人物簡介
汪俊松,1975年7月生,安徽無為人,博士,教授,德國洪堡學者,南京理工大學博士研究生導師,生物工程系主任。先後入選教育部“新世紀優秀人才”和江蘇省“333工程”第三(中青年科學技術帶頭人)、第二層次(中青年科技領軍人才),國家自然科學基金、中國博士後科學基金評審專家。主持德國洪堡學者研究基金,國家自然科學基金青年、面上基金,教育部新世紀優秀人才,參與並獲得省部級、國家級科技獎勵成果共四項。發表SCI論文155篇,其中第一作者或通訊作者的SCI論文64篇,H指數28。
學習與工作經歷
1992年9月-1996年7月,安徽中醫藥大學藥學院中藥系獲得中藥學學士學位;
1996年7月-1999年8月,安徽省中藥材公司質檢員;
1999年9月-2005年3月,於中科院昆明植物研究所植物化學與西部植物資源持續利用國家重點實驗室進行研究並獲得理學博士學位;
2005年9月-2007年1月,於韓國生命工學研究院進行博士後研究;
2007年2月-2008年2月,在世界著名的亞歷山大·馮·洪堡基金會資助下作為洪堡學者在德國癌症研究中心開展研究工作;
2008年3月-2013年1月,作為海外引進人才供職中國藥科大學中藥學院(直聘副教授);
2013年2月至今,南京理工大學環境與生物工程學院、分子代謝中心教授。
研究方向
1.天然藥物化學研究:天然產物活性成分的提取、分離、結構鑑定、修飾、生物活性及方法學研究。
2.中藥複方研究:根據中藥複方多成分、多靶點、整體作用的特點,綜合運用系統科學、計算科學、非線性科學等多學科交叉融合手段處理其化學組成信息和藥效活性信息,探討其生物效應的譜效關係,構建中藥複方的質量標準和評價體系,闡明其物質基礎。
3.代謝組學新技術新方法及其套用研究:以NMR和GC-MS、UPLC-QTOF-MS為主要測試手段,發展代謝組學研究新方法。對生物體內內源性代謝物進行定量分析,結合模式識別和機器學習方法,尋找代謝物與生理病理毒理變化的相對關係,藉助於化學信息和生物信息等交叉學科探究其生物學意義及提出科學假說。
主要文章列表
1.Wan, C.P.#; Li, P.#; Chen, C.Y.; Peng, X.; Li, M.X.; Chen, M.; Wang, J.S.*; Chen, J.Y.*, Antifungal Activity of Ramulus cinnamomi Explored by H-NMR Based Metabolomics Approach. Molecules 2017, 22 (12), 2237.( Impact Factor :3.09)
2.Tang, R.G.; Ding, C.F.; Ma, Y.B.; Wang, J.S.*; Zhang, T.L.; Wang, X.X.*, Metabolic Responses of Eisenia Fetidato Individual Pb and Cd Contamination in Two Types of Soils. Scientific Reports 2017, 7 (1), 13110.( Impact Factor :4.259)
3.Lv, Y.; Wang, J.S.*; Xu, D.Q.; Liao, S.T.; Li, P.; Zhang, Q.; Yang, M.H.; Kong, L.Y.*., Comparative study of single/combination use of Huang-Lian-Jie-Du decoction and berberine on their protection on sepsis induced acute liver injury by NMR metabolic profiling. Journal of Pharmaceutical and Biomedical Analysis 2017, 145, 794-804.( Impact Factor :3.255)
4.Li, M.H.; Du, H.Z.; Kong, G.J.; Liu, L.B.; Li, X.X.; Lin, S.S.; Jia, A.Q.; Yuan, S.T.*; Sun, L.*; Wang, J.S.*, Nuclear Magnetic Resonance-Based Metabolomics Approach to Evaluate the Prevention Effect of Camellia nitidissima Chion Colitis-Associated Carcinogenesis. Frontiers in Pharmacology2017, 8, Article 447, doi: 10.3389/fphar.2017.00447. ( Impact Factor : 4.4)
5.Fu, Y.H.; Si, Z.H.; Li, P.M.; Li, M.H.; Zhao, H.; Jiang, L.; Xing, Y.X.; Hong, W.; Ruan, L.Y.; Wang, J.S.*, Acute psychoactive and toxic effects of D. metelon mice explained by H NMR based metabolomics approach. Metabolic Brain Disease 2017, 32(4), 1295-1309. ( Impact Factor : 2.297)
6.Zhang, Q.; Fu, X.W.; Wang, J.S.*; Yang, M.H.; Kong, L.Y.*, Treatment effects of ischemic stroke by berberine, baicalin and jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) explored by integrated metabolomics approach. Oxidative Medicine and Cellular Longevity 2017, Article ID 9848594, 20 pages, doi:10.1155/2017/9848594. ( Impact Factor : 4.593)
