受教育經歷
2009年9月- 2011年10月：於上海交通大學微生物代謝國家重點實驗室從事博士後研究，主要從事高等真菌次級代謝產物的代謝工程研究。
2004年9月- 2009年9月：就讀於華東理工大學生物反應器工程國家重點實驗室，生物化工專業，獲得工學博士學位。
2001年9月- 2004年7月：就讀於青島化工學院化學工程學院，生物化工專業，獲得碩士學位。
1997年9月- 2001年7月： 就讀於河南大學生物系，發酵工程專業，獲得學士學位。
主要研究方向
套用微生物，生物技術，生物製藥，微生物代謝工程
科研領域描述
利用雲南省微生物資源的優勢，篩選生產生物活性物質的藥用真菌。建立微生物深層培養的方法，實現活性物質生物反應器規模的大量生產。結合基因組學和功能基因組學技術研究生物活性物質的合成調控機制，並以此為基礎改造微生物的代謝途徑，實現活性物質代謝流量的最大化。
目前以高等藥用真菌靈芝為研究對象，通過基因工程和代謝工程的方法解析生物活性物質靈芝酸（抗癌等功能）和靈芝多糖（增強免疫力等功能）的生物合成調控機制，構建高產工程菌株並實現其規模化生產。
承擔科研項目情況
目前主持雲南省科技廳項目一項。
代表性論文和專著
1. Jun-Wei Xu, Yi-Ning Xu and Jian-Jiang Zhong (2012) Enhancement of ganoderic acid accumulation by overexpression of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase gene in the basidiomycete Ganoderma lucidum.Applied and Environmental Microbiology, 78: 7968-7976
2. Jun-Wei Xu, Wei Zhao, Yi-Ning Xu and Jian-Jiang Zhong (2012) Isolation and analysis of differentially expressed genes during asexual sporulation in liquid static culture of Ganoderma lucidum by suppression subtractive hybridization. Molecular Biology Reports, 39: 3603-3610
3. Jun-Wei Xu, Wei Zhao, Jian-Jiang Zhong (2011) Isolation and characterization of a novel Ganoderma lucidum gene that differentially expressed between shaking culture and liquid static culture. Genes & Genomics, 33: 645-651
4. Jun-Wei Xu, Wei Zhao and Jian-Jiang Zhong (2010) Biotechnological production and application of ganoderic acids. Applied Microbiology and Biotechnology, 87: 457-466
5. Jun-Wei Xu, Yi-Ning Xu and Jian-Jiang Zhong (2010) Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. Applied Microbiology and Biotechnology, 85: 941-948
6. Jun-Wei Xu, Yi-Ning Xu and Jian-Jiang Zhong (2009) Comparison of individual ganoderic acids production and identification of differentially expressed genes between liquid static culture and shaking culture of Ganoderrna lucidum. Journal of Bioscience and Bioengineering, 108: S121-122
7. Jun-Wei Xu, Yue-Qiao Liao, Jian-Jiang Zhong (2006) Commentaries & Analyses -Biotechnology in Shanghai. AsiaPacific Biotech News (APBN), 10: 1367-1369
8. Wei Zhao, Jun-Wei Xu, Jian-Jiang Zhong (2011) Enhanced production of ganoderic acids in static liquid culture of Ganoderma lucidum by nitrogen limitation. Bioresource Technology, 102:8185-8190
9. Feng-Ke Yang, Jun-Wei Xu, Jun-Hong Liu (2003) Applications of biocatalyst in the preparation of pharmaceuticals. Chinese Journal of Organic Chemistry, 23: 1205-1212
10. Cui-Xia Liang, Ying-Bo Li, Jun-Wei Xu et al. (2010) Phenobarbital addition enhanced ganoderic acid production and biosynthetic gene expression in liquid static cultures of Ganoderma lucidum. Applied Microbiology and Biotechnology, 86: 1367-1374
Jun-Wei Xu
Ph.D., Deputy Dean of Research Center of Bioengineer
Education:
2009.9-2011.10, Post-doctor, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University.
2004.9-2009.9, Ph.D., Biochemical Engineering, The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology.
2001.9-2004.7, M.S., Biochemical Engineering, Qingdao University of Science and Technology.
1997. 9-2001.7, B.S., Fermentation Engineering, Henan University.
Research Interests:
1. Applied Microbiology
2. Biotechnology
3. Microbial metabolic engineering
Research Profile:
1. Screening of new strains with industrial potential for producing bioactive compounds.
2. Submerged fermentation of higher fungi for production of valuable bioactive compounds in
bioreactor.
3. Elucidation of the biosynthesis and regulatory mechanism of bioactive compounds in higher
fungi by comparative genomic analysis, proteomic analysis and metabolic flux analysis.
4. Metabolic engineering of bioactive compounds-producing higher fungi.
Research Project:
One project from Yunnan Provincial Science and Technology Department.
Selected Publications:
1.Jun-Wei Xu, Yi-Ning Xu and Jian-Jiang Zhong (2012) Enhancement of ganoderic acid accumulation by overexpression of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase gene in the basidiomycete Ganoderma lucidum.Applied and Environmental Microbiology, 78: 7968-7976
2. Jun-Wei Xu, Wei Zhao, Yi-Ning Xu and Jian-Jiang Zhong (2012) Isolation and analysis of differentially expressed genes during asexual sporulation in liquid static culture of Ganoderma lucidum by suppression subtractive hybridization. Molecular Biology Reports, 39: 3603-3610
3. Jun-Wei Xu, Wei Zhao, Jian-Jiang Zhong (2011) Isolation and characterization of a novel Ganoderma lucidum gene that differentially expressed between shaking culture and liquid static culture. Genes & Genomics, 33: 645-651
4. Jun-Wei Xu, Wei Zhao and Jian-Jiang Zhong (2010) Biotechnological production and application of ganoderic acids. Applied Microbiology and Biotechnology, 87: 457-466
5. Jun-Wei Xu, Yi-Ning Xu and Jian-Jiang Zhong (2010) Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. Applied Microbiology and Biotechnology, 85: 941-948
6. Jun-Wei Xu, Yi-Ning Xu and Jian-Jiang Zhong (2009) Comparison of individual ganoderic acids production and identification of differentially expressed genes between liquid static culture and shaking culture of Ganoderrna lucidum. Journal of Bioscience and Bioengineering, 108: S121-122
7. Jun-Wei Xu, Yue-Qiao Liao, Jian-Jiang Zhong (2006) Commentaries & Analyses -Biotechnology in Shanghai. AsiaPacific Biotech News (APBN), 10: 1367-1369
8. Wei Zhao, Jun-Wei Xu, Jian-Jiang Zhong (2011) Enhanced production of ganoderic acids in static liquid culture of Ganoderma lucidum by nitrogen limitation. Bioresource Technology, 102:8185-8190
9. Feng-Ke Yang, Jun-Wei Xu, Jun-Hong Liu (2003) Applications of biocatalyst in the preparation of pharmaceuticals. Chinese Journal of Organic Chemistry, 23: 1205-1212
10. Cui-Xia Liang, Ying-Bo Li, Jun-Wei Xu et al. (2010) Phenobarbital addition enhanced ganoderic acid production and biosynthetic gene expression in liquid static cultures of Ganoderma lucidum. Applied Microbiology and Biotechnology, 86: 1367-1374
