基本信息
肖佳,性別： 男學歷：博士研究生學位： 博士學院： 暨南大學生命科學技術學院副研究員
學習經歷
2009-12：博士，香港大學醫學院解剖學系；
2007-09：碩士，香港大學理學院動物學系；
2005-07：碩士，中山大學生命科學學院；
2001-05：學士，陝西師範大學生物學基地班
工作經歷
2013至今：暨南大學免疫生物學系 副研究員
2012-2013：中國科學院深圳先進技術研究院基因工程中心 助理研究員
研究方向
肝臟免疫學及再生醫學
主要著作
Chapter 3: Protection of the Liver from Wolfberry. From the book of “Wolfberry and Human Health”. 2015 Edition. Edited by Dr. Raymond Chuen-Chung CHANG & Prof. Kwok-Fai So. Published by Springer Group. DOI:10.1007/978-94-017-9658-3.
主要論文
2015 Xiao J, Tipoe GL*. Inflammasomes in non-alcoholic fatty liver disease. World Journal of Gastroenterology (Invited Review, In Revision, IF=2.433)
2015 Xiao J#, Liu YX#, Xing FY, Leung TM, Liong EC, Tipoe GL*. Bee's honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin interacting protein-NLRP3 inflammasome pathway. European Journal of Nutrition (Accepted) (IF=3.84) (被引0次)
2015 Zeng W#, Xiao J#, Zheng G, Xing FY, Tipoe GL, He CY, Chen ZY*, Liu YX*. Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model. Scientific Reports 5:11100 (IF=5.078) (被引0次)
2015 Liu YX, Wang M, Yao SM, Yuan J, Lu J, Li, HJ, Zeng W, Deng Y, Zou RR, Li J*, Xiao J*. Efficacy and safety of telbivudine in different trimesters of pregnancy with high viremia for interrupting perinatal transmission of HBV. Hepatology Research doi: 10.1111/hepr.12525 (IF=2.218) (Co-corresponding author) (被引0次)
2015 Bie M, Lv Y, Ren C, Xing F, Cui Q, Xiao J*, So KF*. Lycium barbarum polysaccharide improves bipolar pulse current induced microglia cell injury through modulating autophagy. Cell Transplantation 24(3):419-428 (IF=4.42) (Co-corresponding author) (被引0次)
2015 Wang Y, Xing F*, Ye S, Xiao J, Di J, Zeng S, Liu J. Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1. Scientific Reports 5:8234 (IF=5.078) (被引0次)
2015 Xiao J#, Lv Y#, Lin B, Tipoe GL, Youdim MBH, Xing FY*, Liu YX*. A novel antioxidant multitarget iron chelator M30 protects hepatocytes against ethanol-induced injury. Oxidative Medicine and Cellular Longevity 2015:607271 (IF=3.363) (被引0次)
2015 Xiao J, Liong EC, Huang H, Tse WO, Lau KS, Pan JF, Nanji AA, Fung ML, Xing FY, Tipoe GL*. Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. Toxicological Sciences 143(2):430-440 (IF=4.478) (被引0次)
2014 Liu YX, Zhang Y, Yuan J, Zeng W, Zhang GL, Yao SM, Li HJ, Yang M, Deng Y, Zou RR, Li SX, Xiao J*. Efficacy of tenofovir disoproxil fumarate therapy in Chinese chronic hepatitis B patients after multiple anti-viral failures. Hepatology Research doi: 10.1111/hepr.12454 (IF=2.218) (被引0次)
2014 Wang K#, Xiao J#, Peng B#, Xing FY, So KF, Tipoe GL, Lin B. Retinal structure and function rescued by polysaccharides of wolfberry in a mouse model of retinal degeneration. Scientific Reports 4:7601 (IF=5.078) (被引6次)
2014 Xiao J, Xing FY, Huo J, Fung ML, Liong EC, Ching YP, Xu AM, Chang RCCC, So KF*, Tipoe GL*. Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. Scientific Reports 4:5587 (IF=5.078) (被引7次)
2014 Zhou RP#, Li ZK#, He CY, Li RL, Xia HB, Li CY, Xiao J*, Chen ZY*. Human umbilical cord mesenchymal stem cells and derived hepatocyte-like cells exhibit similar therapeutic effects on an acute liver failure mouse model. PLOS ONE 9(8): e104392 (IF=3.73) (Co-corresponding author) (被引2次)
2014 Xiao J#, Zhu YH#, Liu YX, Tipoe GL, Xing FY*, So KF*. Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. International Journal of Biological Macromolecules 69:73-78 (IF=3.096) (被引7次)
2014 Peng B, Xiao J, Wang K, So KF, Tipoe GL, Lin B*. Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa. Journal of Neuroscience 34(24):8139-8150 (IF=6.908) (被引6次)
2014 Xiao J#, Wang JT#, Xing FY, Han T, Jiao R, Liong EC, Fung ML, So KF, Tipoe GL*. Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway. PLOS ONE 9(4): e95214 (IF=3.73) (被引2次)
