![蔣慶華[哈工大博士生導師]](/img/6/0cb/nBnauM3XyQTOzMjMxAjN2kTO0UTMyITNykTO0EDMwAjMwUzLwYzLzIzLt92YucmbvRWdo5Cd0FmL0E2LvoDc0RHa.jpg "蔣慶華[哈工大博士生導師]")
學術兼職
•《Nucleic Acids Research》、《 Bioinformatics》、《Briefings in Bioinformatics》、《Scientific Reports》、 《Current Bioinformatics》、《Animal Genetics》、《International Journal of Data Mining and Bioinformatics (IJDMB) 》等期刊審稿人
•《Austin Journal of Computational Biology and Bioinformatics》期刊編委 （2014-)
•《Austin Medical Sciences》期刊編委 （2015-)
教育與工作經歷
教育經歷
•1999.09-2003.07 吉林大學 計算數學 學士
•2003.09-2006.07 吉林大學 計算數學 碩士
•2007.03-2010.06 哈爾濱工業大學 計算機套用技術 博士
工作履歷
•2010.08-2012.12 哈爾濱工業大學 生物醫學工程研究中心 講師
•2011.11-2012.11 哈佛大學 Dana Farber癌症研究所 訪問學者
•2013.12-2015.12 哈爾濱工業大學 生物醫學工程研究中心 副教授
•2015.04-至今 哈爾濱工業大學 生命科學與技術學院 博士生導師
•2016.01-至今 哈爾濱工業大學 生物醫學工程研究中心 教授
研究方向
•生物信息學、癌表觀基因組學：發展信息學方法，對高通量組學及臨床數據進行整合及分析，研究癌症發生、發展過程中表觀及轉錄調控機制，計算預測、實驗驗證癌症相關的非編碼基因（lncRNA、microRNA）。
•基於單核苷酸多態的阿爾斯海默病（AD）遺傳標記的識別與檢測：構建中國或者亞洲人群AD遺傳標記（SNP）知識庫系統，研發疾病預測模型和算法，預測AD疾病風險。
•長鏈非編碼RNA(long non-coding RNA, lncRNA)綜合分析平台：發展生物信息學方法，重點研究lncRNA轉錄調控、功能注釋及疾病lncRNA識別技術，開發集數據中心、分析平台、知識庫於一體的lncRNA分析系統，推動在基因組範圍內對lncRNA調控機制及功能的理解。
•腫瘤診斷與治療：基於腫瘤基因組數據，發展腫瘤相關的遺傳變異識別及功能注釋方法， 基於變異與靶向藥物的關係信息，制定個體化用藥指導方案。
•健康管理：通過分析健康個體的基因組數據，預測潛在的疾病風險、制定個體化用藥指導及健康生活方案。
參加首屆中國腫瘤精準醫療高峰論壇項目與獲獎
主持的科研項目
•2016.1-2019.12，國家自然科學基金面上項目
•2016.1-2019.12，哈工大青年拔尖人才選聘計畫項目
•2016.1-2017.12, 黑龍江省自然科學基金面上項目
•2016.1-2016.12，黑龍江省留學人員擇優資助項目
•2012.7-2015.06，哈工大基礎研究傑出人才培育計畫III
•2012.1-2014.12，國家自然科學青年基金
•2012.9-2014.12，中國博士後第五批特別資助基金
•2011.7-2013.12，中國博士後科學基金（一等資助）
•2011.1-2012.12，哈工大科研創新基金
•2012.1-2013.12，黑龍江省博士後基金
參與的科研項目
•2010.01-2012.12，國家自然科學基金， 排名：9/2
•2014.01-2017.12，國家自然科學基金， 排名：8/2
•2012.01-2015.12，國家863項目， 排名：17/11
•2015.01-2017.12，國家863重大項目，排名18/69
榮譽稱號
•2010年 獲“中國百篇最具影響國際學術論文”
•2011年 獲”第十二屆黑龍江省自然科學技術學術成果一等獎"
•2012年 入選“哈爾濱工業大學基礎研究傑出人才培育計畫III”
•2015年 入選“哈爾濱工業大學青年拔尖人才選聘計畫”
代表性學術論文
2016
Guiyou Liu, Qinghua Jiang*. Alzheimer's disease CD33 rs3865444 variant does not contribute to congnitive performance. 2016. PNAS. DOI: 10.1073/pnas.1600852113 (SCI IF: 9.674) (*通訊作者）
Guiyou Liu, Qinghua Jiang, Yongshuai Jiang, Keshen Li. Junwei Hao*. Ischaemic stroke variants from genome-wide association studies and Alzheimer’s disease susceptibility. Annals of Neurology. 2016. (SCI IF: 9.977) (Accepted)
Qinghua Jiang, Guiyou Liu*. Lack of association between MC1R variants and Parkinson’s disease in European descent. 2016. Annals of Neurology. DOI: 10.1002/ana.24627 (SCI IF: 9.977)
Qinghua Jiang, Guiyou Liu*. REST rs3796529 variant does not influence human subcortical brain structures. Annals of Neurology. 2016 Feb;79(2):334-5. (SCI IF: 9.977)
Qinghua Jiang#, Shuilin Jin#, Yongshuai Jiang, Mingzhi Liao, Rennan Feng,Liangcai Zhang, Guiyou Liu*, Junwei Hao*. Alzheimer's disease variants with the genome-wide significance are significantly enriched in immune pathways and active in immune cells. 2016. doi:10.1007/s12035-015-9670-8. Molecular Neurobiology. (SCI, IF: 5.137)
