樓宜嘉

樓宜嘉,女,博士,教授。在浙江大學 藥理毒理與生化藥學研究所工作。

基本信息

工作簡歷

2006年起:教授,博士生導師。浙江大學藥學院藥理毒理與生化藥學研究所所長;浙江大學藥學院心腦血管與肝臟藥理研究室主任;浙江大學浙江加州國際納米技術研究院兼職教授。浙江省重點學科藥理學科帶頭人之一;浙江省中藥藥理重點學科帶頭人;浙江省中藥藥理與毒理學重點實驗室主任。與美國加州大學洛杉磯分校醫學院分子與醫學藥理系建立幹細胞生物學合作研究關係,並聯合培養博士研究生2名。
1998年-2005年:教授,博士生導師。浙江大學藥學院副院長,藥理與毒理研究室主任,浙江省重點學科藥理學科帶頭人之一。
1978年-1998年:浙江醫科大學藥學院(系)助教、講師、副教授,碩士生導師。獲“全國優秀教師”獎章,遴選為浙江省“151人才工程”一層次培養人員。
國內外研究經歷
2006年:獲德意志研究聯合會(DFG)基金,赴德國杜塞道夫大學藥物與生物技術研究所高訪,合作研究天然小分子化合物,幹細胞生物學;同時受德國基爾大學特邀講學。
2003年:獲德意志研究聯合會(DFG)基金,赴德國杜塞道夫大學藥物與生物技術研究所高訪,合作研究天然小分子化合物,幹細胞生物學3個月。
2002年:獲浙江省政府“151人才工程”出國基金,赴德國杜塞道夫大學藥物與生物技術研究所高訪,研究天然小分子化合物,幹細胞生物學3個月。
1997-1998:獲包玉剛中國留學生獎學金,赴德國杜塞道夫大學醫學院生物化學研究所訪問研究,主攻膜蛋白組學/酶學、信號分子及轉導通路。
1991-1994:中科院上海藥物研究所博士研究生,獲博士學位,主攻發育生物學/藥物毒理學。
1988-1989:赴義大利米蘭大學生物系研修,主攻發育生物學/藥物毒理學。

學術研究

學術兼職

中國毒理學會理事,中國藥學會套用藥理專業委員會委員,中國毒理學會生殖毒理專業委員會副主任委員,中國藥理學會藥物毒理專業委員會委員。浙江省藥學會藥理專業委員會主任委員,浙江省藥理學會副理事長,浙江省藥學會醫院藥學專業委員會委員。
《Acta Pharcologica Sinica》(SCI收錄)5,6,7屆編委,《European Journal Pharmacology》(SCI收錄)特邀註冊審稿人,《Toxicology》(SCI收錄)特邀註冊審稿人,《中國藥理學與毒理學雜誌》編委,《浙江大學學報(醫學版)》編委。

