劉艷[廣東工業大學副教授]

劉艷(Yan LIU),女,博士。2013 年“青年百人計畫”引進到廣東工業大學輕工化工學院任職,副教授,碩士生導師。

工作經歷

2013/01–至今,廣東工業大學“青年百人計畫”,輕工化工學院,副教授,碩士生導師

2013.03–2013.05, 法國CNRS-LCC,訪問學者,導師:Bernard Meunier教授

2010.01–2013.02, 日本京都大學,博士後,導師:Keiji Maruoka教授

2007.07 –2009.12, 香港浸會大學,博士後,導師:姜志宏教授

教育經歷

2010.01–2013.02, 日本京都大學,博士後,導師:Keiji Maruoka教授

2007.07 –2009.12, 香港浸會大學,博士後,導師:姜志宏教授

2004.09–2007.07, 中山大學,博士,導師:許遵樂教授

2002.09–2004.07, 中山大學,碩士,導師:汪波教授

研究方向

從事藥物化學、有機合成、有機催化方法學、計算機輔助設計等交叉領域的研究並積累了豐富的經驗,特別是基於靶標的新藥設計合成方面有較好的研究經歷。博士階段(中山大學)從事有機合成、藥物化學研究,畢業後先後於香港浸會大學和日本京都大學進行中藥化學、不對稱催化等方面的博士後研究,受到良好的科研教育,部分研究成果已經在國際刊物如:J. Phys. Chem. B, Org. Lett., ChemMedChem, ChemCatChem, Bioorg. Med. Chem, Molecules, Invest NewDrugs, Anticancer Drug等權威雜誌發表,發表科技論文及獲得授權專利20餘篇。將從事以下方面研究:1、新型抗老年痴呆藥物研究;2、不對稱催化、有機方法學;3、基於靶點的新藥設計及藥理活性和作用模式研究。

代表論文

1. Liu, Yan, Ma, L., Chen. W.-H., Park, S., Ke, Z., Wang, B. Binding Mechanism and Synergetic Effects of Xanthone Derivatives as Noncompetitive α-Glucosidase Inhibitors: A Theoretical and Experimental Study. J. Phys. Chem. B 2013, 117, 13464−13471.

2. Liu, Yan, Shirakawa, S., Maruoka, K.* Phase-Transfer-Catalyzed Asymmetric Conjugate Cyanation of Alkylidenemalonates with KCN in the Presence of Brønsted Acid Additive. Org. Lett., 2013, 15, 1230−1233.

3. Liu, Yan, Usui, A., Shirakawa, S., Maruoka, K.* Catalytic Asymmetric Synthesis of 3-Substituted Proline Derivatives via Phase-Transfer-Catalyzed Conjugate Addition. Asian. J. Org. Chem. 2012, 1, 180–186.

4. Liu, Yan, Ke, Z., Liu, S., Chen, W.-H., Jiang, S.; Jiang, Z.-H.* An Amphilic Conjugate Approach toward the Design and Synthesis of Betulinic Acid-Polyphenol Conjugates as inhibitors of the HIV-1 gp41 Fusion Core Formation. ChemMedChem, 2011, 6, 1654-1664.

5. Liu, Yan, Shirakawa, S., Usui, A., Maruoka, K.* Efficient Asymmetric Synthesis of Bicyclic Amino Acid as a Core Structure of Telaprevir. ChemCatChem, 2012, 4, 980-982.

6. Su, Q., Liu, Yan, Cai, Y.-C., Sun, Y.-L., Wang. B.,* Xian,L.-J.* Anti-tumour effects of xanthone derivatives and the possible mechanisms of action, Invest. New Drugs, 2011, 29, 1230-1240.

7. Dong, H., Liu, Yan, Jiang Z.-H. et al. Molecule The in Vitro Structure-Related Anti-Cancer Activity of Ginsenosides and Their Derivatives. MOLECULES 2011, 16, 10619-10630.

8. Liu, Yan, Ke, Z., Cui, J., Chen, W.-H., Ma, L., Wang, B.* Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as alpha-glucosidase inhibitors. Bioorg. Med. Chem. 2008, 16, 7185-7192.

9. Liu, Yan, Ma, L., Chen, W.-H., Wang, B.*, Xu, Z. Synthesis of xanthone derivatives with extended pi-systems as alpha-glucosidase inhibitors: Insight into the probable binding mode. Bioorg. Med. Chem. 2007, 15, 2810-2814.

10. Liu, Yan, Zou, L., Ma, L., Chen, W.-H., Wang, B.*, Xu, Z.L. Synthesis and pharmacological activities of xanthone derivatives as alpha-glucosidase inhibitors. Bioorg. Med. Chem. 2006, 14, 5683-5690.

11. Shan, H., Liu, Yan, Wang, Bo., Xian, L.-J. et al. Cytotoxicity of cantharidin analogues targeting protein phosphatase 2A;Anti-Cancer Drug 2006, 17, 905-911.

發明專利

1. 1,2,3,7--四氫茶黃素-3,3’-雙沒食子酸酯及其製備方法和套用,2011.11,CN200910036806.5

2. 1,2,3,7-四氫茶黃素及其製備方法和套用,2011.9,CN200910036815.4

3. 1,2,3,7-四氫茶黃素-3-沒食子酸酯及其製備方法和套用,2008.6,CN200910036807.X

4. 斑蝥素衍生物在製備抗腫瘤藥物中的套用,2008.6,CN200510034017.X

5. 斑蝥素衍生物及其製備方法,2007.3,CN200510034018.4

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