Guiyou Liu#, Yining Xu#, Yongshuai Jiang, Mingzhi Liao, Rennan Feng, Qinghua Jiang*. PICALM rs3851179 variant confers susceptibility to Alzheimer's disease in Chinese population. 2016. Molecular Neurobiology. (SCI, IF: 5.137) (Accepted) (*通訊作者）
Yining Xu, Qinghua Jiang, Guiyou Liu*. PICALM rs3851179 variant and Alzheimer's disease in Asian population. 2016. NeuroMolecular Medicine. (SCI, IF: 3.678) (Accepted)
Weiyang Bai, Wen Yang, Wenjing Wang, Yang Wang, Can Liu, Qinghua Jiang, Jinlian Hua, Mingzhi Liao*. GED: a manually curated comprehensive resource for epigenetic modification of gametogenesis. Briefings in Bioinformatics. 2016 Feb 5. pii: bbw007. (SCI, IF: 9.617)
1.Qinghua Jia
2.Qinghua Jiang
3.Qinghua Jiang
4.Qinghua Jiang
5.Qinghua Jiang
6.Qinghua Jiang
7.Qinghua Jiang
8.Qinghua Jiang
2015
Jiang QH, Wang JX, Wu XL, Ma R, Jin SL, Han ZJ, Tan RJ, Peng JJ, Liu GY, Li Y, Wang YD*. LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression. 2015. Nucleic Acids Research. DOI 10.1093/nar/gku1173 (SCI, IF: 9.112)
Jiang QH, Ma R, Wang JX, Wu XL, Jin SL, Peng JJ, Tan RJ, Zhang TJ, Li Y, Wang YD*. LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data. 2015. BMC genomics. 16(s3):s2. (SCI, IF: 3.986)
Han ZJ, Jiang QH*, Zhang TJ, Wu XL, Ma R, Wang JX, Bai Y, Wang RJ, Tan RJ, Wang YD*. Analyzing large-scale samples confirms the association between the rs1051730 polymorphism and lung cancer susceptibility. 2015. Scientific Reports. (Accepted) (SCI, IF: 5.578) (*通訊作者）
Zhang SY, Li X, Ma G, Jiang YS, Liao MZ, Feng RN, Zhang LC, Liu JF, Wang GY, Zhao B, Jiang QH*, Li KS*, Liu GY*. CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations. 2015. Molecular Neurobiology, 53(3), 1446-1451. (*通訊作者) (SCI, IF: 5.137)
Li YN, Song DJ, Jiang YS, Wang J, Feng R, Zhang LC, Wang GY, Chen ZG, Wang RZ*, Jiang QH*, Liu GY*. CR1 rs3818361 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese Population. Molecular Neurobiology. 2015 July 21. [Epub ahead of print]. (*通訊作者) (SCI, IF: 5.137)
Li KS, Jiang QH, Xu AD, Liu GY. REST rs3796529 variant does not confer susceptibility to Alzheimer's disease. Annals of Neurology. 2015 Aug 18. doi: 10.1002/ana.24503. [Epub ahead of print] (SCI IF: 9.977)
Guiyou Liu, Yongquan Liu, Qinghua Jiang, Yongshuai Jiang, Rennan Feng, Liangcai Zhang, Zugen Chen, Keshen Li , Jiafeng Liu. Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson’s Disease Susceptibility. Molecular Neurobiology. 2015. DOI 10.1007/s12035-015-9416-7. (SCI, IF: 5.137)
Bai Y, Ji SF, Jiang QH, Wang YD. Identification exon skipping events from high-throughput RNA sequencing data. IEEE Transactions on NanoBioscience. 2015 Jul;14(5):562-9 (SCI IF: 2.309)
