嚴琨[武漢大學化學與分子科學學院副教授]:嚴琨，博士、副教授，武漢大學化 -百科知識中文網

基本情況

教育與研究經歷

1996-2000 理學學士，武漢大學化學與分子科學學院

2000-2003 理學碩士，武漢大學化學與分子科學學院，有機化學專業，導師吳成泰教授

2003-2007 哲學博士，香港大學化學系，化學生物學專業，導師支志明院士

2007-2008 博士後，香港大學化學系, 支志明院士課題組

2009-2011 博士後，美國約翰霍普金斯大學醫學院放射學系，Prof. Jinyuan Zhou課題組

2011-2012 博士後，美國約翰霍普金斯大學醫學院Bayview Proteomics Center，Prof. Jennifer Van Eyk課題組

2012.4-至今副教授, 武漢大學化學與分子科學學院

主授課程

主講本科生必修課《無機化學》、《工程化學》；通識課《生物無機化學》

主講研究生必修課《生物無機化學》、《無機化學前沿》（部分）

主要研究領域與項目

研究領域

過渡金屬配合物的合成、生物活性及機理

蛋白質組學在藥物開發和疾病診斷中的套用

核磁共振分子成像、磁性/光學探針腫瘤診斷、多模式影像指導下的腫瘤治療

科研項目

.國家自然科學基金(21401144)

2.湖北省自然科學基金（2013CFB236）

主要學術成果

1. Yan, Kun; Fu, Zongming; Yang, Chen; Zhang, Kai; Jiang, Shenshan; Lee, Dong-Hoon; Heo, Hye-Young; Zhang, Yi; Cole, Robert N.; Van Eyk, Jennifer E.; Zhou, Jinyuan*. “Assessing Amide Proton Transfer (APT) MRI Contrast Origins in 9 L Gliosarcoma in the Rat Brain Using Proteomic Analysis” Mol. Imaging Biol. 2015, DOI: 10.1007/s11307-015-0828-6

2. Lin, Iris Wing-Shan; Lok, Chun-Nam; Yan, Kun; Che, Chi-Ming*. “A silver complex of N,N''''''''-disubstituted cyclic thiourea as an anti-inflammatory inhibitor of IκB kinase” Chem. Commun. 2013, 49, 3297-3299.

3. Siu, Fung-Ming†; Lin, Iris Wing-Shan†; Yan, Kun†; Lok, Chun-Nam; Low, Kam-Hung; Leung, Thomas Yun-Chung; Lam, Tin-Lun; Che, Chi-Ming*. “Anticancer Dirhodium(II) Carboxylates as Potent Inhibitors of Ubiquitin-Proteasome System” Chemical Science 2012, 3, 1785-1793. (Back Cover, †Equal Contributions)

4. Zhou, Jinyuan*; Yan, Kun; Zhu, He. “A Simple Model for Understanding the Origin of the Amide Proton Transfer MRI Signal in Tissue”, Appl. Magn. Reson 2012, 42, 393-402.

5. Wang, Silun; Chen, Yifei; Lal, Bachchu, Ford, Eric; Tryggestad, Erik; Armour, Michael; Yan, Kun; Laterra, John; Zhou, Jinyuan*. “Evaluation of Radiation Necrosis and Malignant Glioma in Rat Models Using Diffusion Tensor MR Imaging”, J Neurooncol. 2012, 107, 51-60.

6. Zhou, Jinyuan*; Tryggestad, Erik; Wen, Zhibo; Lal, Bachchu; Zhou, Tingting; Grossman, Rachel; Wang, Silun; Yan, Kun; Fu, De-Xue; Ford, Eric; Tyler, Betty; Blakeley, Jaishri; Laterra, John; van Zijl, Peter C.M. “Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides”, Nature Medicine 2011, 17, 130-134.

7. Yan, Kun; Lok, Chun-Nam; Bierla, Katarzyna; Che, Chi-Ming*. “Gold(I) complex of N,N’-disubstituted cyclic thiourea with in vitro and in vivo anti-cancer properties - potent tight-binding inhibition of thioredoxin reductase”, Chem. Commun. 2010, 46, 7691–7693. (Inside Cover)

8. Zhang, Zhi; Guo, Qian-ni; Lu, Yun-guo; Jia, Tao; Yan, Kun*; Li, Zao-ying*. “Interaction between novel porphyrin-dextran nanoparticles and human serum albumin”, J. Porphyrins Phthalocyanines 2010, 14, 264–270.

9. Zhang, Zhi; He, Rui; Yan, Kun; Guo, Qian-ni; Lu, Yun-guo; Wang, Xu-xia; Lei, Hao; Li, Zao-ying*. “Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin–dextran as a novel MRI contrast agent”, Bioorg. Med. Chem. Lett. 2009, 19, 6675-6678.

10. Siu, Fung-Ming; Ma, Dik-Lung; Cheung, Yee-Wai; Lok; Chun-Nam, Yan, Kun; Yang, zhiqi; Yang, Mengsu; Xu, SongXiao; Ko, Ben Chi-Bun; He, Qing-Yu; Che, Chi-Ming*. “Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondriamediated apoptotic pathways”, Proteomics 2008, 8, 3105–3117

嚴琨[武漢大學化學與分子科學學院副教授]