![楊福全[中國科學院生物物理研究所研究員]](/img/3/029/nBnauM3X3ITO4gDN1cDMzUTN1UTM1QDN5MjM5ADMwAjMwUzL3AzL3QzLt92YucmbvRWdo5Cd0FmLxE2LvoDc0RHa.jpg "楊福全[中國科學院生物物理研究所研究員]")
研究方向
主要從事有關生物質譜和蛋白質組學新技術、新方法研究與套用。 承擔科研項目情況：1． “973”計畫項目：生物膜組成成分的動態變化分析，2010-2014。 2． 基金重大研究計畫－培育項目：高通量組蛋白翻譯後修飾分析技術的建立及其在表觀遺傳學研究中的套用，2010-2012。 3． 院科研裝備研製項目：高通量組蛋白翻譯後修飾分析技術的建立及其在表觀遺傳學研究中的套用，2010-2012。
主要成就
1. J. J. Hou, Z. Xie, P. Xue, Z. Cui, X. Chen, J. Li, T. Cai, P. Wu and F. Q. Yang*, Phosphoproteome Analysis of Rat L6 Myotubes Using Reversed-Phase C18 Prefractionation and Titanium Dioxide Enrichment, J Proteome Res, 2010, 9, 777–788.
2. Jing Li, Tanxi Cai, Peng Wu, Ziyou Cui, Xiulan Chen, Junjie Hou, Zhensheng Xie, Peng Xue, Linan Shi, Pingsheng Liu, John R. Yates III, Fuquan Yang*, Proteomic analysis of the mitochondria from C. elegans, Proteomics, 2009, 9, 4539-4553.
3. Z. Y. Cui, X. L. Chen, B. W. Lu, S. K. Park, T. Xu, Z. S. Xie, P. Xue, J. J. Hou, H. Y. Hang, J. R. Yates III* and F. Q. Yang*, Preliminary Quantitative Profile of Differential Expression between Rat L6 Myoblasts and Myotubes by Stable Isotope Labeling by Amino acids in Cell Culture, Proteomics, 2009, 9(5), 1274-1292.
4. Shi L, Zhang J, Wu P, Feng K, Li J, Xie Z, Xue P, Cai T, Cui Z, Chen X, Hou J, Zhang J, Yang F*., Discovery and identification of potential biomarkers of pediatric Acute Lymphoblastic Leukemia. Proteome Sci. 2009,7(7):1-12.
5. Xie X, Chen Y, Xue P, Fan Y, Deng Y, Peng G, Yang F*, Xu T*, RUVBL2, a novel AS160-binding protein, regulates insulin-stimulated GLUT4 translocation. Cell Res. 2009, 1-8.
6. Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the {gamma}TuRC to the centrosome., J Cell Sci. 2009, 122(13): 2240-2251.
7. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB., ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response., Proc Natl Acad Sci, 2009, 106(19): 7945-7950.
8. Fan Y, Shi L, Yu J, Yang FQ*, Wang JX*, Discovery and identification of potential biomarkers of papillary thyroid carcinoma, Molecular Cancer, 2009, 28; 8:79.
9. W. He, Y. Zhao, C. Zhang, L. L. An, Z. S. Hu, Y. Liu, L. Han, L. Bi, Z. S. Xie, P. Xue, F. Q. Yang* and H. Y. Hang*, Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1, Nucleic Acids Research, 2008, 1-12.
10. X. Duan, Q. Lu, P. Xue, Z. Dong, F. Q. Yang, N. L. Wang, Proteomic analysis of aqueous humor from patients with myopia, Molecular Vision, 2008, 14, 370-377.
11. D. A. Davis, K. E. Singer, M. Sierra, M. Narazaki, F. Q. Yang, H. M. Fales, R. Yarchoan and G. Tosato, Identification of Carboxypeptidase N as an Enzyme Responsible for C-Terminal Cleavage of Stromal Cell-Derived Factor-1a in the Circulation”, Blood ,105(12)，4561-4568 (2005).
