科學領域
描述(中英文介紹)
基於生物晶片與高通量測序數據，運用相關生物統計學軟體並結合後續的分子生物學實驗，系統化研究與胚胎髮育和幹細胞相關的生物學過程及其分子生物學機理。
Weaimedtosystematicallystudythebiologicalprocessaswellasmolecularbiologymechanismsduringthedevelopmentofembryosorstemcellsbasedontheanalysisofdataofbiochipandnextgenerationsequencing(NGS)byusingassociatedstatisticssoftwareandsubsequentmolecularbiologyexperiments.
隸屬於安徽大學幹細胞與轉化醫學研究中心
研究方向
統計基因組學與生物信息學
1.晶片數據的整合分析及其在胚胎髮育和蛋白質功能研究中的套用；
2.基於高通量測序數據的多組學研究；
3.基於晶片和高通量測序技術的幹細胞資料庫的構建。
發表文章
[1]JiaofangShao*,KanHe*,HaoWang*,WingSzeHo,XiaoliangRen,XiaomengAn,MingKinWong,BinYan,JohnStamatoyannopoulosandZhongyingZhao：CollaborativeRegulationofDevelopmentbutIndependentControlinMetabolismofEpidermisbyNHR-25andELT-3inC.elegans.JournalofBiologicalChemistry2013,288(46):33411-33426.(*Co-firstauthor,doi:10.1074/jbc.M113.487975,IF=5.143)
[2]KanHe,XiaoliangRen,JiaofangShao,DaogangGuan,ZhongyingZhao:DynamicregulationofgeneticpathwaysandtargetsduringaginginC.elegans.BMCGenomics2013(underreview,IF=4.397)
[3]HeK,WangQ,WangZ,PanY:AssociationstudybetweengenepolymorphismsinPPARsignalingpathwayandporcinemeatqualitytraits.MammalianGenome2013,24(7-8):322-331.(DOI:10.1007/s00335-013-9460-4,IF=2.419)
[4]HeK,WangZ,WangQ,PanY:Ameta-analysisstudyofgeneexpressiondatasetsinmouseliverunderPPARαknockout.GeneticsResearch2013,95(2-3):78-88.(DOI:10.1017/S0016672313000098,IF=2)
[5]HeK,ZLChen,YFMaandYCPan:IdentificationofhighcopperresponsivetargetpathwaysinAtp7bknockoutmouseliverbyGSEAonmicroarraydatasets.MammalianGenome2011,22(11-12):703-713.(DOI:10.1007/s00335-011-9359-x).(IF=2.419,citedby4articles).
[6]HeK,QSWang,YMYang,MHWang,YCPan:AComparativeStudyofMouseHepaticandIntestinalGeneExpressionProfilesunderPPARalphaKnockoutbyGeneSetEnrichmentAnalysis.PPARResearch2011,2011:629728.(IF=2.685,citedby6articles)
[7]HeK,FYang,MHWang,QSWang,YCPanandYFMa:IdentificationofpigreproductiveQTLgenesbasedongenesetenrichmentanalysisofmousemicroarraydataset.AfricanJournalofAgriculturalResearch2011,Vol.6(13),pp3196-3202.
[8]HeK,HBZhao,QSWang,YCPan:Acomparativegenomeanalysisofgeneexpressionrevealsdifferentregulatorymechanismsbetweenmouseandhumanembryopre-implantationdevelopment.ReproductiveBiologyandEndocrinology2010,8:41.(IF=2.144,citedby6articles)
[9]HeK,HBZhao,CYBai,QSWang,YCPan:Studyonregulatorymechanismofbovineearlyembryosdevelopmentbasedontheanalysisofgeneexpressiondata.YiChuan2010,32:726-731.
[10]ZhenWang,KanHe,QishanWang,YumeiYangandYuchunPan:Thepredictionoftheporcinepre-microRNAsingenome-widebasedonsupportvectormachine(SVM)andhomologysearching.BMCGenomics2012,13:729.(DOI:10.1186/1471-2164-13-729)(IF=4.397)
[11]XieXX,HeK,ZhangAL,etal.ComparativestudyofthepromotionofporcinefetalfibroblastproliferationbyoverexpressionoftwotranscriptionalvariantsofSIRT6.ChineseScienceBulletin2013,58(10):1174(DOI:10.1007/s11434-013-5706-5)(IF=1.319)
[12]YANGFan,WANGQiongPing,WANGMingHui,HEKan,PANYuChun:Associationsbetweengenepolymorphismsintwocrucialmetabolicpathwaysandgrowthtraitsinpigs.ChineseScienceBulletin2012,21(8):2733-2740.(IF=1.319)
[13]FanYang,Qiong-PingWang,KanHe,Ming-HuiWang,Yu-ChunPan:Associationbetweengenepolymorphismsofpropanoatemetabolismpathwayandmeatqualityaswellascarcasstraitsinpigs.YiChuan2012,34(7):872-878.
[14]ZhaoHB,QSWang,CYBai,KHeandYCPan:Across-studygenesetenrichmentanalysisidentifiescriticalpathwaysinendometriosis.ReproductiveBiologyandEndocrinology2009,7:94.(IF=2.144,citedby8articles)
[15]何侃，蔣越，王起山，俞沛初，潘玉春:基於晶片數據分析關於SREBP-lc調控脂肪代謝過程作用機理的研究.黑龍江畜牧獸醫（科技版）2010,7:1-4.
[16]何侃，趙洪波，潘玉春:子宮內膜異位症晶片的元分析研究.上海交通大學學報(農業科學版)2009,27(5):506-512.
