研究領域：
該研究組主要是通過生化和分子細胞生物學方法，在細胞和動物水平闡明遺傳和營養調節的諸如肥胖、糖尿病和脂肪肝等代謝疾病的分子機制。目前研究集中在中樞神經系統和外周神經系統對亮氨酸缺乏引起的脂肪代謝異常的研究上。該研究將對肥胖、糖尿病和脂肪肝的營養學干預和治療提供依據和可能。
近期論文：
Du Y, Meng Q, Zhang Q, Guo F*. Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT. Amino Acids. 2011 Oct 21. [Epub ahead of print]
Cheng Y#, Zhang Q# (co-author), Meng Q, Xia T, Huang Z, Wang C, Liu B, Chen S, Xiao F, Du Y, and Guo F*. Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in The hypothalamus and Activating The Sympathetic Nervous System. Molecular Endocrinology. 2011, 25(9):1624-1635.
Li H, Meng Q, Xiao F, Chen S, Yu J, Wang C, and Guo F*. ATF4 deficiency protects mice from high-carbohydrate diet-induced liver steatosis. Biochemical Journal. 2011, 438(2):283-289.
Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, Liu Y, and Guo F*. Leucine Deprivation Increases Hepatic Insulin Sensitivity Via GCN2/mTOR/S6K1 and AMPK Pathways. Diabetes. 2011, 60: 746-756.
Zhang Q, Li H and Guo F*. Amygdala, an important regulator for food intake (Invited Review). Frontiers in Biology. 2011, 6: 82-85.
Cheng Y#, Meng Q# (co-author), Wang C, Li H, Huang Z, Chen S, Xiao F, Guo F*. Leucine deprivation decreases fat mass by stimulation of lipolysis in WAT and upregulation of UCP1 in BAT. Diabetes. 2010, 59: 17-25.
Wang C, Huang Z, Du Y, Cheng Y, Chen S and Guo F*. ATF4 regulates lipid metabolism and thermogenesis. Cell Research. 2010, 20:174-184.
Guo F, Cavener D. The GCN2 eIF2α Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of an Essential Amino Acid. Cell Metabolism. 2007, 5:103-114.
Ebihara T, Guo F, Zhang L, Kim JY, Saffen D. Muscarinic acetylcholine receptors stimulate Ca2+ influx in PC12D cells predominantly via activation of Ca2+ store-operated channels. The Journal of Biochemistry. 2006, 139: 449-458.
Zhang L, Guo F, Kim J, Saffen D. Muscarinic Acetylcholine Receptors Activate TRPC6 Channels in PC12D Cells via Ca2+ Store–Independent Mechanisms. The Journal of Biochemistry. 2006, 139: 459-470.
