王敏[天津科技大學生物工程學院教授]

王敏,博士,天津科技大學生物工程學院院長,教授,博士生導師。教育部生物技術與生物工程專業教學指導委員會委員,科技部中青年科技創新領軍人才,教育部新世紀優秀人才,天津市“131”人才計畫第一層次人選,天津市“131“創新型人才團隊負責人。中國發酵工程技術工作委員會委員,天津市微生物學會理事,天津市藥學會理事 。

人物簡介

入選國家科技部2013年中青年科技創新領軍人才計畫。2008年入選教育部新世紀優秀人才計畫、2011年入選天津市131創新型人才培養工程(第一層次)。王敏教授目前擔任教育部生物技術與生物工程類專業指導委員會委員,天津市藥學會、天津市微生物學會理事,《中國糧油學報》編委。

主講課程

本科生:生物製藥工藝學,製藥科技專題講座

研究生:生物製藥技術,發酵工程專題

科研領域及方向

王敏教授科研發展潛力突出,一直致力於具有重要食品與醫藥價值的工業微生物菌種篩選與改良、微生物細胞催化反應與過程調控、傳統發酵食品生產菌種的功能分析與發酵技術研究等。在國家自然科學基金和國家科技支撐計畫子課題的資助下,其科技創新能力和團隊領導能力迅速提升。先後主持國家自然科學基金、科技部科技支撐計畫、國家863計畫、天津市重點科技攻關計畫等10餘項研究課題。在國際專業期刊發表學術論文60餘篇,其中SCI或EI收錄40餘篇,已授權或公開發明專利10餘項。其多項研究成果在企業得到產業化套用,取得顯著的經濟和社會效益,分獲三項天津市科技進步二等獎、兩項天津市科技進步三等獎及天津市計委產學研合作突出貢獻獎等。其發表的學術論文、在重要國際學術會議的大會報告的學術影響力不斷提升,表現出強勁的可持續創新能力。

近5年科研情況

2006-2008 863計畫:甾體類化合物的生物轉化技術

2008-2010國家自然科學基金項目:超分子介質系統中甾體化合物的微生物轉化反應,(20776111)

2008-2010天津市套用基礎及前沿技術研究計畫重點項目:強心苷藥物的微生物轉化與活性篩選,

2008-2011天津市重點科技攻關項目:釀造型果醋高耐性醋酸菌發酵技術的研究與套用(08JCZDJC15200),

2009-2011國家十一五科技支撐計畫子課題:發酵食品生產用功能微生物的改良和發酵技術(2008BAI63B06),

2010-2012教育部新世紀優秀人才計畫項目:疏水化合物生物轉化新型反應體系的構建與基礎研究,(NCET-08-0911)

2011-2015國家自然科學基金項目:環糊精介質對微生物催化反應物質轉運的影響及其調控,(21076158)

2011-2015“甾體類化合物的生物轉化技術—生物法合成去氫膽固醇技術研究”,863子課題(2011AA02A211-06),

2012-2015“果醋飲料發酵技術與開發”,企業合作項目,

2013-2017“大宗食品發酵安全低碳加工關鍵技術研究”,863課題(2013AA102106),

2013-2016“Mycrobacterium neoaurum 生物合成AD的產物遷移機制與調控”,國家自然科學基金項目(21276196),

2014-2016“AD生物合成關鍵酶KsdD的穩定性分析與菌株構建”,教育部科學技術研究重點項目,

2015-2018 “傳統食醋中四甲基吡嗪形成機制及其代謝調控”,國家自然科學基金項目(31471772),

主要學術成果

先後發表各類科研論文70餘篇,其中SCI/EI收錄論文50餘篇,參編教材或專著5部,授權或申請發明專利20餘項。近3年發表的主要學術論文有:

1、Li W J,Fan Z,Diao C H, Wang M.The Binding Behavior of Helical Column Supramolecule Formed by 6-Deoxy-6-(2-pyrimidinethio)-β-cyclodextrin in Both Solution and the Solid State. Carbohydrate Research,2012,349:103-107.

2、Shen Y B, Wang M, Li X D, Zhang J L, Sun H, Luo J M. Highly efficient synthesis of 5-cyanovaleramide by Rhodococcus ruber CGMCC3090 resting cells. Journal of Chemical Technology and Biotechnology. 2012, 87 (DOI 10.1002/jctb.3756)

3、Shen Y B, Wang M, Zhang L T , Ma Y H, Ma B , Zheng Y , Liu H, Luo J M. Effects of hydroxypropyl-β-cyclodextrin on cell growth, activity, and integrity of steroid-transforming Arthrobacter simplex and Mycobacterium sp.. Applied Microbiology and Biotechnology , 2011,90(6):1995-2003

4、Ma B,Shen Y B, Fan Z, Zheng Y, Sun H, Luo J M, Wang M. Characterization of the Inclusion Complex of 16,17α-Epoxyprogesterone with Randomly Methylated β-Cyclodextrin in Aqueous Solution and in the Solid State. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2011,69:273-280

5、He C J ,Sun H, Li P J, Wang M.Crystal structure of 3β,7β,15α-trihydroxy-11-oxo-18β,20β-olean-12-en-30-oic-acid chloroform water(1:1:1), C30H46O6 ·CHCl3·H2O. New Crystal Structures , 2011,226 (2):264~266

