一、研究方向:幽門螺桿菌耐藥機制;消化道菌群與健康
二、 科研成果
(一)承擔課題
1、SpoT(ppGpp)調控幽門螺桿菌適應抗生素壓力分子機制研究(81471991),國家自然基金面上項目,72萬,2015-2018。
2、壓力加重幽門螺桿菌胃炎分子機制研究(81671978),國家自然基金面上項目,70萬,2017-2020。
3、幽門螺桿菌SpoT基因適應INF-γ表達調控機制研究(81071313),國家自然基金面上項目,32萬,2011-2013。
4、SpoT調控幽門螺旋桿菌氧應激嚴謹應答分子機制研究(30800037),國家自然基金青年基金,20萬,2009-2011。
5、σ調控幽門螺桿菌平台期氧損傷分子機制研究(中國博士後特別資助),10萬,2010-2011。
(二) 發表論文( *:通訊作者,#:共同第一)
1、 Sun Y, Zhang M, Chen CC, Gillilland M 3rd, Sun X, El-Zaatari M, Huffnagle GB, Young VB, Zhang J, Hong SC, Chang YM, Gumucio DL, Owyang C, Kao JY*. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology. 144(7):1478-87, 1487.e1-8; 2013 Jun.(消化類雜誌排名第一,IF=18.18)
2、Geng X, Li W, Chen Z, Gao S, Hong W, Ge X, Hou G, Hu Z, Zhou Y, Zeng B, Li W, Jia J, Sun Y *.Bifunctional enzyme SpoT is involved in the clarithromycin tolerance of Helicobacter pylori by up-regulating the transporters HP0939, HP1017, HP0497, and HP0471.Antimicrob Agents Chemother(微生物耐藥研究TOP期刊). 2017 Feb 27. pii: AAC.02011-16. doi:10.1128/AAC.02011-16. [Epub ahead of print]
3、Zhekai Hu, Yu Zhang, Zhiyu Li, Yuedi Yu, Wenyan Kang, Yingnan Han, Xiwen Geng, Shaohua Ge*, Yundong Sun*.Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation.Oncotarget.2016August 20.doi:10.18632/oncotarget.9573.
4、Yuqun Shan, Xingxiao Lu, Yingnan Han, Xinpeng Li, Xiao Wang, Chunhong Shao,Lixiang Wang, Zhifang Liu, Wei Tang, Yundong Sun*and Jihui Jia. Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon-γ Signaling.Biomed Res Int. 2015;2015:571280. doi:10.1155/2015/571280. Epub 2015 Apr6
5、 Sun Y *, Liu S, Li W, Shan Y, Li X, Lu X, Li Y, Guo Q, Zhou Y, Jia J*. Proteomic analysis of the function of sigma factor σ54 in Helicobacter pylori survival with nutrition deficiency stress in vitro. PLoS One. 8(8):e72920;2013 Aug 28. doi: 10.1371
6、 Sun Y, Li X, Li W, Zhao M, Wang L, Liu S, Zeng J, Liu Z, Jia J*. Proteomic analysis of the function of SpoT in Helicobacter pylori anti-oxidative stress in vitro and colonization in vivo. J Cell Biochem.113(11):3393-402; 2012 Nov.
7、 Sun YD, Fu LD, Jia YP, Du XJ, Wang Q, Wang YH, Zhao XF, Yu XQ, Wang JX. A hepatopancreas-specific C-type lectin from the Chinese shrimp Fenneropenaeus chinensis exhibits antimicrobial activity. Mol Immunol. 2008 Jan;45(2):348-61. Epub 2007 Aug 6.
8、 Sun YD, Zhao XF, Kang CJ, Wang JX. Molecular cloning and characterization of Fc-TSP from the Chinese shrimp Fennerpenaeus chinensis. Mol Immunol. 2006 Mar;43(8):1202-10. Epub 2005 Aug 18
9、Shao, Chunhong, Sun, Yundong , Wang, Na, Yu, Han, Zhou, Yabin, Chen, Chunyan, Jia, Jihui* Changes of proteome components of Helicobacter pylori biofilms induced by serum starvation. Molecular Medicine Reports, 8(6), pp 1761-1766, 2013/12.
10、Wang H#, Sun Y#, Liu S, Yu H, Li W, Zeng J, Chen C, Jia J *. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration. FEMS Immunol Med Microbiol, 63(1), pp 82-92.(它引9次)
11、Liu S Sun Y Li W, Yu H, Li X, Liu Z, Zeng J, Zhou Y, Chen C, Jia J.The antibacterial mode of action of allitridi for its potential use as a therapeutic agent against Helicobacter pylori infection(2009). FEMS Microbiol Lett. 2010 Feb 1;303(2):183-9(它引7次)
12、Yu-Ping Jia, Yun-Dong Sun ,Qian Wang, Xiao-fan Zhao, Jin-Xing Wang.A single whey acidic protein domain (SWD)-containing peptide from the fleshy prawn with antimicrobial and proteinase inhibition activities. Aquaculture,Volume 284, Issues 1-4, 1 November 2008, Pages 246-259(它引42次)
三、教學成果
1、醫學微生物學山東省精品課程骨幹成員。
2、2014年山東大學中青年教師講課比賽優秀獎。
3、作為醫學微生物系中青年教學骨幹教師參加山東大學教學與促進發展中心舉辦的教學能力提升研修班。
4、山東省微課比賽三等獎
5、全國醫學類微課比賽鼓勵獎
四、其它工作(指導本科生創新實驗)
1、指導口腔學院校長獎學金獲得者馬駟駸大學生創新實驗
2、指導口腔學院本本科生胡哲凱等大學生創新實驗,並在《oncotarget》發表文章
3、指導醫學院七年制學生趙朗等大學生創新實驗
4、指導醫學院六年制本科生崔岳被賓夕法尼亞大學錄取為全額獎學金博士生
5、指導口腔學院本科生李淑彤,榮興等獲得國家級大學生創新項目