胡黔楠

胡黔楠

胡黔楠,男,副教授,2004年10月至2007年2月,德國,愛爾蘭根-紐倫堡大學,計算機化學中心,Johann Gasteiger教授小組博士後。

姓名:胡黔
性別:男
職務/職稱: 副教授
通訊地址(含郵編):430071 武漢市武漢大學藥學院
學習簡歷:
1997年6月,中南工業大學(現中南大學)化學系,學士,導師:嚴規有教授
2001年6月,中南大學化學化工學院,碩士,導師:任鳳蓮教授
2004年6月,中南大學,博士,導師:梁逸曾教授
工作簡歷:
2004年10月至2007年2月,德國,愛爾蘭根-紐倫堡大學,計算機化學中心,Johann Gasteiger教授小組,博士後。
2007年2月至2008年7月,美國,加州大學歐文分校,信息和計算機科學學院,Pierre Baldi教授實驗室,博士後。
2008年8月至2010年2月,日本,京都大學,生物信息學中心,Minoru Kanehisa教授,產官學提攜研究員。
2010年3月起,武漢大學,藥學院,副教授。
業績概要:
一直從事生物信息學和系統生物學在藥物開發中的套用研究,參與了中國、德國、美國以及日本等國多個橫向和縱向的交叉學科科研項目的科學研究和商業軟體開發。在國內外知名刊物上發表科學論文20多篇,其中10多篇在國際性刊物上發表,被科學引文索引(SCI)收錄10多篇。多次受邀作為國際刊物《Journal of Chemical Information and Modeling》和《Chemometrics and Intelligent Laboratory Systems》的審稿人。

中國化學會優秀青年論文獎 (2004)
陳新民獎(2003)
研究領域: 化學信息學,系統生物學,藥物分子設計,化學計量學,生物信息學
研究興趣與方向:
(1) Systems drug design
(2) Network-based drug metabolism prediction
(3) Computer-aided drug screening and synthsis
(4) Molecular basis of Traditional Chinese Medicines
(5) Genome-wide association study
科研成果(至少應有近五年的代表性成果):
1. Qian-Nan hu, Zhe Deng, Huanan Hu, Dong-Sheng Cao, Yi-Zeng Liang (2011)RxnFinder: Biochemical Reaction Search Engines Using Molecular Structures, Molecular Fragments, and Reaction Similarity. Bioinformatics 27(17): 2465-2467.
2. Dong-Sheng Cao, Qian-Nan Hu, Qing-Song Xu, Yan-Ning Yang, Jian-Chao Zhao, Hong-Mei Lu, Liang-Xiao Zhang, Yi-Zeng Liang(2011)In silico classification of human maximum recommended daily dose based on modified random forest and substructure fingerprint. Analytica Chimica Acta 692, 50-56.
3. Dong-Sheng Cao, Bing Wang, Mao-Mao Zeng, Yi-Zeng Liang, Qing-Song Xu, Liang-Xiao Zhang, Hong-Dong Li, Qian-Nan Hu (2011) A new strategy of exploring metabolomics data using Monte Carlo tree. Analyst 136(5):947-54.
4. Dong-Sheng Cao, Yi-Zeng Liang, Qing-Song Xu, Qian-Nan Hu, Liang-Xiao Zhang, Guang-Hui Fu (2011)Exploring nonlinear relationships in chemical data using kernel-based methods. Chemometrics and Intelligent Laboratory Systems 107(1), 106-115.
5. Dong-Sheng Cao, Yi-Zeng Liang, Qing-Song Xu, Liang-Xiao Zhang, Qian-Nan Hu and Hong-Dong Li (2011) Feature importance sampling-based adaptive random forest as a useful tool to screen underlying lead compounds. Journal of Chemometrics 25(4), 201–207.
6. Emrin Zitha-Bovens, Peter Maas, Dick Wife, Johan Tijhuis, Qian-Nan Hu, Thomas Kleinöder, Johann Gasteiger(2009) COMDECOM: Predicting the Lifetime of Screening Compounds in DMSO Solution. Journal of Biomolecular Screening 14, 557-565.
7. Qian-Nan Hu, Yi-Zeng Liang., Xu, Q. S., Fang, K. T., Peng, X. L. and Yin, H (2005) Structural Features within Degree Distributions of Topological Graphs. J. Math. Chem. 37 (1), 37-56.
8. Xiao-Ling Peng, Qian-Nan Hu, Yi-Zeng Liang (2005) Variable Selection via Nonconcave Penalty Function in Structure-Boiling Points Correlations. J. Mol. Str.: THEOCHEM 714 (2-3), 235-242.
9. Shansheng Yang, Wencong Lu, Nianyi Chen, Qian-Nan Hu(2005) Support vector regression based QSPR for the prediction of some physicochemical properties of alkyl benzenes. Journal of Molecular Structure: THEOCHEM 719(1-3), 119-127.
10. Ya-Li Wang, Yi-Zeng Liang, Ben-Mei Chen, Bo-Yan Li, Qian-Nan Hu(2005)LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. Analytical and Bioanalytical Chemistry 383 (2), 247-254.
11. Qian-Nan Hu, Yi-Zeng Liang, Hong Yin, Xiao-Ling Peng, Kai-Tai Fang (2004) Structure Interpretation of Topological Index (2) Molecular Connectivity Index, Kappa Index and E-State Index. J. Chem. Inf. Comput. Sci. 44, 1193-1201.
12. Xiao-Ling Peng, , Kai-Tai Fang, Qian-Nan Hu, Yi-Zeng Liang (2004) Impersonality of the Connectivity Index and Recomposition of Topological Indices According to Different Properties.Molecule, 9, 1089-1099.
13. Qian-Nan Hu, Yi-Zeng Liang, Xiao-Ling Peng, Hong Yin, Kai-Tai Fang (2004) Structure Interpretation of Topological Index (1) External Factor Variable Connectivity Index. J. Chem. Inf. Comput. Sci. 44, 437-446.
14. Qian-Nan Hu, Yi-Zeng Liang, Feng-Liang Ren (2003) Molecular Graph Center, A Novel Approach to Locate the Center of a Molecule and a New centric Index. J. Mol. Str.: THEOCHEM 635/1-3, 105-113.
15. Huang, L. F., Liang, Y. Z., Guo, F. Q., Qian-Nan Hu, Chen, B. M(2003) Rapid simultaneous determination of arginine and methylated arginines in human urine by high-performance liquid chromatographymass spectrometry. Anal. Chem. Acta 487, 145-153.
16. Qian-Nan Hu, Yi-Zeng Liang, Ya-Li Wang, Cheng-Jian Xu, Zhong-Da Zeng, Kai-Tai Fang, Xiao-Ling Peng, Yin Hong (2003) External Factor Variable Connectivity Index. J. Chem. Inf. Comput. Sci. 43, 773-778.

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