唐曉峰[武漢大學生命科學院教授]

武漢大學生命科學學院微生物學系教授. 中國微生物學會會員，美國微生物學會 (American Society for Microbiology) 會員，中國遺傳學會會員。主持國家自然科學基金3項、教育部留學回國人員科研啟動基金1項，參加973項目子項目。主持武漢大學教改項目1項，參加多項國家級省部級教改項目。教學獲獎:2013年湖北省高等學校教學成果一等獎（排名二）,2008年國家級教學團隊（微生物學系列課程教學團隊主要成員），2005年國家級教學成果二等獎（排名第三），2005年湖北省高等學校教學成果一等獎（排名第三）。

基本信息

• 中文名：唐曉峰
• 性別：男
• 國籍：中國
• 職業：研究員
  
• 畢業院校：廈門大學

人物經歷

學歷

1985.09-1989.07 武漢大學生物系微生物學專業 學士。

1989.09-1992.07 武漢大學生命科學學院微生物學專業 碩士。

1996.10-2001.03 日本京都大學大學院工學研究科合成及生物化學專攻 博士。

2001.04-2003.08 日本國立產業技術綜合研究所生物情報解析研究中心 博士後。

工作簡歷

1992.7-1996.9 武漢大學生命科學學院微生物系 助教、講師。

2003.11- 武漢大學生命科學學院生物技術系 副教授。

主講課程

1、2004- 微生物學，54學時，藥學院及東湖分校，本科生必修。

2、2004- 高級微生物(部分)，生命科學學院，研究生。

3、1993-1995 微生物學(部分)，54學時，生命科學學院，本科生必修。

4、1992-1995 微生物學實驗，54學時，生命科學學院，本科生必修。

5、1992-1995 微生物技術實驗, 36學時,生命科學學院，本科生指定選修。

研究方向

微生物的酶功能與結構研究；微生物基因的表達調控的研究。 目前的主要研究領域：

微生物的酶功能與結構研究；極端環境微生物的嗜極酶耐受極端環境的分子機制以及嗜極酶基因的表達調控的研究。

主要貢獻

1. Du X, Li M, Tang W, Zhang Y, Zhang L, Wang J, Li T, Tang B, Tang XF*. (2015) Secretion of Tat-dependent halolysin SptA capable of autocatalytic activation and its relation to haloarchaeal growth. Mol Microbiol. 96(3):548-65.

2. Zhang Y, Wang M, Du X, Tang W, Zhang L, Li M, Wang J, Tang B, Tang XF*. (2014) Chitin accelerates activation of a novel haloarchaeal serine protease that deproteinizes chitin-containing biomass. Appl Environ Microbiol. 80(18):5698-708.

3. Zeng J, Gao X, Dai Z, Tang B, Tang XF*. (2014) Effects of metal ions on stability and activity of hyperthermophilic pyrolysin and further stabilization of this enzyme by modification of a Ca2+-binding site. Appl Environ Microbiol 80(9):2763-72.

4. Feng J, Wang J, Zhang Y, Du X, Xu Z, Wu Y, Tang W, Li M, Tang B, Tang XF*. (2014) Proteomic analysis of the secretome of haloarchaeon Natrinema sp. J7−2. J Proteome Res 13(3):1248-58.

5. Feng J, Liu B, Zhang Z, Ren Y, Li Y, Gan F, Huang Y, Chen X, Shen P, Wang L, Tang B*, Tang XF*. (2012) The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable of growth on synthetic media without amino acid supplements. PLoS ONE 7(7):e41621. Epub 2012 Jul 23.

6. Dai Z, Fu H, Zhang Y, Zeng J, Tang B, Tang XF*. (2012) Insights into the maturation of hyperthermophilic pyrolysin and the roles of its N-terminal propeptide and long C-terminal extension. Appl Environ Microbiol 78(12):4233-41.

7. Xu Z, Du X, Li T, Gan F, Tang B, Tang XF*. (2011) Functional Insight into the C-Terminal Extension of Halolysin SptA from Haloarchaeon Natrinema sp. J7. PLoS ONE 6(8):e23562. Epub 2011 Aug 19.

8. Wang L, Cheng G, Ren Y, Dai Z, Zhao ZS, Liu F, Li S, Wei Y, Xiong J, Tang XF, Tang B*. (2015) Degradation of intact chicken feathers by Thermoactinomyces sp. CDF and characterization of its keratinolytic protease. Appl Microbiol Biotechnol 99(9): 3949-59.

9. Zhu H, Xu BL, Liang X, Yang YR, Tang XF, Tang B*. (2013) Molecular basis for auto- and hetero-catalytic maturation of a thermostable subtilase from thermophilic Bacillus sp. WF146. J Biol Chem 288(48):34826-38.

