何山[寧波大學海洋學院副教授]

寧波大學海洋學院副教授，博士。長期從事海洋微生物天然產物的發現、代謝調控與高效製備等方面的研究。研究興趣包括：（1）海洋“未培養”微生物資源挖掘與新天然產物發現。（2）海洋微生物次級代謝調控新方法及其機理研究。（3）基於高速逆流色譜技術的海洋天然產物高效製備新方法研究。（4）海綿共附生藍細菌活性物質及其化學生態學研究。（5）海洋微藻毒素的發現、製備與快速檢測方法研究。擔任期刊《Applied Microbiology and Biotechnology》和《Journal of Separation Science》特邀審稿人。

教育背景

2000.09- 2004.06 浙江大學 化學系 本科
2004.09—2009.06 浙江大學 化學系 博士
2009.07—2011.05 美國華盛頓州立大學 生物化學研究所 博士後

代表論文

(1) Lijian Ding, Shan He*, Xiaojun Yan. Efficient preparation of pseudoalteromone A from marine Pseudoalteromonas rubra QD1-2 by combination of response surface methodology and high-speed counter-current chromatography: a comparison with high-performance liquid chromatography. Applied Microbiology and Biotechnology 98 (2014) 4369-4377.
(2) Tingting Wang, Shan He*, Xiaojun Yan, Peng Zhu. Macrolactins: Antitumor Antibiotics as Marine Drug Lead. Current Organic Chemistry 18 (2014) 804-811.
(3) Binbin Gu, Shan He*, Xiaojun Yan, Lixin Zhang. Tentative biosynthetic pathways of some microbial diketopiperazines. Applied Microbiology and Biotechnology 97 (2013) 8439–8453.
(4) Binbin Gu, Yaru Xu, Shan He*. A New Resveratrol Trimer from the Roots and Stems of Vitis wenchowensis. Molecules 18 (2013) 7486-7491.
(5) Shan He*, Xiaojun Yan. From Resveratrol to Its Derivatives: New Sources of Natural Antioxidant. Current Medicinal Chemistry 20 (2013) 1005-1017.
(6) Shan He, Hongqiang Wang, Peng Zhu, Juanjuan Chen, Rui Yang, Xiaojun Yan. Preparative Isolation and Purification of Macrolactin Antibiotics from Marine Bacterium Bacillus amyloliquefaciens using High-Speed Counter-Current Chromatography in Stepwise Elution Mode. Journal of Chromatography A1272 (2013) 15-19.
(7) Shan He, Hongqiang Wang, Bin Wu, Hui Zhou, Peng Zhu, Rui Yang, Xiaojun Yan. Response Surface Methodology Optimization of Fermentation Conditions for Rapid and Efficient Accumulation of Macrolactin A by Marine Bacillus amyloliquefaciens ESB-2. Molecules 18 (2013) 408-417.
(8) Shan He, Jiehong Yang, Bin Wu, Yuanjiang Pan, Haitong Wan, Yu Wang, Yueguang Du, Shudong Wang. Neuroprotective effect of parthenocissin A, a novel antioxidant and free radical scavenger, in focal cerebral ischemia of rats. Phytotherapy Research 24 (2010) S63- S70.
(9) Shan He, Liyan Jiang, Bin Wu, Chang Li, Yuanjiang Pan. Chunganenol: An Unusual Antioxidative Resveratrol Hexamer from Vitis chunganensis. Journal of Organic Chemistry 74 (2009) 7966-7969.
(10) Shan He, Liyan Jiang, Bin Wu, Yuanjiang Pan, Cuirong Sun. Pallidol, a resveratrol dimer from red wine, is a selective singlet oxygen quencher. Biochemical and Biophysical Research Communications 379 (2009) 283–287.
(11) Shan He, Yanbin Lu, Liyan Jiang, Bin Wu, Feiying Zhang, Yuanjiang Pan. Preparative isolation and purification of antioxidative stilbene oligomers from Vitis chunganensis using high-speed counter-current chromatography in stepwise elution mode. Journal of Separation Science 32 (2009) 2339-2345.
(12) Shan He, Liyan Jiang, Bin Wu, Jing Zhou, Yuanjiang Pan. Two Novel Antioxidative Stilbene Tetramers from Parthenocissus laetevirens. Helvetica Chimica Acta 92 (2009) 1260-1267.
(13) Shan He, Bin Wu, Yuanjiang Pan, Liyan Jiang. Stilbene Oligomers from Parthenocissus laetevirens: Isolation, Biomimetic Synthesis, Absolute Configuration and Implication of Antioxidative Defense System in the Plant. Journal of Organic Chemistry 73 (2008) 5233-5241.
(14) Shan He, Cuirong Sun, Yuanjiang Pan. Red Wine Polyphenols for Cancer Prevention. International Journal of Molecular Sciences 9 (2008) 842- 853.
(15) Shan He, Yanbin Lu, Bin Wu, Yuanjiang Pan. Isolation and purification of antioxidative isomeric polyphenols from the roots of Parthenocissus laetevirens by counter-current chromatography. Journal of Chromatography A 1151 (2007) 175- 179.

榮譽獎項

獲2012－2013年度寧波市優秀博士後榮譽稱號。

科研項目

1、 國家自然科學基金(41306134)主持;
2、 國家科技部星火計畫(2013GA701024)主持;
3、 浙江省自然科學基金(LQ13B020004)主持;
4、 浙江省錢江人才計畫(2012R10068)主持;
5、 教育部博士點基金(20133305120007)主持；
6、 浙江省重點科技創新團隊子課題(2012R10029-2)主持;
7、 寧波市自然科學基金(2013A610278)主持；
8、 國家科技部海洋863計畫(2013AA092902)參與。