研究方向
遺傳學、生物技術、基因工程、動物免疫學、動物傳染病和微生物學；
研究內容
利用我國豐富的生物資源，克隆分離相關功能基因，鑑定其功能活性；以現代分子生物學、生物信息學、結構生物學和分子免疫學等理論為指導，用生物工程技術重組改造其結構，提高其表達產物生物調節活性，研製防治動物傳染性疾病的新型動物抗病基因製劑，研發新型生物製劑控制生物病害和微生物感染，保障和促進動物健康生長，並改善動物營養成分，提高其營養價值。
項目主持情況
先後主持國家級科研項目10餘項、國家自然科學基金4項、省部級科研項目20多項。現主持國家支撐計畫項目1項（生物源毒鼠藥劑的研發與套用，經費：175萬元），四川省科技支撐計畫項目2項（若爾蓋濕地保護的關鍵技術研究與示範，經費：50萬元；甘孜、阿壩種植中藥材生態治沙關鍵技術與示範，經費：300萬元），橫向合作項目1項。作為主研人員參加的國家的國際合作項目1項， 省部級項目3項。
科研成果
2006年以來發表的部分重要學術論文（僅列SCI收錄論文）
(1) Qiang Luo, Qun Sun, Lisa Wu, Zhirong Yang. Structural characterization of an immunoregulatory polysaccharide from the fruiting bodies of Lepista sordida. Carbohydrate Polymers. doi:10.1016/j.carbpol.2011.12.0433. （通訊作者） (2) Fan Luo, Su Feng, Qun Sun, Wenliang Xiang, Jian Zhao, Jie Zhang, Zhirong Yang, srceening for bacteriocin-producing lactic acid bacteria from kurut, a traditional naturally-fermented yak milk from QinghaieTibet plateau. Food Control, 2011, 22:50-53. （通訊作者）
(3) Qiang Luo, Jie Zhang, Liang Yan, Yuanlin Tang, Xiang Ding, Zhirong Yang, and Qun Sun. Composition and Antioxidant Activity of Water-Soluble Polysaccharides from Tuber indicum. Journal of Medicinal Food. 14 (0) 2011, 1–8.
(4) Xiang Ding, Su Feng, Mei Cao, Maotao Li, Jie Tang, Chun-xiao Guo, Jie Zhang,Qun Sun, Zhirong Yang, Jian Zhao. Structure characterization of polysaccharide isolated from the fruiting bodies of Tricholoma matsutake. Carbohydrate Polymers, 2010, 81:942-947.
(5) Yiqing Zhao, Xiaodong Zhang, Kishore Guda, Earl Lawrence, Qun Sun, Toshio Watanabe, Yoichiro Iwakura, Masahide Asano, LanlanWei, Zhirong Yang,Weiping Zheng, Dawn Dawson, JosephWillis, Sanford D. Markowitz, Masanobu Sataked, and Zhenghe Wang. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proceedings of the National Academy of Sciences (PNAS), 2010, 107: 2592-2597.
(6) Wei Wei, Linyong Zheng, Mengyao Yu, Nan Jiang, Zhirong Yang, Xia Luo. Anti-fatigue activity of extract form the submerged fermentation of Ganoderma Lucidum using Radix astragali as substrate. Journal of Animal & Plant Sciences, 2010, 6: 677- 684.
(7) Linyong Zheng, Dinghong Jia, Xiaofan Fei, Xia Luo, Zhirong Yang, An assessment of the genetic diversity within Ganoderma strains with AFLP and ITS PCR-RFLP. Microbiological Research, 2009, 164: 312-321. （通訊作者）
(8) Mengyao Yu, Xiaoyan Xu, Yuan Qing Xia Luo, Zhirong Yang, Linyong Zheng. Isolation of an anti-tumor polysaccharide from Auricularia polytricha (jew’s ear) and its effects on macrophage activation. Eur Food Res Technol, 2009, 228: 477–485.
