學習經歷
1982－1986年 北京大學生物系生物化學專業，學士
1986－1989年 北京大學生物系生物化學專業，碩士
1989－1995年 美國Rutgers新澤西州立大學微生物學和分子遺傳學系，博士
工作經歷
1995－2000年 美國加州大學Santa Barbara分校分子、細胞與發育生物學系，博士後
2000－2003年 美國加州AlleCure/Mannkind免疫生物技術公司研發部，Senior Scientist
2003.7－2015.8 中科院上海生命科學研究院營養科學研究所，研究組長，研究員，博士生導師，“百人計畫”擇優支持
2015.9－武漢大學生命科學學院，教授，博士生導師
社會兼職
2008－2015年中科院營養與代謝重點實驗室副主任
2008－2015年中科院上海生命科學研究院學術委員會委員
2011－2015年中科院上海營養科學研究所副所長
2012年－至今 J. Biol. Chem., Editorial Board Member
2013年－至今 中國老年保健醫學研究會老年健康與轉化醫學分會，常務委員
研究領域
1） 細胞應激與糖脂代謝紊亂的分子機制
2） 內質網應激與免疫炎性疾病的分子基礎
致力於研究糖脂代謝調控的生理學機制和慢性炎性疾病的病理學基礎。利用動物模型，在生理學水平上探索營養失衡、內質網應激與糖脂代謝紊亂的機制關聯，深入了解免疫炎性疾病發生髮展的分子病理學基礎，為肥胖、2型糖尿病及脂肪肝等慢性疾病的防治探尋新的干預靶標。
課題項目
2012-2016國家重大科學研究973計畫：“營養失衡導致脂代謝紊亂疾病的病理生理學機制與早期干預研究”，首席科學家
2013-2017國家自然科學基金重點項目：“細胞內質網應激信號通路在代謝適應性調節中的生理學功能和機制”，負責人
2015-2019國家自然科學基金重點國際合作項目：“內質網應激與線粒體損傷在慢性肝病發生髮展中的作用機制”，負責人
代表性論文:
1)Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L, Liu Y*. (2015) Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses. J Hepatol. 62:590-98.
2)Zhang HS, Chen Y, Fan L, Xi QL, Wu GH, Li XX, Yuan TL, He SQ, Yu Y, Shao ML, Liu Y, Bai CG, Ling ZQ, Li M,Liu Y*, Fang J. (2015) The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis.J Biol Chem.290:15327-36.
3)Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z,Liu Y*, Jia WP*. (2014) Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis.J Biol Chem.289:29751-65. (Chosen as one of theBest JBC Papers of the Year)
4)Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X*,Liu Y*. (2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells.Cell Res. 24:1137-40.
5)Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L,LiuY*. (2014) Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Nat Commun. 5:3528.
6)Zhang Q, Liu B, Cheng Y, Meng Q, Xia T, Jiang L, Chen S,Liu Y*, Guo F*. (2014) Leptin signaling is required for leucine deprivation-enhanced energy expenditure. J Biol Chem.289:1779-87.
7)Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z,LiuY*, Zhao L*. (2013) Structural modulation of gut microbiota in life-long calorie-restricted mice.Nat Commun. 4:2163.
8)Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L,Liu Y*. (2012) A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors.J Biol Chem. 287(45):37973-85.
9)Yu Y, Sun Y, He S, Yan C, Rui L, Li W,Liu Y*. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster.Mol Cell Biol. 32:3610-23.
10)Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H,Liu Y* and Han JD*. (2012) Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions.Proc. Natl. Acad.Sci. U.S.A. Plus 109:E1201-9.
11)Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W andLiu Y*. (2011) PKA Phosphorylation Couples Hepatic IRE1a to Glucagon Signaling in Glucose Metabolism.Proc. Natl. Acad.Sci. U.S.A.108:15852-7.
12)Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W*,Liu Y*. (2010) Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.FASEB J.24:3720-32.
13)Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W,Liu Y*. (2010) Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice.J. Lipid Res.51:2516-26.
14)You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C* andLiu Y*. (2010) Tyr signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance.Mol. Cell. Biol.30:1650-9.
(Highlighted byEditor’s Choice,Science 139, 141, 2010 andScience Signaling 3, ec95, 2010)
15)Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y,Liu Y* and Rui L*. (2010) SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals.Cell Metab. 11:427-37.
16)Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W*,Liu Y*. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1α activation in pancreatic β-cells.Sci. Signal. 3, ra7.
(Highlighted inPerspective,Science Signaling 3, pe7, 2010)
17)Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W andLiu Y*.(2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.Hepatology49:1166-75.
18)Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C*,Liu Y*.(2008) Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.Proc. Natl. Acad.Sci. U.S.A.105: 18619-24. (Highlighted byNature China, 2008)
19)Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu F, Franco OH, Wang J, Li H, Liu Y*, Lin X*. (2007) Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J. Clin. Endocr. Metab.92:4827-34.
20) Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W,Liu Y*. (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells.J. Biol. Chem.281:33386-94.