研究方向

幹細胞生物學與再生醫學/藥物發現;
心腦血管與肝臟藥理機制及新藥研究;
基於系統生物學的藥物毒理學研究。

承擔課題

2009-2011:國家自然科學基金重大研究計畫《基於誘導ES細胞定向分化的化合物庫構建和信號轉導分子事件發現》(№ 90813026,基於化學小分子探針的信號轉導過程研究專項-培育項目,合作負責人)
2007-2009:國家自然科學基金課題《ES細胞衍生肝組織系統微粒體GST表達譜及其藥物調控特徵》(№ 30672564,項目負責人);
2007-2009:浙江省“十一五”重點項目中藥現代化專項《抗老年痴呆五類中藥新藥研發》(№2006C13075,項目總負責人);
2005-2007:國家自然科學基金課題《肝膜蛋白mGST介導白三烯旁分泌/自分泌環路及其藥物調控》(№30472112,項目負責人);
2005-2006:“十五”國家科技攻關計畫重點項目《中醫藥療效及安全性基本問題研究》項目,參加“含馬兜鈴酸藥材中成藥安全性評價示範研究”機制研究內容;
2004-2006:商務部援印度尼西亞天然藥物植物研究與開發項目《護肝活性成分和抗糖尿病活性成分篩選與新藥研發》(契約號:(2004)援外成字第020號,分項目負責人);
2003-2006:國家自然科學基金中德科學基金課題《中國蔬菜中黃酮和相關多酚防治疾病活性成分研究》 [NSFC-DFG基金 №GZ051-3(147),項目負責人];
2003-2004:教育部科學技術研究重點項目《幹細胞定向分化心肌細胞藥效篩選模型套用研究》(№03088,項目負責人);
2003-2004:浙江省重點科研計畫國際合作項目《胚胎幹細胞定向分化心肌細胞模型在中藥活性成分評價中的套用研究》(№2003C24005,項目負責人);
2002-2004:國家自然科學基金課題《藥物介導胚胎幹細胞體外定向分化的干預效應研究》(№30171121,項目負責人);
2002-2004:“十五”國家攻關計畫引導項目《花粉中抑制前列腺腫瘤增生的有效成分分離及新藥開發》(任務書編號:2002BA760C,第一參加單位項目負責人);
2001-2003:國家自然科學基金課題《微粒體GST修飾激活及其對外源性物質轉化的相關性》(№30070904,項目負責人);
1999-2001:《微粒體膜GST生物學特性與腫瘤化療藥物抗性的相關性研究》(教育部留學回國人員基金,教外司留[1998]679號);
1995-1997:國家自然科學基金課題《藥源性哺乳動物著床前胚泡異常對胎仔發育影響機制研究》(№39470836,項目負責人);
1992-1994:國家自然科學基金課題《藥源性哺乳動物著床前胚泡異常對胎仔發育影響研究》(№39170875,項目負責人);

