黨樂平

黨樂平,是一名天津大學化工學院工業結晶中心的副研究員。

研究方向:

工業結晶、醫藥結晶、綠色分離技術、化工安全

講授課程:

研究生課程——化工過程計算流體力學

本科生課程 ——食品工程概論

本科生課程——化工設計

學術成就:

2013年6月被評選為天津大學優秀畢業設計指導教師。

科研項目:

1、天津市青年基金(膜定向分子組裝共結晶技術及機理的研究)

2、教育部博士點基金(微流體環境下藥物多晶型形成的影響規律及機制)

3、國家自然委青年基金(微流體環境下界面作用對藥物多晶型形成的影響規律及機制)

4、浙江海正藥業(製藥和生物過程工藝改造和最佳化研究)

5、天津大學-海正藥業醫藥工藝工程聯合研究中心(中試研發實驗室設計、結晶和過程安全平台)

科研項目:

(1) 國家自然科學基金面上項目,項目名稱:“自凝膠和自釋放功能性納米載體腫瘤定位持續釋放siRNA與化療藥物”,項目編號:81371667,經費:70萬,期限:2014.01.01-2017.12.31

(2) 天津大學自主創新基金,項目名稱:“基於多元持續定位遞送系統提高納米藥物抗腫瘤功效的基礎科學問題”,項目編號:2013XJ-0011,經費:15萬,期限:2013.01-2015.12

(3) 863項目,項目名稱:“小核酸技術的前言研究-核酸新型遞送系統的製備和表征”,項目編號:2012AA022501,經費:39.33,期限:2012.11-2015.12

(4) 天津市自然科學基金項目,項目名稱:“注射用新型可生物降解原位凝膠材料的研究”,項目編號:08JCYBJC01800,經費10萬,期限:2008.4~2011.3。

(5) 負責多吉美的聚合物納米粒的製備及初步評價,合作方:上海中醫藥大學附屬普陀醫院,經費2萬,期限:2011.6.22-2011.8.30

(6) 載藥聚乳酸/聚乙二醇嵌段共聚物納米粒的製備,合作方:上海中醫藥大學附屬普陀醫院,經費2.5萬,期限:2011.9.15-2011.11.30

論著專利:

(1) 近3年期刊論文

第一或通訊作者論文12篇,SCI和EI收錄論文24篇, 其中二區以上重要期刊論文16篇。代表性論文如下:

[1] Liu C.J., Dang L.P.*, Tong Y., Wei H.Y., Influence of Polymorphs on the Transformation Water Activity of Theophylline, Industrial & Engineering Chemistry Research, 52 (42), 14979–14983,2013. (SCI二區)

[2] Liu C.J., Dang L.P.*, Bai W.S., Wei H.Y., A facile method for the prediction of anhydrate/hydrate transformation point, Ind. Eng. Chem. Res. , 52 (46), 16506–16512 , 2013. (SCI二區)

[3] Wang Z.Z., Li Y., Fang W.Z., Wang Q., Xiao H.Z., Dang L.P.*, Salting effect of the solubility and transformation kinetics of L-penylalanine anhydrate/monohydrate in aqueous solution. Ind. Eng. Chem. Res., 53 (2),521–529,2014. (SCI二區).

[4] Dang L.P.,Fang W.Z,Wang Q.,Wang Z.Z.*, Ionicliquid-induced structural and activitychanges in hen egg whitelysozyme. Applied Biochemistry and Biotechnology. 1,290-300,2013. (SCI二區).

[5] Liu C.J., Dang L.P.*, Bai W.S., Wang R., Wei H.Y., Solid–Liquid Equilibrium of Theophylline in Solvent Mixtures, Journal of chemical and engineering data, 59 (2), 263–268,2014. (SCI二區)

[6] Wang Z.Z., Dang L.P.*, Ionic liquids asselectors for controlling the crystallization nucleation of hen egg white lysozyme. Biotechnology and Bioprocess Engineering. 17,1025-1030,2012. (SCI三區).

[7] Feng Y.N., Dang L.P.*, Wang X.F., Wei H.Y., Analyzing Solution Complexation of Cocrystals by Mathematic Models and In-Situ ATR-FTIR Spectroscopy, Crystal Growth & Design, 12(4), 2068-2078,2012 (SCI二區)

[8] Wang X.F., Dang L.P.*, Black S., and Wei H.Y., How To Crystallize Anhydrous Racemic Tartaric Acid from an Ethanol–Water Solution, Ind. Eng. Chem. Res., 51, 6, 2789-2796, 2012(SCI二區)

[9] Wei Y.F., Zhang X.Y., Zhang J.Y., Dang L.P.*, Wei H.Y., Solid liquid equilibrium of some polycyclic aromatic hydrocarbons in wash oil, Fluid Phase Equilibria, 14, 23-29, 2012 (SCI二區)

