楊帆,男,1985年生於江西。博士,美國化學學會(ACS)會員。現任職於上海交通大學醫學院附屬仁濟醫院海洋藥物重點實驗室;2012畢業於上海第二
軍醫大學,獲藥物化學博士學位,從事多種海洋生物的抗腫瘤和抗感染活性成分的提取分離、結構鑑定、結構修飾工作以及小分子藥物先導化合物的全合成及結構最佳化;於2011年赴美國國家天然產物中心,密西西比大學從事聯合培養課題。近年來,以第一作者或共同作者發表SCI論文22篇,申請專利15項,其中6項已授權,目前主持國家級和上海市級課題兩項。
研究方向為:1.海綿活性次生代謝產物的發現以及結構鑑定
2.抗腫瘤、抗感染活性海洋天然產物的結構修飾以及全合成
主要論著:
1.FanYang,Yike Zou,Ru-PingWang,MarkT.Hamann,Hong-JunZhang,Wei-Hua
Jiao,Bing-NanHan,Shao-JiangSong*,Hou-WenLin*.RelativeandAbsolute
StereochemistryofDiacarperoxides:AntimalarialNorditerpeneEndoperoxides
fromMarineSpongeDiacarnus
megaspinorhabdosa.MarineDrugs,12,4399-4416,2014.
2.FanYang,Jian-HongGan,Xiao-YanLiu*,Hou-WenLin*.ScalaraneSesterterpenesfromtheParacelIslandsMarine
SpongeHyrtiossp..NaturalProductCommunications,9
(6),763-764,2014.
3.FanYang,Rui-HuaJi,JiangLi,Jian-HongGanandHou-WenLin*.N-ContainingMetabolitesfromtheMarine
SpongeAgelasclathrodes.NaturalProductCommunications,8
(12),1713-1714,2013.
4.
FanYang,MarkT.Hamann,YikeZou,Ming-YuZhang,
Xiao-BinGong,Jian-RuXiao,Wan-ShengChen,Hou-WenLin*.Antimicrobial
MetabolitesfromParacelIslandsSpongeAgelas
mauritiana.JournalofNaturalProducts,75,774-778,2012.
5.
FanYang,Hong-JunZhang,Yuan-YuanZhang,Wan-Sheng
Chen,Hai-LongYuan*,Hou-WenLin*.AHepatitisBVirusInhibitoryNeolignan
fromHerpetospermumcaudigerum.Chemical
&PharmaceuticalBulletin,58,3,402-404,2010.
6.
FanYang,Hong-JunZhang,Xiang-FangLiu,Wan-Sheng
Chen,Hai-FengTang,Hou-WenLin*.OxygenatedSteroidsfromMarineBryozoanBiflustragrandicella.Biochemical
SystematicsandEcology,37,686–689,2009.
7.
FanYang,Hong-JunZhang,Jiao-TaoChen,Shu-Juan
Piao,Wan-ShengChen,Hou-WenLin*.NewCytotoxicOxygenatedSterolsfrom
MarineBryozoanBugulaneritina.Natural
ProductResearch,25,16,1505-11,2011.
8.
Hao-BingYu#,FanYang#,FanSun,Guo-YiMa,
Jian-HongGan,Wen-ZhenHu,Bing-NanHan,Wei-HuaJiao,Hou-WenLin*.Cytotoxic
AaptamineDerivativesfromtheSouthChinaSeaSpongeAaptosaaptos.JournalofNaturalProduct,77(9),2124–2129,2014.
9.
Hao-BingYu#,FanYang#,FanSun#,
JingLi,Wei-HuaJiao,Jian-HongGan,Wen-ZhenHu,Hou-WenLin*Aaptamine
DerivativeswithAntifungalandAnti-HIV-1ActivitiesfromtheSouthChinaSea
SpongeAaptosaaptos.Marine
Drugs,
12,6003-6013,2014.
10.
Jian-HongGan#,Chang-HuaXu#,
Hong-ZheZhu,FangMao,FanYang,*QunZhou,Su-QinSun*.Analysisand
discriminationoftendifferentspongesbymulti-stepinfraredspectroscopy,Chinese
ChemicalLetters(InProof).
11.
Shu-JuanPiao,Yun-LongSong,
Wei-HuaJiao,FanYang,Xiang-Fang
Liu,Wan-ShengChen,Bing-NanHan,Hou-WenLin.HippolachninA,aNewAntifungalPolyketidefromtheSouthChinaSea
SpongeHippospongialachne.Organic
Letters,15(14),3526–3529,2013.