發表論文

1.WO Yan-Bo, ZHU Dan-Yan, HU Ying, WANG Zhi Qiang, LIU Jian, LOU Yi-Jia*: Reactive oxygen species involved in prenylflavonoids icariin, icaritin initiated cardiomyocytes differentiation of mouse embryonic stem cells. Journal of Cellular Biochemistry 2008;103(5):1536-1550.
2.Yandong Zhang, Zhe Chen, Yijia Lou*, YongpingYu*: 2,3-Disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines: a novel class of antitumor agents. European Journal of Medicinal Chemistry 2008;(in press, doi:10.1016/j.ejmech.2008.01.009).
3.Ming Zheng, Linhai Qu, Yijia Lou*: Effects of icariin combined with the Panax notoginseng saponins on ischemia reperfusion-induced cognitive impairments related with oxidative stress and CA1 of hippocampal neurons in rat.
Phytotherapy Research 2008;22(5):597-604.
4.Danyan Zhu, Yue Du, Xin Huang, Meiyuan Guo,kuifen Ma, Yongping Yu, Yijia Lou*:MAPEG Expression in Murine Embryonic Stem Cell-Derived Hepatic Tissue System. Stem cells and Development 2008;17(4):775-84.
5.Ling Ding, Xingguang Liang, Ying Hu, Danyan Zhu, Yijia Lou*: Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro. Stem cells and Development 2008;(in press, doi:10.1089/scd.2007.0206).
6.Yanbo Wo, Danyan Zhu, Yongping Yu, Yijia Lou*: Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells. Eur J Pharmacol. 2008;31;586(1-3):59-66.
7.Kuifen Ma, Ziqi Ye, Zhe Chen, Luoyang Qi, Danyan Zhu, and Yijia Lou*
Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/ lipopolysaccharide induced rat fulminant hepatic failure model. World J Gastroenterology 2008;14(7):2748-2756.
8.Ling Ding, Xingguang Liang, Danyan Zhu, Yijia Lou* Icariin promoted expression of PGC-1α, PPARα, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro. Acta Pharmacologica Sinica 2007;28(10):1541-1549.
9.Ding Ling; Liang Xingguang, Zhu Danyan, Lou Yijia*: Peroxisome proliferator-activated receptor α is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. Cell Biology International 2007; 31:1002-1009.
10.Qing-wei Zhao, Xin Huang, Yij-ia Lou*, Weber Nadine, Peter Proksch: Effects of Ethanol Extracts from Adzuki Bean (Phaseolus angularis Wight.) and Lima Bean (Phaseolus lunatus L.) on Estrogen and Progesterone Receptor Phenotypes of MCF-7 /BOS Cells. Phytotherapy Research 2007; 21:648-652.
11.Jiang Guo-Jun, Li Tie-jun, Qiu Yan, Chen Wan-Sheng, Lou Yi-Jia*: RNA interference for HIF-1α inhibits foam cells formation in vitro. Eur J Pharmacol. 2007;562(3):183-190.
12.Xin Huang, Danyan Zhu, Yijia Lou*: A Novel Anticancer Agent, Icaritin, Induced Cell Growth Inhibition, G1 Arrest and Mitochondrial Transmembrane Potential Drop in Human Prostate Carcinoma PC-3 Cells. Eur J Pharmacol. 2007;564:26-36.
13.Ling DING, Xing-guang LIANG, Yi-jia LOU*: Time-dependence of cardiomyocyte differentiation disturbed by peroxisome proliferator-activated receptor α inhibitor GW6471 in murine embryonic stem cells in vitro. Acta Pharmacologica Sinica 2007;28(5):634-42.
14.Yao-Dong WU, Yi-Jia LOU*:A Steroid Fraction of Chloroform Extract from Bee Pollen of Brassica Campestris L. Induces Cell Cycle Arrest and Apoptosis in Human Prostate Cancer PC-3 Cells. Phytotherapy Research 2007;21(11):1087-1091.
15.Shulong Yang, Li-jun Chen, Yin Kong, Dan Xu, Yijia Lou*: Sodium nitroprusside regulated the mRNA expression of LTC4 synthase in hepatic I/R injury rats via NF-kB signaling pathway. Pharmacology 2007; May,80(1):11-20.
