研究成果
課題組運用新一代組學技術，利用猴作為人類近緣模式動物的優勢，在全基因組尺度開展了一系列以猴為研究視角，探索人類演化和複雜疾病的特色工作，在PLoS Genetics, Molecular Biology and Evolution等權威雜誌發表。鑒於研究的理論和科學意義，被Faculty of 1000、Nature China等專文評價。鑒於相關工作的套用價值，被美國FDA、the Economist、路透社等評介和報導。實驗室創建RhesusBase等多個國際權威資料庫，被美國神經生物學信息系統，BioMart等國際機構建立檢索 。
科研方向
（1）面向轉化醫學，基於新一代測序技術研究基因組/轉錄組對人類複雜疾病的調控，深入理解疾病發生髮展中遺傳因素與環境因素的互作，發現新藥靶；（2）通過進化醫學研究，從基因起源等角度詮釋人類複雜疾病的演化基礎；（3）開發創新的生物信息學算法與綜合資料庫，在基因組框架下理解基因功能與複雜疾病。
代表論文
28. Xiaoming Zhong*, Jiguang Peng*, Qing Sunny Shen*, Jia-Yu Chen, Han Gao, Xuke Luan, Shouyu Yan, Xin Huang, Shi-Jian Zhang, Luying Xu, Xiuqin Zhang, BertrandTan and Chuan-Yun Li#, RhesusBase PopGateway: Genome-wide Population Genetics Atlas in Rhesus Macaque, Molecular Biology and Evolution, 2016
27.Xin-Zhuang Yang*, Jia-Yu Chen*, Chu-Jun Liu, Jiguang Peng, Yin Rei Wee, Xiaorui Han, Chenqu Wang, Xiaoming Zhong, Qing Sunny Shen, Hsuan Liu, Huiqing Cao, Xiaowei Chen, Bertrand Chin-Ming Tan# and Chuan-Yun Li#, Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates, Molecular Biology and Evolution, 2015
26. Jia-Yu Chen*, Qing Sunny Shen*, Wei-Zhen Zhou*, Jiguang Peng, Bin Z He, Yumei Li, Chu-Jun Liu, Xuke Luan, Wanqiu Ding, Shuxian Li, Chunyan Chen, Bertrand Chin-Ming Tan, Yong E Zhang, Aibin He# andChuan-Yun Li#, Emergence, Retention and Selection: a Trilogy of Origination for FunctionalDe NovoProteins from Ancestral LncRNAs in Primates,PLoS Genetics, 2015
25. Shi-Jian Zhang*, Chu-Jun Liu*, Peng Yu*, Xiaoming Zhong, Jia-Yu Chen, Xin-Zhuang Yang, Jiguang Peng, Shouyu Yan, Chenqu Wang, Xiaotong Zhu, Jingwei Xiong, Yong E. Zhang, Bertrand Chin-Ming Tan andChuan-Yun Li#,Evolutionary Interrogation of Human Biology in Well-annotated Genomic Framework of Rhesus Macaque,Molecular Biology and Evolution, 2014 (Cover Story, MBE Most Read)
24. Jia-Yu Chen*, Zhiyu Peng*, Rongli Zhang*, Xin-Zhuang Yang, Bertrand Chin-Ming Tan, Huaying Fang, Chu-Jun Liu, Yong E. Zhang, Mingming Shi, Zhi-Qiang Ye, Minghua Deng, Xiuqin Zhang# and Chuan-Yun Li#,RNA Editome in Rhesus Macaque Shaped by Purifying Selection, PLoS Genetics, 2014
23. Shi-Jian Zhang*, Chu-Jun Liu*, M Shi*, Lei Kong, Jia-Yu Chen, Wei-Zhen Zhou, Xiaotong Zhu, Peng Yu, Jue Wang, Xinzhuan Yang, Ning Hou, Zhiqiang Ye, Rongli Zhang, Ruiping Xiao, Xiuqin Zhang# and Chuan-Yun Li#,RhesusBase: a Knowledgebase for the Monkey Research Community. Nucleic Acids Research, 2013 (Featured by Nucleic Acids Research and Biomart)
22. Chen Xie*, Yong E. Zhang*, Jia-Yu Chen*, Chu-Jun Liu, Wei-Zhen Zhou, Ying Li, Mao Zhang, Rongli Zhang, Liping Wei# and Chuan-Yun Li#,Hominoid-specific De Novo Protein-coding Genes Originating from Long Non-coding RNAs, PLoS Genetics, 2012 (Featured by Faculty of 1000)