[10] Wang X.F., Black S., Dang L.P.*, Wei H.Y., Olid–Liquid Equilibrium of d- and l-Tartaric Acid and Their Importance for Enantioseparation, J. Chem. Eng. Data, 57 ,6, 1779-1786, 2012(SCI二區)

[11] Zhang X.Y., Wang X.F., Hao L., Yang X.W., Dang L.P.*, Wei H.Y.,Solubility and metastable zone width of DL-tartaric acid in aqueous solution,Cryst. Res. & Tech. 47, 3, 1153-1163, 2012(SCI四區)

[12]Wang Z.Z., Wang Q., Dang L.P.*, Ionic Liquids as Selectors for Controlling the Crystallization Nucleation of Hen Egg White Lysozyme, Biotechnology and Bioprocess Engineering, 17, 1025-1030,2012(SCI三區)

[13] Wu H.L., Dang L.P., Wei H.Y.*, Solid–Liquid Phase Equilibrium of Nicotinamide in Different Pure Solvents: Measurements and Thermodynamic Modeling, Ind. Eng. Chem. Res., 53 (4), 1707–1711, 2014. (SCI二區)

[14] Wei Y., Zhang X.Y., Dang L.P., Wei H.Y.*,Solubility and pseudopolymorphic transitions in mixed solvent:Meropenem in methanol–water solution,Fluid Phase Equilibria, 349, 25-30, 2013.(SCI二區)

[15] Black S.*, Dang L.P., Liu C.J.,Wei H.Y., On the Measurement of Solubility, Org. Process Res. Dev., 17 (3), 486–492,2013 (SCI三區)

[16] Mo Y.X., Dang L.P., Wei H.Y.*, l-Glutamic Acid Polymorph Control Using Amino Acid Additives,Ind. Eng. Chem. Res., 50,18, 10385-10392,2011 (SCI二區)

(2)代表性會議論文

[1] Feng Y.N., Dang L.P.*, Wei H.Y., Indicator of Cocrystal Stoichiometry in Solution: Local Composition and Its Application on Selective Cocrystal Growth, 4th European Conference on Crystal Growth (ECCG4), Glasgow. UK, JUN 17-20,2012, 分會場報告

[2] Zhang X.Y., Yang X.W., Dang L.P.*, Wei H.Y., Determination of Operating Conditions for Controlled Batch Crystallization of Mitomycin C, 4th European Conference on Crystal Growth (ECCG4), Glasgow. UK, JUN 17-20,2012, 分會場報告

[3] Feng Y.N., Dang L.P.,Guo J.J., Wei H.Y.*,Theory and Application of Local Composition for Cocrystal Formation in Solution,Asian Crystallization Technology Symposum (ACTS-2012), 10, Korea, May 23-25, 2012,大會報告

[4] Feng Y.N., Dang L.P., Wei H.Y.*,Is Stoichiometric Diversity of Cocrystals Determined by Solution Microstructure? Molecular Dynamics Approach And a Case Study,18 International Symposium on Industrial Crystallization (ISIC18),92-93,Zurich.Switzerland, Sep13-16,2011, 分會場報告

[5] Wang X.F.,Wei Y., Dang L.P.*, Wei H.Y.,Dehydration Kinetics of Monohydrate Racemic Tartaric acid,Asian Crystallization Technology Symposum (ACTS-2012), 98, Korea, May 23-25, 2012,獲最佳poster獎

[6] Wang Z.Z, Dang L.P.*, The Effect of Ionic Liquids on Solubility and Morphology of Lysozyme, 18 International Symposium on Industrial Crystallization,184-185,Zurich.Switzerland, Sep13-16,2011

(3)專利

[1] 黨樂平,郭晶晶,馮寅年,衛宏遠,一種膜技術定向製備茶鹼-糖精共晶的方法,2012已授權,中國, 201210333271X

[2] 王占忠,黨樂平等,一種木糖醇/薄荷醇共結晶體及製備方法,中國,專利申請號201310484714.X(國家發明專利)

[3] 王占忠,黨樂平,肖華志等,基於ILs的誘導結晶效應調控溶菌酶生物活性的方法,中國,專利申請號:201210464023.9(國家發明專利)合作交流:

2009年4月. 接受英國阿斯利康製藥公司資助,到阿斯利康英國總部和曼徹斯特大學進行化工安全培訓及學術交流活動

2011年6月.新加坡.“International Conference on Materials for Advanced Technologies”

2011年9月.瑞士.“18th International Symposium on Industrial Crystallization”

2012年5月.韓國.” Asian Crystallization Technology Symposium 2012”

2012年6月.英國.” 4th European Conference on Crystal Growth (ECCG4)”

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