個人簡介
1995/09-1998/07，華中師範大學有機合成研究所攻讀碩士學位（有機合成專業）
1998/09-2001/07，中國科學院化學研究所攻讀博士學位（有機合成專業），獲理學博士學位
2001/10-2003/04，以色列Ben-Gurion大學，博士後
2003/09-現在，北京工業大學生命學院，教師，副研究員，碩士導師，教授，博士生導師
2011/04-2011/08美國加州大學聖塔-芭芭拉分校（UCSB）化學與生物化學系，訪問學者
研究方向
1）HIV-1整合酶抑制劑的設計合成。
2）具有光、電活性的大環主體分子的設計與合成
3）分子開關、分子機器和螢光探針。
4）有機電化學合成
在研課題
國家自然科學基金（21472011）：鹵素離子為媒介的電化學氧化偶聯形成新的C-C鍵或C-N鍵的研究，90萬 （2015/01-2018/12）
國家自然科學基金（21272021）：新型三芳基咪唑類有機電催化劑的創製及其電氧化活化C-H鍵和C-C鍵研究，80萬（2013/01-2016/12）
國家自然科學基金（20772010）水相中鄰苯醌衍生物的電化學合成與原位轉化。 28萬（2008/01-2010/12）
國家自然科學基金（20402001）磺醯胺苯乙烯基喹啉: 新型HIV整合酶抑制劑的設計、合成及其構效關係研究。 23萬（2005/01-2007/12）
北京市科技新星: 以HIV-1整合酶為靶的吡啶（喹喏）酮羧酸衍生物的設計與合成。29萬 （2005/06-2008/06）
北京市自然科學基金：基於“點擊化學”的HIV-1整合酶抑制劑的設計與合成 (No. 7112008)，11萬（2011/01-2013/12）
北京市自然科學基金: HIV整合酶抑制劑：吡啶（喹喏）酮羧酸衍生物的合成 (No. 2062003)， 13萬 （2006/01-2008/12）
北京市教委科研計畫：多羥基異喹啉的電化學合成與HIV-1整合酶抑制活性研究 15萬 （2010/01-2012/12）
北京市優秀人才培養專項經費: 新型HIV整合酶抑制劑：磺醯胺苯乙烯基喹啉的設計、合成及其構效關係研究。3萬
留學人員歸國基金: 基於HIV整合酶受體的新型多面體烷衍生物的合成與構效關係的研究。2.5萬
參加的研究課題：
重大科學研究計畫項目：載藥納米顆粒的藥效學、生物利用度及其機理研究(No. 2009CB930203）
“十二五”科技支撐計畫項目：食品香料香精製備關鍵技術研究及產業化（No: 2011BAD23B01）
International associate, the Center for Sustainable Use of Renewable Feedstocks (CenSURF)
Participating Chinese member in the PIRE-ECCI program
會議報告(部分)
Keynote Speaker, PIRE-ECCI annual meeting “Metal-free, electrochemically oxidative functionalization of C-H bonds” Santa Barbara, CA, USA, Dec. 17-20, 2013.
Keynote Speaker, Electrochemical Conference on Energy & the Environment, Electrochemistry Society (ECS) “Redox catalysts: Metal-free activations of C-H and N-H bonds” Shanghai, China, March 13-16, 2014.
Keynote Speaker, PIRE-ECCI annual meeting “Electrochemical synthesis of heterocycles mediated by iodine anion” Shanghai & Hangzhou, China, June 25-29, 2014.
大會報告，第十四屆全國有機電化學與工業學術會議，“C-H鍵的間接電化學氧化活化” 海口、July 26-29, 2014.
研究論文
Jie Chen, Wei-Qing Yan, Chiu Marco Lam, Cheng-Chu Zeng,* Li-Ming Hu, and R. Daniel Little, Electrocatalytic aziridination of alkenes mediated by n-Bu4NI: a radical pathway,Org. Lett. 2015, 17, 986-989.
Jie Chen, Cheng-Fu Liu, Cheng-Wen Yang, Cheng-Chu Zeng*, Wei Liu, Li-Ming Hu, Design and synthesis of 5-chloro-2-hydroxy-3-triazolylbenzoic acids as HIV integrase inhibitorsMed. Chem. Res.2015, accepted.