Xinjie Bao, Gengfeng Chen, Yongshuai Jiang, Qinghua Jiang, Mingzhi Liao, Rennan Feng, Liangcai
Zhang, Guoda Ma, Shuyan Zhang, Zugen Chen, Bin Zhao, Renzhi Wang*, Keshen Li*, Guiyou Liu*. Cell adhesion molecules pathways genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer’s disease brains. Neurobiol Aging. 2015 Jun 12 (SCI, IF: 5.013)
Xiao Zhu, Henry C.M. Leung, Rongjie Wang, Francis Y.L. Chin, Siu Ming Yiu, Guangri Quan, Yajie Li, Rui Zhang, Qinghua Jiang, Bo Liu, Yucui Dong, Guohui Zhou, Yadong Wang. misFinder: Identify mis-assemblies in an unbiased manner using reference and paired-end reads. BMC Bioinformatics. 2015 (Accepted) (SCI IF: 2.44)
Peng JJ, Li HX, Liu YZ, Juan LR, Jiang QH, Wang YD*. InteGO2: a web tool for measuring and visualizing gene semantic similarities using Gene Ontology. BMC Bioinformatics. 2015 (Accepted) (SCI, IF: 2.576)
Zhu X, Leung HC, Wang R, Chin FY, Yiu SM, Quan G, Li Y, Zhang R, Jiang Q, Liu B, Dong Y, Zhou G, Wang Y. misFinder: identify mis-assemblies in an unbiased manner using reference and paired-end reads. BMC Bioinformatics. 2015 Nov 16;16(1):386 (SCI, IF: 2.576)
1.Jiang QH
2.Jiang QH
3.Jiang QH
4.Jiang QH
5.Jiang QH
6.Jiang QH
7.Qinghua Jiang
8.Jiang QH
9.Qinghua Jiang
Zhang, Guoda Ma, Shuyan Zhang, Zugen Chen, Bin Zhao, Renzhi Wang*, Keshen Li*, Guiyou Liu*. Cell adhesion molecules pathways genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer’s disease brains. Neurobiol Aging. 2015 Jun 12 (SCI, IF: 5.013)
10.Qinghua Jiang
11.Jiang QH
12.Jiang Q
2014
Jiang QH, Wang JX, Wu XL, Ma R, Jin SL, Han ZJ, Tan RJ, Peng JJ, Liu GY, Li Y, Wang YD. LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression. 2014.Nucleic Acids Research. DOI 10.1093/nar/gku1173 (SCI,IF: 8.808)
Quan BK, Qi XS, Yu ZH, Jiang YS, Liao MZ, Wang GY, Feng RN, Zhang LC, Chen ZG,Jiang QH*, Liu GY*. Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer. 2014.Molecular Genetics and Genomics. DOI 10.1007/s00438-014-0945-y. (*通訊作者) (SCI,IF: 2.831)
Liu GY, Bao XJ, Jiang Y,S Liao MZ,Jiang QH, Feng RN, Zhang LC, Ma GD, Chen ZG, Wang GY, Wang RZ, Zhao B, Li KS.Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network. 2014.Molecular Neurobiology. DOI 10.1007/s12035-014-8946-8 (SCI,IF=5.286)
Li X, Shen N, Zhang SY, Liu JF,Jiang QH, Liao MZ, Feng RN, Zhang LC, Wang GY, Ma GD, Zhou HH, Chen ZG, Jiang YS*, Zhao B*, Li KS*, Liu GY* (2014) CD33 rs3865444 polymorphism contributes to Alzheimer’s disease susceptibility in European and North American but not Asian populations.Molecular Neurobiology. DOI 10.1007/s12035-014-8880-9 (SCI,IF=5.286)
Xiang ZM, Xu ML, Liao MZ, Jiang YS,Jiang QH, Feng RN, Zhang LC, Ma GD, Wang GY, Chen ZG, Zhao B, Sun TS*, Li KS*, Liu GY* (2014) Integrating genome-wide association study and brain expression data highlights cell adhesion molecules and purine metabolism in Alzheimer’s disease.Molecular Neurobiology. DOI 10.1007/s12035-014-8884-5 (SCI,IF=5.286)
