個人簡介
1991年以來主要從事蛋白質酪氨酸激酶（PTK）、磷酸酶（PTP）信號傳導通路與腫瘤激活分子機理的研究。多年來，在國際頂尖學術刊物《Nature》、《Cell》、《EMBO》上發表10餘篇重量級論文。申請者的研究工作在該領域中一直處於國際領先地位，並作出過一些突破性貢獻，特別是在國際上首次用細胞模型闡明了腫瘤蛋白c-Src被PTPα激活，導致細胞癌變的分子機制。
承擔課題
上海浦江特殊人才引進計畫 2005-2007（酪氨酸磷酸化修飾與腫瘤發生的分子機制）
發表文章
1．Moncollin, V., Miyamoto, N., Zheng, XM., and Egly, JM. 1986 Purification of a Specific Factor for the uptream element of the Adenovirus-Major Late Promoter. EMBO.Journal 5,2577-2584
2．Zheng, XM., Moncollin, V., Egly,JM., and Chambon, P. 1987 A General Transcription Factor Form stable Complex with RNA PolymeraseB Cell. 50. 361-368
3．Zheng, XM., Black, G., Chambon, P., and Egly, JM. 1990 Sequencing and Expression of Complementary DNA for General Transcription factor. Nature. 344. 556-559
4．Zheng, XM., Wang, Y., and Pallen, CJ. 1992 Cell Transformation and Activation of pp60c-src by overexpression of protein tyrosine phosphatase. Nature. 359. 336-339
5．Zheng, XM., and Pallen, CJ. 1994 Expression of Receptor-like Protein Tyrosine Phosphatase ? in Rat Embryo
Fibroblasts Activation Map kinase and c-Jun. J.Biol.Chem. 269. 23302-23309
6．Zheng, XM., Resnick, RJ., and Shalloway, D. 2000 A phosphotyrosine displacement mechanism for activation of Src by PTP.EMBO. Journal 19. 964-978
7．Zheng, XM., and Shalloway, D. 2001 Two mechanisms activate PTP? during mitosis. EMBO Journal. 20. 6037-6049
( The study in this paper was highlighted in Science “Signal Transduction Knowledge Enviroment” November 6, 2001, and was also focused by Mustein and Hunter Tony “Perspective” in Science on-line, January 15, 2002 )
8．Yang, JS., Zheng, XM., and Chen, SS. 2002 Changes of phenotypers associated with activated Src by overexpressed PTP? in NIH3T3 cells. Acta Biochem Biophys Sin. 34, 193-198
9．Yang, JS., Zheng, XM., and Chen, SS. 2002 Screening and identification of tumor related genes in early stages of transformed NIH3T3 cells associated with overexpressed PTP?. Acta Biochem Biophys Sin. 34, 59-65
10. Zheng, XM., Resnick, RJ., and Shalloway, D. 2002 Mitotic activation of Protein-tyrosine Phosphatase ? and regulation of Its Src - mediated Transforming Activity by Its Sites of Protein Kinase C Phosphorylation.
J. Biol. Chem. 277. 21922-21929
11. Cheng,WH., Zheng, XM., Quimby,FR., Roneker.,CA. And Lei XG. 2003 Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15
in pro-oxidant-induced aponecrosis. Biochem. J. 370. 927-934
12. Young, RM., Zheng, XM., Holowka,D., and Baird, B. 2005 Reconstitution of regulated phosphorylation of Fc?RI by a Lipid Raft-excluded protein tyrosine phosphatase. J. Biol. Chem. 280. 1230-1235