10. Li XG*, Yang J, Wang R, Tang XF, Meng JJ, Qin HJ, Liu X, Guo F, Wan SB*. (2013) Effects of ectopically expressed hyperthermophilic archaeon (Pyrococcus furiosus) ribulose-1,5-bisphosphate carboxylase/oxygenase on tobacco photosynthesis. Photosynthetica 51 (3): 387-94.

11. Liang X, Bian Y, Tang XF, Xiao G, Tang B*. (2010) Enhancement of keratinolytic activity of a thermophilic subtilase by improving its autolysis resistance and thermostability under reducing conditions. Appl Microbiol Biotechnol 87:999–1006.

12. Fang N, Zhong CQ, Liang X, Tang XF, Tang B*. (2010) Improvement of extracellular production of a thermophilic subtilase expressed in Escherichia coli by random mutagenesis of its N-terminal propeptide. Appl Microbiol Biotechnol 85(5):1473-81.

13. Zhong CQ, Song S, Fang N, Liang X, Zhu H, Tang XF, Tang B*. (2009) Improvement of low-temperature caseinolytic activity of a thermophilic subtilase by directed evolution and site-directed mutagenesis. Biotechnol Bioeng 104(5):862-70.

14. Cheng G, Zhao P, Tang XF, Tang B*. (2009) Identification and characterization of a novel spore-associated subtilase from Thermoactinomyces sp. CDF. Microbiology-SGM 55:3661-72.

15. Zeng C, Zhao YZ, Cui CZ, Zhan H, Zhu JY, Tang XF, Shen P, Huang YP*, Chen XD*. (2009) Characterization of the Haloarcula hispanica amyH gene promoter, an archaeal promoter that confers promoter activity in Escherichia coli. Gene 442: 1–7.

16. Yang YR, Zhu H, Fang N, Liang X, Zhong CQ, Tang XF, Shen P, Tang B*. (2008) Cold-adapted maturation of thermophilic WF146 protease by mimicking the propeptide binding interactions of psychrophilic subtilisin S41. FEBS Lett 582(17):2620-6.

17. Shi W, Tang XF, Huang Y, Gan F, Tang B*, Shen P.（2006）An extracellular halophilic protease SptA from a halophilic archaeon Natrinema sp. J7: gene cloning, expression and characterization. Extremophiles 10:599–606.

18. Bian Y, Liang X, Fang N, Tang XF, Tang B*, Shen P, Peng Z.（2006）The roles of surface loop insertions and disulfide bond in the stabilization of thermophilic WF146 protease. FEBS Lett 580:6007–14.

19. Tang XF, Shen Y, Matsui E, Matsui I*. (2004) Domain topology of the DNA polymerase D complex from a hyperthermophilic archaeon Pyrococcus horikoshii. Biochemistry 43(37):11818-27.

20. Shen Y, Tang XF, Yokoyama H, Matsui E, Matsui I*. (2004) A 21-amino acid peptide from the cysteine cluster II of the family D DNA polymerase from Pyrococcus horikoshii stimulates its nuclease activity which is Mre11-like and prefers manganese ion as the cofactor. Nucleic Acids Res 32:158-68.

21. Shen Y, Tang XF, Matsui E, Matsui I*. (2004) Subunit interaction and regulation of activity through terminal domains of the family D DNA polymerase from Pyrococcus horikoshii. Biochem Soc Trans 32:245-9.

22. Shen Y, Tang XF, Matsui I*. (2003) Subunit interaction and regulation of activity through terminal domains of family D DNA polymerase from Pyrococcus horikoshii. J Biol Chem 278: 21247-57.

23. Tang XF, Ezaki S, Atomi H, Imanaka T*. (2001) Anthranilate synthase without an LLES motif from a hyperthermophilic archaeon is inhibited by tryptophan. Biochem Biophys Res Commun 281:858-65.

24. Matsuda T, Fujikawa M, Haruki M, Tang XF, Ezaki S, Imanaka T, Morikawa M, Kanaya S*. (2001) Interaction of TIP26 from a hyperthermophilic archaeon with TFB/TBP/DNA ternary complex. Extremophiles 5:177-82.

25. Tang XF, Ezaki S, Atomi H, Imanaka T*. (2000) Biochemical analysis of a thermostable tryptophan synthase from a hyperthermophilic archaeon. Eur J Biochem 267:6369-77.

26. Tang X, Ezaki S, Fujiwara S, Takagi M, Atomi H, Imanaka T*. (1999) The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA. Mol Gen Genet 262:815-21.

獲獎記錄

國家優秀教學成果二等獎，2005（排名第三）。

湖北省優秀教學成果一等獎，2004（排名第三）。

武漢大學青年教師優秀教學成果三等獎，1995。