Seung Joon Yoo, Long-Ji Li, Cheng-Chu Zeng, R. Daniel Little* Polymeric Ionic Liquid and Carbon Black Composite as a Reusable Supporting Electrolyte: Modification of the Electrode SurfaceAngew. Chem. Int. Ed.2015,DOI: 10.1002/anie.201410207.
Nan-ning Lu, Ni-tao Zhang, Cheng-Chu Zeng,* Li-Ming Hu, Seung Joon Yoo, R. Daniel Little* Electrochemically induced ring-opening/Friedel-Crafts arylation of chalcone epoxides catalyzed by a triarylimidazole redox mediatorJ. Org. Chem.,2015, 80, 781-789.
Yue-Xia Bai, Long ji Li, Xiao-Li Wang, Cheng-Chu Zeng*, Li-Ming Hu, Design and synthesis of N-hydroxy-triazole-4-carboxamides as HIV integrase inhibitorsMed. Chem. Res.2015, 24, 423-429.
Nan-ning Lu, Seung Joon Yoo, Long-Jie Li, Cheng-Chu Zeng, R. Daniel Little * A comparative study of organic electron transfer redox mediators: electron transfer kinetics for triarylimidazole and triarylamine mediators in the oxidation of 4-methoxybenzyl alcoholElectrochim. Acta,2014. 142, 254-260.
Wei-Jing Gao, Wei-Cui Li, Cheng-Chu Zeng,* Hong-Yu Tian, Li-Ming Hu, R. Daniel Little Electrochemically initiated oxidative amination of benzoxazoles using tetraalkylammonium halides as redox catalystsJ. Org. Chem.2014, 79，9613-9618.
Huan-Lan Xiao, Cheng-Chu Zeng,* Hong-Yu Tian, Li-Ming Hu, R. Daniel Little Electrochemical synthesis of 3,5-disubstituted isoxazolesJ. Electroanal. Chem.2014, 727, 120-124.
Yong Dong Liu,* Meric Selbes, Chengchu Zeng, Rugang Zhong, Tanju Karanfil Formation Mechanism of NDMA from Ranitidine, Trimethylamine and Other Tertiary Amines during Chloramination: A Computational StudyEnviron. Sci. Technol.2014, 48, 8653−8663.
Wei-Cui Li, Zheng-Zheng Zhang, Cheng-Chu Zeng,* Li-Ming Hu, Hong-Yu Tian Electrogenerated Base Induced Dehydrodimerization and Dehydrotrimerization of PyrazolonesCurr. Org. Synth.2014, 11, 454-460.
Xiao-Guang Gao, Ni-Tao Zhang, Cheng-Chu Zeng *, Yong-Dong Liu, Li-Ming Hu, Hong-Yu Tian Electrochemical Synthesis of Polyfunctionalized Indoles in Aqueous Medium from Catechols and Ketene N,S-acetalsCurr. Org. Synth.2014, 11, 141-148.
Wei-Cui Li, Cheng-Chu Zeng,* Li-Ming Hu, Hong-Yu Tian, R. Daniel Little Efficient indirect electrochemical synthesis of 2-substituted benzoxazoles using NaI as a mediatorAdv. Synth. Cat.2013, 355, 2884-2890.
Chao Li, Cheng-Chu Zeng,* Li-Ming Hu, Feng-Lin Yang, Seung Joon Yoo, R. Daniel Little* Electrochemically induced C-H functionalization using bromide ion/TEMPO dual redox catalysts in a two-phase electrolytic systemElectrochimica Acta2013, 114，560-566.
Huan-Lan Xiao, Cheng-Wen Yang, Ni-Tao Zhang, Cheng-Chu Zeng*, Li-Ming Hu, Hong-Yu Tian, R. Daniel Little Electrochemical oxidation of aminophenols in the presence of benzenesulfinateTetrahedron,2013, 69, 658-663.
Ni-tao Zhang, Cheng-chu Zeng,* Chiu Marco Lam, Randi K. Gbur, R. Daniel Little Triarylimidazole Redox Catalysts: Electrochemical Analysis and Empirical CorrelationsJ. Org. Chem.2013,78, 2104-2110.