Peng JJ, Li HX,Jiang QH, Wang YD, Chen J. TITLE: An Integrative Approach for Measuring Semantic Similarities using Gene Ontology.BMC systems biology. 2014, 8 (Suppl 5): S8 (SCI,IF: 2.853)
Tan RJ, Wang YD, Kleinstein S, Liu YZ, Zhu XL,Jiang QH, Zhu MF. An Evaluation of Copy Number Variation Detection Tools from Whole-Exome Sequencing Data.Human mutation.2014 Mar 5. doi: 10.1002/humu.22537. [Epub 2014 May 1] (SCI,IF: 5.213)
Jin SL, Tan RJ,Jiang QH, Xu L, Peng JJ, Wang Y, Wang YD. A generalized topological entropy for analyzing the complexity of DNA sequences.PLoS One. 2014 Feb 12;9(2):e88519 (SCI,IF: 3.73)
Jiang QH, Wang JX, Wang YD, Ma R, Wu XL, Li Y. TF2LncRNA: Identifying common transcription factors for a list of lncRNA genes from ChIP-Seq data.BioMed Research International. vol. 2014, Article ID 317642, 5 pages, 2014. doi:10.1155/2014/317642 (SCI,IF: 2.706)
1.Jiang QH
2.Jiang QH*
3.Jiang QH
4.Jiang QH
5.Jiang QH
6.Jiang QH
7.Jiang QH
8.Jiang QH
9.Jiang QH
2013
Jiang QH, Wang GH, Li Y, Jin SL, Wang YD. Predicting Human microRNA-disease Associations Based on Support Vector Machine. International Journal of Data Mining and Bioinformatics. 2013.vol.8, No.3. 282-239
1.Jiang QH, Wang GH, Li Y, Jin SL, Wang YD. Predicting Human microRNA-disease Associations Based on Support Vector Machine. International Journal of Data Mining and Bioinformatics. 2013.vol.8, No.3. 282-239
2012
Jin SL, Xu L,Jiang QH*, Duan GR. A Joint Spectral Characterization of C* Independence. Infinite Dimensional Analysis Quantum Probability and Related Topics. Vol. 15, No. 2 (2012) 1250013:1-5 ( *通訊作者)
Jin SL, Jiang QH*, Wang YD*, Duan GR. On joint spectrum of infinite direct sums. Operators and Matrices. Vol. 6, No. 3 (2012), 529–533 ( *通訊作者)
Jin SL, Xu L, Jiang QH* and L Li*. Conditions equivalent to C* independence, Studia Math. 2012,211, 191-197 ( *通訊作者)
Jin SL, Xu L, Jiang QH. Joint Spectrum and Joint Distribution. Complex analysis and operator theory. 2012. DOI 10.1007/s11785-012-0258-2
1.Jin SL, Xu L,Jiang QH*, Duan GR. A Joint Spectral Characterization of C* Independence. Infinite Dimensional Analysis Quantum Probability and Related Topics. Vol. 15, No. 2 (2012) 1250013:1-5 ( *通訊作者)
2.Jin SL, Jiang QH*, Wang YD*, Duan GR. On joint spectrum of infinite direct sums. Operators and Matrices. Vol. 6, No. 3 (2012), 529–533 ( *通訊作者)
3.Jin SL, Xu L, Jiang QH* and L Li*. Conditions equivalent to C* independence, Studia Math. 2012,211, 191-197 ( *通訊作者)
4.Jin SL, Xu L, Jiang QH. Joint Spectrum and Joint Distribution. Complex analysis and operator theory. 2012. DOI 10.1007/s11785-012-0258-2
2011
Zhu SJ, Jiang QH, Wang GH, Liu B, Teng MX, Wang YD. Chromatin structure characteristics of pre-miRNA genomic sequences. BMC genomics.2011. 12(1):329.