16.Shulong Yang, Xin Huang, Hai-Fei Chen, Dan Xu, Li-Jun Chen, Yin Kong,
Yijia Lou*: Increased Leukotriene C4 Synthesis Accompanied Enhanced Leukotriene C4 Synthase Expression and Activities of Ischemia-Reperfusion Injured Liver in Rats.
Journal of Surgical Research 2007; 140(1):36-44.
17.朱丹雁*,樓宜嘉:淫羊藿苷誘導小鼠胚胎幹細胞體外定向分化為心肌細胞方法學研究 中國藥學雜誌 2007;42(9):29-33.
18.W. Wätjen*, N. Weber, Y.-J. Lou, Z.-q. Wang, Y. Chovolou, A. Kampkötter, R. Kahl, P. Proksch: Prenylation enhances cytotoxicity of apigenin and liquiritigenen in rat H4IIE hepatoma and C6 glioma cells. Food and Chemical Toxicology 2007;45(1):119-24.
19.史 強,樓宜嘉*:活性氮對肝臟微粒體GST1修飾激活的研究進展. 中國藥理學與毒理學雜誌 2007;21(4):297-300.
20.Yao-Dong WU, Yi-Jia LOU*: Brassinolide, a plant sterol from pollen of Brassica napus L., induces apoptosis in human prostate cancer PC-3 cells. PHARMAZIE 2007;62(5):392-5.
21.Zhiqiang Wang, Xiangnan Zhang, Luoyang Qi, Huanhuan Wang, Yijia Lou*: Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway. Neuroscience. 2007; 145:911-922.
22.Hao-shu Wu, Ying-yin Li, Lin-jia Weng, Chang-xin Zhou, Qiao-jun He, Yi-jia Lou*: Ethyl acetate fraction of Acrous Calamus L. extract enhance adipocyte differentiation in 3T3-L1 cells. Phytotherapy Research 2007;21(6):562-564.
23.Shulong Yang, Yijia Lou*: Sodium Nitroprusside Decreased Leukotriene C4 Generation by Inhibiting Leukotriene C4 Synthase Expression and Activity in Hepatic Ischemia-Reperfusion Injured Rats. Biochemical Pharmacology 2007;73:724–735.
24.樓宜嘉*,陳 哲:細胞組學與藥理毒理學研究新機遇 浙江大學學報(醫學版)2007;36(3):209-216.
25.朱丹雁,張翔南,杜悅,陳燕,王志強,樓宜嘉:淫羊藿素誘導小鼠胚胎幹細胞體外定向分化為神經細胞 浙江大學學報(醫學版)2007;36(3):217-223.
26.張翔南,王歡歡,王志強,吳佳瑩,朱丹雁,樓宜嘉*:淫羊藿素抗Aβ肽致大鼠原代培養神經細胞凋亡作用 浙江大學學報(醫學版)2007;36(3):224-228.
27.郭美媛,朱丹雁,杜悅,樓宜嘉*:微粒體Ⅱ相代謝酶基因在小鼠胚胎幹細胞定向分化肝細胞中的表達 浙江大學學報(醫學版)2007;36(3):229-235.
28.馬葵芬,張相宜,齊羅揚,王燕,周長新,NINA Artanti,NOVIK Nurhidayat,LINCE Yarni,樓宜嘉*:三萜類化合物對化學損傷原代培養大鼠肝細胞的保護作用 浙江大學學報(醫學版)2007;36(3):247-254.
29.齊羅揚 馬葵芬 來芳芳杜 悅 朱丹雁 樓宜嘉*:刀豆蛋白A致小鼠肝損傷的白三烯C4合成酶系基因表達及環孢素A調控作用 浙江大學學報(醫學版)2007;36(3):241-246.
30.陳 哲,葉子奇,史強,朱丹雁,樓宜嘉*:大鼠微粒體谷胱甘肽S-轉移酶1對苯丁酸氮芥體外致腫瘤細胞毒性的影響 浙江大學學報(醫學版)2007;36(3): 236-240.
31.Jie Zhang, Yijia Lou, Jos Hoogmartens, Ann Van Schepdael: Screening of drug metabolism by CE. Electrophoresis 2006;27(23):4827-35.
32.Meihua Bao, Yijia Lou*: Isorhamnetin prevent endothelial cell (EA.hy926) injuries from oxidized LDL via activation of p38MAPK.
European J Pharmacology 2006;547(1-3):22-30;
33.Qiang shi, Haifei Chen, Yijia Lou*: Further evidence that rat liver microsomal glutathione transferase 1 is not a cellular protein target for S-nitrosylantion. Chemico-Biological Interactions 2006;162:228-236.
34.Meihua Bao, Yijia Lou*: Flavonoids from Seabuckthorn protect endothelial cells (EA.hy926) from oxidized low-density lipoprotein induced injuries via regulation of LOX-1 and eNOS expression. Journal of Cardiovascular Pharmacology 2006;48(1):834-841.
35.何旭東,吳洪海,樓宜嘉*:阿伐他汀伍用大豆異黃酮對實驗性高血脂動物的調血脂作用及相關機制研究. 中國藥理學與毒理學雜誌 2006;20(5):381-386.
36.沃燕波,朱丹雁,張翔南,樓宜嘉*:光電成像系統在評價胚胎幹細胞體外定向分化為心肌細胞中的套用 中國藥理學與毒理學雜誌 2006;20(6):504-509.
37.肖幸豐,王志強,樓宜嘉*:淫羊藿苷伍用三七總皂苷對小鼠免疫功能的調節作用.
中草藥 2006;37(6):233-236.
38.Zhiqiang Wang, Nadine Weber, Yijia Lou*, Peter Proksch: Prenylflavonoids as Non-Steroidal Phytoestrogen and Related Structure-activity Relationships. ChemMedChem 2006;1(4):482-488.