12. M. Sierra1, F. Q. Yang1 (co-first author), M. Narazaki, O. Salvucci, D. Davis, R. Yarchoan, J. Farber, H. Zhang, H. M. Fales, and G. Tosato, Differential processing of stromal-derived factor-1 Alpha and Beta explains functional diversity", Blood, 103 (7) 2452-2459 (2004).
13. F. Q. Yang and Y. Ito, On-line flow-injection dectection system and its application to the measurement of ethanol transfer and osmosiss rate in centrifugal precipitation chromatography. J. Liq. Chroma. Rel. Tech., 27, 2979-2985 (2004).
14. Y. Ito, F. Q. Yang, P. E. Fitze, and J. V. Sullivan, Improved column design for high-speed countercurrent chromatography. J. Chromatogr. A. 1017 (2003) 71-81.
15. F. Q. Yang and Y. Ito, “Separation of alkaloids by countercurrent chromatography”, The Encyclopedia of Chromatogrphy (online) Marcel Dekker, 2003, pp1-5.
16. Y. Ito, F. Q. Yang, P. E. Fitze, and J. V. Sullivan, Spiral disk assembly for HSCCC: Column design and basic studies on chromatographic resolution and stationary phase retention. J. Liq. Chroma. Rel. Tech., 26 (2003) 1355-1372.
17. F. Q. Yang, Y. Ito, A novel method for the fractionation of dextran by centrifugal precipitation chromatography”, Anal. Chem., 74 (2002) 440-445.
18. F. Q. Yang and Y. Ito, “Preparative separation of lappaconitine, ranaconitine, N-deacetyllappaconitine and N-deacetylranaconitine from crude alkaloids of sample Aconitum sinomontanum Nakai by high-speed countercurrent chromatography, J. Chromatogr. A. 943 (2002) 219-225.
19. F. Q. Yang, Y. Ma, Y. Ito, Separation and purification of isoflavones from a crude extract from soybean by high-speed countercurrent chromatography, J. Chromatogr. A. 928 (2001)163-170.
20. F. Q. Yang, Y. Ito, "pH-Zone-refining countercurrent chromatography of Lappaconitine from Aconitum sinomontanum Nakai: I. Separation of prepurified extract", J. Chromatogr. A. 923 (2001) 281-285.
21. F. Q. Yang, T. Y. Zhang, G. Q. Xu, F. E. Chou, Y. Ito, pH-modulated stepwise elution countercurrent chromatography CCC and its application on the preparative separation of hydroxyanthrquinones compounds from traditional Chinese medicine herbs. J. Liq. Chrom. & Relat. Tech. Special Issue on CCC, 24 (2001) 1617-1628.
22. F. Q. Yang, T. Y. Zhang, Y. Ito, Large-scale separation of resveratrol, anthraglycoside A and anthraglycoside B from Polygonum cuspidatum Sieb. Et Zucc. by high-speed countercurrent chromatography. J. Chromatogr. A, 919 (2001) 443-448.
23. F. Q. Yang, T. Y. Zhang, Q. H. Liu, G. Q. Xu, Y. B. Zhang, Y. Ito, Preparative isolation and purification of notopterol and isoimperatorin from Chinese traditional medicine Notopterygium forbessi Boiss (Qianghuo in Chinese) by high-speed countercurrent chromatography. J. Chromatogr. A, 883 (2000) 67-73.
24. F. Q. Yang, T. Y. Zhang, Y. Ito, Preparative isolation and purification of hydroxyanthraquinones from Rheum officinale Baill by HSCCC using pH-modulated stepwise elution.J. Chromatogr. A, 858 (1999) 103-107.
25. F. Q. Yang, J. Quan, T. Y. Zhang, Y. Ito, Application of analytical and preparative high-speed countercurrent chromatography in the separation of alkaloids from Coptis chinensis Franch, J. Chromatogr. A, 829 (1998) 137-141.
26. F. Q. Yang, J. Quan, T. Y. Zhang, Y. Ito, "Preparative separation of alkaloids from the root of Sophora flavescens Ait by pH-zone-refining countercurrent chromatography". J. Chromatogr., A., 822 (1998) 316-320.