2014 Xiao J#, Ho CT#, Liong EC, Nanji AA, Leung TM, Lau TYH, Fung ML, Tipoe GL*. Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways. European Journal of Nutrition 53(1): 187-199 (IF=3.84) (被引29次)
2013 Xiao J, Liong EC, Ching YP, Chang RC, Xu AM, Fung ML, So KF, Tipoe GL*. Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis induced injury. Nutrition and Diabetes 3: e81 (IF=1.517) (被引15次)
2013 Xiao J#, Guo R#, Fung ML, Liong EC, Chang RCC, Ching YP, Tipoe GL. Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophagy. eCAM 2013: 642920 (IF=4.774) (被引11次)
2013 Xiao J, Guo R, Fung ML, Liong EC, Tipoe GL*. Therapeutic approaches to non-alcoholic fatty liver disease: Past achievements and future challenges. HBPD INT 12(2):125-35 (IF=1.259) (被引27次)
2013 Lau TYH#, Xiao J#, Fung ML, Liong EC, Leung TM, Liao LC, Nanji AA, Tipoe GL*. Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappaB. Histology and Histopathology 28(4):463-471 (IF=2.502) (Co-first author) (被引4次)
2013 Nanji AA, Liong EC, Xiao J, Tipoe GL*. Thromboxane inhibitors attenuate inflammatory and fibrotic changes in rat liver despite continued ethanol administrations. Alcoholism: Clinical and Experimental Research 37(1): 31-39 (IF=3.468) (被引1次)
2013 Xiao J, Ching YP, Liong EC, Nanji AA, Fung ML, Tipoe GL*. Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model. European Journal of Nutrition, 52(1): 179-191 (IF=3.343) (被引34次)
2012 Xiao J, Liong EC, Ching YP, Chang RC, So KF, Fung ML, Tipoe GL*. Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. Journal of Ethnopharmacology, 139(2): 462-470 (IF=3.014) (被引43次)
2012 Liong EC#, Xiao J#, Lau TY, Nanji AA, Tipoe GL*. Cyclooxygenase inhibitors protect D-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model. Food and Chemical Toxicology, 50(3-4): 861-866 (IF=3.01) (Co-first author) (被引11次)
2012 Xiao J, Liong EC, Ling MT, Ching YP, Fung ML, Tipoe GL*. S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice. European Journal of Nutrition, 51(3): 323-333 (IF=3.343) (被引9次)
2009 Wang L, Zhou ZC, Guo CJ, Rao XY, Xiao J, Weng SP, Yin ZX, Yu XQ, He JG*. The alpha inhibitor of NF-kappaB (IkappaBalpha) from the mandarin fish binds with p65 NF-kappaB. Fish and Shellfish Immunology, 26(3): 473-482 (IF=3.16) (被引15次)
2008 Wang ZL, Xu XP, He BL, Weng SP, Xiao J, Wang L, Lin T, Liu X, Wang Q, Yu XQ, He JG*. Infectious spleen and kidney necrosis virus ORF48R functions as a new viral vascular endothelial growth factor. Journal of Virology, 82(9): 4371-4383 (IF=5.341) (被引18次)
2007 Xiao J#, Zhou ZC#, Chen C, Huo WL, Yin ZX, Weng SP, Chan SM, Yu XQ, He JG*. Tumor necrosis factor-alpha gene from mandarin fish, Siniperca chuatsi: molecular cloning, cytotoxicity analysis and expression profile. Molecular Immunology, 44(14): 1615-1622 (IF=4.768) (被引29次)
承擔課題：
1. 深圳市科技研發資金基礎研究 “Nrf2和DKK-1通路影響間充質幹細胞移植治療肝病機制研究” 2016-2018 15萬（主持人）
2. 廣州市珠江科技新星項目 “Anisomycin抑制肝臟腫瘤關鍵靶標分子的鑑定和機制研究” 2015-2017 60萬（主持人）
3. 香港政府醫療衛生基金 “Therapeutic potential of Wolfberry (Lycium barbarum polysaccharides; LBP) in animal models and patients with non-alcoholic fatty liver disease (NAFLD)” 2015-2018 100萬港幣（中方主持人）
4. 國家自然科學基金青年基金 “人臍帶幹細胞誘導的類肝細胞在小鼠肝內的成熟分化機制研究” 2014-2016 20萬（主持人）
5. 暨南大學科研培育與創新基金 “S-烯丙半胱氨酸對肝癌細胞成瘤性的抑制機制研究” 2014-2015 8萬（主持人）
所授課程
本碩博連讀班課程：微生物學與免疫學（理論及實驗課）
碩士研究生課程：免疫學前沿
碩士研究生課程：信號轉導研究方法及技術
社會職務
2013至今：香港大學醫學院榮譽助理教授
2013至今：深圳市第三人民醫院榮譽教授
榮譽與獎勵
2014：廣東省高等學校“千百十工程”校級培養對象
2013：Abnova研究者獎
2007：蒲蟄龍學者科學基金獎
其他簡介
SCI雜誌編委Frontiers in Bioscience (執行主編)SCI雜誌評審人Hepatology; Scientific Reports; European Journal of Nutrition; BMC Complementary and Alternative Medicine; Digestive Diseases and Sciences; Hepatology Research; Histology and Histopathology; Journal of Molecular Histology; HBPD INT中文雜誌中國組織工程研究（編委），醫學研究雜誌
