關鋒[江南大學生物工程學院教授]

關鋒，男，江南大學生物工程學院 教授

人物經歷

學習經歷：

1997.9-2001.7 學士 西北大學生命科學院 專業：生物化學。

2001.9-2007.1 博士 中國農業大學生物學院 專業：微生物學。

研究經歷：

2007.4-2010.8 博士後 美國西北太平洋研究所；華盛頓大學（西雅圖）病理學系。

2010.8-2011.8 博士後研究員 美國西北太平洋研究所；華盛頓大學（西雅圖）病理學系。

2011.9- 江南大學生物工程學院 教授。

研究方向

1. 糖脂在細胞癌變過程(表皮細胞-間質細胞轉變(EMT))中的調節作用。

2. 糖基轉移酶在乳腺癌細胞中的表達調控機制。

3. 轉錄調節因子TWSIT, Snail等對糖基轉移酶以及對應糖脂分子表達的調控研究。

主要貢獻

1. Feng Guan, Kazuko Handa, Sen-itiroh Hakomori. Regulation of epidermal growth

factor receptor through interaction of ganglioside GM3 with GlcNAc of N-linked glycan of

the receptor: Demonstration in ldlD cells. 2011, DOI: 10.1007/9.

Neurochemical Research. (IF=2.72)

2. Feng Guan, Lana Schaffer, Kazuko Handa, Sen-itiroh Hakomori. Functional Role of

Gangliotetraosylceramide in Epithelial-to-Mesenchymal Transition Process Induced by

Hypoxia and by TGFβ. The FASEB Journal 2010, 24 (12) 4889-4903. (IF=7.049)

3. Feng Guan, Kazuko Handa and Sen-itiroh Hakomori. Specific gly cosphingolipids

mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines.

Proceedings of the National Academy of Sciences. 2009, 106 (18) 7461-7466. (IF=9.38)

4. Feng Guan, Kazuko Handa and Sen-itiroh Hakomori. Effects of glycosphingolipids on

epithelial-mesenchymal transition of epithelial cell lines. Glycobiology.

2008.18(11(Supplement)):956-957. (IF=4.446)

5. Guan Feng, Zhao DeHua, Pan Miao, Jiang Wei and Li Jilun. Analysis of active sites for

N2 and H+ reduction on FeMo-cofactor of nitrogenase. Chinese Science Bulletin. 2007.

52(15): 2088-2094. (IF=0.68)

6. Dehua Zhao, Feng Guan, Miao Pan, Jilun Li. “Different Roles of the Subunit Residue Histitine 194 and Glutamine 190 of MoFe Protein and Homocitrate of FeMoco in Catalysis

of Klebsiella pneumoniae Nitrogenase.” Biological Nitrogen Fixation, Sustainable

Agriculture and the Environment. Springer. 2005, 46.

7. Xiang L, Wei J, Jianbo S, Guili W, Feng G, Ying L. Purified and sterilized

magnetosomes from Magnetospirillum gryphiswaldense MSR-1 were not toxic to mouse

fibroblasts in vitro. Lett Appl Microbiol. 2007 Jul; 45(1):75-81. (IF=1.68)

8. Xiang L, Bin W, Huali J, Wei J, Jiesheng T, Feng G, Ying L. Bacterial magnetic

particles (BMPs)-PEI as a novel and efficient non-viral gene delivery system. J Gene Med.

2007 Aug; 9(8):679-90. (IF=3.14)