研究興趣
以國家戰略需求產品抗腫瘤藥物為導向，致力於生物化工領域天然產物生物製造的研究。以具有良好抗腫瘤活性的天然產物為目標，採用合成生物學的思路，高效製備具有成藥前景的藥物前體，並深入理解天然產物人工合成的調控機制，為天然產物生物製造提供新思路、新理論和新方法。
學術獎勵
1. 湖北省科技進步一等獎(2014)
2. 教育部自然科學一等獎(2014)
3. 湖北省自然科學二等獎(2011)
4. 上海市自然科學二等獎(2010)
5. 教育部自然科學一等獎(2004)
學術榮譽
1. 全國傑出專業技術人才(2014)
2. “萬人計畫”科技創新領軍人才(2014)
3. “新世紀百千萬人才工程”國家級人選(2009)
學術兼職
1. Associate Editor: Bioprocess and Biosystems Engineering (Springer) (2012-)
2. Advisory Board: Biotechnology Journal (Wiley)(2012-)
3.湖北省食品質量安全抽檢監測專家委員會·副主任委員 (2014-)
發明專利
1.Ya-Jie Tang. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and Use Thereof ( US 8569309B2)
2. Ya-Jie Tang, Wei Zhao. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and Use Thereof II ( US 8796279B2)
3. 湯亞傑 李冬生 孔國平. 一種塊菌多糖的製備方法 ( ZL200610166504.6)
4. 湯亞傑 王冠 劉瑞桑 李冬生. α-雄烷醇的製備及含量檢測方法 ( ZL200810000570.5)
5. 湯亞傑 李冬生 朱麗雯. 促進靈芝次生代謝產物合成的細胞培養方法 ( ZL 200810001055.9)
6. 湯亞傑 張偉 李冬生. 一種促進靈芝酸和靈芝多糖生物合成的靈芝細胞培養方法( ZL200810002772.3)
7. 湯亞傑 徐小玲 李冬生. 4′-去甲基表鬼臼酸的製備和分離方法 ( ZL200810002773.8)
8. 湯亞傑 李艷 李冬生. 將鬼臼毒素轉化為鬼臼酸和鬼臼苦素的方法 ( ZL200810002774.2)
9. 湯亞傑 張偉. 促進靈芝酸和靈芝多糖生物合成的發酵方法( ZL 200810007833.5)
10. 湯亞傑 柳巧寧. 中間補料發酵生產塊菌活性菌絲體和塊菌多糖的方法 ( ZL 200810172343.0)
11. 湯亞傑 李園園. 具抗腫瘤活性的羊毛甾烷型三萜化合物及製備方法和套用( ZL 200810184588.5)
12. 湯亞傑, 趙巍. 4′-去甲基表鬼臼毒素衍生物及其合成方法和套用. ( ZL 201010156798.0)
13.湯亞傑,趙巍.4′-去甲基表鬼臼毒素衍生物及其合成方法和套用.(PCT/2010/CN/8569309)
14. 湯亞傑, 趙巍. 4-(2,3,5,6-四甲基吡嗪-1-基)-4′-去甲表鬼臼毒素的生物轉化及分離純化方法. ( ZL 201010159753.9)
15. 湯亞傑 李園園. 腦苷脂的製備、純化及含量檢測方法 ( ZL 201010268280.6)
16. 湯亞傑 白佳珂. 硫取代鬼臼類衍生物及其合成方法和套用 ( ZL 201110106180.8)
17. 湯亞傑 白佳珂. 硫取代鬼臼類衍生物及其生物轉化和分離純化方法 ( ZL 201110106192.0)
18. 湯亞傑 肖黎. 具有抗腫瘤活性的酯化鬼臼類衍生物及其製備方法和用途( ZL201210374710.1)
19. 湯亞傑 肖黎. 具抗腫瘤活性的氮取代鬼臼類衍生物及其製備方法和用途( ZL 201210374359.6)
20.湯亞傑 陳露 趙巍. 具抗腫瘤活性的醯胺取代鬼臼類衍生物及其製備方法和用途( ZL201310292277.1)
代表性論文
1. Ya-Xuan Zhang, Wei Zhao, Ya-Jie Tang*. Multilevel induction of apoptosis by microtubule-interfering inhibitors 4β- S-aromatic heterocyclic podophyllum derivatives causing multi-fold mitochondrial depolarzation and PKA signaling pathways in HeLa cells. Oncotarget (In press) 2016 (IF=6.359) ( with equal contribution to this work)
2. Jun-Han Yu, Li-Wen Zhu, Shi-Tao Xia, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Combinatorial optimization of CO transport and fixation to improve succinate production by promoter engineering. Biotechnology and Bioengineering (In press) 2016 ( with equal contribution to this work)
3. Kai-Zhi Jia, Quan Zhang, Lin-Yang Sun, Yang-Hua Xu, Hong-Mei Li, Ya-Jie Tang*. Clonostachys rosea demethiolase STR3 controls the conversion of methionine into methanethiol. Scientific Reports 2016, 6:21920 (IF=5.578)
4. Quan Zhang, Kai-Zhi Jia, Shi-Tao Xia, Yang-Hua Xu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Regulating ehrlich and demethiolation pathways for alcohols production by the expression of ubiquitin-protein ligase gene HUWE1. Scientific Reports 2016, 6:20828 ( with equal contribution to this work)
