人物簡介
先後於2008年和2012年留學美國麻省理工學院生物工程系和美國明尼蘇達大學癌症中心。主要從事致癌機理及抗癌藥物研究。提出亞硝胺代謝活化導致DNA股間交聯是其致癌作用的關鍵步驟；闡明了亞硝基脲抗癌和致癌作用機制的關鍵差異並提出dG-dC交聯作為評價其抗癌活性的生物標誌物，為設計開發高效低毒的抗癌藥物奠定了基礎。入選2009年北京市“科技新星”計畫、2008年北京市委組織部“優秀人才”計畫和2015年北京工業大學“京華人才”計畫。主持國家自然科學基金青年基金和面上項目、北京市自然科學基金等課題項目。發表研究論文50餘篇，其中SCI、EI收錄 40餘篇。主講本科生《儀器分析》、《食品檢測技術》和研究生《量子生物學》等課程，獲得北京工業大學“優秀教學質量獎”和“優秀教育教學成果獎”等，主持校教育教學研究課題和研究生課程建設項目各1項。
主要研究方向
1. 新型靶向性抗癌烷化劑的設計、合成及活性研究。
2. 烷化劑類抗癌藥物對生物大分子的損傷及其修復作用。
3. 化學致癌物的作用機理及其分子結構與致癌活性關係。
4. 吸菸導致癌症的作用肌理、生物標誌物及化學預防。
主持科研項目
1. 國家自然科學基金面上項目（2013.01-2016.12，項目負責人）：
環境中N-亞硝基化合物分子結構與致癌活性關係及其生物標誌物研究。
2. 北京工業大學“京華人才”支持計畫（2015.01-2017.12，項目負責人）：
新型靶向性亞硝基脲類抗癌藥物的研究。
3. 北京市留學人員科技活動擇優資助項目（2015.01-2015.12，項目負責人）：
菸草特異亞硝胺導致肺癌的生物標誌物研究。
4. 國家自然科學基金青年基金項目（2010.01-2012.12，項目負責人）：
N-亞硝基化合物對DNA的損傷作用機制及相關構效關係。
5. 北京市科技新星計畫B類（2010.01-2012.12，項目負責人）：
N-亞硝基化合物對DNA的損傷作用及致癌機理研究。
6. 北京市自然科學基金預探索項目（2011.01-2012.06，項目負責人）：
烷基亞硝胺對DNA的損傷作用與其致癌靶器官之間的關係。
7. 北京市委組織部優秀人才資助項目（2008.01-2009.12，項目負責人）：
癌症相關標誌物及套用研究。
主要學術論文
1. Lili Li, Sisi Li, Guohui Sun, Ruizeng Peng, Lijiao Zhao,* Rugang Zhong. Influence of the Expression Level of O-6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass Spectrometry. Plos One, 2015, 10(3): UNSP e0121225 (SCI收錄)
2. Guohui Sun, Lijiao Zhao,* Tengjiao Fan, Sisi Li, Rugang Zhong. Investigations on the effect of O6-benzylguanine on the formation of dG-dC interstrand crosslinks induced by chloroethylnitrosoureas in human glioma cells using a stable isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Chem. Res. Toxicol., 2014, 27(7): 1253-1262. (SCI收錄)
3. Lili Li, Lijiao Zhao,* Rugang Zhong. Quanti？cation of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/ electrospray ionization tandemmass spectrometry. Rapid Comm. Mass Spectrom., 2014, 28(5): 439-447. (SCI收錄)
4. Lijiao Zhao,* Lili Li, Jie Xu, Rugang Zhong. Comparative investigation of the DNA inter-strand crosslinks induced by ACNU, BCNU, CCNU and FTMS using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Int. J. Mass Spectrom., 2014, 368(7):30-36. (SCI收錄)
5. Lijiao Zhao, Silvia Balbo, Mingyao Wang, Pramod Upadhyaya, Samir S. Khariwala, Peter W. Villalta, Stephen S. Hecht*.Quantitation of pyridyloxobutyl- DNA adducts in tissues of rats treated chronically with (R)- or (S)-N′-nitrosonornicotine (NNN) in a carcinogenicity study. Chem. Res. Toxicol., 2013, 26(10): 1526-1535. (SCI收錄)
6. Tingting Liu, Lijiao Zhao,* Rugang Zhong. DFT study of phosphotriesters hydrolysis in aqueous solution: a model study for DNA single strand scission induced by N-nitrosoureas. J. Mol. Model., 2013, 19(2): 647-659. (SCI收錄)
7. Lijiao Zhao,* Xinyan Ma, Rugang Zhong. A DFT investigation on the formation mechanisms of DNA interstrand crosslinks induced by chloroethylnitrosoureas. Int. J. Quantum Chem., 2013, 113(9): 1299-1306. (SCI收錄)
8. Ting Ren, Lijiao Zhao,* Bosi Sun, Rugang Zhong. Determination of lead, cadmium, copper, and nickel in the Tonghui River of Beijing, China, by cloud point extraction-high resolution continuum source graphite furnace atomic absorption spectrometry. J. Environ. Qual., 2013, 42(6): 1752-1762. (SCI收錄)
9. Lijiao Zhao,* Xinyan Ma, Rugang Zhong. Comparative theoretical investigation of the mechanism of DNA interstrand crosslinks induced by two N-nitroso compounds: nitrosoureas and nitrosamines. J. Phy. Org. Chem., 2012, 25(12): 1153-1167. (SCI收錄)
10. Jun Cao, Lijiao Zhao,* Shubin Jin, Rugang Zhong. Relationship between the molecular structure and the anticancer activity of N-(2-chloroethyl)-N'-c yclohexyl-N-nitrosoureas: A theoretical investigation. Int. J. Quantum Chem., 2012, 112(3): 747-758. (SCI收錄)
11. Lijiao Zhao,* Ting Ren, Rugang Zhong. Determination of lead in human hair by high resolution continuum source graphite furnace atomic absorption spectrometry with microwave digestion and solid sampling. Anal. Lett., 2012, 45(16): 2467-2481. (SCI收錄)
12. Baoqing Bai, Lijiao Zhao,* Rugang Zhong. Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/ electrospray ionization tandem mass spectrometry. Rapid Comm. Mass Spectrom., 2011, 25(14): 2027-2034. (SCI收錄)
13. Lijiao Zhao,* Tingting Liu, Rugang Zhong. A comparison of the stereoisomeric penta-coordinated phosphorus intermediates formed from 19 dimethoxyl N-phosphoryl amino acids by DFT calculations. J. Theor. Comput. Chem., 2011, 10(2): 217-229. (SCI收錄)