1.Zhu SJ, Jiang QH, Wang GH, Liu B, Teng MX, Wang YD. Chromatin structure characteristics of pre-miRNA genomic sequences. BMC genomics.2011. 12(1):329.
2010
Jiang QH, Hao YY, Wang GH, Juan LR, Zhang TJ, Teng MX, Liu YL, Wang YD. Prioritization of disease microRNAs through a human phenome-microRNAome network, Bmc Systems Biology, 2010, 4 Suppl 1, S2.
Jiang QH, Hao YY, Wang GH, Zhang TJ, Wang YD. Weighted network-based inference of human microRNA-disease associations. The 5th International Conference on Frontier of Computer Science and Technology - Workshop on Bioinformatics and System Biology. 2010. 431-435
Jiang QH, Wang GH, Wang YD. An approach for prioritizing disease-related microRNAs based on genomic data integration. The 3rd International Conference on BioMedical Engineering and Informatics. 2010. 2270-2274
1.Jiang QH, Hao YY, Wang GH, Juan LR, Zhang TJ, Teng MX, Liu YL, Wang YD. Prioritization of disease microRNAs through a human phenome-microRNAome network, Bmc Systems Biology, 2010, 4 Suppl 1, S2.
2.Jiang QH, Hao YY, Wang GH, Zhang TJ, Wang YD. Weighted network-based inference of human microRNA-disease associations. The 5th International Conference on Frontier of Computer Science and Technology - Workshop on Bioinformatics and System Biology. 2010. 431-435
3.Jiang QH, Wang GH, Wang YD. An approach for prioritizing disease-related microRNAs based on genomic data integration. The 3rd International Conference on BioMedical Engineering and Informatics. 2010. 2270-2274
2009
Jiang QH, Wang YD, Hao YY, Juan LR, Teng MX, Zhang XJ, Li MM, Wang GH, Liu YL. miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res．2009，37: D98-104
1.Jiang QH, Wang YD, Hao YY, Juan LR, Teng MX, Zhang XJ, Li MM, Wang GH, Liu YL. miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res．2009，37: D98-104
現承擔課程
•生物信息學（授課對象：生命學院三年級本科生）
•生物信息技術（授課對象：生命學院碩士一年級）
本課程主要介紹生物信息學基本概念及特點、常用生物資料庫、基因組瀏覽器、Linux系統常用命令、R語言編程、基因晶片原理及數據分析、新一代DNA測序技術原理及其數據分析、生物信息學熱點問題分析等內容。通過本課程的講授，旨在使學生了解生命科學學術前沿技術及研究問題、培養學生運用所學的數據分析技術解決生命科學中前沿問題的能力，為今後從事生命科學研究奠定基礎。
研究生培養
2017年招生：博士生2名，碩士生3名，歡迎計算機、數學、生物、生物信息學等相關專業的同學報考。
蔣慶華教授歡迎所有喜歡閱讀頂級期刊論文，希望在哈工大生命學院攻讀碩士學位並以發表學術論文為樂趣的有志青年加入他的研究團隊，有意者可致信qhjiang at hit.edu.cn。
對於沒有任何編程及信息技術基礎的學生，蔣慶華教授會用大約半年的時間與他們一起學習經典實用的程式語言（R、Python等），指導學生掌握基本的統計與數據挖掘方法，發現並跟蹤最前沿的生命科學熱點問題，並用所學的編程技能及信息學方法解決這些問題。
蔣慶華教授鼓勵他的學生將科研作為畢生的追求和事業，支持他的學生在畢業後繼續攻讀博士學位（出國攻博或公派出國進行二年的博士生聯合培養）。
