陳春英[國家納米科學中心研究員]

陳春英，女，博士，國家納米科學中心研究員、博士生導師。研究領域：納米生物醫學。第11屆“中國青年女科學家獎”獲得者。

簡歷

陳春英，女，博士，國家納米科學中心研究員、博士生導師。1996年獲得華中理工大學生物醫學工程專業醫學博士學位。1996年11月至2006年5月，中國科學院高能物理研究所博士後並留所工作；2001年9月-2002年9月，瑞典卡羅林斯卡大學諾貝爾醫學生物化學研究所博士後。2006年6月加入國家納米科學中心。中國毒理學會及國際純粹與套用化學聯合會會員，2007年起擔任《生態毒理學報》雜誌編委。

目前主要研究方向

(1)高效低毒抗腫瘤納米藥物的研製及其作用機制的研究；

(2)典型納米材料與生物體相互作用的規律及其影響因素；

(3)核分析與同步輻射技術及組學技術用於生物體系納米顆粒暴露和效應標誌物的研究。

(4)易感人群環境污染物長期暴露的分子毒理學研究。

研究領域

納米生物醫學

獲獎及榮譽

2015年1月16日榮獲第11屆“中國青年女科學家獎”

代表論著

1.YingLiu,YuliangZhao,BaoyunSun*,ChunyingChen*.UnderstandingtheToxicityofCarbonNanotubes.AccountsofChemicalResearch,2012,DOI:10.1021/ar300028m.pdf
2.Seung-guKang,GuoqiangZhou,PingYang,YingLiu,BaoyunSun,TienHuynh,HuanMeng,LinaZhao,GengmeiXing,ChunyingChen*,YuliangZhao*,RuhongZhou*.MolecularmechanismofpancreatictumormetastasisinhibitionbyGd@C82(OH)22anditsimplicationfordenovodesignofnanomedicine.PNAS,2012,109(38):15431-15436.(HighlightedinthisissueofPNAS,15073–15528andEMSLhttp://www.emsl.pnnl.gov/news/viewArticle.jsp?articleId=416)pdf
3.LigengXu,YeLiu,ZhiyunChen,WeiLi,YingLiu,LimingWang,YongLiu,XiaochunWu*,YingluJi,YuliangZhao,LiyingMa,YimingShao,ChunyingChen*.Surface-EngineeredGoldNanorods:PromisingDNAVaccineAdjuvantforHIV-1Treatment.NanoLetters,2012,12(4):2003-2012pdf
4.ZhenjiangZhang,LimingWang,JingWang,XiumeiJiang,XiaohuiLi,ZhijianHu,YingluJi,XiaochunWu*,ChunyingChen*，MesoporousSilica-coatedGoldNanorodsasaLight-mediatedMultifunctionalTheranosticPlatformforCancerTreatment.AdvancedMaterials,2012,24:1418-1423.2012年第11期，coverimagepdf
5.SiyuanHan,YuexianLiu,XinNie,QingXu,FangJiao,WeiLi,YuliangZhao,YanWu*,ChunyingChen*.EfficientDeliveryofAntitumorDrugtotheNucleiofTumorCellsbyAmphiphilicBiodegradablePoly(L-AsparticAcid-co-LacticAcid)/DPPECo-PolymerNanoparticles.Small,2012,8(10):1596–1606.pdf
6.LiMeng,RuiChen,AihuaJiang,LimingWang,PengWang,Chen-zhongLi,RuBai,YuliangZhao,HermanAutrup,ChunyingChen*.ShortMultiwallCarbonNanotubesPromoteNeuronalDifferentiationofPC12CellsviaUp-RegulationoftheNeurotrophinSignalingPathway.Small,2012,DOI:10.1002/smll.201201388.pdf
7.XuefeiLu,YingLiu,XiangjunKong,PeterE.Lobie,ChunyingChen*,TaoZhu*.Nanotoxicity:thegrowingneedforstudyintheendocrinesystem.Small,2012,DOI:10.1002/smll.201201517.
8.QingXu,YuexianLiu,ShishuaiSu,WeiLi,ChunyingChen*,YanWu*.Anti-tumoractivityofpaclitaxelthroughdual-targetingcarrierofcyclicRGDandtransferrinconjugatedhyperbranchedcopolymernanoparticles.Biomaterials,2012,33(5):1627-1639.pdf
