![吳虹[北京大學生命科學學院院長]](/img/2/56b/nBnauM3X2IzM3kzM3IjM4kTO0UTMyITNykTO0EDMwAjMwUzLyIzLyEzLt92YucmbvRWdo5Cd0FmLyE2LvoDc0RHa.jpg "吳虹[北京大學生命科學學院院長]")
學術研究
主要研究方向為腫瘤細胞信號轉導及分子機制研究，曾以第一作者和通訊作者在Nature、Cell、Blood和PNAS等頂級學術期刊發表多篇有重要影響力的論文。 2011年被選為美國科學促進協會院士。
個人經歷
1978年-1983年，在北京醫學院（原北京醫科大學，現北京大學醫學部）學習，獲得醫學學士學位；
吳虹 教授1984年-1991年，美國哈佛大學生物化學和分子藥理學系，獲得博士學位；
1991年-1996年，在美國Whitehead生物醫學研究所做博士後；
1996年-2013年，美國加州大學洛杉磯分校（UCLA）分子生物學和醫學藥理學系助理教授至終身正教授。
2013年-今，現被聘任為北京大學講席教授、北京大學生命科學學院院長。
媒體報導
9月3日上午，生命科學學院在金光生命科學大樓鄧祐才報告廳召開全院教職工大會，宣布北京大學關於學院新一屆行政領導班子的任命決定。王恩哥校長攜組織部部長郭海等一行出席會議，翟中和院士、朱作言院士、趙進東院士、朱玉賢院士等生命科學學院教職工約70人參加了會議。會議由學院黨委書記柴真主持。
北京大學組織部郭海部長代表北京大學宣讀了關於生命科學學院新一屆行政領導班子的任命決定：院長吳虹，副院長柴真（兼）、王世強、李沉簡、郭紅衛；原班子成員自然免職。郭海部長還介紹了學院新一屆行政領導班子的產生過程，並對新班子寄予厚望，相信他們一定會帶領生命科學學院做出更好的成績。
前任院長饒毅代表上一屆領導班子感謝全院教職工在過去的六年里所給予的工作支持。他表示，生命科學聯合中心將一如既往地支持學院發展，自己也將作為普通教授的一員繼續為學院貢獻力量。
新任院長吳虹代表新一屆行政班子向出席會議的校領導和學院教職工介紹了班子成員的職責分工，並闡述了在本科生和研究生教學、科學研究和公共平台建設、學生工作、行政管理、校友聯絡等各方面工作的構想，以及具體的可行措施。吳虹院長認為，在未來五年的發展中，生命科學學院最重要的任務是明確定位和目標，理性認識學院面臨的機遇與挑戰，並扎紮實實地開展實際工作。學院的未來掌握在每一位教職工自己的手裡，必須依靠學院全體同仁的共同努力去創造；作為新一屆領導班子，要帶領大家積極迎對挑戰，把握機遇，主動出擊，為學院在全國乃至世界生命科學領域前沿贏得一席之地。
王恩哥校長發表總結講話。他首先充分肯定了饒毅教授率領的上一屆行政班子所取得的成績，高度評價並感謝他們為此所付出的努力；同時，他代表北京大學對學院新一屆行政領導班子的履任表示熱烈祝賀，並對吳虹院長闡述的學院發展理念表示贊同，號召學院全體教工支持新班子的工作。王恩哥校長認為，生命科學在今天的發展已經愈加體現出學科交叉的趨向，圍繞生命科學和生命科學學院，相繼成立了一批研究所和中心，形成了一個相互支撐的體系；學校將繼續提供全力支持，努力發展具有北京大學特色的生命科學。
會後，學院新一屆領導班子召開第一次黨政聯席會，就新學期的工作進行了討論和安排。務實是這一屆領導班子的一大特點，相信在生命科學學院積澱的優良傳統和鋪墊的堅實基礎上，新一屆班子一定會帶領學院取得新的成績！
學術論文
Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.