21.Chuan-Yun Li#,Wei-Zhen Zhou, Ping-Wu Zhang, Catherine Johnson, Liping Wei, George R Uhl#. Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction.BMC Genomics, 2011 (Highly accessed article)
20.Chuan-Yun Li, Yong Zhang, Zhanbo Wang, Yan Zhang, Chunmei Cao, Xiao-Mo Li, Ping-Wu Zhang, Shu-Juan Lu, Quan Yu, Xiaofeng Zheng, Quan Du, Qing-Rong Liu* and Liping Wei*. A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions.PLoS Computational Biology, 2010
19.Chuan-Yun Li,Xizeng Mao & Liping Wei. Genes and (Common) Pathways Underlying Drug Addiction.PLoS Computational Biology, 2008 (Featured by Science Signaling “Editor’s Choice”; Nature China “Research Highlights”; the Economist, Scientific America, Reuters and China Daily; Top 10 Papers downloaded from PLoS Computational Biology)
18.Chuan-Yun Li,Qingrong Liu, Ping-Wu Zhang, Xiao-Mo Li, Liping Wei, George R Uhl. OKCAM: An Ontology-based, Human-centered Knowledgebase for Cell Adhesion Molecules.Nucleic Acids Research, 2008
17.Chuan-Yun Li*,Zhi-Qiang Ye*, Quan Yu*, Ying Sun, Quanyuan He, Xiao-Mo Li, Wuxue Zhang, Jingchu Luo, Xiaocheng Gu, Xiaofeng Zheng & Liping Wei. A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir.Cell Research2007 (Cover story and featured by a Research Highlight; Cited by US FDA annual Pediatric Safety Update for Tamiflu; Interviewed by NHK and CCTV)
16. Xiaoming Zhong, Jana Drgonova,Chuan-Yun Li, and George R. Uhl, Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes,ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2015
15. Fenghua Liu, Ruisheng Song, Yuanqing Feng, Jiaojiao Guo, Yanmin Chen, Yong Zhang, Tao Chen, Yanru Wang, Yanyi Huang,Chuan-Yun Li, Chunmei Cao, Yan Zhang, Xinli Hu, Rui-ping Xiao, Upregulation of MG53 Induces Diabetic Cardiomyopathy via Transcriptional Activation of PPAR-α,Circulation, 2015
14. Ran Yang, Shouyu Yan, Xiaojun Zhu,Chuan-Yun Li, Zhenming Liu, Jing-Wei Xiong, Anti-malarial Drug Artemisinin Depletes Erythrocytes by Activating Apoptotic Pathways in Zebrafish,Experimental hematology, 2015
13. Hai-Ying Zhang, Guo-Hua Bi, Xia Li, Jie Li, Hong Qu, Shi-Jian Zhang,Chuan-Yun Li, Emmanuel Onaivi, Eliot Gardner, Zheng-Xiong Xi, and Qing-Rong Liu, Species differences in cannabinoid receptor 2 and receptor responses to cocaine self-administration in mice and rats,NEUROPSYCHOPHARMACOLOGY, 2014
12. Peidong Han, Xiao-Hai Zhou, Nannan Chang, Cheng-Lu Xiao, Shouyu Yan, He Ren, Xin-Zhuang Yang, Mei-Ling Zhang, Qing Wu, Boyang Tang, Ju-Peng Diao, Xiaojun Zhu, Chuanmao Zhang, Chuan-Yun Li, Heping Cheng and Jing-Wei Xiong, Hydrogen peroxide primes heart regeneration with a derepression mechanism, Cell Research2014