9.YangLi,YingLiu,YujianFu,TaotaoWei,LaurentLeGuyader,GeGao,Ru-ShiLiu*,YanzhongChang*,ChunyingChen*.ThetriggeringofapoptosisinmacrophagesbypristinegraphenethroughtheMAPKandTGF-betasignalingpathways.Biomaterials,2012,33(2):402-11.pdf
10.CuicuiGe,JiangfengDu,LinaZhao,LimingWang,YingLiu,DenghuaLi,YanlianYang,YuliangZhao,RuhongZhou*,YuliangZhao*,ZhifangChai,Chunying*.BindingofBloodProteinstoCarbonNanotubesReducesCytotoxicity.ProceedingsoftheNationalAcademyofSciences,2011,108(41):16968-16973.(HighlightbyNPGAsiaMaterialsandSmall).pdf
11.LimingWang,YingLiu,WeiLi,XiumeiJiang,YingluJi,XiaochunWu*,LigengXu,YangQiu,KaiZhao,TaotaoWei,YufengLi,YuliangZhao,ChunyingChen*.SelectiveTargetingofGoldNanorodsattheMitochondriaofCancerCells:ImplicationsforCancerTherapy.NanoLetters,2011,11(2),772-780.(HighlightedbyNanotimes).pdf
12.YingQu,WeiLi,YunlongZhou,XuefengLiu,LiliZhang,LimingWang,Yu-FengLi,AtsuoIida,ZhiyongTang*,YuliangZhao,ZhifangChai,ChunyingChen*.FullAssessmentofFateandPhysiologicalBehaviorofQuantumDotsUtilizingCaenorhabditiselegansasaModelOrganism.NanoLetters,2011,11(8),3174-3183.pdf
13.FengZhao,YingZhao,YingLiu,XuelingChang,ChunyingChen*,YuliangZhao*.CellularUptake,IntracellularTrafficking,andCytotoxicityofNanomaterials.Small,2011,7(10),1322-1337.pdf
14.YufengLi,ChunyingChen.FateandToxicityofMetallicandMetal-containingNanoparticlesforBiomedicalApplications.Small,2011,7(21):2965-2980.pdf
15.YanWu,FangJiao,SiyuanHan,TengfeiFan,YingLiu,WeiLi,LimingHu,YuliangZhao,ChunyingChen*,ConstructionofamphiphiliccopolymernanoparticlesbasedonhyperbranchedPoly(Amine-Ester)and1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamineasdrugcarriersforcancertherapy,Nanomedicine,2011,7(6):945-54.pdf
16.YuexianLiu,WeiLi,FangLao,YingLiu,LimingWang,RuBai,YuliangZhao,ChunyingChen*.IntracellularDynamicsofCationicandAnionicPolystyreneNanoparticleswithoutDirectInteractionwithMitoticSpindleandChromosomes.Biomaterials,2011,32(32),8291-8303.pdf
17.WeiLi,LinaZhao,TaotaoWei*,YuliangZhao*,ChunyingChen*.TheInhibitionofDeathReceptorMediatedApoptosisthroughLysosomeStabilizationFollowingInternalizationofCarboxyfullereneNanoparticles.Biomaterials,2011,32(16),4030-4041.pdf
18.WeiweiHe,YingLiu,JinshanYuan,Jun-JieYin*,XiaochunWu*,XiaonaHu,KeZhang,JianboLiu,ChunyingChen*,YingluJi,YutingGuo.Au@PtNanostructuresasOxidaseandPeroxidaseMimeticsforUseinImmunoassays.Biomaterials,2011,32(4),1139-1147.pdf
