個人簡介
霍文哲，武漢大學基礎醫學院教授，博導、武漢大學動物實驗中心/ABSL-Ⅲ實驗室主任、國家“千人計畫”入選者、美國天普大學醫學院病理系 終身正教授，解剖及細胞生物學系正教授，學科專業：病原生物學系。
學習經歷
2004-2006：美國賓夕法尼亞大學醫學院醫學衛生碩士/ M.P.H., University of Pennsylvania School
of Medicine
1988-1991：美國賓夕法尼亞大學Wistar研究所分子病毒學博士後/ Postdoctoral Fellow, Molecular
Virology, Wistar Institute, University of Pennsylvania
1986-1988：美國賓夕法尼亞大學醫學院兒科系費城兒童醫院傳染及免疫科臨床醫學博士研究員M..D.
Fellow, Division of Infectious Diseases, Children's Hospital of Philadelphia, Department of Pediatrics,University of Pennsylvania School of Medicine
1983-1986：武漢大學人民醫院兒科住院醫生/ Resident, Wuhan University Renmin Hospital
1980-1983：武漢大學醫學院（湖北醫學院）兒科系醫學碩士/ M.S., Wuhan University School of Medicine (Hubei Medical College), China
1975-1979：武漢大學醫學院（湖北醫學院）醫學學士/ B.S., Wuhan University School of Medicine
(Hubei Medical College), China
工作經歷
2010.09-至今：武漢大學動物實驗中心/ABSL-III實驗室主任、教授/ Director and Professor, Center
for Animal Experiment of Wuhan University/ABSL-ⅢLaboratory of Wuhan University, China
2009-至今： 美國天普大學醫學院病理系終身正教授，博士生導師/ Professor(Tenure), Department of Pathology and Laboratory Medicine, Temple University, USA
2009-至今： 美國天普大學醫學院解剖及細胞生物系正教授/ Professor, Department of Anatomy and Molecular Biology, Temple University, USA
2002-2009： 美國賓夕法尼亞大學醫學院費城兒童醫院傳染及免疫科病毒室主任/ Director, Virology Laboratory, Division of Infectious Diseases, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
2005-2009： 美國賓夕法尼亞大學醫學院兒科系正教授/ Professor, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
1998-2005： 美國賓夕法尼亞大學醫學院兒科系副教授/ Associate Professor, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
1993-1998： 美國賓夕法尼亞大學醫學院兒科系助理教授/ Assistant Professor, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
1991-1993： 美國賓夕法尼亞大學醫學院兒科系科研研究員/ Research Associate, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
研究領域
1. 天然免疫與病毒感染機制的研究/ Innate Immunity and Viral Infections
2. 吸毒與HIV、HCV感染的研究/ Drugs of Abuse and HIV/HCV Infection
3. 天然免疫與中樞神經系統保護機制的研究/ Innate Immunity and CNS Protection
代表性論文
1. Wang X, Ye L, Zhou Y, Liu MQ, Zhou DJ, Ho WZ. Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytes. Am J Pathol. 2011;178:41-47.
2. Li J, Ye L, Cook DR, Wang X, Liu J, Kolson DL, Persidsky Y, Ho WZ. Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages.
J Neuroinflammation; 2011;8:15.
3. Li J, Hu S, Zhou L, Ye L, Wang X, Ho J, Ho WZ. Interferon lambda inhibits herpes simplex virus type I infection of human astrocytes and neurons. Glia. 2011;59:58-67.
4. Ye, L., Wang, X., Metzger, D.S., Riedel, E., Montaner, L.J., Ho, WZ.: Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-Infected heroin users. PLoS One5(3):e9602, 2010.
5. Zhou, Y., Wang, X., Liu, M., Hu, Q., Song, L., Ye, L., Zhou, D., Ho, WZ.:
A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages. Immunology. 2010 Jul 16. [Epub ahead of print]
6. Ye L, Wang X, Wang SH, Wang YJ, Song L, Hou W, Zhou L, LI H, Ho WZ. CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes.Hepatology 49:753-762. 2009.
7. Wang X, Ye L, Hou W, Zhou Y, Wang YJ, Metzger DS, Ho WZ.Intracellular restriction factors contribute to susceptibility of monocytes and macrophages to HIV-1 infection. Blood15; 113(3):671-674, 2009.
8.Hou W, Wang X, Ye L, Wang YJ, Zhou L, Yang ZQ, Riedel E, Ho WZ. Interferon lambda inhibits HIV-1 infection of macrophages. J Virol83:3834-3841, 2009.
9.Zhou L, He L, Wang X, Wang YJ, Zhou Y, Ye L, Hou W, Ho WZ. Expression, regulation and antiviral effect of IFN lambda in human neuronal cells. Neuroscience 17; 159(2):629-637, 2009.
10.Liang H,WangW, ChenH, SongL, YeL, Wang SH, Wang YJ, HoWZ. Methamphetamine enhances human immunodeficiency virus infection of human macrophage. Am J Pathol 172:1617-1624, 2008.
11.Wang X, Ye L, Zhou Y, Hou W, Metzger D, Ho WZ. Cellular microRNAs expression correlates with susceptibility of monocyte/macrophage to HIV-1 infection. Blood 113:671-674, 2008.
12.Li Y, Peng JS, Wang CQ, Zhang T, Wan Q, Ho WZ. morphine inhibits intrahepatic interferon alpha expression coupled with full cycle HCV replication. J Infect Dis196:719-730, 2007.
13. Lai, J-P., Ho, WZ., Kilpatrick, L.E., Wang, X., Kolchak, H.M., and Douglas, S.D.: Full-Length and Truncated Neurokinin-1 Receptor (NK-1R) Expression during Monocyte-Macrophage Differentiation. Proc. Natl. Acad. Sci. U. S. A. 103:7771-7776, 2006.