5. Rui-Sang Liu, Guang-Huai Jin, Deng-Rong Xiao, Hong-Mei Li, Feng-Wu Bai*, Ya-Jie Tang*. Screening of the key volatile organic compounds of Tuber melanosporum fermentation by aroma sensory evaluation combination with principle component analysis. Scientific Reports 2015, 5:17954. ( with equal contribution to this work)
6. Li-Wen Zhu, Lei Zhang, Li-Na Wei, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Ling Tang, Xin-Hua Liang, Ya-Jie Tang*. Collaborative regulation of CO transport and fixation during succinate production in Escherichia coli. Scientific Reports 2015, 5:17321 ( with equal contribution to this work)
7. Deng-Rong Xiao, Rui-Sang Liu, Long He, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Aroma improvement by repeated freeze-thawed treatment during Tuber melanosporum fermentation. Scientific Reports 2015, 5:17120 ( with equal contribution to this work)
8. Wei Zhao, Yong Yang, Ya-Xuan Zhang, Hong-Mei Li, and Ya-Jie Tang*. Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells. Scientific Reports 2015, 5:17175 ( with equal contribution to this work)
9. Jian-Long Li, Wei Zhao, Chen Zhou, Ya-Xuan Zhang, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen, Ya-Jie Tang*. Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β- S-aromatic heterocyclic podophyllum derivatives display antitumor activity. Scientific Reports 2015, 5:14814 ( with equal contribution to this work)
10. Wei Zhao, Jia-Ke Bai, Hong-Mei Li, Tao Chen, Ya-Jie Tang*. Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity. Scientific Reports 2015, 5:10172.
11. Ya-Jie Tang *, Rui-Sang Liu, Hong-Mei Li. Current progress on Tuber submerged fermentation: a promising alternative for its fruiting bodies. Applied Microbiology and Biotechnology 2015, 99: 2041-2053. ( with equal contribution to this work)
12. Li Xiao, Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Ya-Jie Tang*. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4′-demethylepipodophyllotoxin derivates with anti-tumor activity by activating ATM/ATR signaling pathways. European Journal of Medicinal Chemistry 2014, 80: 267-277. ( with equal contribution to this work)
13. Wei Zhao, Xiao-Hua Wang, Hong-Mei Li, Shi-Hua Wang, Tao Chen, Zhan-Peng Yuan, Ya-Jie Tang*. Isolation and characterization of polysaccharides with the anti-tumor activity from Tuber fruiting bodies and fermentation system. Applied Microbiology and Biotechnology 2014, 98:1991-2002. ( with equal contribution to this work)
14. Wei Zhao, Lu Chen, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Zhan-Peng Yuan *, Ya-Jie Tang*. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4- O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation. Bioorganic & Medicinal Chemistry 2014, 22:2998-3007. ( with equal contribution to this work)
15. Huai Wang, Li-Jun Tang, Ya-Jie Tang*, Zhan-Peng Yuan*. SAR analysis and biological studies of synthesized podophyllum derivates obtained by N linkage modification at C-4 position. Bioorganic & Medicinal Chemistry 2014, 22: 6183-6192.