11. Yongxin Ye, Min Zhao, Qing-Rong Liu, Chuan-Yun Li, Hong Qu. Human Transporter Database: comprehensive knowledge and discovery tools in the human transporter genes. PLoS One,2014
10. Y Huang, C Xie, Adam Y. Ye, Chuan-Yun Li, G Gao, L Wei. Recent Adaptive Events in Human Brain Revealed by Meta-Analysis of Positively Selected Genes. PLoS One, 2013
9. Chen Xie, Xizeng Mao, Jiaju Huang, Yang Ding, Jianmin Wu, Shan Dong, Lei Kong, Ge Gao, Chuan-Yun Li, Liping Wei. KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Research, 2011
8. Xiuqin Zhang, Rongli Zhang, Susanne Raab, Wen Zheng, Jue Wang, Na Liu, Tiangang Zhu, Lifang Xue, Zhentao Song, Jiaming Mao, Kaitao Li, Huiliang Zhang, Yan Zhang, Chao Han, Yi Ding, Hui Wang, Ning Hou, Yuli Liu, Shujiang Shang, Chuan-Yun Li, Elena Sebokova, Heping Cheng and Paul L. Huang. Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone. Circulation, 2011
7. Liu QR, Pan CH, Hishimoto A, Chuan-Yun Li, Xi ZX, Llorente-Berzal A, Viveros MP, Ishiguro H, Arinami T, Onaivi ES, Uhl GR. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. Genes Brain Behav. 2009
6. Uhl GR, Drgon T, Chuan-Yun Li, Johnson C, Liu QR. Smoking and smoking cessation in disadvantaged women: Assessing genetic contributions.Drug Alcohol Depend. 2009
5. Saccone SF, Bierut LJ, Chesler EJ, Kalivas PW, Lerman C, Saccone NL, Uhl GR, Chuan-Yun Li, Philip VM, Edenberg HJ, Sherry ST, Feolo M, Moyzis RK, Rutter JL. Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm. PLoS One. 2009
4. George R Uhl, Tomas Drgon, Catherine Johnson, Chuan-Yun Li, Judith Hess, Daniel Naimen, Qing-Rong Liu. Molecular genetics of addiction and related heritable phenotypes: genome wide association approaches identify “connectivity constellation” and drug target genes with pleiotropic effects. Ann N Y Acad Sci, 2008
3. Catherine Johnson, Tomas Drgon, Qing-Rong Liu, Ping-Wu Zhang, Donna Walther, Chuan-Yun Li, James Anthony, Yulan Ding, William Eaton and George R Uhl. Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. BMC Medical Genetics, 2008
2. HUANG Mo-Li, SUN Dao-Chun, Lou Ya-Xin, YIN Yan-Bin, Chuan-Yun Li, ZHANG Yong, GAO Ge, WANG Sheng-Qi, BO Xiao-Chen, WEI Li-Ping, LI Song-Gang. Analysis and Preparation of Oligonucletide Microarray of Apoptosis-related Genes. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS. 2008
1. George R Uhl, Tomas Drgon, Catherine Johnson, Oluwatosin O. Fatusin, Qing-Rong Liu, Chuan-Yun Li, Kari Buck, John Crabbe. "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. Biochemical Pharmacology, 2007
專利
1. 魏麗萍， 李川昀，葉志強等；一種預測達菲類藥物用藥安全性的方法；授權日期：2008年3月26日；授權國家：中國；專利號：ZL 200610011569.3；PCT Patent number：WO/2007/115467
2. 中華人民共和國計算機軟體著作權；恆河猴功能基因組學信息注釋系統RhesusBase；授權國家：中國；著作權登記號2013SR055211