39.Danyan Zhu, Yijia Lou*: Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacologica Sinica 2006;27(3):311-20.
40.Zhang J, Ha PT, Lou Y, Hoogmartens J, Van Schepdael A*: Kinetic study of cytochrome P450 3A4 activity on warfarin by capillary electrophoresis with fluorescence detection. J Chromatogr A. 2005;1082(2):235-9.
41.Jie Zhang, Pham Thi Thanh Ha, Yijia Lou, Jos Hoogmartens, Ann Van Schepdael*: Kinetic study of CYP3A4 activity on verapamil by capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis 2005;39:612–617.
42.Qing-wei Zhao, Bo Li, Nading Weber, Yi-jia Lou*, Prter Proksch: Estrogen-like effects of ethanol extracts from several Chinese legumes on MCF-7 cell. European Food Research and Technology 2005;221(6):828-833.
43.Haiyun Ling, Yijia Lou*: Total flavones from Elsholtzia blanda reduce infarct size during acute myocardial ischemia by inhibiting myocardial apoptosis in rats.
J Ethnopharmacology 2005;101:169-175.
44.Danyan Zhu, Linhai Qu, Xiangnan Zhang, Yijia Lou*: Icariin-madiated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells. Eur J Pharmacol. 2005; 514:99-110.
45.Haiyun Ling, Yijia Lou*, Honghai Wu, Honggang Lou: Total flavones from Elsholtzia blanda reduce infarct size and improve heart function during acute myocardial infarction by inhibiting myocardial apoptosis in canines Acta Cardiologica 2005; 60(3):295-301.
46.Haiyong Ye, Yijia Lou*: Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells Phytomedicine 2005;12:735-741.
47.Jie Zhang, Zhiwei Ye, Yijia Lou*: Metabolism of malphalan by rat liver microsomal glutathione S-transferase. Chemico-Biological Interactions 2005;152:101-106;
48.葉海涌,樓宜嘉*:淫羊藿苷衍生物的製備及其雌激素樣作用研究 浙江大學學報(醫學版) 2005;34(2)131-136.
49.Danyan Zhu, Yijia Lou*: Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro Acta Pharmacologica Sinica 2005;26(4):477-485.
50.Qiang Shi, Yijia Lou*: Microsomal glutathione Transferase 1 is not
S-nitrosylated in rat liver microsomes or in endotoxin challenged rats. Pharmacological Research 2005;51(4):303-310.
51.Jian Liu, Haiyong Ye, Yijia Lou*: Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells. Die Pharmazie 2005;60(2):120-125.
52.Zhiqiang Wang, Yijia Lou*: Proliferation-stimulating effects of icaritin and
desmethylicaritin in MCF-7 cells Eur J Pharmacol. 2004; 504:147-153.
53.Jian Liu, Yi-jia Lou*: Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin. J Pharmaceutical and Biomedical Analysis 2004; 36:365-370.
54.Jie Zhang, Zhiwei Ye, Yijia Lou*: Metabolism of chlorambucil by rat liver microsomal glutathione S-transferase. Chemico-Biological Interactions 2004; 149:61-67;
55.Ling Haiyun, Lou Yijia*, Lou Honggang, Wu Honghai: Protective effect of total flavones from Elsholtzia blanda (TFEB) on myocardial ischemia induced by coronary occlusion in canines. J Ethnopharmacology 2004;94(1);101-107.
56.Qinzhu Zheng, Yijia Lou: Pathologic characteristics of immunologic injury in primary cultured rat hepatocytes and hepatoprotection of Glycyrrhizin from cytotoxicity in vitro. Acta Pharmacologica Sinica 2003;24(8):771-777.
57.Jie Zhang, Yi-Jia Lou: Relationship between activation of microsomal glutathione S-transferase and metabolism behavior of chlorambucil. Pharmacological Research 2003;48:623-630.