12.
Wei-HuaJiao,Xiao-JunHuang,
Ji-SiYang,FanYang,Shu-JuanPiao,HaoGao,JiaLi,Wen-CaiYe,Xin-ShengYao,Wan-ShengChen,
Hou-WenLin.DysidavaronesA-D,New
SesquiterpeneQuinonesfromtheMarineSpongeDysideaavara.OrganicLetters,14,1,202–205,2012.
13.
Xiang-FanLiu,Yun-LongSong,
Hong-JunZhang,FanYang,Hao-Bing
Yu,Wei-HuaJiao,Shu-JuanPiao,Wan-ShengChen,Hou-WenLin.SimplextonesAandB,Unusual
PolyketidesfromtheMarineSpongePlakortis
simplex.OrganicLetters,13,12,3154-7,2011.
14.
Shu-JuanPiao,Hong-JunZhang,
Hai-YanLu,FanYang,Wei-HuaJiao,
Yang-HuaYi,Wan-ShengChen,Hou-WenLin.
HippolidesA-H,AcyclicManoalideDerivativesfromtheMarineSpongeHippospongialachne.Journal
ofNaturalProducts,74,5,1248-54,2011.
15.
Hong-JunZhang,Yang-HuaYi,
Gen-JinYang,Ming-YeHu,Gui-DongCao,Fan
Yang,Hou-WenLin.Proline-ContainingCyclopeptidesfromtheMarineSpongePhakelliafusca.JournalofNaturalProducts,
73,4,650–655,2010.
16.
Hong-JunZhang,Yang-HuaYi,FanYang,Wan-ShengChen,Hou-WenLin*.
SesterterpenesandaNewSterolfromtheMarineSpongePhyllospongiafoliascens.Molecules,15,2,834-841,2010.
17.
Xiang-FangLiu,YangShen,FanYang,MarkT.Hamann,Wei-HuaJiao,
Hong-JunZhang,Wan-ShengChen,Hou-WenLin*.SimplexolidesA−EandPlakorfuran
A,SixButyrateDerivedPolyketidesfromtheMarineSpongePlakortissimplex.Tetrahedron,68,4635-4640,2012.
18.Wei-HuaJiao,Ting-TingXu,Hao-BingYu,Guo-Dong
Chen,Xiao-JunHuang,FanYang,
Yu-ShanLi,Bing-NanHan,Xiao-YanLiu,Hou-WenLin.DysideanonesA-C,UnusualSesquiterpeneQuinonesfromtheSouth
ChinaSeaSpongeDysideaavara.Journal
ofNaturalProduct,77(2),346-350,2014.
19.Wei-HuaJiao,Ting-TingXu,Hao-BingYu,
Feng-RongMu,JiaLi,Yu-ShanLi,Fan
Yang,Bing-NanHan,Hou-WenLin*.DysidaminonesA-M,CytotoxicandNF-kBInhibitorySesquiterpeneAminoquinonesfromthe
SouthChinaSeaSpongeDysideafragilis.RSC
Advances,4(18),9236-9246,2014.
20.
Shu-JuanPiao,Wei-HuaJiao,FanYang,Yang-HuaYi,Ying-TongDi,Bing-NanHan,Hou-WenLin*.New
HippolideDerivativeswithProteinTyrosinePhosphatase1BInhibitoryActivity
fromtheMarineSpongeHippospongia
lachne.MarineDrugs,12,4096-4109,2014.
21.
GiuseppinaChianese,MarcoPersico,FanYang,Hou-WenLin*,Yue-WeiGuo,NicolettaBasilico,Silvia
Parapini,DonatellaTaramelli,OrazioTaglialatela-Scafati*,Caterina
Fattorusso.EndoperoxidepolyketidesfromaChinesePlakortissimplex:Furtherevidenceoftheimpactof
stereochemistryonantimalarialactivityofsimple1,2-dioxanes.Bioorganic
&MedicinalChemistry,22,4572-4580,2014.
22.
Wei-HuaJiao,JingLi,QianLiu,Ting-TingXu,Guo-HuaShi,
Hao-BingYu,FanYang,Bing-NanHan,
MinLi,Hou-WenLin*.DysidinoidA,anUnusualMeroterpenoid
withAnti-MRSAActivityfromtheSouthChinaSeaSpongeDysideasp.Molecules,
19(11),18025-18032,2014.