袁林[湖南大學化學化工學院教授]

1982年出生於湖南新邵。2006年於南華大學獲工學學士學位。2013年於湖南大學獲化學博士學位。2014年2月至-2015年3月在新加坡國立大學化學系從事化學生物學方向博士後研究。2012年6月加入湖南大學，2015年10月起任副教授，2017年1月起任教授。曾獲教育部博士研究生學術新人獎，湖南省優秀博士學位論文。近5年發表通訊或第一作者SCI源刊論文32篇，單篇最高他引超過420次，7篇論文他引超過100次的，其中影響因子>5.0的論文23篇，包括J. Am. Chem. Soc. 5篇，Angew. Chem. Int. Ed. 5篇，Chem. Sci. 1篇，Anal. Chem. 1篇，Adv. Funct. Mater 1篇，Biomaterials 2篇等。曾主持國家自然科學基金青年項目，湖南省自然科學基金面上項目等項目；2016年獲國家優秀青年科學基金資助。

代表性論文

1.D. Cheng, Y. Pan, L. Wang, Z. Zeng, L. Yuan*, X. Zhang, Y.-T. Chang.Selective visualization of the endogenous peroxynitrite in an inflamed mouse model by a mitochondria-targetable two-photon ratiometric fluorescent probe. J. Am. Chem. Soc. 2017, 139, 285-292.

2.J. Peng, A. Samanta, X. Zeng, S. Han, L. Wang, D. Su, D.T.B.Loong, N.-Y. Kang, S.-J. Park, A. H. All, W. Jiang, L. Yuan*, X. Liu*, Y.-T. Chang. Real-timeinvivohepatotoxicitymonitoringthroughchromophore-conjugatedupconversionnanoprobes. An gew. Chem. Int. Ed. 2017, Accepted.

3.W. Xu, Z. Zeng, J.-H. Jiang*, Y.-T.Chang*, L. Yuan*. Discerning the chemistry in individual organelles with small molecule fluorescent probes. Angew. Chem. Int. Ed. 2016, 55, 13658-13699.

4.L. Wang, L. Yuan*, X. Zeng, J. Peng, Y. Ni, J. C. Er, W. Xu, B. K. Agrawalla, D. Su, B. Kim, Y.-T. Chang*. Amultisite-binding switchable fluorescent probe for monitoring mitochondrial ATP level fluctuation in live cells. Angew. Chem. Int. Ed. 2016, 55, 1773-1776.

5.J. Peng, C. L. Teoh, X. Zeng, A. Samanta, L. Wang, W. Xu, D. Su, L. Yuan*, X. Liu, Y.-T. Chang*. Development of a highly selective, sensitive, and fast response upconversion luminescent platform for hydrogen sulfide detection. Adv. Funct. Mater. 2016, 26, 191-199.

6.Y. Wei, D. Cheng, T. Ren, Y. Li, Z. Zeng, L. Yuan*. Design of NIR chromenylium–cyanine fluorophore library for “switch-on” and ratiometric detection of bio-active species in vivo. Anal. Chem. 2016, 88, 1842−1849.

7. L. Yuan, L. Wang, K. Bikram, S.-J. Park, H. Zhu, B. Sivaraman, J. Peng, Q. Xu, Y.-T. Chang. Development of targetable two-photon fluorescent probes to image hypochlorous acid in mitochondria and lysosome in live cell and inflamed mouse model. J. Am. Chem.Soc. 2015, 137, 5930−5938.

8. L. Yuan*, F. Jin, Z. Zeng*, C. Liu, S. Luo, J. Wu. Engineering a FRET strategy to achieve a ratiometric two-photon fluorescence response with a large emission shift and its application to fluorescence imaging. Chem Sci, 2015, 6, 2360-2365.

9. L. Yuan, W. Lin*, H. Chen, S. Zhu, L. He. A unique family of rigid analogues of the GFP chromophore with tunable two-photon action cross-sections for biological imaging. Angew. Chem. Int. Ed. 2013, 58,10018–10022.

10. L. Yuan, W. Lin*, L. Tan, K. Zheng, W. Huang. Lighting up carbon monoxide: fluorescent probes for monitoring CO in living cells. Angew. Chem. Int. Ed. 2013, 52, 1628–1630.

11. L. Yuan, W. Lin*, K. Zheng, L. He, W. Huang, Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging. Chem. Soc. Rev., 2013, 42, 622-661.

12. L. Yuan, W. Lin*, K. Zheng, S. Zhu, FRET-based small-molecule fluorescent probes: rational design and bioimaging applications. Acc. Chem. Res. 2013, 46, 1462-1473.

13. L. Yuan, W. Lin, H. Chen, Analogs of Changsha near-infrared dyes with large Stokes Shifts for bioimaging. Biomaterials, 2013, 34, 9566-9571.

14. L. Yuan, W. Lin*, S. Zhao, W. Gao, B. Chen, L. He, S. Zhu, A unique approach to development of near-infrared fluorescent sensors for in vivo imaging. J. Am. Chem.Soc. 2012, 134, 13510-13523.

15. L. Yuan, W. Lin,* Y. Xie, B. Chen, S. Zhu.Single fluorescent probe responds to HO, NO, and HO/NO with three different sets of fluorescence Signals. J. Am. Chem. Soc. 2012, 134, 1305-1315.

16. L. Yuan, W. Lin,*Y. Yang, H. Chen. A unique class of near-infrared functional fluorescent dyes with carboxylic-acid-modulated fluorescence ON/OFF switching: rational design, synthesis, optical properties, theoretical calculations, and applications for fluorescence imaging in living animals. J. Am. Chem. Soc. 2012, 134,1200-1211.