個人簡歷
有機化學博士,北京大學藥學院副教授。1993-1997 理學學士,蘭州大學化學系套用化學專業;1997-2002 理學博士,蘭州大學化學系有機化學專業 (導師:塗永強);2002-2007 博士後,法國國家科學研究中心,天然產物化學研究所(導師:祝介平);從2007年至今任北京大學藥學院副教授
主要研究領域
具有重要生物活性天然產物的全合成及仿生合成;生物活性天然產物的結構改造以及構效關係研究;基於天然產物小分子探針的發現;有機合成新方法、新策略的研究。學術成就
2009 新世紀優秀人才支持計畫2008 第十一屆中國藥學會-施維雅青年藥物化學獎
2002 甘肅省科技進步獎, 一等獎
主要發表論文
1. “Stereocontrolled and Efficient Total Synthesis of (–)-Stephanotic Acid Methyl Ester and (–)-Celogentin C”, Weimin Hu, Fengying Zhang, Zhengren Xu, Qiang Liu, Yuxin Cui, Yanxing Jia*. Org. Lett. 2010, 12, 956-959.2. “Water-Controlled Regioselectivity of Pd-Catalyzed Domino Reaction Involving a C–H Activation Process: Rapid Synthesis of Diverse Carbo- and Heterocyclic Skeletons”, Zhiyao Lu, Chunmei Hu, Jiajie Guo, Jing Li, Yuxin Cui, Yanxing Jia*. Org. Lett. 2010, 12, 480-483.
3. “Formal synthesis of semiaquilegin A”, Jing Li, Yong Jiang, Qingjiang Li, Qiang Xiao, Yanxing Jia*, Pengfei Tu*. Tetrahedron Lett. 2010, 51, 1121-1123.
4. “Palladium-Catalyzed Synthesis of Tryptamines and Tryptamine Homologues: Synthesis of Psilocin”, Chunmei Hu, Hua Qin, Yuxin Cui, Yanxing Jia*. Tetrahedron,2009, 65, 9075-9080.
5. "Efficient Total Synthesis of (–)-cis-Clavicipitic Acid”, Zhengren Xu, Qingjiang Li, Lihe Zhang, Yanxing Jia*. J. Org. Chem. 2009, 74, 6859-6862."
6.“Total Synthesis of (-)-Incarvilline and (-)-Incarvillateine”, Fengying Zhang, Yanxing Jia*. Tetrahedron 2009, 65, 6840-6843.
7.“Palladium-Catalyzed Indole and Azaindole synthesis by Direct Annulation of Electron-Poor o-Chloroanilines and Chloroaminopyridines with Aldehydes”, Zhengren Xu, Weimin Hu, Fengying Zhang, Qingjiang Li, Zhiyao Lü, Lihe Zhang, Yanxing Jia*. Synthesis 2008, 3981-3987.
8.“Synthesis of Diastereomers of Complestatin, and Chloropeptin, High Substrate-dependent Atropstereoselectivity of Intramolecular Suzuki-Miyaura Reaction”, Yanxing Jia, Michèle Bois-Choussy, Jieping Zhu*. Angew. Chem. Int. Ed. 2008, 47, 4167-4172.
9.“Synthesis of DEFG Ring of Complestatin and Chloropeptin I: Highly Atropdiastereoselective Macrocyclization by Intramolecular Suzuki-Miyaura Reaction”, Yanxing Jia, Michèle Bois-Choussy, Jieping Zhu*. Org. Lett. 2007, 9, 2401-2404.
10.“Design and Synthesis of Simple Macrocycles Active Against Vancomycin-resistant Enterococci (VRE)”, Yanxing Jia, Nianchun Ma, Zuosheng Liu, Michèle Bois-Choussy, Eduardo Gonzalez-Zamora, Adriano Malabarba, Cristina Brunati, Jieping Zhu*. Chem. Eur. J. 2006, 12, 5334-5351.
11.“Palladium-Catalyzed, Modular Synthesis of Highly Functionalized Indoles and Tryptophans by Direct Annulation of Substituted o-Haloanilines and Aldehydes”, Yanxing Jia, Jieping Zhu*. J. Org. Chem. 2006, 71, 7826-7834.
12.“Synthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals: Stereocontrolled Synthetic Approach to the Key Mother Spiroketals”, Yanxing Jia, Bin Wu, Xin Li, Shikuo Ren, Yongqiang Tu,* Albert S. C. Chan, William Kitching. Org. Lett. 2001, 3, 847-849.