人工腎：原理、研究方法和進展

本書系統介紹了人工腎的起源、結構系統、工作原理及發展前景，詳細論述了多種人工腎數理模型和計算機模擬最佳化方法，並運用大量實例闡述了人工腎實驗研究方法。本書適合生物醫學工程、臨床醫學、血液透析、膜科學、傳熱傳質、化工領域的學生、教師以及研究人員閱讀，可作為相應課程的教學參考書及新型人工腎研發的實用手冊。 大學最重要的功能是向社會輸送人才.大學對於一個國家、民族乃至世界的重要性和貢獻度，很大程度上是通過畢業生在社會各領域所取得的成就來體現的. 中國科學技術大學建校只有短短的50年，之所以迅速成為享有較高國際聲譽的著名大學之一，主要就是因為她培養出了一大批德才兼備的優秀畢業生.他們志向高遠、基礎紮實、綜合素質高、創新能力強，在國內外科技、經濟、教育等領域做出了傑出的貢獻，為中國科大贏得了“科技英才的搖籃”的美譽.

目錄

Preface to the USTC Alumni's Seriesi
List of Symbols

SectionIIntroduction

Chapter 1 Human Kidneys
1.1 Function and Structure of Human Kidney
1.2 Kidney Failure
1.3 EndStage Renal Disease
1.4 Classification of Uremic Solutes

Chapter 2 Artificial Kidneys
2.1 Function and Structure of Artificial Kidney
2.2 Major Milestones of Artificial Kidney Development
2.3 Classification of Artificial Kidneys
2.4 Dialysis Membranes

Chapter 3 Transport in Artificial Kidneys
3.1 Diffusive Transport
3.2 Convective Transport
3.3 Coupled DiffusiveConvective Transport
References

Section II Numerical Analyses of Mass Transfer in Artificial Kidney

Chapter 4 Equivalent Annulus Model
4.1 Introduction
4.2 Modeling
4.3 Numerical Algorithm
4.4 Results and Discussion
4.5 Conclusions

Chapter 5 Porous Media Model
5.1 Introduction
5.2 Modeling and Algorithm
5.3 Results and Discussion
5.4 Conclusions

Chapter 6 Double Porous Media Model
6.1Introduction
6.2Theory
6.3Simulation Conditions
6.4Validation of Model
6.5Conclusions

Chapter 7 Determinations of Membrane Properties and Parameters
7.1 Introduction
7.2 Preparation of MiniModule Dialyzer
7.3 Selection of Solutes
7.4 Measurement of Hydraulic Permeability
7.5 Measurement of Diffusive Permeability
7.6 Measurement of Reflection Coefficient
7.7 Sample Assays
7.8 Calculation of Pore Size
7.9 Measurement of Darcy Permeability

Chapter 8 Kinetic Modeling in Hemodialysis
8.1 Introduction
8.2 Simulation of Continuous Renal Replacement Therapy(CRRT)
8.3 Intermittent Hemodialysis and Sustained LowEfficiency Dialysis
8.4 Results and Discussion
8.5 Conclusions
References

Section III In Vitro Experimental Study of Hemodialysis

Chapter 9 Introduction to General in Vitro Methodologies
9.1 Hemodialyzers and Hemofilters
9.2 Experimental Solutes
9.3 System Setup
9.4 Data Analysis

Chapter 10 Local Clearance of Hemodialyzer
10.1 Introduction
10.2 Materials and Methods
10.3 Experiment Setup
10.4 Data Collection and Analysis
10.5 Results and Discussion
10.6 Conclusions

Chapter 11 Effects of Dialyzer Reprocessing166
11.1 Introduction
11.2 Materials and Methods
11.3 Results and Discussion
11.4 Conclusions

Chapter 12 CytokineInduced Substance Back Transport in a High Flux Dialyzer
12.1 Introduction
12.2 Materials and Methods
12.3 Results
12.4 Discussion
12.5 Conclusions

Chapter 13 A Study of Dilution Mode and Ultrafiltration Rate in a High Volume Continuous Hemofiltration
13.1 Introduction
13.2 Materials and Methods
13.3 Assays
13.4 Results
13.5 Conclusions

Chapter 14 Determinants of Solute Clearance in Hemodiafiltration226
14.1 Introduction
14.2 Purpose
14.3 Materials and Methods
14.4 Assays
14.5 Results and Discussion
14.6 Conclusions
References

Section IV Novel MRI Approach for Flow Field Measurement

Chapter 15 Basic Principles of MRI
15.1 Magnetic Properties of Atomic Nuclei
15.2 Relaxation Processes
15.3 Standard Imaging Pulse Sequences
15.4 Magnetic Resonance FlowImaging Techniques

Chapter 16 Experimental Design and Image Analysis
16.1 Flow Phantom
16.2 2D PhaseContrast Study
16.3 2D FourierTransform Study
16.4 Results of 2D PhaseContrast Study
16.5 Results of 2D FourierTransform Study
References

Section V Advances in New Membrane Development

Chapter 17 Ceramic Membrane for Hemodialysis
17.1 Introduction
17.2 Principle of Aluminum Anodization
17.3 Materials and Methods
17.4 Results and Discussion
17.5 Conclusions

Chapter 18 Bio-functional Artificial Kidney
18.1 Current Status of Therapy for Renal Failure
18.2 Bioengineered Kidney
Reference