Xu, X. Kobayashi, S. Qiao, W. Li, C. Xiao, C. Radaeva, S. Stiles, B. Wang, R. H. Ohara, N. Yoshino, T. LeRoith, D. Torbenson, M. S. Gores, G. J. Wu, H. Gao, B. Deng, C. X. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006; 116(7): 1843-52.
Wu, H. Khodavirdi, A Roy-Burman, P. Capturing signal anomalies of human prostate cancer into mouse models. Prostate cancer: basic mechanisms and therapeutic approaches 2005; in press.
Kurlawalla-Martinez, C. Stiles, B. Wang, Y. Devaskar, S. U. Kahn, B. B. Wu, H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.
Lasky, J. and Wu, H. Notch signaling pathways, brain development and human disease. Pediatric Research 2005; in press.
Yue, Q. Groszer, M. Gil, J. S. Berk, A. J. Messing, A. Wu, H. Liu, X. PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development. 2005; 132(14): 3281-91.
Stanger, B. Z. Stiles, B. Lauwers, G. Y. Bardeesy, N. Mendoza, M. Wang, Y. Greenwood, A. Cheng, K. H. McLaughlin, M. Brown, D. Depinho, R. A. Wu, H. Melton, D. A. Dor, Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95.
Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005; 25(6): 2498-510.
Lasky J, and Wu H Notch signaling pathways, brain development and human disease.Pediatric Research 2005; in press.
Liu B, Yang R, Wong KA, Getman C, Stein N, Cheng G, Wu H, and Shuai K PIAS1 Participates in the Negative Regulation of NF-kB Signaling. Mol. Cell Biol. 2005; 25: 1113-23.
Mulholland DJ, Dedhar S, Wu H and Nelson CC PTEN & GSK3?O: Key Regulators of Progression to Androgen Independent Prostate Cancer. . Oncogene 2005; in press.
Sanchez T, Thangada S, Wu MT, Kontos C, Wu D, Wu H And Hla T PTEN as an effector in the signaling of anti-migratory G protein-coupled receptor. Proc. Natl. Acad. Sci. USA 2005; 102: 4312-7.
Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization.Development. 2005; 132(14): 3281-91.
Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005; 8(3): 185-95.
Roy-Burman, P. Wu, H. Powell, W. C. Hagenkord, J. Cohen, M. B. Genetically defined mouse models that mimic natural aspects of human prostate cancer development.Endocr Relat Cancer. 2004; 11(2): 225-54.
Sundaresan, G. Paulmurugan, R. Berger, F. Stiles, B. Nagayama, Y. Wu, H. Gambhir, S. S. MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18.
Liu, B. Mink, S. Wong, K. A. Stein, N. Getman, C. Dempsey, P. W. Wu, H. Shuai, K. PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.
Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004; 24(12): 5577-86.
Roy-Burman P, Wu H, Powell WC, Hagenkord J, Cohen MB Genetically defined mouse models that mimic natural aspects of human prostate cancer development. Endocr Relat Cancer. 2004; 11(2): 225-54.
Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene Ther. 2004; 11(7): 609-18.
Liu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.
Wong, K. A. Tsai, P. T. Jegalian, A. Kertesz, N. Lee, R. Wu, H. Erythropoietin, biochemistry of.. Encyclopedia of hormones 2003; 561-569.
Freeman, D. J. Li, A. G. Wei, G. Li, H. H. Kertesz, N. Lesche, R. Whale, A. D. Martinez-Diaz, H. Rozengurt, N. Cardiff, R. D. Liu, X. Wu, H. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003; 3(2): 117-30.
Wang, S. Gao, J. Lei, Q. Rozengurt, N. Pritchard, C. Jiao, J. Thomas, G. V. Li, G. Roy-Burman, P. Nelson, P. S. Liu, X. Wu, H. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.
Anzelon, A. N. Wu, H. Rickert, R. C. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol. 2003; 4(3): 287-94.
