教育經歷
2006/9 - 2011/6,山東大學,生理學,博士,導師:郝愛軍
2000/9 - 2003/6,山東大學,生理學,碩士,導師:陳連璧
1993/9 - 1998/6,新鄉醫學院,臨床醫學,學士
工作經歷
2014/9 - 至今,山東大學,醫學院,副教授
2016/2 - 2017/1,美國肯塔基大學,醫學院,訪問學者
2011/11 - 2014/10, 山東大學,醫學院,博士後,已出站
2008/8 - 2009/12,美國肯塔基大學,醫學院Gill Heart心臟病研究所,訪問學者
2005/9 - 2014/8,山東大學,醫學院,講師
主持或參加科研項目及人才計畫項目情況
項目類別、批准號、名稱、研究起止年月、獲資助金額、項目狀態(已結題或在研等)、主持或參加。
1. 山東大學基本科研業務費(交叉學科培育)項目:2015JC008,左旋半胱氨酸在腦出血後認知障礙中的臨床套用及機制研究,2015.01-2017.12,35萬,在研,主持。
2 中國博士後科學基金特別資助,2013T60672,硫化氫對缺血缺氧性腦損傷神經系統發育的影響及機制,2013.07-2015.07,15萬,在研,主持。
3. 國家自然科學基金(青年科學基金項目),81200879,飽和脂肪酸對胚胎神經系統發育的影響及機制研究,2013年01月- 2015年12月,23萬,在研,主持。
4. 山東大學自主創新基金:IIFSDU2012TS120,硫化氫對神經幹細胞增殖分化的影響及其機制研究,2013.01-2015.12,7萬,已結題,主持。
5. 中國博士後科學基金面上資助,2012M511514,孕期肥胖對胚胎神經系統發育的影響及機制研究,2012.05-2013. 12,5萬,已結題,主持。
6. 山東省自然科學基金(青年項目),ZR2011HQ035,清道夫受體CD36在脂肪組織脂類代謝和炎症反應中的作用及機制的研究,2011.07-2014.07,5萬,已結題,主持。
近五年發表主要論著
1. Zhang Q, Yuan L, Liu D, Wang J, Wang S, Zhang Q, Gong Y, Liu H, Hao A, Wang Z*(王貞) . Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation.Pharmacological Research. 2014 Jun;84:32-44. PubMed
2.Liu D,Zhang Q,Gu J,Wang X,Xie K,Xian X,Wang J,Jiang H, Wang Z*(王貞) . Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats.Prog Neuropsychopharmacol Biol Psychiatry.2014 Mar 3;49:21-9. PubMed
3.Liu D,Xie K,Yang X,Gu J,Ge L,Wang X, Wang Z*(王貞) .Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats.Behav Brain Res.2014 May 1;264:9-16. PubMed
4. Wang Z(王貞),Zhang Q,Yuan L,Wang S,Liu L,Yang X,Li G*, Liu D*. The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration.Behav Brain Res.2014 Nov 1;274:282-90. PubMed
5. Wang Z(王貞), Liu D, Zhang Q, Wang J, Zhan J, Xian X, Du Z, Wang X,Hao A*. Palmitic acid affects proliferation and differentiation of neural stem cells in vitro. Journal of Neuroscience Research, 2014 May;92(5):574-86. PubMed
6. Wang Z(王貞), Liu D, Zhan J, Xie K, Wang X, Xian X, Gu J, Chen W, Hao A*. Melatonin improves short and long-term neurobehavioral deficits and attenuates hippocampal impairments after hypoxia in neonatal mice. Pharmacological Research. 2013 Oct; 76:84-97. PubMed
7. Wang Z(王貞), Zhan J, Wang X, Gu J, Xie K, Zhang Q, Liu D*. Sodium hydrosulfide prevents hypoxia-induced behavioral impairment in neonatal mice. Brain Res 2013 Nov 13;1538:126-34. PubMed
8. Wang Z(王貞) , Gu J,Wang X,Xie K,Luan Q,Wan N,Zhang Q,Jiang H,Liu D*. Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK.Pharmacol Biochem Behav.2013 Nov;112:104-10. PubMed
9. Wang Z(王貞) ,Liu DX, Wang FW, Zhang Q, Du ZX, Zhan JM, Yuan QH, Ling EA, Hao AJ*. L-cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/HS pathway.Neuroscience.2013, 237:106-117. PubMed
10. Wang Z(王貞), Liu D, Wang J, Liu S, Gao M, Ling EA, Hao A*. Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro.Journal of pineal research.2012 Mar;52(2):253-64 PubMed
11. Wang Z(王貞), Liu D, Wang F, Liu S, Zhao S, Ling EA, Hao A*. Saturated fatty acids activate microglia via Toll-like receptor 4/nuclear factor κB signaling. British journal of nutrition. 2012 Jan;107(2):229-41. PubMed
12. Cai L, Wang Z(王貞), Ji A, Meyer JM, van der Westhuyzen DR*. Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. PloS one. 2012;7(5):e36785. PubMed
13. Jiang H, Wang Z(王貞), Wang Y, Xie K, Zhang Q, Luan Q, Chen W, Liu D* Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry.2013. Dec 2;47:33-9 PubMed
14.Liu D, Wang Z(王貞),Liu S,Wang F,Zhao S,Hao A*. Anti-inflammatory effects of fluoxetine in lipopolysaccharide (LPS)-stimulated microglial cells.Neuropharmacology.2011 Sep;61(4):592-9. PubMed
15. Zhang Q,Yuan L,Zhang Q,Gao Y,Liu G,Xiu M,Wei X, Wang Z(王貞)*,Liu D*. Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation. Int Immunopharmacol.2015 Jul 27;28(1):578-587. PubMed
16.Liu D#, Wang Z(王貞),Zhan J,Zhang Q,Wang J,Zhang Q,Xian X,Luan Q,Hao A*. Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells and protects hypoxia-induced decrease in hippocampal neurogenesis.Pharmacol Biochem Behav.2014 Jan;116:55-63. PubMed