個人簡歷
1978-1982年，西北師範大學生物系本科生1982-1985年，福建師範大學實驗胚胎學專業碩士研究生
1986-1995年，西北師範大學生物系，講師、副教授
1995-1999年，挪威奧斯陸大學發育生物學專業博士研究生
1999-2004年，美國杜蘭大學發育生物學博士後
2004-2005年，挪威奧斯陸大學，副教授
2006-2009年，美國羅切斯特大學，助理教授
2009年至今， 杭州師範大學生命與環境科學學院，教授
2010年起，杭州師範大學生命科學院動物發育與胚胎幹細胞研究所任PI
研究方向
製備及利用遺傳修飾模式小鼠研究頭面部器官發生研究方向：哺乳動物頭面部器官發育及新生缺陷形成中的分子及遺傳學機制
主要成績
分子生物科學基礎研究獎，Tulane大學健康研究，2000年SIGMA XI 優秀博士後研究獎，Tulane大學健康研究，2001年
科研項目
1999－2004NIH R01，R01DE12329，博士後，為此課題的主要參與及完成者2002－2004NIH R01，R01DE14044, 博士後，重點執行該課題的研究
2003－2004NIHR26，博士後，重點參與課題
2005－2007NIH T32DE007202，NIH 訓練基金獲得者
論文專著
Zhang, Z.Y., James, E., Balmer, A., L?vlie, A., Fromm, S.H. and Blomhoff, R. (1996). Specific teratogenic effects of Different Retinoic acid isomers and Analogs in the Developing Anterior Central Nervous system of zebrafish. Dev. Dyn. 206,73-86Zhang, Z.Y., Yu, X.Y., Zhang, Y.D., Zhao, X., Hu, Y.P., Geronimo, B; L?vlie, A., Fromm, S.H. and Chen, Y.P (2000). Targeted expression of constitutively active BMP receptor-IB causes bifurcation and duplication and posterior transformation of digit in mouse limb. Dev. Biol. 220, 154-167.
Zhang, Y.D.*, Zhang, Z.Y.*, Zhao. X., Yu, X.Y., Hu, Y.P., Fromm, SH. and Chen, Y.P. (2000). A new function of BMP4: BMP4 positively and negatively regulates Sonic hedgehog expression in the mouse tooth germ.. Development 127, 1431-1443.(*: equal first author)
Zhao, X.*, Zhang, Z.Y.*, Song, Y., Zhang, Y.D., Zhang, X., Hu, Y., Fromm, S.H, and Chen, Y.P. (2000). Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ. Mech. Dev. 99, 29-38. (*: equal first author)
Zhang, Z.Y., Song, Y.Q., Zhao,X., Zhang, X.Y, Fermin. C. and Chen, Y.P. (2002). Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and SHH signaling in the regulation of mammalian palate development. Development 129, (17). 4135-3146.
Zhang, Z.Y., Zhang, X.Y., Song, Y.Q., Jones, T., Jones, S., Fermin, C. and Chen Y.P. (2003). The process brevlis (lateral processes) of malleus is dispensable for normal hearing in mice. Dev.Dyn 227, 69-77.(Corresponding author)
Zhang, Z.Y., Song Y.Q, Zhang X.Y. Tang J., Chen, J., and Chen, Y.P.(2003). Msx1/Bmp4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1. Mech. Dev. 120, 1469-1479. (Corresponding author)
Alappat, S., Zhang, Z.Y., Chen,Y.P (2003). Msx Homeobox gene family and craniofacial development. Cell Research 13, 429-442.
Shusheng Wang, Xueyan Yu, Tao Zhang, Xiaoyun Zhang, Zunyi Zhang, and Yiping Chen (2004). CPCL2 regulates the left-right asymmetry by repressing SHH expression in Hensen’s Node. Development 131, 4381-4391.
Sylvia R. Alappat*, Zunyi Zhang*, Kenraro Suzuki, Xiaoyun Zhang, Rulang Jiang, Gen Yamada, and Yiping Chen. (2005). The cellular and molecular etiology of isolated cleft secondary palate in FGF10 mutant mice. Dev. Biol 277, 102-113. (* Equal first autors).
Hidenao Ogi, Kentaro Suzuki, Yukiko Ogino, Mika Kamimura, Mami, Miyado, Xu Ying, Zunyi Zhang, Masanori Shinohara, YiPing Chen and Gen Yamada (2005). The ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice. Anatomical Record 284A:424-430.
Ling Yu, Shuping Gu, Sylvia Alappat, Yiqiang Song, Mingqun Yan, Xiaoyun Zhang, Gouzhong Zhang, Yanding Zhang, Zunyi Zhang, and Yiping Chen (2005) Shox-2-deficient mice exhibit a rare type of incomplete cleft secondary palate. Development 132, 4397-406
Hilliard, A, Yu L, Gu, SP, Zhang ZY and Chen YP (2005). Regional regulation of palatal growth and patterning along the anterior–posterior axis in mice. J. Anat. 207, 655-667.
Yiqiang Song, Zunyi Zhang, Xueyan Yu, Minquan Yan, Xiaoyun Zhang, Shuping Gu, Thomas Stuart, Chao Liu, Jakob Reiser, Yanding Zhang, Yiping Chen (2006). Application of lentivirus-mediated RNAi in studying gene function in mammalian tooth development. Dev Dyn 235,1347-1357. (*Equal first authors)
Yu Lan, Rosemary C. Ryan, Zunyi Zhang, Steven A. Bullard, Jeffrey O. Bush, Kathleen M. Maltby, Andrew C. Lidral, Rulang Jiang (2006). Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn 235, 1448-1454
Zunyi Zhang, Yu Lan, Yang Chai, Rulang Jiang (2009). Antagonistic actions of Msx1 and? Osr2 Pattern Mammalian Teeth into Single Row. Science 323, 1232-1234
Xiong W, He F, Morikawa Y, Yu X, Zhang Z, Lan Y, Jiang R, Cserjesi P, Chen Y.(2009). Hands is required in the epithelium for palatogenesis in mice. Dev. Biol. 330,131-141.