16. Wei Zhao, Dan-Dan Chai, Hong-Mei Li, Tao Chen, Ya-Jie Tang*. Significance of metal ion supplementation in the fermentation medium on the structure and anti-tumor activity of Tuber polysaccharides produced by Tuber submerged fermentation. Process Biochemistry 2014, 49: 2030-2038. ( with equal contribution to this work)
17. Dao-Cheng Li, Rui-sang Liu, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Ranking the significance of fermentation condition on the volatile organic compounds of Tuber melanosporum fermentation system by combination of head-space solid phase microextraction and chromatographic fingerprint similarity analysis. Bioprocess and Biosystems Engineering 2014, 37(3):543-552.
18. Li-Wen Zhu, Xiao-Hong Li, Lei Zhang, Hong-Mei Li, Jian-Hua Liu, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli. Metabolic Engineering 2013, 20:9-19. ( with equal contribution to this work)
19. Rui-Sang Liu, Huan Zhou, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen, Ya-Jie Tang*. Metabolism of L-methionine linked to the biosynthesis of volatile organic sulfur-containing compounds during the submerged fermentation of Tuber melanosporum.Applied Microbiology and Biotechnology 2013, 97:9981-9992. ( with equal contribution to this work)
20. Yuan-Yuan Li, Ping Liu, Yang Tang, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Ya-Jie Tang*. Novel cerebrosides isolated from the fermentation mycelia of Tuber indicum. Helvetica Chimica Acta 2013, 96:702-709.
21. Jia-Ke Bai, Wei Zhao, Hong-Mei Li, Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to 4β-sulfur-substituted podophyllum derivates with anti-tumor activity by Penicillium purpurogenum Y.J. Tang. Current Medicinal Chemistry 2012, 19:927-936.
22. Rui-Sang Liu, Dao-Cheng Li, Hong-Mei Li, Ya-Jie Tang*. Evaluation of aroma active compounds in Tuber fruiting bodies by gas chromatography-olfactometry in combination with aroma reconstitution and omission test. Applied Microbiology and Biotechnology 2012, 94:353-363.
23. Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Manipulation of heterogeneity product in 4′-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source. Applied Microbiology and Biotechnology 2012, 93:107-115.
24. Yuan-Yuan Li, Guan Wang, Hong-Mei Li, Jian-Jiang Zhong, Ya-Jie Tang*. Volatile organic compounds from Tuber melanosporum fermentation system. Food Chemistry 2012, 135:2628-2637.
25. Ping Liu, Hong-Mei Li, Ya-Jie Tang*. Comparison of free amino acids and 5’-nucleotides between Tuber fermentation mycelia and natural fruiting bodies. Food Chemistry 2012,132:1413-1419.
26. Yang Tang, Hong-Mei Li, Ya-Jie Tang*. Comparison of sterol composition between Tuber fermentation mycelia and natural fruiting bodies. Food Chemistry 2012,132:1207-1213.
27. Li-Wen Zhu, Cheng-Cheng Wang, Rui-Sang Liu, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Actinobacillus succinogenes ATCC 55618 fermentation medium optimization for the production of succinic acid by response surface methodology. BioMed Research International Volume2012, Article ID626137, 9 pages doi:10.1155/2012/626137.
28. Wei Zhao, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Duan-Ji Wan, Ya-Jie Tang*. Optimization of a biotransformation process to produce 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin. Process Biochemistry 2012, 47:1522-1531.
29. Ya-Jie Tang *, Guan Wang, Yuan-Yuan Li, Hong-Mei Li, Yang Tang, Ping Liu. Quantitative determination for the major volatile organic compounds of Tuber melanosporum fermentation system by distillation-solid phase extraction-gas chromatography. Food Analytical Methods 2012,5:651-658.
30. Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Lycopene production from synthetic medium by Blakeslea trispora NRRL 2895 (+) and 2896 (-) in a stirred-tank fermenter. Bioprocess and Biosystems Engineering 2012, 35:729-749.
31. Jin-Feng Wang, Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li, Ya-Jie Tang*. Optimization of the mated fermentation process for the production of lycopene by Blakeslea trispora NRRL 2895 (+) and NRRL 2896 (-). Bioprocess and Biosystems Engineering 2012, 35:553-564.
32. Cheng-Cheng Wang, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Performance analyses of a neutralizing agent combination strategy for the production of succinic acid by Actinobacillus succinogenes ATCC 55618. Bioprocess and Biosystems Engineering 2012, 35:659-664.
33. Ping Liu, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Determination of the nucleosides and nucleobases in Tuber samples by dispersive solid-phase extraction combined with liquid chromatography–mass spectrometry. Analytica Chimica Acta 2011, 687:159-167.