6、Liu Y, Lv T, Ren J, WangM, Wu Q Q, Zhu D M. The catalytic promiscuity of a microbial 7α-hydroxysteroidal dehydrogenase. Reduction of non-steroidal carbon-yl compounds. Steroids, 2011,76:1136-1140

7、Shen Y B, Wang M , Liang Q K, Luo J M. 1a,15a-Dihydroxyandrost-4-ene-3,17-dione. Acta Crystallographica Section E ,2011, E67, o2752

8、Chen F, Wang M, Zheng Y, Luo J M, Yang X R, Wang X L. Quantitative changes of plant defense enzymes and phytohormone in biocontrol of cucumber Fusarium wilt by Bacillus subtilis B579. World J Microbiol Biotechnol. 2010,26:675-684

9、Zheng Y, Zhang K P, Wang C X, Liu H X, Luo J M, Wang M. Improving acetic acid production of Acetobacter pasteurianus AC2005 in hawthorn vinegar fermen-tation by using beer for seed culture. International Journal of Food Science and Technology, 2010, 45: 2394–2399

10、He C J, Wang M, Sun H, Liu Z B, Fu Y W. 12beta,14-Dihydroxy-3-oxo-5 beta,20(22)- cardenolide monohydrate[J]. Acta Crystallographica Section E. 2010, 66(11): O2704-U1623

11、Sun H, Liu T,Shen Y J,Zhang L M, Wang M. Preparation and Crystal Structure of 15α-hydroxyl-oleanolic acid . Chinese J Struct Chem. 2010,29(12):1798-1801

12、 Wang M, Zhang L T, Shen Y B, Ma Y H, Zheng Y, Luo J M.Effects of Hydro-xy-propyl-β-cyclodextrin on steroids 1-en-dehydrogenation biotransformation by Arthrobacter simplex TCCC 11037. Journal of Molecular Catalysis B: Enzymatic, 2009, 59: 58-63

13、Ma Y H, Wang M, Fan Z, Shen Y B, Zhang L T. he Influence of host-guest inclusion complex formation on the biotransformation of cortisone acetate Δ1-dehydrogenation. The Journal of Steroid Biochemistry and Molecular Biology, 2009: 117(4-5): 146-151

14、Zhang LT, Wang M, Shen Y B, Ma Y H, Luo J M. Improvement of steroid biotransformation with hydroxypropyl-β-cyclodextrin induced complexation. Applied Biochemistry and Biotechnology, 2009, 159(3):642-654

15、Zhang J L, Wang M, Sun H, Li X D, Zhong L P. Isolation and Characterization of Rhodococcus ruber CGMCC3090 that Hydrolyzes Aliphatic, Aromatic and Heterocyclic Nitriles. African Journal of Biotechnology,2009, 8(20):5467-5486

16、Nie ZQ, Zheng Y, Du HF, Xie SK, Wang M*. Dynamics and diversity of microbial community succession in traditional fermentation of Shanxi aged vinegar[J]. Food Microbiology, 2015,47:62-68.

17、Xie RL, Shen YB, Qin N, Wang YB, Su LQ, Wang M*. Genetic differences in ksdD influence on the ADD/AD ratio of Mycobacterium neoaurum[J]. Journal of Industrial Microbiology and Biotechnology, 2015, 42: 507-513.

18、 Shen YB, Liang JT, Li HN, Wang M*. Hydroxypropyl- β-cyclodextrin-mediated alterations in cell permeability, lipid and protein profiles of steroid-transforming Arthrobacter simplex[J]. Applied Microbiology and Biotechnology, 2015, 99(1): 387-397.

19、 Chen C, Wei D, Shi JP, Wang M*, Hao J*. Mechanism of 2, 3-butanediol stereoisomer formation in Klebsiella pneumoniae[J]. Applied Microbiology and Biotechnology,2014,98(10): 4603-4613.

20、Chen X, Shen YB, Liang QK, Flavell R, Hong ZY, Yin ZN, Wang M*. Effect of Bavachinin and its derivatives on T cell differentiation[J]. International Immunopharmacology, 2014, 19(2): 399 -404.

21、Luo JM, Liang QK, Shen YB, Chen X, Yin ZN, Wang M*. Biotransformation of bavachinin by three fungal cell cultures[J]. Journal of Bioscience and Bioengineering, 2014, 117(2): 191-196.

22、Nie ZQ, Zheng Y, Wang M*, Han Y, Wang YN, Luo JM, Niu DD. Exploring microbial succession and diversity during solid-state fermentation of Tianjin duliu mature vinegar[J]. Bioresource Technology, 2013, 148: 325-333.

23、Luo JM*, Yang J, He HH, Jin T, Zhou L, Wang M, Zhou MH*. A new electrochemically active bacterium phylogenetically related to Tolumonas osonensis and power performance in MFCs[J]. Bioresource Technology, 2013, 139: 141-148.

24、Cheng X, Wen T, Wei J, Wu ZZ, Wang PY, Hong ZY, Liqing Zhao LQ, Bin Wang, Richard Flavell, Shumei Gao, Wang M*, Yin Zhinan. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs[J]. Cellular & Molecular Immunology, 2013, 10, 497–505

25、Wang S W, Dai Y J, Wang J X, Shen Y B, Zhai Y Zheng H, Wang M*. Molecular insights into substrate specificity of Rhodococcus ruber CGMCC3090 by Gene Cloning and Homology Modeling. Enzyme and Microbial Technology. 2013,52:111-117

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