主編著作

1.全國高等醫藥規劃教材《藥物毒理學》,人民衛生出版社,2003,第一版;2007年,第二版(“十一五”國家重點建設高等教育規劃教材)。
2.全國高等醫藥教育規劃教材《新藥臨床前評價教程》(藥理與毒理學評價過程),浙江大學出版社,2007(面向21世紀精品課程教材,套用型本科規劃教材)。
參編著作:
1.周宏灝主編:臨床醫學專業衛生部規劃教材·英文版《Pharmacology》,人民衛生出版社,2007;第一版。承擔二個章節編寫。
2.潘家祜,李學軍主編:研究生規劃教材《生化與分子藥理學》,復旦大學出版社,2008(“十一五”國家重點建設高等教育規劃教材),
承擔:第六章 微粒體藥理學;第十六章 生化與分子藥理學的關鍵技術,第三節 幹細胞研究技術。
國際與全國會議:
1. Xiangnan Zhang, Jiaying Wu, Huanhuan Wang, Gerald Rimbach, Yijia Lou 1*: Asiatic acid attenuated Ceramide induced Neurotoxicity and Caspase 3 activation in Primary cultured rat Neuronal Cells. Nutrition Genomics Organization. SEP, 2008, Potsdam,
德國.
2.Lily Ou, Yijia Lou, Yongping YU*: Design, synthesis and effects on directional differentiation of embryonic stem cells of Icaritin Derivatives. SINO-French Workshop on Bioorgannic and Medicinal Chemistry. OCT. 2007; P84. Hangzhou, China.
3.Yandong Zhang, Zhe Chen, Jieping Yan, Ziqi Ye, Yongping Yu*, Yijia Lou*:Solid-phase Synthesis and Biological Evaluation of Quinazoline Derivatives. SINO-French Workshop on Bioorgannic and Medicinal Chemistry. OCT. 2007;;P75. Hangzhou, China.
4.Zhiqiang Wang, Jiaying Wu, Minhua Xu, Yijia Lou*:Prenylflavonoids as Nonsterodal Phytoestrogens and Relataed Struture-Activity Relationship第三屆國際分子模擬與信息技術套用學術會議 MAR. 2007. Hangzhou, China.
5.YIjia Lou, Stem cell biology and drug discovery 1st Asian-Link Workshop for Marine Natural Products and Medicinal Plants AGU. 2007. Beijing China. 20-27.
6.第三屆全國幹細胞移植在心血管疾病套用研討會,大會特邀專題報告《幹細胞生物學與藥物研究》2007年11月,杭州。
7. Yijia Lou*, Yaodong Wu: Antitumor and immunomodulatory activities of polysaccharide-protein complex from bee pollen of Brassica campestris L. ONCOLOGY RESEARCH (Meeting Abstract) 2006;15(10-12):484.
8.Xin Huang, Zhiqiang Wang, Danyan Zhu, Yijia Lou*: Cytotoxic effects of icariin and isobavachin on pc-3 cell lines. The International Congress of Asian Society of Toxicology. JUN. 2006; Zhuhai, China.
9. Zhe Chen, Luoyang Qi, Danyan Zhu, Yijia Lou*: Relationship between activation of microsomal glutathione S-transferase and development of drug resistance on PC-3, K-562 and HepG2 cell lines. The International Congress of Asian Society of Toxicology. JUN. 2006; Zhuhai, China.
10. Haifei Chen, Yijia Lou*: Activation of microsomal glutathione S-transferase 1 by acetaminophen overdose is associated with protein dimmer formation in rat primarily cultured hepatocytes. The International Congress of Asian Society of Toxicology. JUN. 2006; Zhuhai, China.
11. Qiang Shi, Yijia Lou*: Activation of microsomal glutathione S-transferase 1 by acetaminophen overdose is associated with protein dimmer formation but not metabolite adduction. The International Congress of Asian Society of Toxicology. JUN. 2006; Zhuhai, China.
12. N. Weber , W. Wätjen, R. Edrada ,V. Wray, Y. Lou, Z.-q. Wang and P. Proksch: Flavonoids from Vigna angularis – composition and antioxidative effects The congress of the 54th Annual Meeting of the Society for Medicinal Plant. 2006; Helsinki. Finland.
13. Ling Ding, Xinguang Liang, Danyan Zhu, Yijia Lou*: .Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. The 5th Asian-Pacific Organization for Cell Biolog Congress. OCT. 2006. Beijing, China.
14. Kui-fen Ma, Luo-yang Qi, Dan-yan Zhu, Lin-hai Qu, Yi-jia Lou*: Cysteinyl Leukotrienes Autocrine Loop Associated with Microsomal Glutatione S-transferase-Ⅱ in Rat Hepatocytes. XI‘AN SATELLITE MEETING OF THE 15th WORLD CONGRESS OF PHARMACOLOGY,2006,Xi’an, China. 111-112.
15. Zhe Chen, Danyan Zhu, Yijia Lou*: Cytotoxic effects of chlorambucil on PC-3, K562, HepG2, and P388D1 cell lines affected by rat microsomal glutathione S-transferase 1. The Second Asia-Pasific Forum on Andrology, 2006. Shanghai,China.
16. Xin Huang, Zhiqiang Wang, Danyan Zhu, Yijia Lou*: Anti-carcinoma activities of icariin, icaritin and isobavachin on PC-3 cell lines. The Second Asia-Pasific Forum on Andrology, 2006. Shanghai,China.
17.羊紅玉,劉璐璐,朱丹雁,樓宜嘉*:Beagle 犬單次口服青木香或冠心蘇合膠囊馬兜鈴酸I毒代動力學研究。中國毒理學會第二屆中青年學者科技論壇。2007年10月:36
18.葉子奇,陳海飛,陳哲,朱丹雁,樓宜嘉*:過量對乙醯氨基酚致大鼠原代培養肝細胞與人肝癌細胞HepG2 mGST1修飾激活機制研究。中國毒理學會第二屆中青年學者科技論壇。2007年10月:117