34. Ya-Jie Tang*, Wei Zhao, Hong-Mei Li. Novel tandem biotransformation process for the biosynthesis of a novel compound 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin. Applied and Environmental Microbiology 2011, 77:3023-3034.
35. Wei Zou, Li-Wen Zhu, Hong-Mei Li, Ya-Jie Tang*. Significance of CO donor on the production of succinic acid by Actinobacillus succinogenes ATCC 55618. Microbial Cell Factories 2011, 10:87.
36. Yang Tang, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang*. Comparison of lipid content and fatty acid composition between Tuber fermentation mycelia and natural fruiting-bodies. Journal of Agricultural and Food Chemistry 2011, 59:4736-4742.
37. Ya-Jie Tang*, Wei Zhang, Rui-Sang Liu, Li-Wen Zhu, Jian-Jiang Zhong. Scale-up study on the fed-batch fermentation of the medicinal mushroom Ganoderma lucidum for the hyperproduction of ganoderic acid and Ganoderma polysaccharides in stirred-tank bioreactor .Process Biochemistry 2011, 46: 404-408.
38. Rui-Sang Liu, Ya-Jie Tang*. Tuber melanosporum fermentation medium optimization by Plackett-Burman design coupled with Draper-Lin small composite design and desirability function. Bioresource Technology 2010, 101:3139-3146.
39. Rui-Sang Liu, Ya-Jie Tang*. Quantitative analysis for the effect of plant oil and fatty acid on Tuber melanosporum culture by uniform design combined with partial least squares regression. Applied Microbiology and Biotechnology 2010, 87: 1689-1697.
40. Li-Wen Zhu, Jian-Jiang Zhong, Ya-Jie Tang*. Multi-fed batch culture integrated with three-stage light irradiation and multiple additions of copper ions for the hyperproduction of ganoderic acid and Ganoderma polysaccharides by the medicinal mushroom Ganoderma lucidum. Process Biochemistry 2010, 45:1904-1911.
41. Ya-Jie Tang *, Li-Wen Zhu. Improvement of ganoderic acid and Ganoderma polysaccharide biosynthesis by Ganoderma lucidum fermentation under the inducement of Cu. Biotechnology Progress 2010, 26:417-423.
42. Li-Wen Zhu, Ya-Jie Tang*. Significance of protein elicitor isolated from Tuber melanosporum on the production of ganoderic acid and Ganoderma polysaccharides by Ganoderma lucidum.Bioprocess and Biosystems Engineering 2010, 33: 999-1005.
43. Ya-Jie Tang*, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4´-demethylepipodophyllotoxin to 4´-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463, Part II: Process Optimization. Bioprocess and Biosystems Engineering 2010, 33:237-246.
44. Qiao-Ning Liu, Rui-Sang Liu, Yi-Hua Wang, Zhi-Yuan Mi, Dong-Sheng Li, Jian-Jiang Zhong, Ya-Jie Tang*. Fed-batch fermentation of Tuber melanosporum for the hyperproduction of mycelia and bioactive Tuber polysaccharides. Bioresource Technology 2009, 100:3644-3649.
45. Yan Li, Yuan-Yuan Li, Zhi-Yuan Mi, Dong-Sheng Li, Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, Part II: Process Optimization. Bioresource Technology 2009, 100:2271-2277.
46. Ya-Jie Tang *, Wei Zhang, Jian-Jiang Zhong. Performance analyses of a pH-shift and DO-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum. Bioresource Technology 2009, 100:1852-1859.
47. Ya-Jie Tang *, Guan Wang, Yuan-Yuan Li, Jian-Jiang Zhong. Fermentation condition outweighed truffle species in affecting volatile organic compounds analyzed by chromatographic fingerprint system. Analytica Chimica Acta 2009, 647: 40-45.
48. Ya-Jie Tang *, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4´-demethylepipodophyllotoxin to 4´-demethylepipodophyllic acid by Bacillus fusiformis CICC 20463. Process Biochemistry 2009, 44:572-577.
49. Ya-Jie Tang *, Yan Li, Jian-Jiang Zhong. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, Part I: Process Development. Bioprocess and Biosystems Engineering 2009, 32:663-671.
