王釗[清華大學醫學院博士生導師]

王釗，清華大學生命科學學院教授，清華大學醫學院教授，博士生導師。

人物經歷

1978-1983，河南中醫學院醫療系，醫學學士。

1984-1987，北京中醫藥大學基礎醫學院，醫學碩士。

1990-1993，日本岡山大學藥學院，藥學碩士。

1993-1996，日本岡山大學藥學院，藥學博士。

1996-1998，日本岡山大學醫學院，助理教授。

1998-現在，清華大學生命科學學院副教授、教授、校內雙聘教授。

2004-現在，清華大學醫學院教授。

2006-2007，美國紐約大學西奈山醫學院，訪問教授。

研究方向

分子細胞藥理毒理學：中藥的藥理與毒理、神經藥理、腫瘤藥理、骨代謝與藥物干預等；衰老機制及藥物干預的研究：尤其是腦衰老及藥物對神經退行性疾病等衰老相關疾病的研究；天然藥物與功能保健品的研究與開發。

主要貢獻

1·Jing Du, Junlei Chang, Songxi Guo, Qing Zhang, Zhao Wang*. ApoE4 Reduces the degrading enzyme IDE by Activating the NMDA Receptor inExpression of A Hippocampal Neurons. Neuroscience Letters. (2009) (in press)

2·Jing Du, Bing Sun, Kui Chen, Li Fan, Zhao Wang*. Antagonist of Peroxisome Proliferator-activated Receptor <gamma> Induces Cerebellar Amyloid-<beta> Levels and Motor Dysfunction in APP/PS1 Transgenic Mice. Biochem Bioph Res Co. 384 (3): 357-361 (2009)

3·Zong-Chun Yi, Yan-Ze Liu, Hai-Xia Li, Zhao Wang*. Chebulinic acid and tellimagrandin I inhibit DNA strand breaks by hydroquinone/Cu(II) and H2O2/Cu(II), but potentiate DNA strand breaks by H2O2/Fe(II). Toxicology in Vitro. 23 (4) 667–673 (2009)

4·Jing Du, Bing Sun, Kui Chen, Lang Zhang, Shubo Liu, Qingquan Gu, Li Fan, Nanming Zhao, Zhao Wang*. Metabolites of Neurons Play Essential Role in Pathogenesis of Alzheimer's Disease. PLoS ONE. 4 (5): e5530 (2009)

5·Jing Du, Lang Zhang, Shubo Liu, Chi Zhang, Xiuqing Huang, Jian Li, Nanming Transcriptionally Regulates the Expression ofZhao, Zhao Wang*. PPAR Insulindegrading Enzyme in Primary Neurons. Biochem Bioph Res Co. 383 (4): 485-490 (2009) ·

6·Min Fu, Ruxin Li, Li Fan, Guowei He, Kent L Thornburg, Zhao Wang*: Sarcoplasmic Reticulum Ca2+ Release Channel Ryanodine Receptor (RyR2) Plays a Crucial Role in Aconitine-induced Arrhythmias. Biochemical Pharmacology. 75 (11) 2147-2156 (2008)

7·Mingchao XIE, Chao AI, Shangfeng LIU, Shixin TAO, Zhao WANG*Cloning and characterization of chicken SPATA4 gene and analysis of its specific expression. Molecular and Cellular Biochemistry. 306 (1-2): 79-85 (2007)

8·Min Fu, Meng Wu, Jifeng Wang, Yanjiang Qiao, Zhao Wang*: Disruption of the Intracellular Ca2+ Homeostasis in the Cardiac Excitation-Contraction Coupling is a Crucial Mechanism of Arrhythmic Toxicity in Aconitine-induced Cardiomyocytes. Biochem Bioph Res Co. 354 (4): 929-936 (2007)

9·Liu Hai-Luo, Liu Shang-Feng, Ge Ye-Jing, Liu Jing, Wang Xiao-Yan, Xie Li-Ping, Zhang Rong-Qing, Wang Zhao*: Identification and characterization of a biomineralization related gene PFMG1 highly expressed in the mantle of pinctada fucata. Biochemistry. 46 (3): 844-851 (2007)

10·Zong-Chun Yi, Zhao WANG*, Hai-Xia Li, Yan Yin, Feng-Yuan Zhuang, and Yu-Bo Fan: Tellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro. Cancer Letters. 242 (1)77-87 (2006)