![劉菲菲[南開大學醫學院副教授]](/img/2/dd8/nBnauM3X2UDO2gjMyIjM2kTO0UTMyITNykTO0EDMwAjMwUzLyIzL1YzLt92YucmbvRWdo5Cd0FmLzE2LvoDc0RHa.jpg "劉菲菲[南開大學醫學院副教授]")
人物經歷
教育經歷
2008 – 2011 博士後研究員，美國哈佛大學醫學院, MGH麻省總醫院2002 - 2007 免疫學博士, 美國杜克大學。
2002 – 2007 細胞分子生物學專業，美國杜克大學。
1995 – 2002 七年制臨床醫學本碩連讀，南開大學，醫學院。
工作經歷
2011.11 至今 南開大學 醫學院 副教授。
2008 – 2011 博士後研究員，哈佛大學醫學院，麻省總醫院，波士頓。
2004 – 2007 博士研究生,杜克大學醫學中心，免疫系，北卡羅來納州。
主講課程
主講醫學免疫學。
研究方向
研究領域為Ikaros基因在T淋巴細胞發育和急性淋巴細胞白血病的控制機制。 Ikaros基因編碼調控早期造血系和淋巴系的轉錄因子。 DNA結合區域缺陷的Ikaros小鼠缺乏T，B和自然殺傷細胞，並且缺乏早期淋巴系前體幹細胞。因此Ikaros調控全能造血幹細胞向淋巴系分化。研究在基因敲除小鼠中, 確定Ikaros基因敲除導致transitional 過渡T細胞的分化和增殖，在第三期中產生急性T淋巴細胞白血病並有Notch1高表達，並運用Chip-seq和基因晶片進行三期T淋巴細胞的表觀遺傳信息和基因轉錄表達。
1. T lymphocyte commitment and differentiation
2. role of chromatin binding protein in the regulation of gene expression and epigenetics
3. molecular mechanism of leukemic development
主要貢獻
Jiangwen Zhang, Audrey F Jackson, Taku Naito, Marei Dose, John Seavitt, Feifei Liu, Elizabeth J Heller, Mariko Kashiwagi, Toshimi Yoshida, Fotini Gounari, Howard T Petrie & Katia Georgopoulos. Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. Nature Immunology. 2011 Nov. 13;13(1):86-94 (impact factor 26; Fourth author) 2. Pablo Gómez-del Arco, Mariko Kashiwagi, Audrey Jackson, Taku Naito, Jiangwen Zhang, Feifei Liu, Barbara Kee, Marc Vooijs, Freddy Radtke, Juan Miguel Redondo and Katia Georgopoulos. Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis. Immunity. 2010 Nov; Vol. 33(5) p. 685 – 698. (impact factor 24.2; Fourth author) 3. Marco Davila*, Feifei Liu*, Lindsay G. Cowell, Anne E. Lieberman, Emily Heikamp, Anjali Patel, Garnett Kelsoe. Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro-B cells. Journal of Experimental Medicine. 2007 Dec 24; Vol. 204, p3195-3208. (* co-first author) (sci impact factor 15.61) 4. Feifei Liu, Ying Hu, Wei Ge, Robert Chunhua Zhao. Biological characteristics and multiple differentiation pathways of human embryonic stem cells. Shanxi Medical Journal. 2002, Vol. 31, p524-527.
科研項目
項目負責人：國家自然科學基金青年基金：B細胞骨髓免疫耐受機制－抗原非依賴性IgH和Igkappa 的V(D)J基因重排（23萬，2013-2015）。
南開大學校內基金特別資助類： (50萬，2012－2014)。
1.Jiangwen Zhang, Audrey F Jackson, Taku Naito, Marei Dose, John Seavitt, Feifei Liu, Elizabeth J Heller, Mariko Kashiwagi, Toshimi Yoshida, Fotini Gounari, Howard T Petrie & Katia Georgopoulos. Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. Nature Immunology. 2011 Nov. 13;13(1):86-94 (impact factor 26; Fourth author) 2. Pablo Gómez-del Arco, Mariko Kashiwagi, Audrey Jackson, Taku Naito, Jiangwen Zhang, Feifei Liu, Barbara Kee, Marc Vooijs, Freddy Radtke, Juan Miguel Redondo and Katia Georgopoulos. Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis. Immunity. 2010 Nov; Vol. 33(5) p. 685 – 698. (impact factor 24.2; Fourth author) 3. Marco Davila*, Feifei Liu*, Lindsay G. Cowell, Anne E. Lieberman, Emily Heikamp, Anjali Patel, Garnett Kelsoe. Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro-B cells. Journal of Experimental Medicine. 2007 Dec 24; Vol. 204, p3195-3208. (* co-first author) (sci impact factor 15.61) 4. Feifei Liu, Ying Hu, Wei Ge, Robert Chunhua Zhao. Biological characteristics and multiple differentiation pathways of human embryonic stem cells. Shanxi Medical Journal. 2002, Vol. 31, p524-527.
2.項目負責人：國家自然科學基金青年基金：B細胞骨髓免疫耐受機制－抗原非依賴性IgH和Igkappa 的V(D)J基因重排（23萬，2013-2015）。
3.南開大學校內基金特別資助類： (50萬，2012－2014)。
獲獎記錄
2006 - 2007 Duke Conference Travel Fellowship, Duke University
2006 Bernard Amos Research Award
2006 Certificate for professionalism and academic excellence
The Graduate School, Duke University
專業協會
American Association of Immunologists (AAI)
American Association for the Advancement of Science (AAAS)
Member of the Leukemia & Lymphoma Society
