簡介
楊雪瑞，男，博士，研究員(PI)，清華大學生命科學學院博導。
1999-2003 清華大學，化學工程系，學士
2003-2009 美國密西根州立大學，化學工程系/生物化學及分子生物學系，雙學科博士
2009-2012 美國哥倫比亞大學，Irving癌症研究中心，系統生物學聯合中心，博士後
2012-至今 清華大學生命科學學院，研究員(PI)、博導
研究領域與方向
利用交叉學科的優勢，結合系統生物學，基因組學，生物信息學，遺傳學，及分子與細胞生物學的方法，系統性地研究主要疾病，如癌症，在分子水平的基因調節通路與網路。同時，針對特定的重要基因及調節通路，開展深入的分子生物學研究，闡明其具體的作用機理，為疾病診斷及藥物研發提供分子生物學基礎。
實驗室有機地結合計算與實驗的優勢，並開展廣泛的合作研究。目前的研究集中於轉錄後(post-transcription)及轉譯(translation)相關的調節機理及其在腫瘤發生中的作用。
代表性科研論文
1. Sumazin P*, Yang X*, Chiu HS*, Chung W, Iyer A, Llobet-Navas D, Silva J & Califano A. An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma, Cell, 147(2), 2011: 370-81. (*: co-first author. Featured cover article)
2. Wang X, Nath A, Yang X, Portis A, Walton SP, and chan C. Synergy analysis reveals association between insulin signaling and desmoplakin expression in palmitate treated HepG2 cells. PLoS ONE, 6(11), 2011: e28138.
3. Yang X, Nath A, Opperman MJ and Chan C. The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells, Molecular Biology of the Cell, 21(19), 2010: 3449-58.
4. Yang X, Zhou Y, Jin R and Chan C. Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization, Bioinformatics, 25(17), 2009: 2236-43.
5. Yang X and Chan C. repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through Bcl-2, Cell Research, 19(4), 2009: 469-86.
6. Wu M*, Yang X*, and Chan C. A dynamic analysis of IRS-PKR signaling in liver cells: a discrete modeling approach, PLoS ONE, 4(12), 2009: e8040. (*: co-first author)
7. Yang X, Wang X, Wu M, Dalkic E, and Chan C. Construction of gene networks by synergy analysis of the genes related to palmitate-induced cytotoxicity, Methods in Bioengineering: Systems Analysis of Biological Networks, chapter 5, 2009: 75-93.
8. Zhou Y, Li Z, Yang X, Zhang L, Srivastava S, Jin R and Chan C. Using knowledge driven matrix factorization to reconstruct modular gene regulatory network. Assn for the Adv. of Artificial Intelligence proceedings, 2008: 811-6.
9. Li Z, Srivastava S, Yang X, and Chan C. A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells, BMC Systems Biology, 1, 2007: 21-35.
10. Srivastava S, Li Z, Yang X, Yedwabnick M, Shaw S, and Chan C. Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity in hepatoma cells, BMC Genomics, 8(1), 2007: 364-75.
11. Li Z, Srivastava S, Mittal S, Yang X, Sheng L, and Chan C. A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways, BMC Bioinformatics, 8, 2007: 202-18.