7.Zhang, Q.; Wang, J.S.*; Liao, S.; Li, P.; Xu, D.; Lv, Y.; Yang, M.; Kong, L.Y.*, Optimization of Huang-Lian-Jie-Du-Decoction for ischemic stroke treatment and mechanistic study by metabolomic profiling and network analysis. Frontiers in Pharmacology 2017, 8, Article 165, doi: 10.3389/fphar.2017.00165. ( Impact Factor : 4.4)
8.Li, M.H.; Ruan, L.Y.; Zhou, J.W.; Fu, Y.H.; Jiang, L.; Zhao, H.; Wang, J.S.*, Metabolic profiling of goldfish ( Carassius auratis) after long-term glyphosate-based herbicide exposure. Aquatic Toxicology 2017, 188, 159-169. ( Impact Factor : 4.129)
9.Xu, D.Q; Lv, Y.; Wang, J.S.*.; Yang, M.H.; Kong, L.Y.*, Deciphering the mechanism of Huang-Lian-Jie-Du-Decoction on the treatment of sepsis by formula decomposition and metabolomics: enhancement of cholinergic pathways and inhibition of HMGB-1/TLR4/NF-κB signaling. Pharmacological Research 2017, 121, 94-113. ( Impact Factor : 4.48)
10.Chen, T.T.; Sheng, J.Y.; Fu, Y.H.; Li, M.H.; Wang, J.S.*; Jia, A.Q.*, H NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol. Journal of Proteome Research 2017, 16 (2), 824-830. ( Impact Factor : 4.268)
11.Jiang, L.; Si, Z.H.; Li, M.H.; Zhao, H.; Fu, Y.H.; Xing, Y.X.; Hong, W.; Ruan, L.Y.; Li, P.M.; Wang, J.S.*, H NMR-based metabolomics study of liver damage induced by ginkgolic acid (15:1) in mice. Journal of Pharmaceutical and Biomedical Analysis 2017, 136, 44-54. ( Impact Factor : 3.255)
12.Li, P.; Liao S.T.; Wang, J.S.*; Xu, D.Q.; Zhang, Q.; Xu, D.Q.; Lv, Y.; Yang, M.H.; Kong, L.Y.*, Protection by Huang-Lian-Jie-Du decoction and its constituent herbs of lipopolysaccharide-induced acute kidney injury. FEBS Open Bio 2017, 7(2), 221-236.( Impact Factor : 2.143)
13.Zhao, H.; Si, Z.H.; Li, M.H.; Jiang, L.; Fu, Y.H.; Xing, Y.X.; Hong, W.; Ruan, L.Y.; Li, P.M.; Wang, J.S.*, Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by H NMR based metabolomics approach. Toxicology Research 2017,6, 17-29. ( Impact Factor : 1.969)
14.Zhang, Q.; Wang, J.S.*; Zhang, C.; Liao S.T.; Li, P.; Xu, D.Q.; Lv, Y.; Yang, M.H.; Kong, L.Y.*, The components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model. Oncotarget 2016, 7(49), 80872–80887 ( Impact Factor : 5.168)
15.Liao S.T.; Li, P.; Wang, J.S.*; Zhang, Q.; Xu, D.Q.; Lv, Y.; Yang, M. H.; Kong, L. Y.*, Huang-Lian-Jie-Du decoction treated sepsis via regulating ERK and SRC/STAT3 pathways and ameliorating metabolic status. RSC Advances 2016, 6(92), 89855-89866. ( Impact Factor : 3.108)
16.Li, P.; Liao S.T.; Wang, J.S.*; Xu, D.Q.; Zhang, Q.; Yang, M.H.; Kong, L.Y.*, NMR metabolic profiling of lipopolysaccharide-induced mice sepsis and the treatment effects of berberine. RSC advances 2016, 6, 47474-47485. ( Impact Factor : 3.108)