19.Yu-FengLi,LiangHu,BaiLi,XiaohanHuang,ErikHLarsen,YuxiGao,ZhifangChaiandChunyingChen*.FullQuantificationofSeleniumSpeciesbyRPandAF-ICP-qMSwithOn-lineIsotopeDilutioninSerumSamplesfromMercury-exposedPeopleSupplementedwithSelenium-enrichedYeast.J.Anal.Atom.Spectrom.,2011,26,224-229.pdf
20.YangQiu,YingLiu,LimingWang,LigengXu,RuBai,YingluJi,XiaochunWu*,YuliangZhao,YufengLi,ChunyingChen*.SurfaceChemistryandAspectRatioMediatedCellularUptakeofAuNanorods.Biomaterials,2010,31(30),7606-7619.pdf
21.FangJiao,YingLiu,YingQu,WeiLi,GuoqiangZhou,BaoyunSun,YufengLi,ChunyingChen*.StudiesonAntitumorandAnti-metastaticActivitiesofFullerenolinaMouseBreastCancerModel.Carbon,2010,48,2231-2243.pdf
22.LigengXu,YingLiu,RuBai,ChunyingChen*.ApplicationsandToxicologicalIssuesSurroundingNanotechnologyintheFoodIndustry.PureAppl.Chem.,2010,82(2),349-372(Invitedreview).pdf
23.LimingWang,Yu-FengLi,LiangjunZhou,YingLiu,LiMeng,KeZhang,XiaochunWu*,LiliZhang,BaiLi,ChunyingChen*.CharacterizationofGoldNanorodsinvivobyIntegratedAnalyticalTechniques:TheirUptake,Retention,andChemicalForms.AnalBioanalChem,2010,396,1105-1114.pdf
24.XingjieLiang*,HuanMeng,YingzeWang,HaiyongHe,JieMeng,JuanLu,PaulC.Wang,YuliangZhao*,XueyunGao,BaoyunSun,ChunyingChen,GenmeiXing,DingwuShen,LeeJia,YanWu,Jun-jieYin,MichaelM.Gottesmand.MetallofullereneNanoparticlesCircumventTumorResistancetoCisplatinbyReactivatingEndocytosis.ProceedingsoftheNationalAcademyofSciences,2010,107(16),7449-7454.pdf
25.Yu-FengLi,XiaoyanWang,LimingWang,BaiLi,YuxiGaoandChunyingChen*.DirectQuantitativeSpeciationofSeleniuminSelenium-enrichedYeastandYeast-basedProductsbyX-rayAbsorptionSpectroscopy.J.Anal.At.Spectrom.,2010,25,426-430.pdf
26.FangLao,LongChen,WeiLi,CuicuiGe,YingQu,QuanmeiSun,YuliangZhao,DongHan*,ChunyingChen*.FullereneNanoparticlesSelectivelyEnterOxidation-damagedCerebralMicrovesselEndothelialCellsandInhibitJNK-RelatedApoptosis.ACSNano,2009,3(11),3358-3368.pdf
27.YingLiu,FangJiao,YangQiu,WeiLi,FangLao,GuoqiangZhou,BaoyunSun,GenmeiXing,JinquanDong,YuliangZhao*,ZhifangChai,ChunyingChen*.TheEffectofGd@C82(OH)22NanoparticlesontheReleaseofTh1/Th2CytokinesandInductionofTNF-alphaMediatedCellularImmunity.Biomaterials,2009,30,3934-3945.pdf
28.JunjieYin,FangLao,PeterFu,WayneG.Wamer,YuliangZhao*,PaulC.Wang,YangQiu,BaoyunSun,GengmeiXing,JinquanDong,XingjieLiang*,ChunyingChen*.Thescavengingofreactiveoxygenspeciesandthepotentialforcellprotectionbyfunctionalizedfullerenematerials.Biomaterials,2009,30,611-621.pdf

承擔科研項目

科技部973項目、中科院知識創新工程項目、歐盟FP7合作項目、丹麥國際合作項目、國際原子能機構合作項目等。