![姚玉峰[上海交通大學博士生導師]](/img/b/54f/nBnauM3XwYDO5YDO4MTOzkDN1UTM1QDN5MjM5ADMwAjMwUzLzkzLwUzLt92YucmbvRWdo5Cd0FmLzE2LvoDc0RHa.jpg "姚玉峰[上海交通大學博士生導師]")
研究方向
細菌微進化及致病機制主要包括：1）利用高通量生物學技術研究結核分枝桿菌北京家族基因組微進化與其毒力、耐藥、傳播力以及對宿主免疫逃逸的關係；2）採用體外結合體內模型的方法鑑定新的結核分枝桿菌毒力因子並研究其在結核分枝桿菌致病過程中的具體功能；3）利用分子生物學和蛋白質組學技術研究細菌VI型分泌系統的結構組成以及鑑定分泌蛋白並研究其功能；4）細菌蛋白質乙醯化修飾與致病機制的關係。
主要成就
目前主持科技部“973”計畫課題、國家自然科學基金、“十一五”傳染病重大專項以及上海市科委啟明星計畫等課題。近5年來發表論文和綜述20多篇，其中SCI論文18篇，申請國際和國內專利3項。主講醫學本科生《醫學微生物學》和研究生《細胞微生物學》等課程。參編《病原生物學實驗》（科學出版社，2010年）和《醫學微生物學技術》（人民衛生出版社，2010年）等規劃教材。
代表性論著
Lu L, Sun Q, Fan X, Zhong Y, Yao Y, Zhao GP. Mycobacterial MazG is a novel NTP pyrophospho-hydrolyase involved in oxidative stress response. J Biol Chem. 2010 (co-corresponding author)
Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning Z, Zeng R, Xiong Y, Guan K, Zhao S, Zhao G. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science. 2010, 327(5968):1004-7
Yao Y, Xie Y, Kim KS. Genomic comparison of E. coli K1 strains isolated from the cerebrospinal fluid of patients with meningitis. Infect & Immun. 2006, 74(4): 2196-206.
Yao Y, Vuong C, Kocianova S, Villaruz A, Lai Y, Sturdevant D, Otto M. Characterization of the Staphylococcus epidermidis accessory-gene regulator response: Quorum-sensing regulation of resistance to human innate host defense. J Infect Dis. 2006, 193(6): 841-8.
Yao Y, Sturdevant D, Otto M. Genome-wide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into S. epidermidis biofilm pathophysiology. J Infect Dis. 2005, 191(2): 289-98.
Yao Y, Sturdevant D, Villaru A, Xu L, Gao Q, Otto M. Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics. Infect & Immun. 2005, 73(3): 1856-60.
1.Lu L, Sun Q, Fan X, Zhong Y, Yao Y, Zhao GP. Mycobacterial MazG is a novel NTP pyrophospho-hydrolyase involved in oxidative stress response. J Biol Chem. 2010 (co-corresponding author)
2.Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning Z, Zeng R, Xiong Y, Guan K, Zhao S, Zhao G. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science. 2010, 327(5968):1004-7
3.Yao Y, Xie Y, Kim KS. Genomic comparison of E. coli K1 strains isolated from the cerebrospinal fluid of patients with meningitis. Infect & Immun. 2006, 74(4): 2196-206.
4.Yao Y, Vuong C, Kocianova S, Villaruz A, Lai Y, Sturdevant D, Otto M. Characterization of the Staphylococcus epidermidis accessory-gene regulator response: Quorum-sensing regulation of resistance to human innate host defense. J Infect Dis. 2006, 193(6): 841-8.
5.Yao Y, Sturdevant D, Otto M. Genome-wide analysis of gene expression in Staphylococcus epidermidis biofilms: insights into S. epidermidis biofilm pathophysiology. J Infect Dis. 2005, 191(2): 289-98.
6.Yao Y, Sturdevant D, Villaru A, Xu L, Gao Q, Otto M. Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics. Infect & Immun. 2005, 73(3): 1856-60.