發明專利

1.《淫羊藿苷在誘導胚胎幹細胞體外定向分化方面的用途》
授權公告日:2004年9月1日,專利號:ZL 02 1 60367.7;
2.《淫羊藿素或去甲淫羊藿素在製備雌激素受體調節劑中的套用》
授權公告日:2005年3月30日,專利號:ZL 03 1 29242.9;
3.《雞肝散提取物總黃酮在製備抗心血管疾病藥中的套用》
授權公告日:2006年2月15日,專利號:ZL 02 1 33759.4;
4.《含辛伐他汀、泛硫乙胺和黃酮類的組合物及其用途》
專利號:ZL 02 1 33759.4;
5.《雞肝散提取物總黃酮在製備抗眼科疾病藥中的套用》
公開號:CN1757402,公開日:2006.04.12;
6.《一種水菖蒲有效部位提取物及其用途》
公開號:CN1973877, 公開日:2007年6月6日;
7.《淫羊藿總黃酮與三七總皂苷組合物的套用》(調節代謝型谷氨酸受體自身受體作用)公開號: CN101229210, 公開日:2008.07.30;
8.《8-芳胺基-3H-咪唑[4,5-g]喹唑啉類衍生物的用途》(在製備抗腫瘤藥物中套用)公開號:CN101120945,公開日:2008.02.13;
9.《 喹唑啉咪唑化合物的用途》(組合化學庫內化合物誘導胚胎幹細胞定向分化心肌細胞)公開號:CN101254191,公開日:2008.09.03;

獲獎榮譽

2008年:《缺氧誘導因子-1的表達與泡沫細胞形成的關係》登記為浙江省科學技術成果(登記號:08001090,排名第二);
2007年:科研成果《若干中藥活性成分研究的現代評價體系》由三位院士推薦申報浙江省科學技術獎,獲浙江省科學技術二等獎(排名第一,證書號:0602109-1);
2005年:科研成果《幹細胞體外定向分化為心肌細胞的藥物調控及其套用研究》通過教育部及省級驗收,(排名第一)。

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