個人簡介
1992-1997年 博士，University of Rochester1998-2002年 博士後，Albert Einstein College of Medicine&University of California at LOSAngeles
2002-2004年 助理研究員及助理教授，University of California at Los Angeles
2004年11月- 研究員(“百人計畫”)， 中國科學院生物物理研究所
研究方向
病毒複製的分子機理及病毒與宿主的相互作用。目前正在從事的研究工作包括：腫瘤相關皰疹病毒的基因表達調控、基因組複製及病毒包裝的機理；腫瘤相關皰疹病毒與宿主細胞和免疫系統之間的相互作用；全新基因遞送載體的構建與測試；病毒性肝炎的致病機理。代表論文
Deng, H.*, JT Chu, NH Park, and R. Sun. Identification of cis-sequences required for lytic replication and packaging of murine gammaherpesvirus-68. Journal of Virology 78: 9123-9131, 2004. (*Corresponding author)Arumugaswami V., TT. Wu, D. Martinez-Guzman, Q. Jia,H. Deng, N. Reyes, and R. Sun. ORF18 is a transfactor that is essential for late gene transcription of a gammaherpesvirus. Journal of Virology 80:9730-40, 2006.
Deng, H., Y. Liang, and R. Sun. Regulation of KSHV lytic gene expression. Current Topics in Microbiology and Immunology, 312:157-83, 2007. (Invited review)
Yu F., JN Harada, HJ Brown, H. Deng, MJ Song, TT Wu, J. Kato-Stankiewicz, CG Nelson, J. Vieira, F. Tamanoi, SK Chanda, and R. Sun. Systematic identification of cellular signals reactivating Kaposi’ sarcoma-associated herpesvirus. PLoS Pathogens 3(3):e44, 2007.
Wong E., TT Wu, N. Reyes, H. Deng, and R. Sun. Murine gammaherpesvirus 68 open reading frame 24 is required for late gene expression after DNA replication. Journal of Virology 81:6761-6764, 2007.
Bortz E., L. Wang, Q. Jia, TT Wu, JP Whitelegge, H. Deng, ZH Zhou, R. Sun. Murine Gammaherpesvirus-68 ORF52 Encodes a Tegument Protein Required for Virion Morphogenesis in the Cytoplasm. Journal of Virology 81: 10137-10150, 2007. Epub 2007 Jul 18.
J. Benach, L. Wang, Y. Chen, CK Ho, S. Lee, J. Seetharaman, R. Xiao, TB Acton, GT Montelione, H. Deng, R. Sun, and L. Tong. Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus-68. Journal of Biological Chemistry 282: 31534-31541, 2007. Epub 2007 Aug 15.
Lee S., H. Deng*, F. Yu, W. Melega, R. Damioseaux, K. Bradley, and R. Sun*. Regulation of KSHV Reactivation by Dopamine Receptor-Mediated Signaling Pathways. J Acquir Immune Defic Syndr. 2008 Aug 15;48(5):531-40.(*Co-Corresponding authors)
Di Bartolo DL, Hyjek E, Keller S, Guasparri I,Deng H, Sun R, Chadburn A, Knowles DM, Cesarman E. Role of defective Oct-2 and OCA-B expression in immunoglobulin production and KSHV lytic reactivation in primary effusion lymphoma. Journal of Virology 83: 4308-15, 2009.
Yang Z., H. Tang, H. Huang, andH. Deng*. RTA promoter demethylation and histone acetylation regulation of murine gammaherpesvirus 68 reactivation.PLoS One 4(2):e4556, 2009. (Recommended by “Faculty of 1000 Biology”：http://www.f1000biology.com/article/id/1157092/evaluation)
Gong D., J. Qi, V. Arumugaswami, R. Sun and H. Deng*. Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus-68. Virology 387: 285-295, 2009.
Liao HI, Olson CA, Hwang S, Deng H, Wong E, Baric RS, Roberts RW, Sun R. mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein. J Biol Chem. 2009 Jun 26;284(26):17512-20. Epub 2009 Apr 13.
Xu X, Lou Z, Ma Y, Chen X, Yang Z, Tong X, Zhao Q, Xu Y, Deng H, Bartlam M, and Rao Z. Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59. PLoS One 4(7):e6217, 2009.
Guo H., Wang LL, Peng L., Zhou ZH, and H. Deng*. ORF33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress. Journal of Virology Oct;83(20):10582-95, 2009. Epub 2009 Aug 5..
Li X, Feng J, Chen S, Peng L, He WW, Qi J, Deng H, Sun R. Tpl2/AP-1 Enhances Murine Gammaherpesvirus 68 Lytic Replication. J Virol. 2010 Feb;84(4):1881-90. Epub 2009 Nov 25.
Li X, Chen S, Feng J, Deng H, Sun R. Myc Is Required for the Maintenance of Kaposi's Sarcoma-Associated Herpesvirus Latency. J Virol. 2010 Sep;84(17):8945-8. Epub 2010 Jun 23. (*Corresponding author)