Efrat Korin, Beny Cohen, Yong-Dong Liu, Cheng-Chu Zeng Alexander I. Shames James Y. Becker Examining the binding mechanism of 3,4-dihydro-3-(2-oxo-2-phenylethylidene)-quinoxalin-2(1H)-one and its fragments to Cu2+J. Coord. Chem.2013, 66, 2351-2366.
Zeng, Cheng-Chu*; Zhang Ni-tao; Lam, C. M.; Little, R. D.* Novel triarylimidazole redox catalysts: synthesis, electrochemical properties and applicability to electrooxidative C-H activationOrg. Lett.2012, 14, 1314-1317.
Cheng-Wen Yang, Yue-Xia Bai, Ni-Tao Zhang, Cheng-Chu Zeng*, Li-Ming Hu, Hong-Yu Tian One-pot sequential combination of multi-component and multi-catalyst: synthesis of 5-aminobenzofurans from aminophenol and ketene acetalsTetrahedron2012, 68, 10201-10208.
Zhang, Ni-Tao; Gao, Xiao-Guang; Zeng, Cheng-Chu*; Hu, Li-Ming; Tian, Hong-Yu; She, Yuan-Bin Electrochemical oxidation of catechols in the presence of enaminone: exclusive a-arylationRSC Advances,2012, 2, 298-306.
Efrat Korin, Beny Cohen,*, Yue-Xia Bai, Cheng-Chu Zeng,* James Y. Becker,*The effect of substituents on the response of 3,4-dihydro-3-(2-oxo-2-phenylethylidene)-quinoxalin-2(1H)-one derivatives toward binding of CuTetrahedron2012, 68, 7450-7455.
Liming Hu,* Song Yan, Zaigang Luo, Xiao Han, Yujie Wang, Zhanyang Wang, Chengchu Zeng Design, Practical Synthesis, and Biological Evaluation of Novel 6-(Pyrazolylmethyl)-4-quinoline-3-carboxylic Acid Derivatives as HIV-1 Integrase InhibitorsMolecules2012, 17, 10652-10666.
Bai, Yue-Xia; Ping, Da-Wei; Little, R. Daniel; Tian, Hong-Yu; Hu, Li-Ming; Zeng Cheng-Chu* Electrochemical oxidation of catechols in the presence of ketene N,O-acetals: indole formation versus α-arylationTetrahedron,2011, 67, 9334-9341.
Zhang, Zheng-Zheng; Zhang, Ni-Tao; Hu, Li-Ming; Wei, Zhong-Qing; Zeng, Cheng-Chu;* Zhong, Ru-Gang*; She, Yuan-Bin Electrochemically induced cascade Knoevenagel– Michael reactions of tetronic acid and aldehydes: synthesis of methylenebistetronic acidsRSC Advances,2011, 1, 1383–1388.
Korin, Efrat; Cohen, Beny*; Zeng, Cheng-Chu*; Xu, Yi-Sheng; Becker, James Y.* Phenylethylidene-3,4-dihydro-1H-quinoxalin-2-ones: promising building blocks for CurecognitionTetrahedron,2011, 67, 6252-6258.
Zeng, Chengchu*; Ping, Dawei; Hu, Liming; Song, Xiuqing; Zhong, Rugang, Anodic oxidation of catechols in the presence of α-oxoketene N,N-acetales with a tetrahydropyrimidine ring: selective α-arylation reactionOrg. Biomol. Chem.,2010, 8, 2465-2472.
Xiao-Guang Gao, Cheng-Wen Yang, Zheng-Zheng Zhang, Cheng-Chu Zeng*, Xiu-Qing Song, Li-Ming Hu, Ru-Gang Zhong and Yuan-Bin She, Electrochemical oxidation of substituted catechols in the presence of pyrazol-5-ones: characterization of products and reaction mechanismTetrahedron,2010, 66, 9880-9887.
Jiao, Zhiguo; He, Hongqiu; Zeng, Chengchu*; Tan, Jianjun; Hu, Liming; Wang Cunxin* Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide DerivativesMolecules,2010, 15, 1903-1917.
Yang, Leifu; Xu, Xuemei; Huang, Yali; Zhang, Bin; Zeng, Chengchu; He, Hongqiu; Wang, Cunxin; Hu, Liming* Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor,Bioorg. Med. Chem. Letters,2010, 20, 5469-5471.