Wong K, Tsai P, Jegalian A, Kertesz N, Lee R and Wu H Erythropoietin, Biochemistry of.. In Encyclopedia of Hormones. 2003; 561-569..
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms.Cancer Cell. 2003; 3(2): 117-30.
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell. 2003; 4(3): 209-21.
Li, G. Robinson, G. W. Lesche, R. Martinez-Diaz, H. Jiang, Z. Rozengurt, N. Wagner, K. U. Wu, D. C. Lane, T. F. Liu, X. Hennighausen, L. Wu, H. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.Development. 2002; 129(17): 4159-70.
Lesche, R. Groszer, M. Gao, J. Wang, Y. Messing, A. Sun, H. Liu, X. Wu, H.Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis.2002; 32(2): 148-9.
Jegalian, A. G. Wu, H. Differential roles of SOCS family members in EpoR signal transduction. J Interferon Cytokine Res. 2002; 22(8): 853-60.
Stiles, B. Gilman, V. Khanzenzon, N. Lesche, R. Li, A. Qiao, R. Liu, X. Wu, H. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.Mol Cell Biol. 2002; 22(11): 3842-51.
Jegalian A and Wu H Differential Regulation of SOCS Gene Expression and Distinct Roles of SOCS family Members in Erythropoietin Receptor Signal Transduction.. J. Cyto.Research . 2002; 22: 3842-3851.
Jegalian, A., Acurio, A., Dranoff, G., Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukine 3.. Blood . 2002; 99: 2603-2605.
Makita T, Hernandez-Hoyos G, Chen T, Wu H, Rothenberg E and Sucov H A Developmental Transition in Definitive Erythropoiesis Controlled by Competitive Regulation of Erythropoietin Expression by Retinoid Acid Receptor and HNF4.. Gene & Devel.. 2001; 15: 889-901.
Neshat M, Mellinghoff I, Tran C, Stiles B, Thomas G, Wu H, and Sawyers C Enhanced sensitively of PTEN-Deficient Tumors to Inhibition of FRAP/mTOR.. Proc. Natl. Acad. Sci. USA. . 2001; 98: 10314-1031.
Hisakawa H, Sugiyama D, Nishijima I, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K Human Granulocyte-Macrophage Colony-Stimulating Factor (hGM-CSF) Stimulates Primitive and Definitive Erythropoiesis in Mouse Embryo Expressing hGM-CSF Receptors but not Erythropoietin Receptors.. Blood . 2001; 98: 3618-3625.
Mamillapalli R, Gavrilova N, Mihaylova V, Tsvetkov L, Wu H, Zhang H and Sun H PTEN Regulates The Ubiquitin-Dependent Degradation Of The Cdk Inhibitor P27kip1 Through The Ubiquitin E3 Ligase Scfskp2.. Current Biology . 2001; 11: 263-267.
Wu, H. Lee, S. H. Gao, J. Liu, X. Iruela-Arispe, M. L. Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development. 1999; 126(16): 3597-605.
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Garvarina N, Mueller B, Liu X and Wu H PTEN Modulates Cell Cycle Prograssion and Cell Survival by Regulating PIP3 and AKT/PKB Signaling Pathway.. Proc. Natl. Acad. Sci.. 1999; 96: 6199-6204.
Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U and Pfeffer K Jak2 Deficiency Defines an Essential Developmental Checkpoint in Definitive Hematopoiesis.. Cell. 1998; 93: 397-409.
Liu, X. Wu, H. Loring, J. Hormuzdi, S. Disteche, C. M. Bornstein, P. Jaenisch, R. Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.
Wu H, Klingmuller U, Acurio A, Hsiao JG and Lodish HF Functional Interaction of Erythropoietin and Stem Cell Factor Receptors is Essential for Erythroid Colony Formation.. Proc. Natl. Acad. Sci. USA. . 1997; 94: 1806-1810.
Klingmuller K, Wu H, Hsiao J, Duckworth B, Toker A, Cantley LC and Lodish HF Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.. Proc. Natl. Acad. Sci. USA . 1997; 94: 3016-3021.
Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn. 1997; 209(1): 85-91.
Watowich, S. S. Wu, H. Socolovsky, M. Klingmuller, U. Constantinescu, S. N. Lodish, H. F. Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 1996; 12: 91-128.
Wu, H. and Lodish, H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.
Iruela-Arispe, M. L. Vernon, R. B. Wu, H. Jaenisch, R. Sage, E. H. Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Dev Dyn. 1996; 207(2): 171-83.
Wu H and Lodish H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.
Iruela ML, Vernon RB, Wu H, Jeanisch R and Sage H Type I collagen is required for the association of SPARC with the extracellular matrix in Mov-13 mice: implications for fibroblast function.. Developmental Dynamics . 1996; 207: 171-183.
Liu, X. Wu, H. Byrne, M. Jeffrey, J. Krane, S. Jaenisch, R. A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J Cell Biol. 1995; 130(1): 227-37.
Lodish, H. F. Hilton, D. J. Klingmuller, U. Watowich, S. S. Wu, H. The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harb Symp Quant Biol. 1995; 60: 93-104.
Dzamba, B. J. Wu, H. Jaenisch, R. Peters, D. M. Fibronectin binding site in type I collagen regulates fibronectin fibril formation. J Cell Biol. 1993; 121(5): 1165-72.
Hasty, K. A. Wu, H. Byrne, M. Goldring, M. B. Seyer, J. M. Jaenisch, R. Krane, S. M. Mainardi, C. L. Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase. Matrix. 1993; 13(3): 181-6.
Wu, H. Fassler, R. Schnieke, A. Barker, D. Lee, K. H. Chapman, V. Francke, U. Jaenisch, R. An X-linked human collagen transgene escapes X inactivation in a subset of cells. Development. 1992; 116(3): 687-95.
Barker, D. D. Wu, H. Hartung, S. Breindl, M. Jaenisch, R. Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice. Mol Cell Biol. 1991; 11(10): 5154-63.
Wu, H. Byrne, M. H. Stacey, A. Goldring, M. B. Birkhead, J. R. Jaenisch, R. Krane, S. M. Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc Natl Acad Sci U S A. 1990; 87(15): 5888-92.
Horvath, S. Zhang, B. Carlson, M. Lu, K. V. Zhu, S. Felciano, R. M. Laurance, M. F. Zhao, W. Qi, S. Chen, Z. Lee, Y. Scheck, A. C. Liau, L. M. Wu, H. Geschwind, D. H. Febbo, P. G. Kornblum, H. I. Cloughesy, T. F. Nelson, S. F. Mischel, P. S. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A. 2006; 103(46): 17402-7.
Huang, W. Chang, H. Y. Fei, T. Wu, H. Chen, Y. G. GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene. 2006; .
Freeman, D. Lesche, R. Kertesz, N. Wang, S. Li, G. Gao, J. Groszer, M. Martinez-Diaz, H. Rozengurt, N. Thomas, G. Liu, X. Wu, H. Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006; 66(13): 6492-6.
Zhang, J. Grindley, J. C. Yin, T. Jayasinghe, S. He, X. C. Ross, J. T. Haug, J. S. Rupp, D. Porter-Westpfahl, K. S. Wiedemann, L. M. Wu, H. Li, L. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention.Nature. 2006; 441(7092): 518-22.
Yilmaz, O. H. Valdez, R. Theisen, B. K. Guo, W. Ferguson, D. O. Wu, H. Morrison, S. J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006; 441(7092): 475-82.
Li, G. Hu, Y. Huo, Y. Liu, M. Freeman, D. Gao, J. Liu, X. Wu, D. Wu, H. PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. J Biol Chem. 2006; .
Yoo, L. I. Liu, D. W. Le Vu, S. Bronson, R. T. Wu, H. Yuan, J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner.Cancer Res. 2006; 66(4): 1929-39.
Yao, D. Alexander, C. L. Quinn, J. A. Porter, M. J. Wu, H. Greenhalgh, D. A. PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways. Cancer Res. 2006; 66(3): 1302-12.