50. Ya-Jie Tang *, Hong-Mei Li, Jean-François P. Hamel. Significance of pH and temperature on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors. Bioprocess and Biosystems Engineering 2009, 32:267-276.
51. Ya-Jie Tang *, Hong-Mei Li, Jean-François P. Hamel. Effect of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors. Bioprocess and Biosystems Engineering 2009, 32:475-484.
52. Yuan-Yuan Li, Zhi-Yuan Mi, Yang Tang, Guan Wang, Dong-Sheng Li, Ya-Jie Tang*. Lanostanoids isolated from Ganoderma lucidum mycelium cultured by submerged fermentation. Helvetica Chimica Acta 2009, 92:1586-1593.
53. Ya-Jie Tang *, Ling-Li Zhu, Rui-Sang Liu, Hong-Mei Li, Dong-Sheng Li, Zhi-Yuan Mi. Quantitative response of cell growth and Tuber polysaccharides biosynthesis by medicinal mushroom Chinese truffle Tuber sinense to metal ion in culture medium. Bioresource Technology 2008, 99:7606-7615.
54. Guan Wang, Yuan-Yuan Li, Dong-Sheng Li, Ya-Jie Tang*. Determination of 5α-androst-16-en-3α-ol in truffle fermentation broth by solid-phase extraction coupled with gas chromatography-flame ionization detector/electron impact mass spectrometry. Journal of Chromatography B 2008, 870:209-215. ( with equal contribution to this work)
55. Li-Wen Zhu, Jian-Jiang Zhong, Ya-Jie Tang*. Significance of fungal elicitors on the production of Ganoderma polysaccharides and ganoderic acid by submerged fermentation of medicinal mushroom Ganoderma lucidum. Process Biochemistry 2008, 43:1359-1370.
56. Rui-Sang Liu, Dong-Sheng Li, Hong-Mei Li, Ya-Jie Tang*. Response surface modeling the significance of nitrogen source on the cell growth and Tuber polysaccharides production by submerged cultivation of Chinese truffle Tuber sinense. Process Biochemistry 2008, 43:868-876.
57. Ya-Jie Tang *, Ling-Li Zhu, Dong-Sheng Li, Zhi-Yuan Mi, Hong-Mei Li. Significance of inoculation density and carbon source on the mycelial growth and Tuber polysaccharides production by submerged fermentation of Chinese truffle Tuber sinense. Process Biochemistry 2008, 43:576-586.
58. Wei Zhang, Ya-Jie Tang*. A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides. Biotechnology Progress 2008, 24:1249-1261.
59. Ya-Jie Tang *, Li-Wen Zhu, Hong-Mei Li, Dong-Sheng Li. Submerged culture of mushroom in bioreactors - challenges, current state-of-the-art, and future prospects. Food Technology and Biotechnology 2007, 45(3):221-229. (Invited Review)
60. Ya-Jie Tang *, Hong-Mei Li, Jean-Francois P. Hamel. Suspension culture process of MethA tumor cell for the production of heat-shock protein glycoprotein 96: process optimization in spinner flasks. Biotechnology Progress2007, 23 (6):1363-1377.
61. Ya-Jie Tang *, Ryo Ohashi, Jean-Francois P. Hamel. Perfusion culture of hybridoma cell for hyperproduction of IgG monoclonal antibody in a wave bioreactor-perfusion culture system. Biotechnology Progress 2007, 23:255-264.
62. Ya-Jie Tang, Jian-Jiang Zhong*. Modeling the kinetics of cell growth and ganoderic acid production in liquid static cultures of medicinal mushroom Ganoderma lucidum. Biochemical Engineering Journal 2004, 21:259-264.
63. Ya-Jie Tang, Jian-Jiang Zhong*. Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid. Enzyme and Microbial Technology 2003, 34: 478-484.
64. Ya-Jie Tang, Jian-Jiang Zhong*. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnology Progress 2003, 19:1842-1846.
65. Ya-Jie Tang, Jian-Jiang Zhong*. Exopolysaccharide biosynthesis and related enzyme activities of the medicinal fungus, Ganoderma lucidum, grown on lactose in a bioreactor. Biotechnology Letters 2002, 24: 1023-1026 .
66. Ya-Jie Tang, Jian-Jiang Zhong*. Fed-batch fermentation of Ganoderma lucidum for hyperproduction of polysaccharide and ganoderic acid. Enzyme and Microbial Technology 2002, 31: 20-28.
