學習經歷：
2003.09 – 2006.12 武漢大學生命科學學院 博士
2000.09 – 2003.06 武漢大學生命科學學院 碩士
1990.09 – 1994.06 武漢大學生命科學學院 學士
主要工作經歷與任職情況：
2009.11 – 至今 武漢大學生命科學學院 副教授，碩士研究生導師
2012.01 – 2012.12 美國紐約州奧爾巴尼醫學院 訪問學者
2007.02 – 2009.11 武漢大學生命科學學院 講師
1994.07 – 2000.08 湖北中醫藥大學基礎部 教師
主要社會兼職：
中國細胞生物學學會會員
主要研究領域及興趣：
1、利用cDNA文庫構建、mRNAs和microRNAs表達譜晶片、組織晶片等現代實驗技術，結合生物信息學、分子生物學、細胞生物學等研究方法和技術手段，篩選與人類早期胚胎髮育相關的新基因（包括蛋白編碼基因和microRNAs基因）；
2、與人類早期胚胎髮育相關新基因的轉錄調控研究及其在人胚分子發育和惡性腫瘤發生髮展過程中的生物學功能探索。
主持和參與課題項目：
1. 主持：中央高校基本科研業務費專項資金（學科交叉類資助項目）（2042014kf0243），2014-2015；
2. 主持：國家自然科學基金面上項目（31271511），2013-2016；
3. 主持：國家自然科學基金面上項目（30871245），2009-2011；
4. 主持：教育部高校博士點基金新教師項目（200804861004），2009-2011；
5. 參與：國家高技術研究發展計畫（863計畫）（2006AA02A306），2006-2010
代表性論文（* Co-first author, # Corresponding author）
1) Wei Wang, Jinyang Cai, Yi Lin, Zikou Liu, Qihao Ren, Li Hu, Zan Huang, Mingxiong Guo #, and Wenxin Li #. Zinc Fingers Function Cooperatively with KRAB Domain for Nuclear Localization of KRAB-containing Zinc Finger Proteins. PLoS One, 2014, Mar 19; 9(3):e92155
2) Yi Lin, Yan Zeng, Fan Zhang, Lu Xue, Zan Huang, Wenxin Li #, Mingxiong Guo #. Characterization of MicroRNA Expression Profiles and the Discovery of Novel MicroRNAs Involved in Cancer during Human Embryonic Development. PLoS ONE 2013, 8(8): e69230.
3) Wei Wang *, Jinyang Cai *, Yingliang Wu, Jun Hu, Zongyun Chen, Wenxin Li, Mingxiong Guo #, Zan Huang #. KRAB domain functions as a novel nuclear localization signal by interacting with KAP1. Cell Mol Life Sci., 2013, 70(20): 3947-3958.
4) Li Hu *, Wei Wang *, Jinyang Cai, Jun Luo, Yi Huang, Shilu Xiong, Wenxin Li, Mingxiong Guo #. Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. Oncol Lett., 2013, 6: 49-54.
5) Hai-Ming Hu, Yicheng Chen, Lu Liu, Chuan-Geng Zhang, Wei Wang, Ke Gong, Zan Huang, Ming-Xiong Guo, Wen-Xin Li # and Wenhua Li #. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis. FASEB J., 2013, 27(1): 163-73
6) Wei Wang *, Mingxiong Guo *, Li Hu, Jinyang Cai, Yan Zeng, Jun Luo, Zhiqiang Shu, Wenxin Li #, Zan Huang #. The Zinc Finger Protein ZNF268 is Overexpressed in Human Cervical Cancer and Contributes to Tumorigenesis via Enhancing NF-κB Signaling. J. Biol. Chem., 2012, 287(51): 42856-66.
7) Yan Zeng, Wei Wang, Jian Ma, Xianguo Wang, Mingxiong Guo #, Wenxin Li #. Knockdown of ZNF268, Which Is Transcriptionally Downregulated by GATA-1, Promotes Proliferation of K562 Cells. PLoS ONE., 2012, 7(1): e29518.
8) Lu Xue *, Hong-Ling Qiu *, Jian Ma, Ming-Xiong Guo, Wen-Xin Li #. ZNF300, A Recently Identified Human Transcription Factor, Activates the Human IL-2R Beta Promoter through the Overlapping ZNF300/Egr1 Binding Site. Cell. Mol. Biol. Lett. 2010, 15(4): 530-40.
9) Hong Yi *, Lu Xue *, Ming-Xiong Guo *, Jian Ma, Yan Zeng, Wei Wang, Jin-Yang Cai, Hai-Ming Hu, Hong-Bing Shu, Yun-Bo Shi #, Wen-Xin Li #. Gene Expression Atlas for Human Embryogenesis. FASEB J. 2010, 24(9): 3341-50.
10) Jun-Hua Xu, Tao Wang, Xian-Guo Wang, Xiang-Peng Wu, Zhou-Zhou Zhao, Chen-Gang Zhu, Hong-Ling Qiu, Lu Xue, Huan-Jie Shao, Ming-Xiong Guo, Wen-Xin Li #. PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60. Leukemia Research, 2010, 34(12): 1636-46.
