人物經歷
中國生物物理學會分子影像專業委員會常委;中國國際科學交流基金會專家委員會委員;美國化學學會會員。於北京中醫藥大學學習獲醫學學士學位(1991-1996)、於美國路易斯安那理工大學生物醫學工程系學習獲博士學位(1997-2002)、美國凱斯西儲大學生物醫學工程系做Research Associate兼博士後(2002-2005)。從2005年至今任四川大學教授。
研究方向
艾華教授主要從事新型納米生物材料在分子影像和藥物控釋中套用的研究,開發了具腫瘤靶向的高靈敏度新型磁共振造影劑和納米藥物載體;在此基礎上,對影像跟蹤藥物載體、影像跟蹤細胞、分子影像探針與細胞的相互作用機理等方面開展了深入的研究。
主要貢獻
1. Ai, H.*, Layer-by-layer capsules for magnetic resonance imaging and drug delivery, Advanced Drug Delivery Reviews, 2011, 63, 772-788. (邀請綜述) (IF: 13.577)。
2.Xie, J., Liu, G., Ai, H.*, Chen, X.* Surface-engineered magnetic nanoplatforms for theranostics. Accounts of Chemical Research, 2011, 44, 883-892. (邀請綜述) (IF: 21.840)。
3.Liu, G., Xie, J., Zhang, F., Wang, Z., Luo, K., Zhu, L., Quan, Q., Niu, G., Lee, S., Ai, H.*, Chen, X.* N-Alkyl-PEI functional iron oxide nanocluster for efficient siRNA delivery, Small, 2011, 7, 2742-2749.(IF: 7.333)。
4.Luo, K., Liu, G., She, W., Wang, Q., Wang, G., He, B., Ai, H.,* Gong, Q., Song, B., Gu, Z. Gadolinium-labeled peptide dendrimers with controlled structures as potential magnetic resonance imaging contrast agents, Biomaterials, 2011, 32, 7951-7960. (IF: 7.882)。
5.Liu, G., Wang, Z., Lu, J., Xia, C., Gao, F., Gong, Q., Song, B., Zhao, X., Shuai, X., Chen, X., Ai, H.*, Gu, Z. Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging, Biomaterials, 2011, 32, 528-537. (IF: 7.882)。
6.Luo, K., Liu, G., He, B., Wu, Y., Gong, Q., Song, B., Ai, H.*, Gu, Z.* Multifunctional gadolinium-based dendritic macromolecules as liver targeting imaging probes, Biomaterials, 2011, 32, 2575-2585. (IF: 7.882)。
7.Cao, N., Cheng, D., Zou, S., Ai, H., Gao, J., Shuai, X. The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells. Biomaterials, 2011, 32, 2222-2232. (IF: 7.882)。
8.Cheng, D., Hong, G., Wang, W., Yuan, R., Ai, H., Shen, J., Liang, B., Gao, J., Shuai, X. Nonclustered magnetite nanoparticle encapsulated biodegradable polymeric micelles with enhanced properties for in vivo tumor imaging. Journal of Materials Chemistry, 2011, 21, 4796-4804. (封面文章) (IF: 5.099)。
9.Dai, J., Zou, S., Pei, Y., Cheng, D., Ai, H., Shuai, X. Polyethylenimine-grafted copolymer of poly(l-lysine) and poly(ethylene glycol) for gene delivery. Biomaterials, 2011, 32, 1694-1705. (IF: 7.882)。
10. Lu, J., Ma, S., Sun, J., Xia, C., Liu, C., Wang, Z., Zhao, X., Gong, Q., Song, B., Shuai, X., Ai, H.*, Gu, Z. "Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging”, Biomaterials, 2009, 30, 2919. (IF: 7.882)。
11.Luo, K., Liu, G., Zhang, X., She, W., He, B., Nie, Y., Li, L., Wu, Y., Zhang, Z., Gong, Q., Gao, F., Song, B., Ai, H.*, Gu, Z.* Functional L-lysine dendritic macromolecules as liver-imaging probes. Macromolecular Bioscience, 2009, 9, 1227-1236. (封面文章) (IF: 3.458)。
12. Liu, G., Tian, J., Liu, C., Gou, J., Mo, X., Ai, H.*, Gu, Z. “Cell Labeling Efficiency of Layer-by-Layer Self-Assembly Modified Silica Nanoparticles”, Journal of Materials Research, 2009, 24, 1317-1321. (IF: 1.395)。
13. Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J.S., Chin, S.F., Sherry, A.D., Boothman, D.A., Gao, J. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Letters 2006, 6, 2427-2430. (IF: 12.186)。
14. Ai, H., Flask, C., Weinberg, B., Shuai, X., Pagel, M.D., Farrell, D., Duerk, J., Gao, J. Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes. Advanced Materials, 2005, 17, 1949-1952. (IF: 10.857)。
15. Nasongkla, N., Shuai, X., Ai, H., Weinberg, B.D., Pink, J., Boothman, D.A., Gao, J. cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angew. Chem. Int. Ed. Engl. 2004, 43, 6323-6327. (IF: 12.730)。
16. Shuai, X., Ai*, H., Nasonkla, N., Pink, J., Gao, J. Micellar Carriers Based on Block Copolymers of Poly(epsilon-caprolactone) and Poly(ethylene glycol) for Doxorubicin Delivery, Journal of Controlled Release, 2004, 98, 415-426. (*: 共同第一作者). (IF: 7.164)。
17. Ai, H., Jones, S., de Villiers, M., Lvov, Y., Nano-Encapsulation of Furosemide Microcrystals for Controlled Drug。
Release, Journal of Controlled Release, 2003, 86, 59-68. (IF: 7.164)。
現擔任生物材料領域頂級雜誌Biomaterials(IF:7.882)雜誌編委,Adv. Drug Deliv. Rev.、Biomaterials及一系列相關領域雜誌評審。曾應邀擔任美國國家宇航局(NASA)資助的科研項目(Nanoparticle Delivery of Repair Enzymes for Radiation Protection/DNA repair)顧問。先後參加多個美國NIH和NSF資助的重大科研項目,並作為負責人承擔美國國防部基金項目。回國後主持了國家自然科學基金、教育部新世紀優秀人才計畫、四川省傑出青年基金等項目。作為四川大學985工程“生物醫學工程與技術科技創新平台”藥物控釋方向學術帶頭人,國家重點一級學科“生物醫學工程”藥物控釋方向學術帶頭人,國家重點學科“影像醫學”分子影像方向學術帶頭人(四川大學華西醫院),國家973項目(組織誘導性生物醫用材料的基礎研究-裝載基因材料的分子設計及組織誘導作用和機理,2005-2010)四川大學第一主研,積極開展國內外多學科合作的科研工作。
獲獎記錄
獲得2006年“四川省有突出貢獻的優秀專家”稱號。