17.Liao S.T.; Li, P.; Wang, J.S.*; Zhang, Q.; Xu, D.Q.; Yang, M.H.; Kong, L.Y.*, Protection of baicalin on lipopolysaccharide induced liver and kidney injury based on H NMR metabolomic profiling. Toxicology Research 2016, 5, 1148-1159. ( Impact Factor : 1.969)
18.Li, M.H.; Xu, H.D.; Liu, Y.; Chen, T.; Jiang, L.; Fu, Y. H.; Wang, J.S.*, Multi-tissue metabolic responses of goldfish ( Carassius auratis) exposed to glyphosate-based herbicide. Toxicology Research 2016, 5, 1039 - 1052. ( Impact Factor : 1.969)
19.Chen, T.; Liu, Y.; Li, M.H.; Xu, H. D.; Sheng, J.Y.; Zhang, L.; Wang, J.S.*, Integrated H NMR-based metabolomics analysis of earthworm responses to sub-lethal Pb exposure. Environmental Chemistry 2016, 13, 792-803 ( Impact Factor : 3.516)
20.Li, P.; Wei, D.D.; Wang, J.S.*; Yang, M.H.; Kong, L.Y. *, H NMR metabolomics to study the effects of diazepam on anisatin induced convulsive seizures. Journal of Pharmaceutical and Biomedical Analysis 2016, 117, 184-194.( Impact Factor :3.255)
21.Zhang, Q.; Guo, P.P.; Wang, J.S.*; Yang, M.H.; Kong, L.Y.*,Gender-specific metabolic responses in focal cerebral ischemia of rats and Huang-Lian-Jie-Du decoction treatment. RSC Advances 2015, 5(116), 95558-95575. ( Impact Factor : 3.84)
22.Lou, Y.H; Wang, J.S.*; Dong, G.; Guo, P.P.; Wei, D.D.; Xie, S.S.; Yang, M.H.; Kong, L.Y.*, The acute hepatotoxicity of tacrine explained by H NMR based metabolomic profiling. Toxicology Research 2015, 4, 1465-1478 ( Impact Factor : 3.983)
23.Li, M.H.; Ruan, L.Y.; Liu, Y.; Xu, H. D.; Chen, T.; Fu, Y.H.; Jiang, L.; Wang, J.S.*, Insight into biological system responses in goldfish ( Carassius auratus) to multiple doses of avermectin exposure by integrated H NMR-based metabolomics. Toxicology Research 2015, 4, 1374–1388. ( Impact Factor : 2.161)
24.Li, P.C.; Tao, J.; Wei, D.D.; Yang, X.; Lu, Z.G.; Deng, X.H.; Cheng, Y.; Gu, J.B.; Yang, X.J.; Wang, Z.J., Lu, Q.,* Wang, J.S.*, Yin, C.J., Serum metabolomic analysis of human upper urinary tract urothelial carcinoma. Tumor Biology 2015, 36(19): 7531-7537.( Impact Factor : 2.926)
25.Wei, D.D.; Liao S.T.; Wang, J.S.*; Yang, M.H.; Kong, L.Y.*, Cholestatic liver injury model of bile duct ligation and the protection of Huang-Lian-Jie-Du decoction by NMR metabolomic profiling. RSC advances 2015, 5, 66200–66211. ( Impact Factor : 3.289)
26.Liu, Y.; Chen, T.; Li, M.H.; Xu, H.D.; Jia, A.Q.; Zhang, J.F.; Wang, J.S.*, H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish ( Carassius auratus). Chemosphere 2015, 138, 537-545.( Impact Factor : 3.698)
27.Dong, G.; Wei, D.D.; Wang, J.S.*; Guo, P.P; Li, M.H.; Yang, M.H.; Kong, L.Y.*, Study of the cardiotoxicity of Venenum Bufonisin rats using an H NMR-based metabolomics approach. Plos one 2015, 10(3): e0119515. ( Impact Factor : 3.057)