(9)Mei Zeng Yilu Lu1, Xiaolin Liao1, Dan Li Huaqin Sun1, Suhua Liang Sizhong Zhang1, Yongxin Ma and Zhirong Yang ,DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression MOLECULAR BIOLOGY REPORTS 卷: 36 期: 8 頁: 2009 2399-2403
(10)Hao Chen Chaorong Peng , Yongyi Yao Jingxia Wang Zhuping Chen Zhirong Yang Lijun Xia Siyang Liu ,Preparation and Characterization of poly(L-lactide) Membranes Prepared by gamma-Radiation-Induced Grafting of N-Vinyl Pyrrolidone JOURNAL OF APPLIED POLYMER SCIENCE 5 2009 3152-3157
(11)Jiang LH, Shi Y, Wang LS, Yang ZR ,The influence of orally administered docosahexaenoic acid on cognitive ability in aged mice JOURNAL OF NUTRITIONAL BIOCHEMISTRY 2009 735-741
(12)Chen Q, Cao M, Xiang WL, Sun Q, Zhang J, Hou RT, Yan ZY, Yang ZR, Liu J, Zhao J.,STUDY ON GENES WITH ALTERED EXPRESSION IN alpha-AMANITIN POISONED MICE AND EVALUATION ON ANTAGONISTIC EFFECTS OF TRADITIONAL CHINESE MEDICINES AGAINST TOXICITY OF alpha-AMANITIN ACTA BIOLOGICA HUNGARICA 2009 281-291
(13)Jie Zhang Jian Zhao Daxu Li Sujun Liu1, Li Li Qun Sun1, Ming Huang and Zhirong Yang, Cloning of the gene encoding an insecticidal protein in Pseudomanas pseudoalcaligenes ANNALS OF MICROBIOLOGY 2009 45-50
(14)Huang Min Da-Xu Li Wen-Liang Xiang Chen Hao Jian-Hua Guo Zhao Jian Zhang Jie Zhi-Rong Yang Sun Qun ,
Effect of the untranslated region and signal peptide sequence of the insecticidal gene from Pseudomonas pseudoalcaligenes on the activity of its expression products in tobacco WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2009 619-625
(15)Wenliang Xiang Jianhua Guo Wei Feng Min Huang Hao Chen Jian Zhao Jie Zhang Zhirong Yang1 and Qun Sun,Community of extremely halophilic bacteria in historic Dagong Brine Well in southwestern China WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2008 2297-2305
(16)GUO Jian-Hua ; XIANG Wen-Liang ; ZHAO Qing-Rong ; TAO LUO ; MIN HUANG ; JIE ZHANG ; JIAN ZHAO ; YANG Zhi-Rong ; QUN SUN Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Sichuan Province in China JAPANESE JOURNAL OF INFECTIOUS DISEASES 2008 264-268
(17)Luo X (Luo, Xia) Xu XY Yu MY) Yang ZR Zheng LY ,Characterisation and immunostimulatory activity of an alpha-(1 -> 6)-D-glucan from the cultured Armillariella tabescens mycelia FOOD CHEMISTRY 15 2008 357-363
(18)Zou LK , Wang HN Pan X Tian GB Xie ZW Wu Q Chen H Xie T Yang ZR Expression, purification and characterization of a phyA(m)-phyCs fusion phytase JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE 2008 536-545
(19)Zeng M Sun HQ Chen S Wang XY Yang Y Liu YQ Tao DC Yang ZR Zhang SZMa YX ,Identification of target messenger RNA substrates for mouse RBMY OLECULAR HUMAN REPRODUCTION 2008 331-336
(20)Zhe R Zhang MY Kitazato K Kobayash N Zhu QC Zhang PZ Yang ZR Wang YF , Effect of siRNA on HSV-1 plaque formation and relative expression levels of UL39 mRNA ARCHIVES OF VIROLOGY 2008 1401-1406
Effect of siRNA on HSV-1 plaque formation and relative expression levels of UL39 mRNA
(21)Chen S, Xin Y, Zhan Y, Yang ZR. Synthesis and antimicrobial activities of brominated dihydroxy nitro diphenyl ethers CHINESE JOURNAL OF ORGANIC CHEMISTRY 2008 498-502
(22) Mengyao Yu Bo Ma1, Xia Luo Linyong Zheng Xiaoyan Xu and Zhirong Yang ,Molecular diversity of Auricularia polytricha revealed by inter-simple sequence repeat and sequence-related amplified polymorphism markers CURRENT MICROBIOLOGY
2008 240-245
(23)Hai-Long Sun, Shao-Cai Li Wen-Lan Xiong Zhi-Rong Yang, Bao-Shan Cui and Tao-Yang ,Influence of slope on root system anchorage of Pinus yunnanensis ECOLOGICAL ENGINEERING 3 2008 60-67
(24)鄒燕 吳潔，侯若彤，吳凱群, 王玉良，陳淑華，楊志榮，王玉忠,Study on the synthesis and bactericidal activities of new brominated hydroxy diphenyl ether CHINESE JOURNAL OF ORGANIC CHEMISTRY 2008 111-114
