北京大學 終身講席教授、生命科學學院院長
北京生命科學研究所 資深研究員,學術副所長
Yi Rao, Ph.D.
Endowed Professor, Peking University
Dean, School of Life Sciences, Peking University
Investigator and Associate Director for Academic Affairs, National Institute of Biological Sciences (nibs), Beijing
Phone:010-8072-6672;8072-6688/368
Fax:010-8072-6673
E-mail:yrao@pku.edu.cn
研究概述:
本實驗室主要興趣在於:
1 神經發育的分子機理。
2 社會行為的分子生物學。
極性是細胞的一個基本性質。神經細胞有軸突和樹突,它們起不同的作用,樹突一般接受信號,而軸突通常傳送信號。如果沒有神經細胞的極性,神經系統的信息傳遞就會紊亂。實驗室在分子和亞細胞水平研究神經細胞極性發生的機理,除了可以幫助基礎理解以外,如果能知道怎樣形成軸突,也許可以提示如何在損傷後幫助促進神經纖維再生。目前實驗室主要研究調節神經細胞極性的信號轉導通路。
我們通過遺傳學途徑研究社會行為的分子機理。主要用果蠅和鼠研究同性間爭鬥、異性間求偶、和親子間撫育等行為。用可以定量的實驗模型,觀察行為的模式和變化。用遺傳學方法,控制特定腦區神經活動,以確立腦中參與特定行為的區域。通過分析基因突變後的行為表型,找到調控行為的分子。希望理解一個行為執行需要的分子和神經通路,了解行為如何發育,行為發育的分子和細胞機理。
Research Description:
We have two major lines of research: the molecular studies of neuronal polarity in mammals and genetic analysis of social behavior.
Polarity is a basic cellular feature. Each neuron usually has an axon and multiple dendrites, each of which play different roles: axons usually send signals and dendrites receive them. Abnormalities in neuronal polarity disrupt informational flow in the nervous system. Molecular and subcellular studies of neuronal polarity will contribute to our understanding of the basic mechanisms and may also suggest new approaches to facilitate recovery after neural injuries. Our lab currently focuses on signal transduction pathways involved in establishing and maintaining neuronal polarity.
We take genetic approaches to study social behavior in drosophila and mice. Our focus is on aggression among members of the same sex, courtship between members of the opposite sex and parental behavior between members of different generations. We use quantifiable behavioral paradigms to observe behaviors and their changes. Genetic manipulations allow us to control neuronal activities in defined regions, which make it possible to determine brain regions involved in a specific behavior. Analysis of behavioral phenotype of genetic mutations allows us to discover molecules underlying behaviors. We hope to understand the molecules and neural pathways involved in behavior and the molecular and cellular mechanisms required for the development of behaviors.
http://raolab.nibs.ac.cn/
代表性原始論文
Selected Original Papers:
1.Jiang H., Guo W., Liang X.H., and Rao Y.. Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3b and its upstream regulators. Cell. 2005; 120: 123-135.
2. Liu G., Beggs H., Jürgensen C., Park H.T., Tang H., Gorski J., Jones K.R., Reichardt L.F., Wu J.Y., and Rao Y.. Netrin requires the focal adhesion kinase and the Src family kinases to induce axon outgrowth and to attract axons. Nature Neurosci. 2004; 7: 1222.
3. Ward M.E., Wu J.Y. and Rao Y.. Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells. Proc Natl Acad Sci USA. 2004; 101:970-974.
4. Zhu Y., Yu T., Zhang X-C, Nagasawa T., Wu J.Y., and Rao Y.. Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nat Neurosci. 2002; 5: 719-720.
5. Wong K., Ren X-R, Huang Y-Z, Xie Y., Liu G., Saito H., Tang H., Wen L., Brady-Kalnay S.M., Mei L., Wu J.Y., Xiong W-C, and Rao Y.. Signal Transduction in Neuronal Migration: Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway. Cell. 2001; 107: 209-221.
6. Wu J.Y., Feng L., Park H-T, Havlioglu N., Wen L., Tang H., Bacon K.B., Jiang Z., Zhang X-C, and Rao Y.. Slit, a molecule known to guide axon projection and neuronal migration, inhibits leukocyte chemotaxis induced by chemotactic factors. Nature. 2001; 410: 948-952.
7.Wu W., Wong K., Chen J.H., Jiang Z.H., Dupuis S., Wu J.Y., and Rao Y.. Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature. 1999; 400: 331-336.
8.Li H.S., Chen J.H., Wu W., Fagaly T., Yuan W.L., Zhou L., Dupuis S., Jiang Z., Nash W., Gick C., Ornitz D., Wu J.Y., and Rao Y.. Vertebrate Slit, a secreted ligand for the transmembrane protein Roundabout, is a repellent for olfactory bulb axons. Cell. 1999; 96: 807-818.
9.Li H.S., Tierney C., Wen L., Wu J.Y. and Rao Y.. A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal mesoderm. Development. 1997; 124: 603-615.
10.Rao Y., Jan L.Y., and Jan Y.N.. Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature. 1990; 345: 163-167.
綜述
Reviews
Rao Y and Wu JY (2001). A neuronal migratory pathway and the evolution of a bigger brain. Nature Neurosci. 4:860-862.
Rao Y, Wong K, Ward M, Jurgensen C, and Wu JY (2002). Neuronal migration and molecular conservation with leukocyte chemotaxis. Genes Dev 16:2973-2984.
Guan KL and Rao Y (2003). Signal transduction mechanisms mediating neuronal responses to guidance cues. Nature Rev Neurosci 4:941-956.
Ward ME and Rao Y (2004). Investigations of neuronal migration in the central nervous system. In Guan, J.-L. (ed) Cell Migration: Developmental Methods and Protocols. Humana Press, Totowa, NJ.
Liu G and Rao Y (2004). Neuronal migration in the central nervous system. The Cognitive Neurosciences, 3rd edition, Gazzaniga MS, editor in chief, MIT press.
Jiang H, and Rao Y (2005). Axon formation: fate versus growth. Nature Neurosci 8:544
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