, 143, 97-105.
Guang Chen, Jun Li Shijuan Zhang Cuihua Song Guoliang Li Zhiwei Sun Yourui Suo, Jinmao You*, A sensitive and efficient method to systematically detect two biophenols in medicinal herb, herbal products and rat plasma based on thorough study of derivatization and its convenient application to pharmacokinetics with semi-automated device, Journal of Chromatography A (IF=4.02, JCR 二區 )Volume 1249, 3,190-200,2012.
Guang Chen*, Jun Li Cuihua Song Yourui Suo Jinmao You*,A sensitive and efficient method for simultaneous trace detection and identification of triterpene acids and its application to pharmacokinetic study, Talanta (IF=4.16, JCR 二區 ),98, 30, 101–111, 2012.
其他:
04年9月-05年12月:04級化工班輔導員
06年1月-10年3月:研究生教學秘書、本科生教學秘書
2010年3月-至今:院辦公室主任、研究生教學秘書