11) Zhouzhou Zhao, Di Wang, Chengang Zhu, Huanjie Shao, Chong Sun, Hongling Qiu, Lu Xue, Junhua Xu, Mingxiong Guo*, Wenxin Li*. Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. Oncol. Rep., 2008, 20(5): 1243-8.
12) Di Wang *, Ming-Xiong Guo *, Zhou-Zhou Zhao, Hong-Ling Qiu, Hai-Ming Hu, Huan-Jie Shao, Chen-Gang Zhu, Lu Xue, Yun-Bo Shi and Wen-Xin Li. Human T-cell leukemiavirus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive Element-binding Protein/Activating Transcription Factor pathway. J. Biol. Chem., 2008, 283(24): 16299-308.
13) Mingxiong Guo, Tao Huang, Yejian Cui, Baiqun Pan, Ao Shen, Yuting Sun, Yourong Yi, Yan Wang, Gengfu Xiao, Guihong Sun. PrPC interacts with tetraspanin-7 through bovine PrP154-182 containing alpha-helix 1. Biochem. Bioph. Res. Co., 2008, 365(1): 154-7.
14) Chengang Zhu, Zhouzhou Zhao, Mingxiong Guo, Huanjie Shao, Hongling Qiu, Di Wang, Junhua Xu, Lu Xue, Wenxin Li. The mammalian gene ZNF268 is regulated by hUpf1. Biochemistry-Moscow, 2008, 73(8): 881-5.
15) Li Xu, Zhouzhou Zhao, Jiqun Sheng, Chenggang Zhu, Hui Liu, Dahe Jiang, Xin Mao, Mingxiong Guo, and Wenxin Li. Co-expression of complement regulatory proteins human DAF and MCP with an IRES-mediated dicistronic mammalian vector enhances their cell protective effects. Biochemistry-Moscow. 2008, 73(9): 1025-30.
16) Hongling Qiu, Lu Xue, Li Gao, Huanjie Shao, Di Wang, Mingxiong Guo and Wenxin Li. Identification of the DNA binding element of the human ZNF300 protein. Cell. Mol. Biol. Lett., 2008, 13(3): 391-403.
17) Ming-Xiong Guo *, Di Wang *, Huan-Jie Shao, Hong-Ling Qiu, Lu Xue, Zhou-Zhou Zhao, Chen-Gang Zhu, Yun-Bo Shi, and Wen-Xin Li. Transcription of Human Zinc Finger ZNF268 Gene Requires an Intragenic Promoter Element. J. Biol. Chem., 2006, 281(34): 24623-36.
18) Shao H, Zhu C, Zhao Z, Guo M, Qiu H, Liu H, Wang D, Xue L, Gao L, Sun C, Li W. KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains. Int. J. Mol. Med., 2006, 18(3): 457-63.
19) Guihong Sun, Mingxiong Guo, Ao Shen, Fanghua Mei, Xiaoxue Peng, Rui Gong, Deyin Guo, Jianguo Wu, Po Tien, Gengfu Xiao. Bovine PrPC directly interacts with alpha B-crystalline. FEBS Lett., 2005, 579: 5419-24.
已申請或授權專利：
1. 李文鑫；郭明雄；黃贊；林義. miR-638在抗急性髓系白血病中的套用. 專利申請號：201410466367.2
2. 李文鑫; 郭明雄; 汪維; 吳淼. 一種突變型載體pEGFP-N1m的構建方法及套用. 專利申請號：201010291680.9.
3. 李文鑫; 郭明雄; 汪維; 趙舟宙; 曾艷. 靶向ZNF268基因的RNA干擾表達載體構建及套用. 專利號：ZL201010230390.3.
4. 李文鑫; 郭明雄; 王濤; 汪顯國; 許均華; 邱紅玲; 武祥鵬. 一種ZNF300基因重組載體及套用. 專利申請號：200910273231.9
5. 李文鑫; 郭明雄; 王濤; 許均華; 汪顯國; 邱紅玲; 祝旋. 人ZNF300抗體在製備治療和預防白血病藥物中的套用. 專利申請號：200910063162.9.
6. 李文鑫; 郭明雄; 趙舟宙; 邵煥傑; 孫翀. 一種ZNF268基因剪接異構體在抗白血病中的套用. 專利號：ZL200710053681.8.
7. 陳蔚梅; 馮勝彥; 郭明雄; 艾建宇; 吳斌; 熊曉然; 吳顯輝. 一種抗病毒藥物利巴韋林的製備方法. 專利申請號：02115486.4.
8. 馮勝彥; 陳蔚梅; 吳斌; 熊曉然; 吳顯輝; 郭明雄; 艾建宇. 一種可見光交聯複合樹脂固定黃嘌呤氧化酶活性細胞的方法. 專利申請號：02115489.9.