27. F. Q. Yang, T. Y. Zhang, and Y. Ito, Multidimensional countercurrent chromatography and is applications. J. Chromatogr. A., 803, 298-301 (1998).
28. F. Q. Yang, T. Y. Zhang, B. X. Mo, and Y. Ito, Preparative separation and purification of kaempferol, isorhamnetin and quercetin by high-speed countercurrent chromatography. J. Liq. Chrom. & Rel. Technol., 21(1&2), 209-216, 1998.
29. J. S. Edmonds, Y. Shibata, F. Q. Yang and M. Morita, Isolation and synthesis of 1-Deoxy-1-dimethylarsinoylribitol-5-sulfate, a natural constituent of Chondria crassicaulis and other red algae, Tetrahedron Letters, 38(33), 5819, 1997.
30. F. Q. Yang, Q. Y. Ou, W. L. Yu, Semi-preparative separation of araxerylacetate and coumarins from Artemisia dalailamae Kraschen by high-speed countercurrent chromatography. J. Liq. Chromatogr., 18(2), 395-403, 1995.
發表中文論文：
1 利用雙向電泳技術分析正常大鼠腎小球蛋白質組方法的建立 呂楊; 謝院生; 張術佳; 李曉帆; 謝振聲; 楊福全; 陳香美 解放軍總醫院腎病科; 全軍腎臟病研究所暨重點實驗室; 中國科學院生物物理研究所 【期刊】中國中西醫結合腎病雜誌 2010-03-20
2 脂質組學研究進展 蔡潭溪; 劉平生; 楊福全; 楊福愉 中國科學院生物物理研究所 【期刊】生物化學與生物物理進展 2010-02-15
3 帕金森病患者腦脊液蛋白質組學分析 孫太欣; 彭國光; 薛鵬; 楊福全 華北電網有限公司北京電力醫院神經內科; 重慶醫科大學附屬第一醫院神經內科; 重慶市神經病學重點實驗室; 中國科學院生物物理研究所 【期刊】中國生物化學與分子生物學報 2010-01-20
4 甘肅棘豆揮發性成分研究Ⅰ．精油成分分離與鑑定 梁冰; 顏世芬; 陳茂齊; 楊福全; 歐慶瑜 中國科學院蘭州化學物理研究所 【期刊】分析測試學報 1994-01-25
5 驢驢蒿的化學成分研究 楊福全; 歐慶瑜; 俞惟樂 中國科學院蘭州化學物理研究所 【期刊】中國中藥雜誌 1994-03-25
6 逆流色譜的基本關係式 楊福全 中國科學院蘭州化學物理研究所 【期刊】色譜 1993-06-30
7 膜蛋白質組學技術研究進展(綜述) 楊福全 中國科學院生物物理研究所 【會議】首屆全國蛋白質組學學術研討會論文集 2005-04-01
8 大豆種子貯藏蛋白突變體的分子鑑定 朱保葛; 聶晶; 呂慧穎; 楊福全; 張利明 中國科學院遺傳與發育生物學研究所; 中國科學院遺傳與發育生物學研究所; 中國科學院生物物理研究所 【會議】全國作物生物技術與誘變技術學術研討會論文摘要集 2005-11-01
9 磷酸化蛋白質組學新技術研究與套用 侯俊傑; 謝振聲; 薛鵬; 崔自由; 楊福全 中國科學院生物物理研究所計算與系統生物學研究中心; 中國科學院生物物理研究所計算與系統生物學研究中心 【會議】第十次中國生物物理學術大會論文摘要集 2006-05-01
10 膜蛋白質組學技術比較研究與套用 陳秀蘭; 謝振聲; 薛鵬; 崔自由; 楊福全 中國科學院生物物理研究所計算與系統生物學研究中心; 中國科學院生物物理研究所計算與系統生物學研究中心 【會議】第十次中國生物物理學術大會論文摘要集 2006-05-01 版著作