Zeng, Cheng-Chu*; Liu, Fu-Jian; Ping, Da-Wei; Hu, Li-Ming; Cai, Yuan-li; Zhong, Ru-Gang One-pot electrochemical synthesis of fused indole derivatives containing active hydroxyl groups in aqueous mediumJ. Org. Chem.,2009, 74 (16): 6386-6389.
Zeng, Cheng-Chu *; Ping, Da-Wei; Xu, Yi-Sheng; Hu, Li-Ming; Zhong, Ru-Gang A facile synthesis of α-aryl α-oxoheterocyclic ketene N,N-acetales bearing an electron-rich catechol subunit: an electrochemical oxidation approachEur. J. Org. Chem.2009, 5832-5840.
Zeng, Cheng-Chu*; Liu, Fu-Jian; Ping, Da-Wei; Hu, Li-Ming; Cai, Yuan-li; Zhong, Ru-Gang Electrochemical synthesis of 1,3,4-thiadiazol-2-ylthio -substituted catechols in aqueous mediumTetrahedron2009, 65 (23): 4505-4512.
Zeng, Cheng-Chu*; Liu, Fu-Jian; Ping, Da-Wei; Cai, Yuan-li; Zhong, Ru-Gang; Becker, James Y*. Electrochemical oxidation of catechols in the presence of 4-amino-3-methyl-5-mercapto-1,2,4-triazole bearing two nucleophilic groupsJ. Electroanal. Chem.2009, 625 (2): 131-137.
Xu, Yi-Sheng; Zeng, Cheng-Chu*; Jiao, Zi-Guo; Hu, Li-Ming; Zhong, Ru-Gang Design, synthesis and anti-HIV integrase evaluation of 4-oxo-4H-quinolizine-3-carboxylic acid derivativesMolecules,2009, 14(2): 868-883.
Zeng, Jia; Lu, Xiu-Hua; Zeng, Cheng-Chu*; Hu, Li-Ming; Zhong, Ru-Gang Design, synthesis and anti-HIV integrase evaluation of 1,2,3-triazol-4-yl-substituted 1,4-dihydro-4-oxo-1,5-napthyridine-3-carboxy -lic acidsChin. J. Chem.2009, 27 (5): 953-962.
Zeng, ChengChu*; Niu, Liting; Ping, Dawei; Zhong, Rugang Design, synthesis and anti-HIV integrase inhibitory activity of styrylquinolinyl sulfonamidesChin. J. Org. Chem.,2009, 29 (7): 1105-1114. (In Chinese)
Luo, Zai-Gang; Zeng, Cheng-Chu; Yang, Dao-Shao; Huang, Ya-Li; Wang, Fang; Hu, Li-Ming* Electrospray ionization mass spectra of dipeptide derivativesChin. J. Chem.2009, 27 (7): 1333-1338.
Luo, Zai-Gang; Zeng, Cheng-Chu; Yang, Lei-Fu; He, Hong-Qiu; Wang, Cun-Xin; Hu, Li-Ming* Synthesis of 6-sulfamoyl-4-oxoquinoline -3-carboxylic acid derivatives as integrase antagonists with anti-HIV activityChin. Chem. Lett.,2009, 20 (7): 789-792.
Luo, Zhaigang, Zeng, Chengchu; Wang, Fang; He, Hongqiu; Wang, Cunxin; Du, Hongguang; Hu, Liming*, Synthesis and biological activities of quinoline derivatives as HIV-1 integrase inhibitorsChem. Res. In Chinese Univ.2009, 15(6), 841-845.
專利
曾程初、張錚錚、鍾儒剛、胡利明 5,5’-二羥基- 4,4’-雙吡唑類化合物的電化學製備方法 中國發明專利，專利號 ZL201010145334X.
曾程初、張倪濤、白月霞、胡利明 三芳基咪唑化合物在電有機合成中作為催化劑的套用，專利號 ZL201210035739.7
胡利明、黃雅理、徐雪梅、曾程初、何紅秋、王存新 取代苯丙烯基哌嗪基烷基多羥基苯甲醯胺化合物及其製備方法和套用，專利號 ZL 200910093639
胡利明、楊磊夫、黃雅理、曾程初1-乙醯基-N-苯基-N-(3-(4-(3-苯基-1-H-吡唑-5-基)哌啶-1-基)丙基)-4-醯胺衍生物及其製備方法，專利號 ZL 201010167052