(25)Shu-Lin Zhang, Jian-Guo Shen, Gwan-Han Shen, Zhan-Qiang Sun, Ping-Hui Xu, Yi-Li Peng, Zhi-Rong Yang and Qun Sun ,Use of a novel multiplex probe array for rapid identification of Mycobacterium species from clinical isolates WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2007 1779-1788 出版年:
(26)Zhang SL , Shen JG, Xu PH, Li DX, Sun ZQ, Li L, Yang ZR, Sun Q A novel genotypic test for rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates by a multiplex probe array JOURNAL OF APPLIED MICROBIOLOGY 2007 1262-1271
(27)Jin D, Lu W, Ping SZ, Zhang W, Chen J, Dun BQ, Ma RQ, Zhao ZL, Sha JY, Li L, Yang ZR, Chen M , Lin M ,Identification of a new gene encoding EPSPS with high glyphosate resistance from the metagenomic library CURRENT MICROBIOLOGY 2007350-355
(28)Li SC , Sun HL, Yang ZR, Xiong WL, Cui BS Root anchorage of Vitex negundo L. on rocky slopes under different weathering degrees ECOLOGICAL ENGINEERING 1 2007 27-33
(29)Zhang SL, Qi H (, Qiu DL, Li DX, Zhang J, Du CM, Wang GB, Yang ZR, Sun Q ,Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from Central China BIOCHEMICAL GENETICS 2007281-290
(30)Zhao J, Cao M, Zhang J Yang ZR ,Pathological effects of the mushroom toxin alpha-amanitin on BALB/c mice PEPTIDES 2006 3047-3052
(31)Zhao J , Cao M, Zhang J, Sun Q, Chen Q, Yang ZR ,Cloning and expression of a 5-enolpyruvylshikimate-3-phosphate synthase gene from Halomonas variabilis DNA SEQUENCE 208-214 2006
(32)Jin H, Chen S, Hou RT, Wang YL, Chen SH, Yang ZR Study on the synthesis and antimicrobial activities of brominated dihydroxy diphenyl ethers CHINESE JOURNAL OF ORGANIC CHEMISTRY 2006 1424-1428
(33)Liu SJ, Luo X, Li DX, Zhang J, Qiu DL, Liu W, She LA, Yang ZR, Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC INTERNATIONAL IMMUNOPHARMACOLOGY : 2006 1387-1393
(34)Liu Z, Lu W, Chen M, Yang ZR, Lin M ,Genetic analysis of glyphosate tolerance in Halomonas variabilis strain HTG(7) WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2006 681-686
(35)Li L, Zhang J, Zhu JQ, Gu S, Sun Q, Zhou GM, Fu CX, Li Q, Yang ZR, Genetic diversity of nine populations of the black goat (Capra hircus) in Sichuan, PR china ZOOLOGICAL SCIENCE 2006 229-234 出版年:
(36)Li DX, Zhang J, Zhao J, Zhang Y, Chen F, Zhu JQ, Liu SJ, Yang ZR, Plant regeneration via somatic embryogenesis of Elymus sibiricus cv. 'chuancao No. 2' PLANT CELL TISSUE AND ORGAN CULTURE 2006 285-292
(37) Yi Y, Cao Y, Li Q, Liu M, Cheng L, Bai LH, Yang ZR, Qiao DR, Cloning and sequence analysis of the gene encoding (6-4)photolyase from Dunaliella salina BIOTECHNOLOGY LETTERS 2006 309-314
(38)Ke YP, Sun Q, Yang ZR, Xin JJ, Chen L, Hou XD, Determination of trace cadmium and zinc in corn kernels and related soil samples by atomic absorption and chemical vapor generation atomic fluorescence after microwave-assisted digestion SPECTROSCOPY 2006 29-43
獲獎記錄
在動物免疫學和疫苗（常規疫苗、基因工程重組疫苗和核酸疫苗等）免疫應答研究方面，作為主研人員獲省部級科技進步二等獎4項，省教委科技進步一等獎2項、二等獎1項；主持或主研了國家自然科學基金、國家863計畫、國家重大基礎項目等共10項國家級課題和15項教育部、四川省重點科研課題研究
《雞傳染性法氏囊病的免疫機理》，黑龍江省科技進步二等獎，黑龍江省教委科技進步一等獎，1994年。
《雞馬立克氏病及其疫苗的免疫機理》，黑龍江省科技進步二等獎，黑龍江省教委科技進步一等獎，1996年。
《小日齡火雞新城疫免疫機理研究》，黑龍江省教委科技進步一等獎，1999年。
《豬囊蟲病防治關鍵技術研究》，四川省科技進步二等獎，2000年
專利
已申報國家技術發明專利10項
1)豬白細胞介素－2基因抗感染製劑的製備及套用，申請號：200410040210.X
2)細胞介素－6基因抗感染免疫增強劑的製備和套用，申請號：200410040699.0
3)豬白細胞介素-4、6融合基因抗病製劑，申請號：200410040763.5
4)融合豬免疫基因抗感染納米分子製劑的製備和套用，申請號：200410040749.5
5)CpG DNA分子抗感染免疫製劑的製備和套用，申請號：200410040701.4
6)豬白細胞介素-4基因抗病製劑的製備和使用技術，申請號：200410040700.X
7)CpG寡聚核苷酸抗感染DNA製劑的製備及套用技術，申請號：200410040209.7
8)豬白細胞介素6基因與CpG分子融合抗感染免疫製劑的製備及套用，申請號：200510021954.1
9)複合豬白細胞介素基因抗感染納米分子製劑的製備和套用，申請號：200510021955.6
10)10、新型豬白細胞介素2和6基因表達質粒抗感染製劑的套用技術，申請號：200510021956.0