Wang, S. Garcia, A. J. Wu, M. Lawson, D. A. Witte, O. N. Wu, H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.
Tsai, P. T. Ohab, J. J. Kertesz, N. Groszer, M. Matter, C. Gao, J. Liu, X. Wu, H. Carmichael, S. T. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.
Mulholland, D. J. Dedhar, S. Wu, H. Nelson, C. C. PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene. 2006; 25(3): 329-37.
Khodavirdi, A. C. Song, Z. Yang, S. Zhong, C. Wang, S. Wu, H. Pritchard, C. Nelson, P. S. Roy-Burman, P. Increased expression of osteopontin contributes to the progression of prostate cancer. Cancer Res. 2006; 66(2): 883-8.
Groszer, M. Erickson, R. Scripture-Adams, D. D. Dougherty, J. D. Le Belle, J. Zack, J. A. Geschwind, D. H. Liu, X. Kornblum, H. I. Wu, H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
Berquin, I. M. Min, Y. Wu, R. Wu, H. Chen, Y. Q. Expression signature of the mouse prostate. J Biol Chem. 2005; 280(43): 36442-51.
Nakano, I. Paucar, A. A. Bajpai, R. Dougherty, J. D. Zewail, A. Kelly, T. K. Kim, K. J. Ou, J. Groszer, M. Imura, T. Freije, W. A. Nelson, S. F. Sofroniew, M. V. Wu, H. Liu, X. Terskikh, A. V. Geschwind, D. H. Kornblum, H. I. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.J Cell Biol. 2005; 170(3): 413-27.
Shi, Y. Sharma, A. Wu, H. Lichtenstein, A. Gera, J. Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. J Biol Chem. 2005; 280(12): 10964-73.
Sanchez, T. Thangada, S. Wu, M. T. Kontos, C. D. Wu, D. Wu, H. Hla, T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005; 102(12): 4312-7.
Lim, M. A. Yang, L. Zheng, Y. Wu, H. Dong, L. Q. Liu, F. Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells.Oncogene. 2004; 23(58): 9348-58.
Kertesz, N. Wu, J. Chen, T. H. Sucov, H. M. Wu, H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004; 276(1): 101-10.
Stiles, B. Groszer, M. Wang, S. Jiao, J. Wu, H. PTENless means more. Dev Biol. 2004; 273(2): 175-84.
Chang, C. J. Freeman, D. J. Wu, H. PTEN regulates Mdm2 expression through the P1 promoter. J Biol Chem. 2004; 279(28): 29841-8.
Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.. The Journal of biological chemistry. . 2004; 279(23): 24794-802.
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004; 101(7): 2082-7.
Tsai, P. T. Lee, R. A. Wu, H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Blood. 2003; 102(12): 3947-53.
Anzelon AN, Wu H, Rickert RC Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.. Nature immunology. . 2003; 4(3): 287-94.
Osawa, M. Yamaguchi, T. Nakamura, Y. Kaneko, S. Onodera, M. Sawada, K. Jegalian, A.Wu, H. Nakauchi, H. Iwama, A. Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood. 2002; 100(8): 2769-77.
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.. Development (Cambridge, England) . 2002; 129(17): 4159-70.
Kertesz, N. Samson, J. Debacker, C. Wu, H. Labastie, M. C. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene. 2002; 294(1-2): 13-24.
Jegalian, A. G. Acurio, A. Dranoff, G. Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3. Blood. 2002; 99(7): 2603-5.
Jegalian, AG Wu, H Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.. The Journal of biological chemistry. . 2002; 277(3): 2345-52.
Hisakawa, H. Sugiyama, D. Nishijima, I. Xu, M. J. Wu, H. Nakao, K. Watanabe, S. Katsuki, M. Asano, S. Arai, K. Nakahata, T. Tsuji, K. Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. Blood. 2001; 98(13): 3618-25.
Groszer, M. Erickson, R. Scripture-Adams, D. D. Lesche, R. Trumpp, A. Zack, J. A. Kornblum, H. I. Liu, X. Wu, H. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. 2001; 294(5549): 2186-9.
Lee, R. Kertesz, N. Joseph, S. B. Jegalian, A. Wu, H. Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001; 98(5): 1408-15.
Neshat, M. S. Mellinghoff, I. K. Tran, C. Stiles, B. Thomas, G. Petersen, R. Frost, P. Gibbons, J. J. Wu, H. Sawyers, C. L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001; 98(18): 10314-9.
Dubey, P. Wu, H. Reiter, R. E. Witte, O. N. Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. Cancer Res. 2001; 61(8): 3256-61.
Makita, T. Hernandez-Hoyos, G. Chen, T. H. Wu, H. Rothenberg, E. V. Sucov, H. M. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev. 2001; 15(7): 889-901.
Mamillapalli, R. Gavrilova, N. Mihaylova, V. T. Tsvetkov, L. M. Wu, H. Zhang, H. Sun, H. PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol. 2001; 11(4): 263-7.
Satterthwaite, A. B. Willis, F. Kanchanastit, P. Fruman, D. Cantley, L. C. Helgason, C. D. Humphries, R. K. Lowell, C. A. Simon, M. Leitges, M. Tarakhovsky, A. Tedder, T. F. Lesche, R. Wu, H. Witte, O. N. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000; 97(12): 6687-92.
Liliental, J. Moon, S. Y. Lesche, R. Mamillapalli, R. Li, D. Zheng, Y. Sun, H. Wu, H. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000; 10(7): 401-4.
Ghaffari, S. Wu, H. Gerlach, M. Han, Y. Lodish, H. F. Daley, G. Q. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc Natl Acad Sci U S A. 1999; 96(23): 13186-90.
Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML Inactivation of erythropoietin leads to defects in cardiac morphogenesis.. Development (Cambridge, England) . 1999; 126(16): 3597-605.
Sun, H. Lesche, R. Li, D. M. Liliental, J. Zhang, H. Gao, J. Gavrilova, N. Mueller, B. Liu, X. Wu, H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A. 1999; 96(11): 6199-204.
Neubauer, H. Cumano, A. Muller, M. Wu, H. Huffstadt, U. Pfeffer, K. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998; 93(3): 397-409.
Constantinescu, S. N. Wu, H. Liu, X. Beyer, W. Fallon, A. Lodish, H. F. The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid. Blood. 1998; 91(4): 1163-72.
Klingmuller, U. Wu, H. Hsiao, J. G. Toker, A. Duckworth, B. C. Cantley, L. C. Lodish, H. F. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A. 1997; 94(7): 3016-21.
Wu, H. Klingmuller, U. Acurio, A. Hsiao, J. G. Lodish, H. F. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci U S A. 1997; 94(5): 1806-10.
Liu, X. Wu, H. Byrne, M. Krane, S. Jaenisch, R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997; 94(5): 1852-6.
Krane, S. M. Byrne, M. H. Lemaitre, V. Henriet, P. Jeffrey, J. J. Witter, J. P. Liu, X. Wu, H. Jaenisch, R. Eeckhout, Y. Different collagenase gene products have different roles in degradation of type I collagen. J Biol Chem. 1996; 271(45): 28509-15.
Wu, H. Liu, X. Jaenisch, R. Lodish, H. F. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995; 83(1): 59-67.
Wu, H. Klingmuller, U. Besmer, P. Lodish, H. F. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 1995; 377(6546): 242-6.
Wu, H. Liu, X. Jaenisch, R. Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A. 1994; 91(7): 2819-23.
Barker DD, Wu H, Hartung S, Breindl M, Jaenisch R Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.. Molecular and cellular biology. . 1991; 11(10): 5154-63.
Silverman, D. H. Wu, H. Karnovsky, M. L. Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide release. Biochem Biophys Res Commun. 1985; 131(3): 1160-7.
